1l4v - Revision history

OCA at 08:06, 3 April 2024

OCA — Wed, 03 Apr 2024 08:06:13 GMT

←Older revision		Revision as of 08:06, 3 April 2024
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	==SOLUTION STRUCTURE OF SAPECIN==		==SOLUTION STRUCTURE OF SAPECIN==
-	<StructureSection load='1l4v' size='340' side='right'caption='[[1l4v~~]], [[NMR_Ensembles_of_Models \| 18 NMR models~~]]' scene=''>	+	<StructureSection load='1l4v' size='340' side='right'caption='[[1l4v]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sarcophaga_peregrina Sarcophaga peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sarcophaga_peregrina Sarcophaga peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L4V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4v OCA], [https://pdbe.org/1l4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l4v RCSB], [https://www.ebi.ac.uk/pdbsum/1l4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l4v ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4v OCA], [https://pdbe.org/1l4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l4v RCSB], [https://www.ebi.ac.uk/pdbsum/1l4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l4v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SAPE_SARPE SAPE_SARPE]] Sapecins, which are potent bactericidal proteins, are produced in response to injury. Sapecin is cytotoxic to Gram-positive bacteria, and to a lesser extent against Gram-negative bacteria.	+	[https://www.uniprot.org/uniprot/SAPE_SARPE SAPE_SARPE] Sapecins, which are potent bactericidal proteins, are produced in response to injury. Sapecin is cytotoxic to Gram-positive bacteria, and to a lesser extent against Gram-negative bacteria.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l4v ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l4v ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The solution conformation of an antibacterial protein sapecin has been determined by 1H nuclear magnetic resonance (NMR) and dynamical simulated annealing calculations. It has been shown that the polypeptide fold consists of one flexible loop (residues 4-12), one helix (residues 15-23), and two extended strands (residues 24-31 and 34-40). It was found that the tertiary structure of sapecin is completely different from that of rabbit neutrophil defensin NP-5, which is homologous to sapecin in the amino acid sequences and also has the antibacterial activity. The three-dimensional structure determination has revealed that a basic-residue rich region and the hydrophobic surface face each other on the surface of sapecin.
-
-	1H nuclear magnetic resonance study of the solution conformation of an antibacterial protein, sapecin.,Hanzawa H, Shimada I, Kuzuhara T, Komano H, Kohda D, Inagaki F, Natori S, Arata Y FEBS Lett. 1990 Sep 3;269(2):413-20. PMID:2401368<ref>PMID:2401368</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1l4v" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sarcophaga peregrina]]		[[Category: Sarcophaga peregrina]]
-	[[Category: Arata, Y]]	+	[[Category: Arata Y]]
-	[[Category: Hanzawa, H]]	+	[[Category: Hanzawa H]]
-	[[Category: Inagaki, F]]	+	[[Category: Inagaki F]]
-	[[Category: Iwai, H]]	+	[[Category: Iwai H]]
-	[[Category: Kohda, D]]	+	[[Category: Kohda D]]
-	[[Category: Komano, H]]	+	[[Category: Komano H]]
-	[[Category: Kuzuhara, T]]	+	[[Category: Kuzuhara T]]
-	[[Category: Natori, S]]	+	[[Category: Natori S]]
-	[[Category: Shimada, I]]	+	[[Category: Shimada I]]
-	[[Category: Takeuchi, K]]	+	[[Category: Takeuchi K]]
-	~~[[Category: Antibacterial protein]]~~	+
-	~~[[Category: Antibiotic]]~~	+
-	~~[[Category: Insect defensin~~]]	+

OCA at 08:12, 23 February 2022

OCA — Wed, 23 Feb 2022 08:12:21 GMT

←Older revision		Revision as of 08:12, 23 February 2022
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	<StructureSection load='1l4v' size='340' side='right'caption='[[1l4v]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>		<StructureSection load='1l4v' size='340' side='right'caption='[[1l4v]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Boettcherisca_peregrina Boettcherisca~~ peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sarcophaga_peregrina Sarcophaga peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L4V FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4v OCA], [https://pdbe.org/1l4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l4v RCSB], [https://www.ebi.ac.uk/pdbsum/1l4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l4v ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4v OCA], [https://pdbe.org/1l4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l4v RCSB], [https://www.ebi.ac.uk/pdbsum/1l4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l4v ProSAT]</span></td></tr>
	</table>		</table>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Boettcherisca peregrina]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Sarcophaga peregrina]]
	[[Category: Arata, Y]]		[[Category: Arata, Y]]
	[[Category: Hanzawa, H]]		[[Category: Hanzawa, H]]

