1lo1 - Revision history

OCA at 08:47, 22 May 2024

OCA — Wed, 22 May 2024 08:47:15 GMT

←Older revision		Revision as of 08:47, 22 May 2024
Line 22:		Line 22:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lo1 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lo1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	While most nuclear receptors bind DNA as homo or heterodimers, the human estrogen related receptors (hERRs) are members of a subfamily of orphan receptors that bind DNA as monomers. We have determined the solution structure of the DNA binding domain (DBD) of hERR2 bound to its cognate DNA. The structure and base interactions of the core DBD are similar to those of other nuclear receptors. However, high-affinity, sequence-specific DNA binding as a monomer necessitates formation of additional base contacts outside the core DBD. This is accomplished using a modified guanosine-binding "AT-hook" within the C-terminal extension (CTE) flanking the DBD, which makes base-specific minor groove interactions. The structure of the CTE is stabilized both by interactions with the DNA and by packing against a region of the core DBD normally reserved for dimerization. This pseudo-dimer interface provides a basis for the expansion of DNA recognition and suggests a mechanism through which dimerization may have evolved from an ancestral monomeric receptor.
		+
		+	Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition.,Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE J Mol Biol. 2003 Apr 4;327(4):819-32. PMID:12654265<ref>PMID:12654265</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 1lo1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:25, 10 April 2024

OCA — Wed, 10 Apr 2024 08:25:37 GMT

←Older revision		Revision as of 08:25, 10 April 2024
Line 1:		Line 1:

	==ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA==		==ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA==
-	<StructureSection load='1lo1' size='340' side='right'caption='[[1lo1~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1lo1' size='340' side='right'caption='[[1lo1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lo1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LO1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lo1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LO1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~hERR2 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [https://pdbe.org/1lo1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [https://www.ebi.ac.uk/pdbsum/1lo1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [https://pdbe.org/1lo1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [https://www.ebi.ac.uk/pdbsum/1lo1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:[https://omim.org/entry/608565 608565]]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:18179891</ref>	+	[https://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN] Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:[https://omim.org/entry/608565 608565]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:18179891</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Nuclear receptor, may regulate ESR1 transcriptional activity.<ref>PMID:19755138</ref>	+	[https://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN] Nuclear receptor, may regulate ESR1 transcriptional activity.<ref>PMID:19755138</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 22:		Line 22:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lo1 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lo1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	While most nuclear receptors bind DNA as homo or heterodimers, the human estrogen related receptors (hERRs) are members of a subfamily of orphan receptors that bind DNA as monomers. We have determined the solution structure of the DNA binding domain (DBD) of hERR2 bound to its cognate DNA. The structure and base interactions of the core DBD are similar to those of other nuclear receptors. However, high-affinity, sequence-specific DNA binding as a monomer necessitates formation of additional base contacts outside the core DBD. This is accomplished using a modified guanosine-binding "AT-hook" within the C-terminal extension (CTE) flanking the DBD, which makes base-specific minor groove interactions. The structure of the CTE is stabilized both by interactions with the DNA and by packing against a region of the core DBD normally reserved for dimerization. This pseudo-dimer interface provides a basis for the expansion of DNA recognition and suggests a mechanism through which dimerization may have evolved from an ancestral monomeric receptor.
-
-	Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition.,Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE J Mol Biol. 2003 Apr 4;327(4):819-32. PMID:12654265<ref>PMID:12654265</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1lo1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 38:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dyson~~, H J~~]]	+	[[Category: Dyson HJ]]
-	[[Category: Evans~~, R M~~]]	+	[[Category: Evans RM]]
-	[[Category: Gearhart~~, M D~~]]	+	[[Category: Gearhart MD]]
-	[[Category: Holmbeck~~, S M.A~~]]	+	[[Category: Holmbeck SMA]]
-	[[Category: Wright~~, P E]]~~	+	[[Category: Wright PE]]
-	~~[[Category: Dna binding domain]]~~	+
-	~~[[Category: Estrogen related receptor 2]]~~	+
-	~~[[Category: Herr2]]~~	+
-	~~[[Category: Hormone nuclear receptor]]~~	+
-	~~[[Category: Hormone-growth factor receptor-dna complex~~]]	+

OCA at 14:50, 27 October 2021

OCA — Wed, 27 Oct 2021 14:50:19 GMT

OCA at 08:00, 25 November 2020

OCA — Wed, 25 Nov 2020 08:00:26 GMT

←Older revision		Revision as of 08:00, 25 November 2020
Line 1:		Line 1:

	==ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA==		==ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA==
-	<StructureSection load='1lo1' size='340' side='right' caption='[[1lo1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1lo1' size='340' side='right'caption='[[1lo1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lo1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LO1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lo1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1LO1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hERR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hERR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [http://pdbe.org/1lo1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [http://pdbe.org/1lo1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1lo1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1lo1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Estrogen-related receptor 3D structures\|Estrogen-related receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dyson, H J]]		[[Category: Dyson, H J]]
	[[Category: Evans, R M]]		[[Category: Evans, R M]]

OCA at 07:49, 31 January 2018

OCA — Wed, 31 Jan 2018 07:49:01 GMT

←Older revision		Revision as of 07:49, 31 January 2018
Line 1:		Line 1:
		+
	==ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA==		==ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA==
	<StructureSection load='1lo1' size='340' side='right' caption='[[1lo1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1lo1' size='340' side='right' caption='[[1lo1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hERR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hERR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [http://pdbe.org/1lo1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [http://pdbe.org/1lo1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1lo1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1lo1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1lo1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1lo1" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Estrogen-related receptor\|Estrogen-related receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:57, 9 February 2016

