1lb5 - Revision history

OCA at 07:31, 14 February 2024

OCA — Wed, 14 Feb 2024 07:31:28 GMT

←Older revision		Revision as of 07:31, 14 February 2024
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	<StructureSection load='1lb5' size='340' side='right'caption='[[1lb5]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1lb5' size='340' side='right'caption='[[1lb5]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lb5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1LB5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lb5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LB5 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1lb4\|1lb4]], [[1lb6\|1lb6]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">TRAF6 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN]), RANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb5 OCA], [https://pdbe.org/1lb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lb5 RCSB], [https://www.ebi.ac.uk/pdbsum/1lb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lb5 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1lb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb5 OCA], [~~http~~://pdbe.org/1lb5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1lb5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1lb5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1lb5 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TRAF6_HUMAN TRAF6_HUMAN]] E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.<ref>PMID:8837778</ref> <ref>PMID:11057907</ref> <ref>PMID:16378096</ref> <ref>PMID:17135271</ref> <ref>PMID:18093978</ref> <ref>PMID:18758450</ref> <ref>PMID:19675569</ref> <ref>PMID:19713527</ref> <ref>PMID:12140561</ref> <ref>PMID:19465916</ref>	+	[https://www.uniprot.org/uniprot/TRAF6_HUMAN TRAF6_HUMAN] E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.<ref>PMID:8837778</ref> <ref>PMID:11057907</ref> <ref>PMID:16378096</ref> <ref>PMID:17135271</ref> <ref>PMID:18093978</ref> <ref>PMID:18758450</ref> <ref>PMID:19675569</ref> <ref>PMID:19713527</ref> <ref>PMID:12140561</ref> <ref>PMID:19465916</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lb5 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lb5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Tumour-necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is the only TRAF family member that participates in signal transduction of both the TNF receptor (TNFR) superfamily and the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily; it is important for adaptive immunity, innate immunity and bone homeostasis. Here we report crystal structures of TRAF6, alone and in complex with TRAF6-binding peptides from CD40 and TRANCE-R (also known as RANK), members of the TNFR superfamily, to gain insight into the mechanism by which TRAF6 mediates several signalling cascades. A 40 degrees difference in the directions of the bound peptides in TRAF6 and TRAF2 shows that there are marked structural differences between receptor recognition by TRAF6 and other TRAFs. The structural determinant of the petide TRAF6 interaction reveals a Pro-X-Glu-X-X-(aromatic/acidic residue) TRAF6-binding motif, which is present not only in CD40 and TRANCE-R but also in the three IRAK adapter kinases for IL-1R/TLR signalling. Cell-permeable peptides with the TRAF6-binding motif inhibit TRAF6 signalling, which indicates their potential as therapeutic modulators. Our studies identify a universal mechanism by which TRAF6 regulates several signalling cascades in adaptive immunity, innate immunity and bone homeostasis.
-
-	Distinct molecular mechanism for initiating TRAF6 signalling.,Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H Nature. 2002 Jul 25;418(6896):443-7. PMID:12140561<ref>PMID:12140561</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1lb5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arron~~, J R~~]]	+	[[Category: Arron JR]]
-	[[Category: Choi, Y]]	+	[[Category: Choi Y]]
-	[[Category: Cirilli, M]]	+	[[Category: Cirilli M]]
-	[[Category: Darnay~~, B G~~]]	+	[[Category: Darnay BG]]
-	[[Category: Du, K]]	+	[[Category: Du K]]
-	[[Category: Dzivenu, O]]	+	[[Category: Dzivenu O]]
-	[[Category: Kobayashi, T]]	+	[[Category: Kobayashi T]]
-	[[Category: Lamothe, B]]	+	[[Category: Lamothe B]]
-	[[Category: Pike~~, J W~~]]	+	[[Category: Pike JW]]
-	[[Category: Segal, D]]	+	[[Category: Segal D]]
-	[[Category: Shevde~~, N K~~]]	+	[[Category: Shevde NK]]
-	[[Category: Singh, S]]	+	[[Category: Singh S]]
-	[[Category: Vologodskaia, M]]	+	[[Category: Vologodskaia M]]
-	[[Category: Wu, H]]	+	[[Category: Wu H]]
-	[[Category: Ye, H]]	+	[[Category: Ye H]]
-	[[Category: Yim, M]]	+	[[Category: Yim M]]
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Traf6-rank complex~~]]	+

