1lah - Revision history

OCA at 08:08, 3 April 2024

OCA — Wed, 03 Apr 2024 08:08:07 GMT

←Older revision		Revision as of 08:08, 3 April 2024
Line 3:		Line 3:
	<StructureSection load='1lah' size='340' side='right'caption='[[1lah]], [[Resolution\|resolution]] 2.06Å' scene=''>		<StructureSection load='1lah' size='340' side='right'caption='[[1lah]], [[Resolution\|resolution]] 2.06Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LAH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.06Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lah OCA], [https://pdbe.org/1lah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lah RCSB], [https://www.ebi.ac.uk/pdbsum/1lah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lah ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lah OCA], [https://pdbe.org/1lah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lah RCSB], [https://www.ebi.ac.uk/pdbsum/1lah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lah ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ARGT_SALTY ARGT_SALTY]] This periplasmic binding protein is involved in an arginine transport system. ArgT and histidine-binding protein J (HisJ) interact with a common membrane-bound receptor, HisP.	+	[https://www.uniprot.org/uniprot/ARGT_SALTY ARGT_SALTY] This periplasmic binding protein is involved in an arginine transport system. ArgT and histidine-binding protein J (HisJ) interact with a common membrane-bound receptor, HisP.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lah ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lah ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The substrate-binding site of a protein with multiple specificity should satisfy geometric and energetic complementarity for several different substrates. The structural basis of the multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (LAO) was investigated by determining and analyzing the structures of the protein unliganded and liganded with each of the three high-affinity ligands (L-lysine, L-arginine, and L-ornithine) and with one low-affinity ligand (L-histidine). The geometric complementarity is achieved primarily by virtue of the large size of the ligand-binding site which can accommodate the maximum common volume of the four ligands plus three water molecules. The optimization of energetic complementarity is achieved by the relocation of protein-bound water molecules and by the movement of the Asp-11 side chain. The structure of the LAO-histidine complex indicates that the 30-fold reduced affinity of the protein for histidine is primarily due to unavailability of one ionic interaction of the histidine side chain with the protein which is present in the other three complexes.
-
-	Structural basis for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein.,Oh BH, Ames GF, Kim SH J Biol Chem. 1994 Oct 21;269(42):26323-30. PMID:7929349<ref>PMID:7929349</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1lah" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Kim, S H~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-	[[Category: ~~Oh, B~~ H]]	+	[[Category: Kim S-H]]
-	[[Category: ~~Amino acid transport~~]]	+	[[Category: Oh B-H]]

OCA at 06:42, 18 August 2021

OCA — Wed, 18 Aug 2021 06:42:01 GMT

←Older revision		Revision as of 06:42, 18 August 2021
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	<StructureSection load='1lah' size='340' side='right'caption='[[1lah]], [[Resolution\|resolution]] 2.06Å' scene=''>		<StructureSection load='1lah' size='340' side='right'caption='[[1lah]], [[Resolution\|resolution]] 2.06Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LAH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lah OCA], [~~http~~://pdbe.org/1lah PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1lah RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1lah PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1lah ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lah OCA], [https://pdbe.org/1lah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lah RCSB], [https://www.ebi.ac.uk/pdbsum/1lah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lah ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ARGT_SALTY ARGT_SALTY]] This periplasmic binding protein is involved in an arginine transport system. ArgT and histidine-binding protein J (HisJ) interact with a common membrane-bound receptor, HisP.	+	[[https://www.uniprot.org/uniprot/ARGT_SALTY ARGT_SALTY]] This periplasmic binding protein is involved in an arginine transport system. ArgT and histidine-binding protein J (HisJ) interact with a common membrane-bound receptor, HisP.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:38, 13 November 2019

OCA — Wed, 13 Nov 2019 12:38:55 GMT

←Older revision		Revision as of 12:38, 13 November 2019
Line 1:		Line 1:

	==STRUCTURAL BASES FOR MULTIPLE LIGAND SPECIFICITY OF THE PERIPLASMIC LYSINE-, ARGININE-, ORNITHINE-BINDING PROTEIN==		==STRUCTURAL BASES FOR MULTIPLE LIGAND SPECIFICITY OF THE PERIPLASMIC LYSINE-, ARGININE-, ORNITHINE-BINDING PROTEIN==
-	<StructureSection load='1lah' size='340' side='right' caption='[[1lah]], [[Resolution\|resolution]] 2.06Å' scene=''>	+	<StructureSection load='1lah' size='340' side='right'caption='[[1lah]], [[Resolution\|resolution]] 2.06Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LAH FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LAH FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/la/1lah_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/la/1lah_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Kim, S H]]		[[Category: Kim, S H]]
	[[Category: Oh, B H]]		[[Category: Oh, B H]]
	[[Category: Amino acid transport]]		[[Category: Amino acid transport]]

OCA at 10:54, 18 October 2017

OCA — Wed, 18 Oct 2017 10:54:17 GMT

←Older revision		Revision as of 10:54, 18 October 2017
Line 1:		Line 1:
		+
	==STRUCTURAL BASES FOR MULTIPLE LIGAND SPECIFICITY OF THE PERIPLASMIC LYSINE-, ARGININE-, ORNITHINE-BINDING PROTEIN==		==STRUCTURAL BASES FOR MULTIPLE LIGAND SPECIFICITY OF THE PERIPLASMIC LYSINE-, ARGININE-, ORNITHINE-BINDING PROTEIN==
	<StructureSection load='1lah' size='340' side='right' caption='[[1lah]], [[Resolution\|resolution]] 2.06Å' scene=''>		<StructureSection load='1lah' size='340' side='right' caption='[[1lah]], [[Resolution\|resolution]] 2.06Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1lah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LAH FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LAH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lah OCA], [http://pdbe.org/1lah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lah RCSB], [http://www.ebi.ac.uk/pdbsum/1lah PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lah OCA], [http://pdbe.org/1lah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lah RCSB], [http://www.ebi.ac.uk/pdbsum/1lah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lah ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lah ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:11, 11 September 2015

OCA — Fri, 11 Sep 2015 17:11:53 GMT

←Older revision		Revision as of 17:11, 11 September 2015
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	<StructureSection load='1lah' size='340' side='right' caption='[[1lah]], [[Resolution\|resolution]] 2.06Å' scene=''>		<StructureSection load='1lah' size='340' side='right' caption='[[1lah]], [[Resolution\|resolution]] 2.06Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lah]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LAH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lah RCSB], [http://www.ebi.ac.uk/pdbsum/1lah PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lah OCA], [http://pdbe.org/1lah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lah RCSB], [http://www.ebi.ac.uk/pdbsum/1lah PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1lah" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Kim, S H]]		[[Category: Kim, S H]]
	[[Category: Oh, B H]]		[[Category: Oh, B H]]
	[[Category: Amino acid transport]]		[[Category: Amino acid transport]]

OCA at 19:27, 25 December 2014

OCA — Thu, 25 Dec 2014 19:27:10 GMT

←Older revision		Revision as of 19:27, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LAH FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LAH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lah RCSB], [http://www.ebi.ac.uk/pdbsum/1lah PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lah RCSB], [http://www.ebi.ac.uk/pdbsum/1lah PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ARGT_SALTY ARGT_SALTY]] This periplasmic binding protein is involved in an arginine transport system. ArgT and histidine-binding protein J (HisJ) interact with a common membrane-bound receptor, HisP.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
-	[[Category: Kim, S H.]]	+	[[Category: Kim, S H]]
-	[[Category: Oh, B H.]]	+	[[Category: Oh, B H]]
	[[Category: Amino acid transport]]		[[Category: Amino acid transport]]

