1lmi - Revision history

OCA at 07:34, 14 February 2024

OCA — Wed, 14 Feb 2024 07:34:17 GMT

←Older revision		Revision as of 07:34, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1lmi' size='340' side='right'caption='[[1lmi]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1lmi' size='340' side='right'caption='[[1lmi]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lmi]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1LMI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lmi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LMI FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Rv1926c~~, ~~MPT63 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5&~~id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1lmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lmi OCA], [~~http~~://pdbe.org/1lmi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1lmi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1lmi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1lmi ProSAT], [~~http~~://www.topsan.org/Proteins/TBSGC/1lmi TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lmi OCA], [https://pdbe.org/1lmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lmi RCSB], [https://www.ebi.ac.uk/pdbsum/1lmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lmi ProSAT], [https://www.topsan.org/Proteins/TBSGC/1lmi TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MP63_MYCTU MP63_MYCTU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lmi ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lmi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	MPT63 is a small, major secreted protein of unknown function from Mycobacterium tuberculosis that has been shown to have immunogenic properties and has been implicated in virulence. A BLAST search identified that MPT63 has homologs only in other mycobacteria, and is therefore mycobacteria specific. As MPT63 is a secreted protein, mycobacteria specific, and implicated in virulence, MPT63 is an attractive drug target against the deadliest infectious disease, tuberculosis (TB). As part of the TB Structural Genomics Consortium, the X-ray crystal structure of MPT63 was determined to 1.5-Angstrom resolution with the hope of yielding functional information about MPT63. The structure of MPT63 is an antiparallel beta-sandwich immunoglobulin-like fold, with the unusual feature of the first beta-strand of the protein forming a parallel addition to the small antiparallel beta-sheet. MPT63 has weak structural similarity to many proteins with immunoglobulin folds, in particular, Homo sapiens beta2-adaptin, bovine arrestin, and Yersinia pseudotuberculosis invasin. Although the structure of MPT63 gives no conclusive evidence to its function, structural similarity suggests that MPT63 could be involved in cell-host interactions to facilitate endocytosis/phagocytosis.
-
-	Crystal structure of a major secreted protein of Mycobacterium tuberculosis-MPT63 at 1.5-A resolution.,Goulding CW, Parseghian A, Sawaya MR, Cascio D, Apostol MI, Gennaro ML, Eisenberg D Protein Sci. 2002 Dec;11(12):2887-93. PMID:12441386<ref>PMID:12441386</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1lmi" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Apostol, M]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: Cascio, D]]	+	[[Category: Apostol M]]
-	[[Category: Eisenberg, D]]	+	[[Category: Cascio D]]
-	[[Category: Gennaro~~, M L~~]]	+	[[Category: Eisenberg D]]
-	[[Category: Goulding~~, C W~~]]	+	[[Category: Gennaro ML]]
-	[[Category: Parseghian, A]]	+	[[Category: Goulding CW]]
-	[[Category: Sawaya~~, M R]]~~	+	[[Category: Parseghian A]]
-	~~[[Category: Structural genomic]]~~	+	[[Category: Sawaya MR]]
-	~~[[Category: Beta-sandwich]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Tbsgc~~]]	+

OCA at 08:00, 25 November 2020

OCA — Wed, 25 Nov 2020 08:00:02 GMT

←Older revision		Revision as of 08:00, 25 November 2020
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	==1.5 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF A SECRETED PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS-MPT63==		==1.5 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF A SECRETED PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS-MPT63==
-	<StructureSection load='1lmi' size='340' side='right' caption='[[1lmi]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='1lmi' size='340' side='right'caption='[[1lmi]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lmi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMI OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LMI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lmi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1LMI FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1926c, MPT63 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1926c, MPT63 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1lmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lmi OCA], [http://pdbe.org/1lmi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lmi RCSB], [http://www.ebi.ac.uk/pdbsum/1lmi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lmi ProSAT], [http://www.topsan.org/Proteins/TBSGC/1lmi TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1lmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lmi OCA], [http://pdbe.org/1lmi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lmi RCSB], [http://www.ebi.ac.uk/pdbsum/1lmi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lmi ProSAT], [http://www.topsan.org/Proteins/TBSGC/1lmi TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Apostol, M]]		[[Category: Apostol, M]]
	[[Category: Cascio, D]]		[[Category: Cascio, D]]