OCA at 05:52, 28 April 2021

OCA — Wed, 28 Apr 2021 05:52:21 GMT

←Older revision		Revision as of 05:52, 28 April 2021
Line 3:		Line 3:
	<StructureSection load='1l4v' size='340' side='right'caption='[[1l4v]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>		<StructureSection load='1l4v' size='340' side='right'caption='[[1l4v]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Boettcherisca_peregrina Boettcherisca peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1L4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Boettcherisca_peregrina Boettcherisca peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L4V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4v OCA], [~~http~~://pdbe.org/1l4v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1l4v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1l4v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1l4v ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4v OCA], [https://pdbe.org/1l4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l4v RCSB], [https://www.ebi.ac.uk/pdbsum/1l4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l4v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SAPE_SARPE SAPE_SARPE]] Sapecins, which are potent bactericidal proteins, are produced in response to injury. Sapecin is cytotoxic to Gram-positive bacteria, and to a lesser extent against Gram-negative bacteria.	+	[[https://www.uniprot.org/uniprot/SAPE_SARPE SAPE_SARPE]] Sapecins, which are potent bactericidal proteins, are produced in response to injury. Sapecin is cytotoxic to Gram-positive bacteria, and to a lesser extent against Gram-negative bacteria.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:34, 24 July 2019

OCA — Wed, 24 Jul 2019 09:34:08 GMT

←Older revision		Revision as of 09:34, 24 July 2019
Line 1:		Line 1:

	==SOLUTION STRUCTURE OF SAPECIN==		==SOLUTION STRUCTURE OF SAPECIN==
-	<StructureSection load='1l4v' size='340' side='right' caption='[[1l4v]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>	+	<StructureSection load='1l4v' size='340' side='right'caption='[[1l4v]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Boettcherisca_peregrina Boettcherisca peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Boettcherisca_peregrina Boettcherisca peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L4V FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l4/1l4v_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l4/1l4v_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Boettcherisca peregrina]]		[[Category: Boettcherisca peregrina]]
		+	[[Category: Large Structures]]
	[[Category: Arata, Y]]		[[Category: Arata, Y]]
	[[Category: Hanzawa, H]]		[[Category: Hanzawa, H]]

OCA at 10:51, 18 October 2017

OCA — Wed, 18 Oct 2017 10:51:25 GMT

←Older revision		Revision as of 10:51, 18 October 2017
Line 1:		Line 1:
		+
	==SOLUTION STRUCTURE OF SAPECIN==		==SOLUTION STRUCTURE OF SAPECIN==
	<StructureSection load='1l4v' size='340' side='right' caption='[[1l4v]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>		<StructureSection load='1l4v' size='340' side='right' caption='[[1l4v]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sarcophaga_peregrina Sarcophaga~~ peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Boettcherisca_peregrina Boettcherisca peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L4V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4v OCA], [http://pdbe.org/1l4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l4v RCSB], [http://www.ebi.ac.uk/pdbsum/1l4v PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4v OCA], [http://pdbe.org/1l4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l4v RCSB], [http://www.ebi.ac.uk/pdbsum/1l4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l4v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l4v ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Sarcophaga~~ peregrina]]	+	[[Category: Boettcherisca peregrina]]
	[[Category: Arata, Y]]		[[Category: Arata, Y]]
	[[Category: Hanzawa, H]]		[[Category: Hanzawa, H]]

OCA at 15:37, 11 September 2015

OCA — Fri, 11 Sep 2015 15:37:08 GMT

←Older revision		Revision as of 15:37, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarcophaga_peregrina Sarcophaga peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarcophaga_peregrina Sarcophaga peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L4V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l4v RCSB], [http://www.ebi.ac.uk/pdbsum/1l4v PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4v OCA], [http://pdbe.org/1l4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l4v RCSB], [http://www.ebi.ac.uk/pdbsum/1l4v PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1l4v" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:29, 25 December 2014

