1l8x - Revision history

OCA at 09:10, 16 August 2023

OCA — Wed, 16 Aug 2023 09:10:59 GMT

←Older revision		Revision as of 09:10, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1l8x' size='340' side='right'caption='[[1l8x]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1l8x' size='340' side='right'caption='[[1l8x]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l8x]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1L8X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l8x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L8X FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>HEMZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~4932 ATCC 18824])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8x OCA], [https://pdbe.org/1l8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l8x RCSB], [https://www.ebi.ac.uk/pdbsum/1l8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8x ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1l8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8x OCA], [~~http~~://pdbe.org/1l8x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1l8x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1l8x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8x ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HEMH_YEAST HEMH_YEAST]] Catalyzes the ferrous insertion into protoporphyrin IX.[HAMAP-Rule:MF_00323]	+	[https://www.uniprot.org/uniprot/HEMH_YEAST HEMH_YEAST] Catalyzes the ferrous insertion into protoporphyrin IX.[HAMAP-Rule:MF_00323]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
-	[[Category: Ferrochelatase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Al-Karadaghi, S]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Gora, M]]	+	[[Category: Al-Karadaghi S]]
-	[[Category: Hansson, M]]	+	[[Category: Gora M]]
-	[[Category: Karlberg, T]]	+	[[Category: Hansson M]]
-	[[Category: Labbe-Bois, R]]	+	[[Category: Karlberg T]]
-	[[Category: Lecerof, D]]	+	[[Category: Labbe-Bois R]]
-	[[Category: Silvegren, G]]	+	[[Category: Lecerof D]]
-	~~[[Category: Cobalt]]~~	+	[[Category: Silvegren G]]
-	~~[[Category: Ferro-lyase]]~~	+
-	~~[[Category: Heme biosynthesis]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Mitochondrial inner membrane protein]]~~	+
-	~~[[Category: Porphyrin metallation]]~~	+
-	~~[[Category: Protoheme~~]]	+

OCA at 07:56, 25 November 2020

OCA — Wed, 25 Nov 2020 07:56:29 GMT

←Older revision		Revision as of 07:56, 25 November 2020
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	==Crystal Structure of Ferrochelatase from the Yeast, Saccharomyces cerevisiae, with Cobalt(II) as the Substrate Ion==		==Crystal Structure of Ferrochelatase from the Yeast, Saccharomyces cerevisiae, with Cobalt(II) as the Substrate Ion==
-	<StructureSection load='1l8x' size='340' side='right' caption='[[1l8x]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='1l8x' size='340' side='right'caption='[[1l8x]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l8x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8X OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1L8X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l8x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8X OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1L8X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HEMZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HEMZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1l8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8x OCA], [http://pdbe.org/1l8x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l8x RCSB], [http://www.ebi.ac.uk/pdbsum/1l8x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8x ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1l8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8x OCA], [http://pdbe.org/1l8x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l8x RCSB], [http://www.ebi.ac.uk/pdbsum/1l8x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/1l8x_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/1l8x_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1l8x" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1l8x" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ferrochelatase 3D structures\|Ferrochelatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
	[[Category: Ferrochelatase]]		[[Category: Ferrochelatase]]
		+	[[Category: Large Structures]]
	[[Category: Al-Karadaghi, S]]		[[Category: Al-Karadaghi, S]]
	[[Category: Gora, M]]		[[Category: Gora, M]]

OCA at 09:51, 12 October 2017

OCA — Thu, 12 Oct 2017 09:51:26 GMT

←Older revision		Revision as of 09:51, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Ferrochelatase from the Yeast, Saccharomyces cerevisiae, with Cobalt(II) as the Substrate Ion==		==Crystal Structure of Ferrochelatase from the Yeast, Saccharomyces cerevisiae, with Cobalt(II) as the Substrate Ion==
	<StructureSection load='1l8x' size='340' side='right' caption='[[1l8x]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1l8x' size='340' side='right' caption='[[1l8x]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HEMZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HEMZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8x OCA], [http://pdbe.org/1l8x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l8x RCSB], [http://www.ebi.ac.uk/pdbsum/1l8x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8x OCA], [http://pdbe.org/1l8x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l8x RCSB], [http://www.ebi.ac.uk/pdbsum/1l8x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1l8x" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1l8x" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ferrochelatase\|Ferrochelatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:52, 7 February 2016

