1lbg - Revision history

OCA at 07:31, 14 February 2024

OCA — Wed, 14 Feb 2024 07:31:43 GMT

←Older revision		Revision as of 07:31, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1lbg' size='340' side='right'caption='[[1lbg]], [[Resolution\|resolution]] 4.80Å' scene=''>		<StructureSection load='1lbg' size='340' side='right'caption='[[1lbg]], [[Resolution\|resolution]] 4.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lbg]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1LBG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lbg]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LBG FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>LACI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~562~~ "~~Bacillus coli~~" ~~Migula 1895~~])</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.8Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1lbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lbg OCA], [~~http~~://pdbe.org/1lbg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1lbg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1lbg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1lbg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lbg OCA], [https://pdbe.org/1lbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lbg RCSB], [https://www.ebi.ac.uk/pdbsum/1lbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lbg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LACI_ECOLI LACI_ECOLI]] Repressor of the lactose operon. Binds allolactose as an inducer.	+	[https://www.uniprot.org/uniprot/LACI_ECOLI LACI_ECOLI] Repressor of the lactose operon. Binds allolactose as an inducer.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lbg ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lbg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The lac operon of Escherichia coli is the paradigm for gene regulation. Its key component is the lac repressor, a product of the lacI gene. The three-dimensional structures of the intact lac repressor, the lac repressor bound to the gratuitous inducer isopropyl-beta-D-1-thiogalactoside (IPTG) and the lac repressor complexed with a 21-base pair symmetric operator DNA have been determined. These three structures show the conformation of the molecule in both the induced and repressed states and provide a framework for understanding a wealth of biochemical and genetic information. The DNA sequence of the lac operon has three lac repressor recognition sites in a stretch of 500 base pairs. The crystallographic structure of the complex with DNA suggests that the tetrameric repressor functions synergistically with catabolite gene activator protein (CAP) and participates in the quaternary formation of repression loops in which one tetrameric repressor interacts simultaneously with two sites on the genomic DNA.
-
-	Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.,Lewis M, Chang G, Horton NC, Kercher MA, Pace HC, Schumacher MA, Brennan RG, Lu P Science. 1996 Mar 1;271(5253):1247-54. PMID:8638105<ref>PMID:8638105</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1lbg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Lac repressor\|Lac repressor]]		*[[Lac repressor\|Lac repressor]]
-	*[[Regulation of Gene Expression\|Regulation of Gene Expression]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chang, G]]	+	[[Category: Chang G]]
-	[[Category: Horton~~, N C~~]]	+	[[Category: Horton NC]]
-	[[Category: Kercher~~, M A~~]]	+	[[Category: Kercher MA]]
-	[[Category: Lewis, M]]	+	[[Category: Lewis M]]
-	[[Category: Lu, P]]	+	[[Category: Lu P]]
-	[[Category: Pace~~, H C]]~~	+	[[Category: Pace HC]]
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Repressor]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Transcription-dna complex~~]]	+

OCA at 07:57, 25 November 2020

OCA — Wed, 25 Nov 2020 07:57:43 GMT

←Older revision		Revision as of 07:57, 25 November 2020
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	==LACTOSE OPERON REPRESSOR BOUND TO 21-BASE PAIR SYMMETRIC OPERATOR DNA, ALPHA CARBONS ONLY==		==LACTOSE OPERON REPRESSOR BOUND TO 21-BASE PAIR SYMMETRIC OPERATOR DNA, ALPHA CARBONS ONLY==
-	<StructureSection load='1lbg' size='340' side='right' caption='[[1lbg]], [[Resolution\|resolution]] 4.80Å' scene=''>	+	<StructureSection load='1lbg' size='340' side='right'caption='[[1lbg]], [[Resolution\|resolution]] 4.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lbg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LBG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lbg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1LBG FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LACI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LACI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1lbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lbg OCA], [http://pdbe.org/1lbg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lbg RCSB], [http://www.ebi.ac.uk/pdbsum/1lbg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lbg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1lbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lbg OCA], [http://pdbe.org/1lbg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lbg RCSB], [http://www.ebi.ac.uk/pdbsum/1lbg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lbg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
		+	*[[Lac repressor\|Lac repressor]]
	*[[Regulation of Gene Expression\|Regulation of Gene Expression]]		*[[Regulation of Gene Expression\|Regulation of Gene Expression]]
	== References ==		== References ==
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Chang, G]]		[[Category: Chang, G]]
	[[Category: Horton, N C]]		[[Category: Horton, N C]]

