1l6o - Revision history

OCA at 08:06, 3 April 2024

OCA — Wed, 03 Apr 2024 08:06:45 GMT

←Older revision		Revision as of 08:06, 3 April 2024
Line 3:		Line 3:
	<StructureSection load='1l6o' size='340' side='right'caption='[[1l6o]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1l6o' size='340' side='right'caption='[[1l6o]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l6o]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~African_clawed_frog African clawed frog~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L6O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l6o]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L6O FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non~~-~~Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l6o OCA], [https://pdbe.org/1l6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l6o RCSB], [https://www.ebi.ac.uk/pdbsum/1l6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l6o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l6o OCA], [https://pdbe.org/1l6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l6o RCSB], [https://www.ebi.ac.uk/pdbsum/1l6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l6o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DVL2_XENLA DVL2_XENLA]] Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta-catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin-related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along the A/P axis in a dose-dependent manner by activating several early patterning genes. In the PCP pathway, required at the cell membrane for PCP-mediated neural and mesodermal convergent extension during gastrulation and subsequent neural tube closure, acting to activate jnk. Also involved in blastopore closure and archenteron elongation during early, but not late, gastrulation. Associates with ephrin receptors and ligands and acts as part of a downstream PCP pathway to mediate ephrin-mediated cell repulsion via activation of rhoa. Required for efnb1/ephrin-B1-driven movement of non-retinal progenitor cells into the retina during eye field formation. Patterns the hindbrain. Required for ciliogenesis. Controls the docking of basal bodies to the apical plasma membrane; mediates the activation, but not localization of rhoa at the apical surface of ciliated cells during basal body docking. Furthermore, required for the association of basal bodies with membrane-bound vesicles and the vesicle-trafficking protein exoc4/sec8, and this association is in turn required for basal body docking. Once basal bodies are docked, required for the planar polarization of basal bodies that underlies ciliary beating and the directional fluid flow across ciliated epithelia.<ref>PMID:7600981</ref> <ref>PMID:8939601</ref> <ref>PMID:9076682</ref> <ref>PMID:10427095</ref> <ref>PMID:10688669</ref> <ref>PMID:10811222</ref> <ref>PMID:11493574</ref> <ref>PMID:12421719</ref> <ref>PMID:11941372</ref> <ref>PMID:12574121</ref> <ref>PMID:15548584</ref> <ref>PMID:15936275</ref> <ref>PMID:16026968</ref> <ref>PMID:15677333</ref> <ref>PMID:16362052</ref> <ref>PMID:18552847</ref> <ref>PMID:11970895</ref>	+	[https://www.uniprot.org/uniprot/DVL2_XENLA DVL2_XENLA] Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta-catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin-related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along the A/P axis in a dose-dependent manner by activating several early patterning genes. In the PCP pathway, required at the cell membrane for PCP-mediated neural and mesodermal convergent extension during gastrulation and subsequent