OCA — Sun, 07 Feb 2016 11:52:03 GMT

←Older revision		Revision as of 11:52, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l8x ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:14, 10 September 2015

OCA — Thu, 10 Sep 2015 01:14:09 GMT

←Older revision		Revision as of 01:14, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1l8x' size='340' side='right' caption='[[1l8x]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1l8x' size='340' side='right' caption='[[1l8x]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l8x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L8X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l8x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L8X FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HEMZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HEMZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l8x RCSB], [http://www.ebi.ac.uk/pdbsum/1l8x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8x OCA], [http://pdbe.org/1l8x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l8x RCSB], [http://www.ebi.ac.uk/pdbsum/1l8x PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1l8x" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
	[[Category: Ferrochelatase]]		[[Category: Ferrochelatase]]
-	[[Category: Saccharomyces cerevisiae]]
	[[Category: Al-Karadaghi, S]]		[[Category: Al-Karadaghi, S]]
	[[Category: Gora, M]]		[[Category: Gora, M]]

OCA at 14:52, 24 December 2014

OCA — Wed, 24 Dec 2014 14:52:29 GMT

←Older revision		Revision as of 14:52, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l8x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L8X FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l8x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L8X FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HEMZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HEMZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l8x RCSB], [http://www.ebi.ac.uk/pdbsum/1l8x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l8x RCSB], [http://www.ebi.ac.uk/pdbsum/1l8x PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HEMH_YEAST HEMH_YEAST]] Catalyzes the ferrous insertion into protoporphyrin IX.[HAMAP-Rule:MF_00323]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Ferrochelatase]]		[[Category: Ferrochelatase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Al-Karadaghi, S.]]	+	[[Category: Al-Karadaghi, S]]
-	[[Category: Gora, M.]]	+	[[Category: Gora, M]]
-	[[Category: Hansson, M.]]	+	[[Category: Hansson, M]]
-	[[Category: Karlberg, T.]]	+	[[Category: Karlberg, T]]
-	[[Category: Labbe-Bois, R.]]	+	[[Category: Labbe-Bois, R]]
-	[[Category: Lecerof, D.]]	+	[[Category: Lecerof, D]]
-	[[Category: Silvegren, G.]]	+	[[Category: Silvegren, G]]
	[[Category: Cobalt]]		[[Category: Cobalt]]
	[[Category: Ferro-lyase]]		[[Category: Ferro-lyase]]
-	[[Category: Ferrochelatase]]
	[[Category: Heme biosynthesis]]		[[Category: Heme biosynthesis]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA at 15:48, 28 September 2014

OCA — Sun, 28 Sep 2014 15:48:26 GMT

←Older revision		Revision as of 15:48, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1l8x.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Ferrochelatase from the Yeast, Saccharomyces cerevisiae, with Cobalt(II) as the Substrate Ion==
		+	<StructureSection load='1l8x' size='340' side='right' caption='[[1l8x]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1l8x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L8X FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HEMZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l8x RCSB], [http://www.ebi.ac.uk/pdbsum/1l8x PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/1l8x_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ferrochelatase is the terminal enzyme in the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into protoporphyrin IX to produce protoheme IX. The crystal structures of ferrochelatase from Saccharomyces cerevisiae in free form, in complex with Co(II), a substrate metal ion, and in complex with two inhibitors, Cd(II) and Hg(I), are presented in this work. The enzyme is a homodimer, with clear asymmetry between the monomers with regard to the porphyrin binding cleft and the mode of metal binding. The Co(II) and Cd(II) complexes reveal the metal binding site which consists of the invariant amino acids H235, E314, and S275 and solvent molecules. The shortest distance to the metal reveals that amino acid H235 is the primary metal binding residue. A second site with bound Cd(II) was found close to the surface of the molecule, approximately 14 A from H235, with E97, H317, and E326 participating in metal coordination. It is suggested that this site corresponds to the magnesium binding site in Bacillus subtilis ferrochelatase. The latter site is also located at the surface of the molecule and thought to be involved in initial metal binding and regulation.