OCA — Thu, 25 Dec 2014 18:29:04 GMT

←Older revision		Revision as of 18:29, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarcophaga_peregrina Sarcophaga peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarcophaga_peregrina Sarcophaga peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L4V FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l4v RCSB], [http://www.ebi.ac.uk/pdbsum/1l4v PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l4v RCSB], [http://www.ebi.ac.uk/pdbsum/1l4v PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SAPE_SARPE SAPE_SARPE]] Sapecins, which are potent bactericidal proteins, are produced in response to injury. Sapecin is cytotoxic to Gram-positive bacteria, and to a lesser extent against Gram-negative bacteria.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Sarcophaga peregrina]]		[[Category: Sarcophaga peregrina]]
-	[[Category: Arata, Y.]]	+	[[Category: Arata, Y]]
-	[[Category: Hanzawa, H.]]	+	[[Category: Hanzawa, H]]
-	[[Category: Inagaki, F.]]	+	[[Category: Inagaki, F]]
-	[[Category: Iwai, H.]]	+	[[Category: Iwai, H]]
-	[[Category: Kohda, D.]]	+	[[Category: Kohda, D]]
-	[[Category: Komano, H.]]	+	[[Category: Komano, H]]
-	[[Category: Kuzuhara, T.]]	+	[[Category: Kuzuhara, T]]
-	[[Category: Natori, S.]]	+	[[Category: Natori, S]]
-	[[Category: Shimada, I.]]	+	[[Category: Shimada, I]]
-	[[Category: Takeuchi, K.]]	+	[[Category: Takeuchi, K]]
	[[Category: Antibacterial protein]]		[[Category: Antibacterial protein]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
	[[Category: Insect defensin]]		[[Category: Insect defensin]]

OCA at 17:25, 28 September 2014

OCA — Sun, 28 Sep 2014 17:25:50 GMT

←Older revision		Revision as of 17:25, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1l4v.~~png\|left~~\|200px]]	+	==SOLUTION STRUCTURE OF SAPECIN==
		+	<StructureSection load='1l4v' size='340' side='right' caption='[[1l4v]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarcophaga_peregrina Sarcophaga peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L4V FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l4v RCSB], [http://www.ebi.ac.uk/pdbsum/1l4v PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l4/1l4v_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The solution conformation of an antibacterial protein sapecin has been determined by 1H nuclear magnetic resonance (NMR) and dynamical simulated annealing calculations. It has been shown that the polypeptide fold consists of one flexible loop (residues 4-12), one helix (residues 15-23), and two extended strands (residues 24-31 and 34-40). It was found that the tertiary structure of sapecin is completely different from that of rabbit neutrophil defensin NP-5, which is homologous to sapecin in the amino acid sequences and also has the antibacterial activity. The three-dimensional structure determination has revealed that a basic-residue rich region and the hydrophobic surface face each other on the surface of sapecin.

-	~~{{STRUCTURE_1l4v\| PDB=1l4v \| SCENE= }}~~	+	1H nuclear magnetic resonance study of the solution conformation of an antibacterial protein, sapecin.,Hanzawa H, Shimada I, Kuzuhara T, Komano H, Kohda D, Inagaki F, Natori S, Arata Y FEBS Lett. 1990 Sep 3;269(2):413-20. PMID:2401368<ref>PMID:2401368</ref>

-	~~===SOLUTION STRUCTURE OF SAPECIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_2401368}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1l4v]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sarcophaga_peregrina Sarcophaga peregrina]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:002401368<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Sarcophaga peregrina]]		[[Category: Sarcophaga peregrina]]
	[[Category: Arata, Y.]]		[[Category: Arata, Y.]]

OCA: Protected "1l4v" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 20:23:10 GMT

Protected "1l4v" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:23, 5 December 2012

OCA at 20:23, 5 December 2012

OCA — Wed, 05 Dec 2012 20:23:08 GMT

←Older revision		Revision as of 20:23, 5 December 2012
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-	{{Seed}}
	[[Image:1l4v.png\|left\|200px]]		[[Image:1l4v.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1l4v", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1l4v\| PDB=1l4v \| SCENE= }}		{{STRUCTURE_1l4v\| PDB=1l4v \| SCENE= }}

	===SOLUTION STRUCTURE OF SAPECIN===		===SOLUTION STRUCTURE OF SAPECIN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_2401368}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 2401368 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_2401368}}		{{ABSTRACT_PUBMED_2401368}}

	==About this Structure==		==About this Structure==
-	~~1L4V~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sarcophaga_peregrina Sarcophaga peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA].	+	[[1l4v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarcophaga_peregrina Sarcophaga peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~2401368~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:002401368</ref><references group="xtra"/>
	[[Category: Sarcophaga peregrina]]		[[Category: Sarcophaga peregrina]]
	[[Category: Arata, Y.]]		[[Category: Arata, Y.]]
Line 35:		Line 23:
	[[Category: Shimada, I.]]		[[Category: Shimada, I.]]
	[[Category: Takeuchi, K.]]		[[Category: Takeuchi, K.]]
-	[[Category: Antibacterial protein~~,insect defensin~~]]	+	[[Category: Antibacterial protein]]
-		+	[[Category: Antibiotic]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 02~~:~~29:16 2009''~~	+	[[Category: Insect defensin]]