neural tube closure, acting to activate jnk. Also involved in blastopore closure and archenteron elongation during early, but not late, gastrulation. Associates with ephrin receptors and ligands and acts as part of a downstream PCP pathway to mediate ephrin-mediated cell repulsion via activation of rhoa. Required for efnb1/ephrin-B1-driven movement of non-retinal progenitor cells into the retina during eye field formation. Patterns the hindbrain. Required for ciliogenesis. Controls the docking of basal bodies to the apical plasma membrane; mediates the activation, but not localization of rhoa at the apical surface of ciliated cells during basal body docking. Furthermore, required for the association of basal bodies with membrane-bound vesicles and the vesicle-trafficking protein exoc4/sec8, and this association is in turn required for basal body docking. Once basal bodies are docked, required for the planar polarization of basal bodies that underlies ciliary beating and the directional fluid flow across ciliated epithelia.<ref>PMID:7600981</ref> <ref>PMID:8939601</ref> <ref>PMID:9076682</ref> <ref>PMID:10427095</ref> <ref>PMID:10688669</ref> <ref>PMID:10811222</ref> <ref>PMID:11493574</ref> <ref>PMID:12421719</ref> <ref>PMID:11941372</ref> <ref>PMID:12574121</ref> <ref>PMID:15548584</ref> <ref>PMID:15936275</ref> <ref>PMID:16026968</ref> <ref>PMID:15677333</ref> <ref>PMID:16362052</ref> <ref>PMID:18552847</ref> <ref>PMID:11970895</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l6o ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l6o ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Dapper was isolated in a screen for proteins interacting with Dishevelled, a key factor in Wnt signaling. Dapper and Dishevelled colocalize intracellularly and form a complex with Axin, GSK-3, CKI, and beta-catenin. Overexpression of Dapper increases Axin and GSK-3 in this complex, resulting in decreased soluble beta-catenin and decreased activation of beta-catenin-responsive genes. Dapper also inhibits activation by Dishevelled of c-Jun N-terminal kinase (JNK), a component of beta-catenin-independent Frizzled signaling. Inhibition of Dapper activates both beta-catenin-responsive genes and an AP1-responsive promoter, demonstrating that Dapper is a general Dishevelled antagonist. Depletion of maternal Dapper RNA from Xenopus embryos results in loss of notochord and head structures, demonstrating that Dapper is required for normal vertebrate development.
-
-	Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation.,Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, Fox EP, Earnest T, Moon RT Dev Cell. 2002 Apr;2(4):449-61. PMID:11970895<ref>PMID:11970895</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1l6o" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: African clawed frog]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cheyette~~, B N.R~~]]	+	[[Category: Xenopus laevis]]
-	[[Category: Earnest, T]]	+	[[Category: Cheyette BNR]]
-	[[Category: Fox~~, E P~~]]	+	[[Category: Earnest T]]
-	[[Category: Khlebtsova, N]]	+	[[Category: Fox EP]]
-	[[Category: Miller~~, J R~~]]	+	[[Category: Khlebtsova N]]
-	[[Category: Moon~~, R T~~]]	+	[[Category: Miller JR]]
-	[[Category: Sheldahl~~, L C~~]]	+	[[Category: Moon RT]]
-	[[Category: Takemaru, K I]]	+	[[Category: Sheldahl LC]]
-	[[Category: Waxman~~, J S]]~~	+	[[Category: Takemaru K-I]]
-	~~[[Category: Dishevelled]]~~	+	[[Category: Waxman JS]]
-	~~[[Category: Gene regulation]]~~	+
-	~~[[Category: Molecular recognition]]~~	+
-	~~[[Category: Pdz]]~~	+
-	~~[[Category: Wnt pathway~~]]	+