-	~~{{STRUCTURE_1l8x\| PDB=1l8x \| SCENE= }}~~	+	Metal binding to Saccharomyces cerevisiae ferrochelatase.,Karlberg T, Lecerof D, Gora M, Silvegren G, Labbe-Bois R, Hansson M, Al-Karadaghi S Biochemistry. 2002 Nov 19;41(46):13499-506. PMID:12427010<ref>PMID:12427010</ref>

-	~~===Crystal Structure~~ of ~~Ferrochelatase from~~ the ~~Yeast, Saccharomyces cerevisiae, with Cobalt(II) as the Substrate Ion===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_12427010}}~~	+	==See Also==
-		+	*[[Ferrochelatase\|Ferrochelatase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1l8x~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8X OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:012427010<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Ferrochelatase]]		[[Category: Ferrochelatase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]

OCA: Protected "1l8x" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 20:23:39 GMT

Protected "1l8x" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:23, 5 December 2012

OCA at 20:23, 5 December 2012

OCA — Wed, 05 Dec 2012 20:23:35 GMT

←Older revision		Revision as of 20:23, 5 December 2012
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-	{{Seed}}
	[[Image:1l8x.png\|left\|200px]]		[[Image:1l8x.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1l8x", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1l8x\| PDB=1l8x \| SCENE= }}		{{STRUCTURE_1l8x\| PDB=1l8x \| SCENE= }}

	===Crystal Structure of Ferrochelatase from the Yeast, Saccharomyces cerevisiae, with Cobalt(II) as the Substrate Ion===		===Crystal Structure of Ferrochelatase from the Yeast, Saccharomyces cerevisiae, with Cobalt(II) as the Substrate Ion===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12427010}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12427010 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12427010}}		{{ABSTRACT_PUBMED_12427010}}

	==About this Structure==		==About this Structure==
-	~~1L8X~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8X OCA].	+	[[1l8x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8X OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12427010~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012427010</ref><references group="xtra"/>
	[[Category: Ferrochelatase]]		[[Category: Ferrochelatase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
Line 37:		Line 25:
	[[Category: Ferrochelatase]]		[[Category: Ferrochelatase]]
	[[Category: Heme biosynthesis]]		[[Category: Heme biosynthesis]]
		+	[[Category: Lyase]]
	[[Category: Mitochondrial inner membrane protein]]		[[Category: Mitochondrial inner membrane protein]]
	[[Category: Porphyrin metallation]]		[[Category: Porphyrin metallation]]
	[[Category: Protoheme]]		[[Category: Protoheme]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:37:02 2009''

OCA at 11:37, 16 February 2009

OCA — Mon, 16 Feb 2009 11:37:05 GMT

←Older revision		Revision as of 11:37, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1L8X is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8X OCA].	+	1L8X is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8X OCA].

	==Reference==		==Reference==
-	~~Metal binding to Saccharomyces cerevisiae ferrochelatase., Karlberg T, Lecerof D, Gora M, Silvegren G, Labbe-Bois R, Hansson M, Al-Karadaghi S, Biochemistry. 2002 Nov 19;41(46):13499-506.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12427010 12427010]~~	+	<ref group="xtra">PMID:12427010</ref><references group="xtra"/>
	[[Category: Ferrochelatase]]		[[Category: Ferrochelatase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Single protein]]
	[[Category: Al-Karadaghi, S.]]		[[Category: Al-Karadaghi, S.]]
	[[Category: Gora, M.]]		[[Category: Gora, M.]]
Line 42:		Line 41:
	[[Category: Protoheme]]		[[Category: Protoheme]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 2 11~~:58:~~52 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:37:02 2009''