OCA at 07:57, 25 November 2020

OCA — Wed, 25 Nov 2020 07:57:25 GMT

←Older revision		Revision as of 07:57, 25 November 2020
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	==TRAF6-RANK Complex==		==TRAF6-RANK Complex==
-	<StructureSection load='1lb5' size='340' side='right' caption='[[1lb5]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1lb5' size='340' side='right'caption='[[1lb5]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lb5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LB5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lb5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1LB5 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lb4\|1lb4]], [[1lb6\|1lb6]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lb4\|1lb4]], [[1lb6\|1lb6]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1lb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb5 OCA], [http://pdbe.org/1lb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1lb5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lb5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1lb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb5 OCA], [http://pdbe.org/1lb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1lb5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lb5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/1lb5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/1lb5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1lb5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1lb5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[TNF receptor-associated factor 3D structures\|TNF receptor-associated factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arron, J R]]		[[Category: Arron, J R]]
	[[Category: Choi, Y]]		[[Category: Choi, Y]]

OCA at 10:28, 12 October 2017

OCA — Thu, 12 Oct 2017 10:28:07 GMT

←Older revision		Revision as of 10:28, 12 October 2017
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		+
	==TRAF6-RANK Complex==		==TRAF6-RANK Complex==
	<StructureSection load='1lb5' size='340' side='right' caption='[[1lb5]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1lb5' size='340' side='right' caption='[[1lb5]], [[Resolution\|resolution]] 2.40Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lb4\|1lb4]], [[1lb6\|1lb6]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lb4\|1lb4]], [[1lb6\|1lb6]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb5 OCA], [http://pdbe.org/1lb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1lb5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb5 OCA], [http://pdbe.org/1lb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1lb5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lb5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1lb5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1lb5" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[TNF receptor-associated factor\|TNF receptor-associated factor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:14, 10 February 2016

OCA — Wed, 10 Feb 2016 04:14:24 GMT

←Older revision		Revision as of 04:14, 10 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lb5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:17, 11 September 2015

OCA — Fri, 11 Sep 2015 05:17:03 GMT

←Older revision		Revision as of 05:17, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1lb5' size='340' side='right' caption='[[1lb5]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1lb5' size='340' side='right' caption='[[1lb5]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lb5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LB5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lb5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LB5 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lb4\|1lb4]], [[1lb6\|1lb6]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lb4\|1lb4]], [[1lb6\|1lb6]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), RANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1lb5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb5 OCA], [http://pdbe.org/1lb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1lb5 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1lb5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[TNF receptor-associated factor\|TNF receptor-associated factor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arron, J R]]		[[Category: Arron, J R]]
	[[Category: Choi, Y]]		[[Category: Choi, Y]]

OCA at 11:43, 25 December 2014

OCA — Thu, 25 Dec 2014 11:43:26 GMT

←Older revision		Revision as of 11:43, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lb5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LB5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lb5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LB5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lb4\|1lb4]], [[1lb6\|1lb6]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lb4\|1lb4]], [[1lb6\|1lb6]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), RANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), RANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1lb5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1lb5 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRAF6_HUMAN TRAF6_HUMAN]] E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.<ref>PMID:8837778</ref> <ref>PMID:11057907</ref> <ref>PMID:16378096</ref> <ref>PMID:17135271</ref> <ref>PMID:18093978</ref> <ref>PMID:18758450</ref> <ref>PMID:19675569</ref> <ref>PMID:19713527</ref> <ref>PMID:12140561</ref> <ref>PMID:19465916</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arron, J R.]]	+	[[Category: Arron, J R]]
-	[[Category: Choi, Y.]]	+	[[Category: Choi, Y]]
-	[[Category: Cirilli, M.]]	+	[[Category: Cirilli, M]]
-	[[Category: Darnay, B G.]]	+	[[Category: Darnay, B G]]
-	[[Category: Du, K.]]	+	[[Category: Du, K]]
-	[[Category: Dzivenu, O.]]	+	[[Category: Dzivenu, O]]
-	[[Category: Kobayashi, T.]]	+	[[Category: Kobayashi, T]]
-	[[Category: Lamothe, B.]]	+	[[Category: Lamothe, B]]
-	[[Category: Pike, J W.]]	+	[[Category: Pike, J W]]
-	[[Category: Segal, D.]]	+	[[Category: Segal, D]]
-	[[Category: Shevde, N K.]]	+	[[Category: Shevde, N K]]
-	[[Category: Singh, S.]]	+	[[Category: Singh, S]]
-	[[Category: Vologodskaia, M.]]	+	[[Category: Vologodskaia, M]]
-	[[Category: Wu, H.]]	+	[[Category: Wu, H]]
-	[[Category: Ye, H.]]	+	[[Category: Ye, H]]
-	[[Category: Yim, M.]]	+	[[Category: Yim, M]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Traf6-rank complex]]		[[Category: Traf6-rank complex]]