OCA at 05:52, 28 April 2021

OCA — Wed, 28 Apr 2021 05:52:38 GMT

←Older revision		Revision as of 05:52, 28 April 2021
Line 3:		Line 3:
	<StructureSection load='1l6o' size='340' side='right'caption='[[1l6o]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1l6o' size='340' side='right'caption='[[1l6o]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l6o]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1L6O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l6o]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L6O FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1l6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l6o OCA], [~~http~~://pdbe.org/1l6o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1l6o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1l6o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1l6o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l6o OCA], [https://pdbe.org/1l6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l6o RCSB], [https://www.ebi.ac.uk/pdbsum/1l6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l6o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DVL2_XENLA DVL2_XENLA]] Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta-catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin-related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along the A/P axis in a dose-dependent manner by activating several early patterning genes. In the PCP pathway, required at the cell membrane for PCP-mediated neural and mesodermal convergent extension during gastrulation and subsequent neural tube closure, acting to activate jnk. Also involved in blastopore closure and archenteron elongation during early, but not late, gastrulation. Associates with ephrin receptors and ligands and acts as part of a downstream PCP pathway to mediate ephrin-mediated cell repulsion via activation of rhoa. Required for efnb1/ephrin-B1-driven movement of non-retinal progenitor cells into the retina during eye field formation. Patterns the hindbrain. Required for ciliogenesis. Controls the docking of basal bodies to the apical plasma membrane; mediates the activation, but not localization of rhoa at the apical surface of ciliated cells during basal body docking. Furthermore, required for the association of basal bodies with membrane-bound vesicles and the vesicle-trafficking protein exoc4/sec8, and this association is in turn required for basal body docking. Once basal bodies are docked, required for the planar polarization of basal bodies that underlies ciliary beating and the directional fluid flow across ciliated epithelia.<ref>PMID:7600981</ref> <ref>PMID:8939601</ref> <ref>PMID:9076682</ref> <ref>PMID:10427095</ref> <ref>PMID:10688669</ref> <ref>PMID:10811222</ref> <ref>PMID:11493574</ref> <ref>PMID:12421719</ref> <ref>PMID:11941372</ref> <ref>PMID:12574121</ref> <ref>PMID:15548584</ref> <ref>PMID:15936275</ref> <ref>PMID:16026968</ref> <ref>PMID:15677333</ref> <ref>PMID:16362052</ref> <ref>PMID:18552847</ref> <ref>PMID:11970895</ref>	+	[[https://www.uniprot.org/uniprot/DVL2_XENLA DVL2_XENLA]] Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta-catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin-related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along the A/P axis in a dose-dependent manner by activating several early patterning genes. In the PCP pathway, required at the cell membrane for PCP-mediated neural and mesodermal convergent extension during gastrulation and subsequent neural tube closure, acting to activate jnk. Also involved in blastopore closure and archenteron elongation during early, but not late, gastrulation. Associates with ephrin receptors and ligands and acts as part of a downstream PCP pathway to mediate ephrin-mediated cell repulsion via activation of rhoa. Required for efnb1/ephrin-B1-driven movement of non-retinal progenitor cells into the retina during eye field formation. Patterns the hindbrain. Required for ciliogenesis. Controls the docking of basal bodies to the apical plasma membrane; mediates the activation, but not localization of rhoa at the apical surface of ciliated cells during basal body docking. Furthermore, required for the association of basal bodies with membrane-bound vesicles and the vesicle-trafficking protein exoc4/sec8, and this association is in turn required for basal body docking. Once basal bodies are docked, required for the planar polarization of basal bodies that underlies ciliary beating and the directional fluid flow across ciliated epithelia.<ref>PMID:7600981</ref> <ref>PMID:8939601</ref> <ref>PMID:9076682</ref> <ref>PMID:10427095</ref> <ref>PMID:10688669</ref> <ref>PMID:10811222</ref> <ref>PMID:11493574</ref> <ref>PMID:12421719</ref> <ref>PMID:11941372</ref> <ref>PMID:12574121</ref> <ref>PMID:15548584</ref> <ref>PMID:15936275</ref> <ref>PMID:16026968</ref> <ref>PMID:15677333</ref> <ref>PMID:16362052</ref> <ref>PMID:18552847</ref> <ref>PMID:11970895</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:30, 24 July 2019

OCA — Wed, 24 Jul 2019 09:30:38 GMT

←Older revision		Revision as of 09:30, 24 July 2019
Line 1:		Line 1:

	==XENOPUS DISHEVELLED PDZ DOMAIN==		==XENOPUS DISHEVELLED PDZ DOMAIN==
-	<StructureSection load='1l6o' size='340' side='right' caption='[[1l6o]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1l6o' size='340' side='right'caption='[[1l6o]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l6o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L6O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l6o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L6O FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l6/1l6o_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l6/1l6o_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: African clawed frog]]		[[Category: African clawed frog]]
		+	[[Category: Large Structures]]
	[[Category: Cheyette, B N.R]]		[[Category: Cheyette, B N.R]]
	[[Category: Earnest, T]]		[[Category: Earnest, T]]

OCA at 10:44, 18 October 2017

OCA — Wed, 18 Oct 2017 10:44:38 GMT

←Older revision		Revision as of 10:44, 18 October 2017
Line 1:		Line 1:
		+
	==XENOPUS DISHEVELLED PDZ DOMAIN==		==XENOPUS DISHEVELLED PDZ DOMAIN==
	<StructureSection load='1l6o' size='340' side='right' caption='[[1l6o]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1l6o' size='340' side='right' caption='[[1l6o]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1l6o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L6O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l6o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L6O FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l6o OCA], [http://pdbe.org/1l6o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l6o RCSB], [http://www.ebi.ac.uk/pdbsum/1l6o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l6o OCA], [http://pdbe.org/1l6o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l6o RCSB], [http://www.ebi.ac.uk/pdbsum/1l6o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l6o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l6o ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:11, 12 September 2015