OCA at 21:15, 24 January 2018

OCA — Wed, 24 Jan 2018 21:15:21 GMT

←Older revision		Revision as of 21:15, 24 January 2018
Line 1:		Line 1:
		+
	==LACTOSE OPERON REPRESSOR BOUND TO 21-BASE PAIR SYMMETRIC OPERATOR DNA, ALPHA CARBONS ONLY==		==LACTOSE OPERON REPRESSOR BOUND TO 21-BASE PAIR SYMMETRIC OPERATOR DNA, ALPHA CARBONS ONLY==
	<StructureSection load='1lbg' size='340' side='right' caption='[[1lbg]], [[Resolution\|resolution]] 4.80Å' scene=''>		<StructureSection load='1lbg' size='340' side='right' caption='[[1lbg]], [[Resolution\|resolution]] 4.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1lbg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LBG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lbg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LBG FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LACI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LACI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lbg OCA], [http://pdbe.org/1lbg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lbg RCSB], [http://www.ebi.ac.uk/pdbsum/1lbg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lbg OCA], [http://pdbe.org/1lbg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lbg RCSB], [http://www.ebi.ac.uk/pdbsum/1lbg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lbg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/1lbg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/1lbg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:

	==See Also==		==See Also==
-	*[[Lac repressor\|Lac repressor]]
-	*[[Lac repressor 3D structures\|Lac repressor 3D structures]]
	*[[Regulation of Gene Expression\|Regulation of Gene Expression]]		*[[Regulation of Gene Expression\|Regulation of Gene Expression]]
	== References ==		== References ==

OCA at 03:55, 9 February 2016

OCA — Tue, 09 Feb 2016 03:55:33 GMT

←Older revision		Revision as of 03:55, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lbg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:23, 10 September 2015

OCA — Thu, 10 Sep 2015 18:23:04 GMT

←Older revision		Revision as of 18:23, 10 September 2015
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	<StructureSection load='1lbg' size='340' side='right' caption='[[1lbg]], [[Resolution\|resolution]] 4.80Å' scene=''>		<StructureSection load='1lbg' size='340' side='right' caption='[[1lbg]], [[Resolution\|resolution]] 4.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lbg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LBG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lbg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LBG FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LACI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LACI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lbg RCSB], [http://www.ebi.ac.uk/pdbsum/1lbg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lbg OCA], [http://pdbe.org/1lbg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lbg RCSB], [http://www.ebi.ac.uk/pdbsum/1lbg PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1lbg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Chang, G]]		[[Category: Chang, G]]
	[[Category: Horton, N C]]		[[Category: Horton, N C]]

OCA at 04:15, 25 December 2014

OCA — Thu, 25 Dec 2014 04:15:05 GMT

←Older revision		Revision as of 04:15, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lbg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LBG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lbg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LBG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LACI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LACI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lbg RCSB], [http://www.ebi.ac.uk/pdbsum/1lbg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lbg RCSB], [http://www.ebi.ac.uk/pdbsum/1lbg PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LACI_ECOLI LACI_ECOLI]] Repressor of the lactose operon. Binds allolactose as an inducer.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Chang, G.]]	+	[[Category: Chang, G]]
-	[[Category: Horton, N C.]]	+	[[Category: Horton, N C]]
-	[[Category: Kercher, M A.]]	+	[[Category: Kercher, M A]]
-	[[Category: Lewis, M.]]	+	[[Category: Lewis, M]]
-	[[Category: Lu, P.]]	+	[[Category: Lu, P]]
-	[[Category: Pace, H C.]]	+	[[Category: Pace, H C]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Repressor]]		[[Category: Repressor]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Transcription-dna complex]]		[[Category: Transcription-dna complex]]