OCA at 08:10, 31 January 2018

OCA — Wed, 31 Jan 2018 08:10:55 GMT

←Older revision		Revision as of 08:10, 31 January 2018
Line 1:		Line 1:
		+
	==1.5 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF A SECRETED PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS-MPT63==		==1.5 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF A SECRETED PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS-MPT63==
	<StructureSection load='1lmi' size='340' side='right' caption='[[1lmi]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1lmi' size='340' side='right' caption='[[1lmi]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1lmi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LMI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lmi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LMI FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1926c, MPT63 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1926c, MPT63 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lmi OCA], [http://pdbe.org/1lmi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lmi RCSB], [http://www.ebi.ac.uk/pdbsum/1lmi PDBsum], [http://www.topsan.org/Proteins/TBSGC/1lmi TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lmi OCA], [http://pdbe.org/1lmi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lmi RCSB], [http://www.ebi.ac.uk/pdbsum/1lmi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lmi ProSAT], [http://www.topsan.org/Proteins/TBSGC/1lmi TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lm/1lmi_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lm/1lmi_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:15, 9 February 2016

OCA — Tue, 09 Feb 2016 21:15:03 GMT

←Older revision		Revision as of 21:15, 9 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lmi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:06, 11 September 2015

OCA — Fri, 11 Sep 2015 02:06:13 GMT

←Older revision		Revision as of 02:06, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1lmi' size='340' side='right' caption='[[1lmi]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1lmi' size='340' side='right' caption='[[1lmi]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lmi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LMI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lmi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LMI FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1926c, MPT63 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 ~~Mycobacterium~~ tuberculosis])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1926c, MPT63 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lmi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lmi RCSB], [http://www.ebi.ac.uk/pdbsum/1lmi PDBsum], [http://www.topsan.org/Proteins/TBSGC/1lmi TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lmi OCA], [http://pdbe.org/1lmi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lmi RCSB], [http://www.ebi.ac.uk/pdbsum/1lmi PDBsum], [http://www.topsan.org/Proteins/TBSGC/1lmi TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1lmi" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Apostol, M]]		[[Category: Apostol, M]]
	[[Category: Cascio, D]]		[[Category: Cascio, D]]

OCA at 16:08, 5 January 2015

OCA — Mon, 05 Jan 2015 16:08:50 GMT

←Older revision		Revision as of 16:08, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lmi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LMI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lmi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LMI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1926c, MPT63 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1926c, MPT63 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lmi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lmi RCSB], [http://www.ebi.ac.uk/pdbsum/1lmi PDBsum], [http://www.topsan.org/Proteins/TBSGC/1lmi TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lmi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lmi RCSB], [http://www.ebi.ac.uk/pdbsum/1lmi PDBsum], [http://www.topsan.org/Proteins/TBSGC/1lmi TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Apostol, M.]]	+	[[Category: Apostol, M]]
-	[[Category: Cascio, D.]]	+	[[Category: Cascio, D]]
-	[[Category: Eisenberg, D.]]	+	[[Category: Eisenberg, D]]
-	[[Category: Gennaro, M L.]]	+	[[Category: Gennaro, M L]]
-	[[Category: Goulding, C W.]]	+	[[Category: Goulding, C W]]
-	[[Category: Parseghian, A.]]	+	[[Category: Parseghian, A]]
-	[[Category: Sawaya, M R.]]	+	[[Category: Sawaya, M R]]
-	[[Category: ~~TBSGC, TB~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
	[[Category: Beta-sandwich]]		[[Category: Beta-sandwich]]
	[[Category: Immune system]]		[[Category: Immune system]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category: Psi]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Tb structural genomics consortium~~]]	+
	[[Category: Tbsgc]]		[[Category: Tbsgc]]