OCA — Sat, 12 Sep 2015 00:11:23 GMT

←Older revision		Revision as of 00:11, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1l6o' size='340' side='right' caption='[[1l6o]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1l6o' size='340' side='right' caption='[[1l6o]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l6o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Xenopus_laevis Xenopus laevis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L6O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l6o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L6O FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l6o RCSB], [http://www.ebi.ac.uk/pdbsum/1l6o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l6o OCA], [http://pdbe.org/1l6o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l6o RCSB], [http://www.ebi.ac.uk/pdbsum/1l6o PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1l6o" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Xenopus laevis~~]]	+	[[Category: African clawed frog]]
	[[Category: Cheyette, B N.R]]		[[Category: Cheyette, B N.R]]
	[[Category: Earnest, T]]		[[Category: Earnest, T]]

OCA at 21:14, 25 December 2014

OCA — Thu, 25 Dec 2014 21:14:34 GMT

←Older revision		Revision as of 21:14, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l6o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L6O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l6o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L6O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l6o RCSB], [http://www.ebi.ac.uk/pdbsum/1l6o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l6o RCSB], [http://www.ebi.ac.uk/pdbsum/1l6o PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DVL2_XENLA DVL2_XENLA]] Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta-catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin-related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along the A/P axis in a dose-dependent manner by activating several early patterning genes. In the PCP pathway, required at the cell membrane for PCP-mediated neural and mesodermal convergent extension during gastrulation and subsequent neural tube closure, acting to activate jnk. Also involved in blastopore closure and archenteron elongation during early, but not late, gastrulation. Associates with ephrin receptors and ligands and acts as part of a downstream PCP pathway to mediate ephrin-mediated cell repulsion via activation of rhoa. Required for efnb1/ephrin-B1-driven movement of non-retinal progenitor cells into the retina during eye field formation. Patterns the hindbrain. Required for ciliogenesis. Controls the docking of basal bodies to the apical plasma membrane; mediates the activation, but not localization of rhoa at the apical surface of ciliated cells during basal body docking. Furthermore, required for the association of basal bodies with membrane-bound vesicles and the vesicle-trafficking protein exoc4/sec8, and this association is in turn required for basal body docking. Once basal bodies are docked, required for the planar polarization of basal bodies that underlies ciliary beating and the directional fluid flow across ciliated epithelia.<ref>PMID:7600981</ref> <ref>PMID:8939601</ref> <ref>PMID:9076682</ref> <ref>PMID:10427095</ref> <ref>PMID:10688669</ref> <ref>PMID:10811222</ref> <ref>PMID:11493574</ref> <ref>PMID:12421719</ref> <ref>PMID:11941372</ref> <ref>PMID:12574121</ref> <ref>PMID:15548584</ref> <ref>PMID:15936275</ref> <ref>PMID:16026968</ref> <ref>PMID:15677333</ref> <ref>PMID:16362052</ref> <ref>PMID:18552847</ref> <ref>PMID:11970895</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Xenopus laevis]]		[[Category: Xenopus laevis]]
-	[[Category: Cheyette, B N.R.]]	+	[[Category: Cheyette, B N.R]]
-	[[Category: Earnest, T.]]	+	[[Category: Earnest, T]]
-	[[Category: Fox, E P.]]	+	[[Category: Fox, E P]]
-	[[Category: Khlebtsova, N.]]	+	[[Category: Khlebtsova, N]]
-	[[Category: Miller, J R.]]	+	[[Category: Miller, J R]]
-	[[Category: Moon, R T.]]	+	[[Category: Moon, R T]]
-	[[Category: Sheldahl, L C.]]	+	[[Category: Sheldahl, L C]]
-	[[Category: Takemaru, K I.]]	+	[[Category: Takemaru, K I]]
-	[[Category: Waxman, J S.]]	+	[[Category: Waxman, J S]]
	[[Category: Dishevelled]]		[[Category: Dishevelled]]
	[[Category: Gene regulation]]		[[Category: Gene regulation]]