OCA at 13:32, 28 September 2014

OCA — Sun, 28 Sep 2014 13:32:26 GMT

←Older revision		Revision as of 13:32, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1lah.~~png\|left~~\|200px]]	+	==STRUCTURAL BASES FOR MULTIPLE LIGAND SPECIFICITY OF THE PERIPLASMIC LYSINE-, ARGININE-, ORNITHINE-BINDING PROTEIN==
		+	<StructureSection load='1lah' size='340' side='right' caption='[[1lah]], [[Resolution\|resolution]] 2.06Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1lah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LAH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lah RCSB], [http://www.ebi.ac.uk/pdbsum/1lah PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/la/1lah_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The substrate-binding site of a protein with multiple specificity should satisfy geometric and energetic complementarity for several different substrates. The structural basis of the multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (LAO) was investigated by determining and analyzing the structures of the protein unliganded and liganded with each of the three high-affinity ligands (L-lysine, L-arginine, and L-ornithine) and with one low-affinity ligand (L-histidine). The geometric complementarity is achieved primarily by virtue of the large size of the ligand-binding site which can accommodate the maximum common volume of the four ligands plus three water molecules. The optimization of energetic complementarity is achieved by the relocation of protein-bound water molecules and by the movement of the Asp-11 side chain. The structure of the LAO-histidine complex indicates that the 30-fold reduced affinity of the protein for histidine is primarily due to unavailability of one ionic interaction of the histidine side chain with the protein which is present in the other three complexes.

-	~~{{STRUCTURE_1lah\| PDB=1lah \| SCENE= }}~~	+	Structural basis for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein.,Oh BH, Ames GF, Kim SH J Biol Chem. 1994 Oct 21;269(42):26323-30. PMID:7929349<ref>PMID:7929349</ref>

-	~~===STRUCTURAL BASES FOR MULTIPLE LIGAND SPECIFICITY OF THE PERIPLASMIC LYSINE-~~, ~~ARGININE-, ORNITHINE-BINDING PROTEIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_7929349}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1lah]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Salmonella_enterica_subsp~~.~~_enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:007929349<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Kim, S H.]]		[[Category: Kim, S H.]]
	[[Category: Oh, B H.]]		[[Category: Oh, B H.]]
	[[Category: Amino acid transport]]		[[Category: Amino acid transport]]

OCA: Protected "1lah" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 20:26:06 GMT

Protected "1lah" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:26, 5 December 2012

OCA at 20:26, 5 December 2012

OCA — Wed, 05 Dec 2012 20:26:03 GMT

←Older revision		Revision as of 20:26, 5 December 2012
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-	{{Seed}}
	[[Image:1lah.png\|left\|200px]]		[[Image:1lah.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1lah", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1lah\| PDB=1lah \| SCENE= }}		{{STRUCTURE_1lah\| PDB=1lah \| SCENE= }}

	===STRUCTURAL BASES FOR MULTIPLE LIGAND SPECIFICITY OF THE PERIPLASMIC LYSINE-, ARGININE-, ORNITHINE-BINDING PROTEIN===		===STRUCTURAL BASES FOR MULTIPLE LIGAND SPECIFICITY OF THE PERIPLASMIC LYSINE-, ARGININE-, ORNITHINE-BINDING PROTEIN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_7929349}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 7929349 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_7929349}}		{{ABSTRACT_PUBMED_7929349}}

	==About this Structure==		==About this Structure==
-	~~1LAH~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Salmonella_typhimurium~~ Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA].	+	[[1lah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~7929349~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:007929349</ref><references group="xtra"/>
-	[[Category: Salmonella typhimurium]]	+	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Kim, S H.]]		[[Category: Kim, S H.]]
	[[Category: Oh, B H.]]		[[Category: Oh, B H.]]
	[[Category: Amino acid transport]]		[[Category: Amino acid transport]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:27:41 2009''

OCA at 02:27, 18 February 2009

OCA — Wed, 18 Feb 2009 02:27:44 GMT

←Older revision		Revision as of 02:27, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1LAH is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA].	+	1LAH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAH OCA].

	==Reference==		==Reference==
-	~~Structural basis for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein., Oh BH, Ames GF, Kim SH, J Biol Chem. 1994 Oct 21;269(42):26323-30.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/7929349 7929349]~~	+	<ref group="xtra">PMID:7929349</ref><references group="xtra"/>
	[[Category: Salmonella typhimurium]]		[[Category: Salmonella typhimurium]]
-	[[Category: Single protein]]
	[[Category: Kim, S H.]]		[[Category: Kim, S H.]]
	[[Category: Oh, B H.]]		[[Category: Oh, B H.]]
	[[Category: Amino acid transport]]		[[Category: Amino acid transport]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 2 12~~:07:~~24 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:27:41 2009''