OCA — Tue, 09 Feb 2016 12:57:37 GMT

←Older revision		Revision as of 12:57, 9 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lo1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:28, 10 September 2015

OCA — Thu, 10 Sep 2015 22:28:39 GMT

←Older revision		Revision as of 22:28, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1lo1' size='340' side='right' caption='[[1lo1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1lo1' size='340' side='right' caption='[[1lo1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lo1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lo1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hERR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hERR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [http://pdbe.org/1lo1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo1 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1lo1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dyson, H J]]		[[Category: Dyson, H J]]
	[[Category: Evans, R M]]		[[Category: Evans, R M]]

OCA at 15:33, 5 January 2015

OCA — Mon, 05 Jan 2015 15:33:01 GMT

←Older revision		Revision as of 15:33, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lo1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lo1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hERR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hERR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo1 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:[http://omim.org/entry/608565 608565]]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:18179891</ref>		[[http://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:[http://omim.org/entry/608565 608565]]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:18179891</ref>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dyson, H J.]]	+	[[Category: Dyson, H J]]
-	[[Category: Evans, R M.]]	+	[[Category: Evans, R M]]
-	[[Category: Gearhart, M D.]]	+	[[Category: Gearhart, M D]]
-	[[Category: Holmbeck, S M.A.]]	+	[[Category: Holmbeck, S M.A]]
-	[[Category: Wright, P E.]]	+	[[Category: Wright, P E]]
	[[Category: Dna binding domain]]		[[Category: Dna binding domain]]
	[[Category: Estrogen related receptor 2]]		[[Category: Estrogen related receptor 2]]

OCA at 13:59, 29 September 2014

OCA — Mon, 29 Sep 2014 13:59:06 GMT

←Older revision		Revision as of 13:59, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1lo1\| PDB=1lo1 \| SCENE= }}~~	+	==ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA==
-	===ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA===	+	<StructureSection load='1lo1' size='340' side='right' caption='[[1lo1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_12654265}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1lo1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hERR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo1 PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:[http://omim.org/entry/608565 608565]]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:18179891</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Nuclear receptor, may regulate ESR1 transcriptional activity.<ref>PMID:19755138</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1lo1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	While most nuclear receptors bind DNA as homo or heterodimers, the human estrogen related receptors (hERRs) are members of a subfamily of orphan receptors that bind DNA as monomers. We have determined the solution structure of the DNA binding domain (DBD) of hERR2 bound to its cognate DNA. The structure and base interactions of the core DBD are similar to those of other nuclear receptors. However, high-affinity, sequence-specific DNA binding as a monomer necessitates formation of additional base contacts outside the core DBD. This is accomplished using a modified guanosine-binding "AT-hook" within the C-terminal extension (CTE) flanking the DBD, which makes base-specific minor groove interactions. The structure of the CTE is stabilized both by interactions with the DNA and by packing against a region of the core DBD normally reserved for dimerization. This pseudo-dimer interface provides a basis for the expansion of DNA recognition and suggests a mechanism through which dimerization may have evolved from an ancestral monomeric receptor.

-	~~==Disease==~~	+	Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition.,Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE J Mol Biol. 2003 Apr 4;327(4):819-32. PMID:12654265<ref>PMID:12654265</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Defects in ESRRB are the cause of deafness autosomal recessive type 35~~ (~~DFNB35~~) ~~[MIM~~:~~[http~~://omim.org/entry/608565 608565]]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:~~18179891~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Nuclear receptor, may regulate ESR1 transcriptional activity~~.<~~ref~~>~~PMID:19755138~~</~~ref~~>	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[1lo1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA].	+

	==See Also==		==See Also==
	*[[Estrogen-related receptor\|Estrogen-related receptor]]		*[[Estrogen-related receptor\|Estrogen-related receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:012654265</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dyson, H J.]]		[[Category: Dyson, H J.]]

OCA at 09:19, 24 March 2013

OCA — Sun, 24 Mar 2013 09:19:26 GMT

←Older revision		Revision as of 09:19, 24 March 2013
Line 2:		Line 2:
	===ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA===		===ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA===
	{{ABSTRACT_PUBMED_12654265}}		{{ABSTRACT_PUBMED_12654265}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:[http://omim.org/entry/608565 608565]]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:18179891</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Nuclear receptor, may regulate ESR1 transcriptional activity.<ref>PMID:19755138</ref>

	==About this Structure==		==About this Structure==
Line 10:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:012654265</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012654265</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dyson, H J.]]		[[Category: Dyson, H J.]]

←Older revision		Revision as of 14:50, 27 October 2021
Line 3:		Line 3:
	<StructureSection load='1lo1' size='340' side='right'caption='[[1lo1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1lo1' size='340' side='right'caption='[[1lo1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lo1]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1LO1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lo1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LO1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hERR2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hERR2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [~~http~~://pdbe.org/1lo1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1lo1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [https://pdbe.org/1lo1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [https://www.ebi.ac.uk/pdbsum/1lo1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:[~~http~~://omim.org/entry/608565 608565]]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:18179891</ref>	+	[[https://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:[https://omim.org/entry/608565 608565]]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:18179891</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Nuclear receptor, may regulate ESR1 transcriptional activity.<ref>PMID:19755138</ref>	+	[[https://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Nuclear receptor, may regulate ESR1 transcriptional activity.<ref>PMID:19755138</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]