OCA at 15:45, 28 September 2014

OCA — Sun, 28 Sep 2014 15:45:28 GMT

←Older revision		Revision as of 15:45, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1l6o.~~png\|left~~\|200px]]	+	==XENOPUS DISHEVELLED PDZ DOMAIN==
		+	<StructureSection load='1l6o' size='340' side='right' caption='[[1l6o]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1l6o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L6O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l6o RCSB], [http://www.ebi.ac.uk/pdbsum/1l6o PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l6/1l6o_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dapper was isolated in a screen for proteins interacting with Dishevelled, a key factor in Wnt signaling. Dapper and Dishevelled colocalize intracellularly and form a complex with Axin, GSK-3, CKI, and beta-catenin. Overexpression of Dapper increases Axin and GSK-3 in this complex, resulting in decreased soluble beta-catenin and decreased activation of beta-catenin-responsive genes. Dapper also inhibits activation by Dishevelled of c-Jun N-terminal kinase (JNK), a component of beta-catenin-independent Frizzled signaling. Inhibition of Dapper activates both beta-catenin-responsive genes and an AP1-responsive promoter, demonstrating that Dapper is a general Dishevelled antagonist. Depletion of maternal Dapper RNA from Xenopus embryos results in loss of notochord and head structures, demonstrating that Dapper is required for normal vertebrate development.

-	~~{{STRUCTURE_1l6o\| PDB=1l6o \| SCENE= }}~~	+	Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation.,Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, Fox EP, Earnest T, Moon RT Dev Cell. 2002 Apr;2(4):449-61. PMID:11970895<ref>PMID:11970895</ref>

-	~~===XENOPUS DISHEVELLED PDZ DOMAIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11970895}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1l6o]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Xenopus_laevis Xenopus laevis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011970895<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Xenopus laevis]]		[[Category: Xenopus laevis]]
	[[Category: Cheyette, B N.R.]]		[[Category: Cheyette, B N.R.]]

OCA: Protected "1l6o" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 20:18:49 GMT

Protected "1l6o" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:18, 5 December 2012

OCA at 20:18, 5 December 2012

OCA — Wed, 05 Dec 2012 20:18:46 GMT

←Older revision		Revision as of 20:18, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1l6o.png\|left\|200px]]		[[Image:1l6o.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1l6o", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1l6o\| PDB=1l6o \| SCENE= }}		{{STRUCTURE_1l6o\| PDB=1l6o \| SCENE= }}

	===XENOPUS DISHEVELLED PDZ DOMAIN===		===XENOPUS DISHEVELLED PDZ DOMAIN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11970895}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11970895 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11970895}}		{{ABSTRACT_PUBMED_11970895}}

	==About this Structure==		==About this Structure==
-	~~1L6O~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA].	+	[[1l6o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11970895~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011970895</ref><references group="xtra"/>
	[[Category: Xenopus laevis]]		[[Category: Xenopus laevis]]
	[[Category: Cheyette, B N.R.]]		[[Category: Cheyette, B N.R.]]
Line 35:		Line 23:
	[[Category: Waxman, J S.]]		[[Category: Waxman, J S.]]
	[[Category: Dishevelled]]		[[Category: Dishevelled]]
		+	[[Category: Gene regulation]]
	[[Category: Molecular recognition]]		[[Category: Molecular recognition]]
	[[Category: Pdz]]		[[Category: Pdz]]
	[[Category: Wnt pathway]]		[[Category: Wnt pathway]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:49:13 2009''

OCA at 05:49, 18 February 2009

OCA — Wed, 18 Feb 2009 05:49:16 GMT

←Older revision		Revision as of 05:49, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1L6O is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA].	+	1L6O is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA].

	==Reference==		==Reference==
-	Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation., Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, Fox EP, Earnest T, Moon RT, Dev Cell. 2002 Apr;2(4):449-61. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11970895 11970895]~~	+	<ref group="xtra">PMID:11970895</ref><references group="xtra"/>
-	~~[[Category: Protein complex]]~~	+
	[[Category: Xenopus laevis]]		[[Category: Xenopus laevis]]
	[[Category: Cheyette, B N.R.]]		[[Category: Cheyette, B N.R.]]
Line 40:		Line 39:
	[[Category: Wnt pathway]]		[[Category: Wnt pathway]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 2 11~~:49:~~11 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:49:13 2009''