OCA at 15:23, 29 September 2014

OCA — Mon, 29 Sep 2014 15:23:17 GMT

←Older revision		Revision as of 15:23, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1lbg\| PDB=1lbg \| SCENE= }}~~	+	==LACTOSE OPERON REPRESSOR BOUND TO 21-BASE PAIR SYMMETRIC OPERATOR DNA, ALPHA CARBONS ONLY==
-	===LACTOSE OPERON REPRESSOR BOUND TO 21-BASE PAIR SYMMETRIC OPERATOR DNA, ALPHA CARBONS ONLY===	+	<StructureSection load='1lbg' size='340' side='right' caption='[[1lbg]], [[Resolution\|resolution]] 4.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_8638105}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1lbg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LBG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LACI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lbg RCSB], [http://www.ebi.ac.uk/pdbsum/1lbg PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/1lbg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The lac operon of Escherichia coli is the paradigm for gene regulation. Its key component is the lac repressor, a product of the lacI gene. The three-dimensional structures of the intact lac repressor, the lac repressor bound to the gratuitous inducer isopropyl-beta-D-1-thiogalactoside (IPTG) and the lac repressor complexed with a 21-base pair symmetric operator DNA have been determined. These three structures show the conformation of the molecule in both the induced and repressed states and provide a framework for understanding a wealth of biochemical and genetic information. The DNA sequence of the lac operon has three lac repressor recognition sites in a stretch of 500 base pairs. The crystallographic structure of the complex with DNA suggests that the tetrameric repressor functions synergistically with catabolite gene activator protein (CAP) and participates in the quaternary formation of repression loops in which one tetrameric repressor interacts simultaneously with two sites on the genomic DNA.

-	~~==About this Structure==~~	+	Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.,Lewis M, Chang G, Horton NC, Kercher MA, Pace HC, Schumacher MA, Brennan RG, Lu P Science. 1996 Mar 1;271(5253):1247-54. PMID:8638105<ref>PMID:8638105</ref>
-	~~[[1lbg]] is a 8 chain~~ structure with ~~sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1LBG OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Lac repressor\|Lac repressor]]		*[[Lac repressor\|Lac repressor]]
		+	*[[Lac repressor 3D structures\|Lac repressor 3D structures]]
	*[[Regulation of Gene Expression\|Regulation of Gene Expression]]		*[[Regulation of Gene Expression\|Regulation of Gene Expression]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:008638105<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Chang, G.]]		[[Category: Chang, G.]]

OCA at 10:47, 11 March 2013

OCA — Mon, 11 Mar 2013 10:47:57 GMT

←Older revision		Revision as of 10:47, 11 March 2013
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-	[[Image:1lbg.png\|left\|200px]]
-
	{{STRUCTURE_1lbg\| PDB=1lbg \| SCENE= }}		{{STRUCTURE_1lbg\| PDB=1lbg \| SCENE= }}
-
	===LACTOSE OPERON REPRESSOR BOUND TO 21-BASE PAIR SYMMETRIC OPERATOR DNA, ALPHA CARBONS ONLY===		===LACTOSE OPERON REPRESSOR BOUND TO 21-BASE PAIR SYMMETRIC OPERATOR DNA, ALPHA CARBONS ONLY===
-
	{{ABSTRACT_PUBMED_8638105}}		{{ABSTRACT_PUBMED_8638105}}

OCA at 12:33, 20 October 2012

OCA — Sat, 20 Oct 2012 12:33:46 GMT

←Older revision		Revision as of 12:33, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1lbg]] is a 8 chain structure ~~of [[Lac repressor]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBG OCA].	+	[[1lbg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBG OCA].

	==See Also==		==See Also==

OCA: Protected "1lbg" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 09:07:40 GMT

Protected "1lbg" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:07, 26 July 2012