OCA at 13:39, 28 September 2014

OCA — Sun, 28 Sep 2014 13:39:54 GMT

←Older revision		Revision as of 13:39, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1lb5.~~png~~\|~~left~~\|200px]]	+	==TRAF6-RANK Complex==
		+	<StructureSection load='1lb5' size='340' side='right' caption='[[1lb5]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1lb5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LB5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lb4\|1lb4]], [[1lb6\|1lb6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), RANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1lb5 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/1lb5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tumour-necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is the only TRAF family member that participates in signal transduction of both the TNF receptor (TNFR) superfamily and the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily; it is important for adaptive immunity, innate immunity and bone homeostasis. Here we report crystal structures of TRAF6, alone and in complex with TRAF6-binding peptides from CD40 and TRANCE-R (also known as RANK), members of the TNFR superfamily, to gain insight into the mechanism by which TRAF6 mediates several signalling cascades. A 40 degrees difference in the directions of the bound peptides in TRAF6 and TRAF2 shows that there are marked structural differences between receptor recognition by TRAF6 and other TRAFs. The structural determinant of the petide TRAF6 interaction reveals a Pro-X-Glu-X-X-(aromatic/acidic residue) TRAF6-binding motif, which is present not only in CD40 and TRANCE-R but also in the three IRAK adapter kinases for IL-1R/TLR signalling. Cell-permeable peptides with the TRAF6-binding motif inhibit TRAF6 signalling, which indicates their potential as therapeutic modulators. Our studies identify a universal mechanism by which TRAF6 regulates several signalling cascades in adaptive immunity, innate immunity and bone homeostasis.

-	~~{{STRUCTURE_1lb5\| PDB=1lb5 \| SCENE= }}~~	+	Distinct molecular mechanism for initiating TRAF6 signalling.,Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H Nature. 2002 Jul 25;418(6896):443-7. PMID:12140561<ref>PMID:12140561</ref>

-	~~===TRAF6-RANK Complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12140561}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1lb5]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012140561<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arron, J R.]]		[[Category: Arron, J R.]]

OCA: Protected "1lb5" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 20:39:20 GMT

Protected "1lb5" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:39, 5 December 2012

OCA at 20:39, 5 December 2012

OCA — Wed, 05 Dec 2012 20:39:16 GMT

←Older revision		Revision as of 20:39, 5 December 2012
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-	{{Seed}}
	[[Image:1lb5.png\|left\|200px]]		[[Image:1lb5.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1lb5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1lb5\| PDB=1lb5 \| SCENE= }}		{{STRUCTURE_1lb5\| PDB=1lb5 \| SCENE= }}

	===TRAF6-RANK Complex===		===TRAF6-RANK Complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12140561}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12140561 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12140561}}		{{ABSTRACT_PUBMED_12140561}}
-
-	==Disease==
-	Known disease associated with this structure: Osteolysis, familial expansile OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603499 603499]], Osteopetrosis, autosomal recessive 7 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603499 603499]], Paget disease of bone OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603499 603499]]

	==About this Structure==		==About this Structure==
-	~~1LB5~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA].	+	[[1lb5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12140561~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012140561</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arron, J R.]]		[[Category: Arron, J R.]]
Line 44:		Line 29:
	[[Category: Ye, H.]]		[[Category: Ye, H.]]
	[[Category: Yim, M.]]		[[Category: Yim, M.]]
		+	[[Category: Signaling protein]]
	[[Category: Traf6-rank complex]]		[[Category: Traf6-rank complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:20:55 2009''

OCA at 13:20, 17 February 2009

OCA — Tue, 17 Feb 2009 13:20:56 GMT

←Older revision		Revision as of 13:20, 17 February 2009
Line 20:		Line 20:

	==Disease==		==Disease==
-	Known disease associated with this structure: Osteolysis, familial expansile OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603499 603499]], Paget disease of bone OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603499 603499]]	+	Known disease associated with this structure: Osteolysis, familial expansile OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603499 603499]], Osteopetrosis, autosomal recessive 7 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603499 603499]], Paget disease of bone OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603499 603499]]

	==About this Structure==		==About this Structure==
-	1LB5 is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA].	+	1LB5 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA].

	==Reference==		==Reference==
-	Distinct molecular mechanism for initiating TRAF6 signalling., Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H, Nature. 2002 Jul 25;418(6896):443-7. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12140561 12140561]~~	+	<ref group="xtra">PMID:12140561</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Protein complex]]
	[[Category: Arron, J R.]]		[[Category: Arron, J R.]]
	[[Category: Choi, Y.]]		[[Category: Choi, Y.]]
Line 47:		Line 46:
	[[Category: Traf6-rank complex]]		[[Category: Traf6-rank complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 2 12~~:11:~~42 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:20:55 2009''