OCA at 15:47, 28 September 2014

OCA — Sun, 28 Sep 2014 15:47:40 GMT

←Older revision		Revision as of 15:47, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1lmi.~~png\|left~~\|200px]]	+	==1.5 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF A SECRETED PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS-MPT63==
		+	<StructureSection load='1lmi' size='340' side='right' caption='[[1lmi]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1lmi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LMI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1926c, MPT63 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lmi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lmi RCSB], [http://www.ebi.ac.uk/pdbsum/1lmi PDBsum], [http://www.topsan.org/Proteins/TBSGC/1lmi TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lm/1lmi_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	MPT63 is a small, major secreted protein of unknown function from Mycobacterium tuberculosis that has been shown to have immunogenic properties and has been implicated in virulence. A BLAST search identified that MPT63 has homologs only in other mycobacteria, and is therefore mycobacteria specific. As MPT63 is a secreted protein, mycobacteria specific, and implicated in virulence, MPT63 is an attractive drug target against the deadliest infectious disease, tuberculosis (TB). As part of the TB Structural Genomics Consortium, the X-ray crystal structure of MPT63 was determined to 1.5-Angstrom resolution with the hope of yielding functional information about MPT63. The structure of MPT63 is an antiparallel beta-sandwich immunoglobulin-like fold, with the unusual feature of the first beta-strand of the protein forming a parallel addition to the small antiparallel beta-sheet. MPT63 has weak structural similarity to many proteins with immunoglobulin folds, in particular, Homo sapiens beta2-adaptin, bovine arrestin, and Yersinia pseudotuberculosis invasin. Although the structure of MPT63 gives no conclusive evidence to its function, structural similarity suggests that MPT63 could be involved in cell-host interactions to facilitate endocytosis/phagocytosis.

-	~~{{STRUCTURE_1lmi\| PDB=1lmi \| SCENE= }}~~	+	Crystal structure of a major secreted protein of Mycobacterium tuberculosis-MPT63 at 1.5-A resolution.,Goulding CW, Parseghian A, Sawaya MR, Cascio D, Apostol MI, Gennaro ML, Eisenberg D Protein Sci. 2002 Dec;11(12):2887-93. PMID:12441386<ref>PMID:12441386</ref>

-	~~===1.5 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF A SECRETED PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS-MPT63===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12441386}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1lmi]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1LMI OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012441386<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Apostol, M.]]		[[Category: Apostol, M.]]

OCA: Protected "1lmi" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 20:22:58 GMT

Protected "1lmi" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:22, 5 December 2012

OCA at 20:22, 5 December 2012

OCA — Wed, 05 Dec 2012 20:22:55 GMT

←Older revision		Revision as of 20:22, 5 December 2012
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-	{{Seed}}
	[[Image:1lmi.png\|left\|200px]]		[[Image:1lmi.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1lmi", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1lmi\| PDB=1lmi \| SCENE= }}		{{STRUCTURE_1lmi\| PDB=1lmi \| SCENE= }}

	===1.5 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF A SECRETED PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS-MPT63===		===1.5 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF A SECRETED PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS-MPT63===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12441386}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12441386 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_12441386}}		{{ABSTRACT_PUBMED_12441386}}

	==About this Structure==		==About this Structure==
-	~~1LMI~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMI OCA].	+	[[1lmi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMI OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12441386~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012441386</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Apostol, M.]]		[[Category: Apostol, M.]]
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	[[Category: TBSGC, TB Structural Genomics Consortium.]]		[[Category: TBSGC, TB Structural Genomics Consortium.]]
	[[Category: Beta-sandwich]]		[[Category: Beta-sandwich]]
		+	[[Category: Immune system]]
	[[Category: Protein structure initiative]]		[[Category: Protein structure initiative]]
	[[Category: Psi]]		[[Category: Psi]]
Line 39:		Line 28:
	[[Category: Tb structural genomics consortium]]		[[Category: Tb structural genomics consortium]]
	[[Category: Tbsgc]]		[[Category: Tbsgc]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:48:17 2009''

OCA at 10:48, 17 February 2009

OCA — Tue, 17 Feb 2009 10:48:18 GMT

←Older revision		Revision as of 10:48, 17 February 2009
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	==Reference==		==Reference==
-	Crystal structure of a major secreted protein of Mycobacterium tuberculosis-MPT63 at 1.5-A resolution., Goulding CW, Parseghian A, Sawaya MR, Cascio D, Apostol MI, Gennaro ML, Eisenberg D, Protein Sci. 2002 Dec;11(12):2887-93. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12441386 12441386]~~	+	<ref group="xtra">PMID:12441386</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Apostol, M.]]		[[Category: Apostol, M.]]
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	[[Category: Tbsgc]]		[[Category: Tbsgc]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Nov 16 15~~:42:~~46 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:48:17 2009''