1lo6 - Revision history

OCA at 09:16, 16 August 2023

OCA — Wed, 16 Aug 2023 09:16:06 GMT

←Older revision		Revision as of 09:16, 16 August 2023
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	<StructureSection load='1lo6' size='340' side='right'caption='[[1lo6]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='1lo6' size='340' side='right'caption='[[1lo6]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lo6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LO6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lo6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LO6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.56Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height~~: ~~3em;~~'>~~[[1l2e\|1l2e]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo6 OCA], [https://pdbe.org/1lo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lo6 RCSB], [https://www.ebi.ac.uk/pdbsum/1lo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo6 OCA], [https://pdbe.org/1lo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lo6 RCSB], [https://www.ebi.ac.uk/pdbsum/1lo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KLK6_HUMAN KLK6_HUMAN]] Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.<ref>PMID:12878203</ref> <ref>PMID:12928483</ref> <ref>PMID:15557757</ref> <ref>PMID:16987227</ref> <ref>PMID:16321973</ref> <ref>PMID:11983703</ref>	+	[https://www.uniprot.org/uniprot/KLK6_HUMAN KLK6_HUMAN] Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.<ref>PMID:12878203</ref> <ref>PMID:12928483</ref> <ref>PMID:15557757</ref> <ref>PMID:16987227</ref> <ref>PMID:16321973</ref> <ref>PMID:11983703</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bernett~~, M J~~]]	+	[[Category: Bernett MJ]]
-	[[Category: Blaber, M]]	+	[[Category: Blaber M]]
-	[[Category: Blaber~~, S I~~]]	+	[[Category: Blaber SI]]
-	[[Category: Dhanarajan, P]]	+	[[Category: Dhanarajan P]]
-	[[Category: Scarisbrick~~, I A~~]]	+	[[Category: Scarisbrick IA]]
-	[[Category: Thompson~~, S M]]~~	+	[[Category: Thompson SM]]
-	~~[[Category: Benzamidine]]~~	+
-	~~[[Category: Brain serine protease]]~~	+
-	~~[[Category: Hk6]]~~	+
-	~~[[Category: Human kallikrein 6]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Kallikrein]]~~	+
-	~~[[Category: Msp]]~~	+
-	~~[[Category: Myelencephalon specific protease]]~~	+
-	~~[[Category: Neurosin]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Protease m]]~~	+
-	~~[[Category: Serine protease]]~~	+
-	~~[[Category: Zyme~~]]	+

OCA at 06:47, 18 August 2021

OCA — Wed, 18 Aug 2021 06:47:06 GMT

←Older revision		Revision as of 06:47, 18 August 2021
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	<StructureSection load='1lo6' size='340' side='right'caption='[[1lo6]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='1lo6' size='340' side='right'caption='[[1lo6]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lo6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LO6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lo6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LO6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l2e\|1l2e]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1l2e\|1l2e]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo6 OCA], [~~http~~://pdbe.org/1lo6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1lo6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1lo6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo6 OCA], [https://pdbe.org/1lo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lo6 RCSB], [https://www.ebi.ac.uk/pdbsum/1lo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KLK6_HUMAN KLK6_HUMAN]] Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.<ref>PMID:12878203</ref> <ref>PMID:12928483</ref> <ref>PMID:15557757</ref> <ref>PMID:16987227</ref> <ref>PMID:16321973</ref> <ref>PMID:11983703</ref>	+	[[https://www.uniprot.org/uniprot/KLK6_HUMAN KLK6_HUMAN]] Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.<ref>PMID:12878203</ref> <ref>PMID:12928483</ref> <ref>PMID:15557757</ref> <ref>PMID:16987227</ref> <ref>PMID:16321973</ref> <ref>PMID:11983703</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:24, 13 November 2019

OCA — Wed, 13 Nov 2019 12:24:11 GMT

←Older revision		Revision as of 12:24, 13 November 2019
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	==Human Kallikrein 6 (hK6) active form with benzamidine inhibitor at 1.56 A resolution==		==Human Kallikrein 6 (hK6) active form with benzamidine inhibitor at 1.56 A resolution==
-	<StructureSection load='1lo6' size='340' side='right' caption='[[1lo6]], [[Resolution\|resolution]] 1.56Å' scene=''>	+	<StructureSection load='1lo6' size='340' side='right'caption='[[1lo6]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lo6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lo6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO6 FirstGlance]. <br>
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lo6 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lo6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Kallikrein 3D structures\|Kallikrein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bernett, M J]]		[[Category: Bernett, M J]]
	[[Category: Blaber, M]]		[[Category: Blaber, M]]

OCA at 07:59, 31 January 2018

OCA — Wed, 31 Jan 2018 07:59:49 GMT

←Older revision		Revision as of 07:59, 31 January 2018
Line 1:		Line 1:
		+
	==Human Kallikrein 6 (hK6) active form with benzamidine inhibitor at 1.56 A resolution==		==Human Kallikrein 6 (hK6) active form with benzamidine inhibitor at 1.56 A resolution==
	<StructureSection load='1lo6' size='340' side='right' caption='[[1lo6]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='1lo6' size='340' side='right' caption='[[1lo6]], [[Resolution\|resolution]] 1.56Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l2e\|1l2e]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l2e\|1l2e]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo6 OCA], [http://pdbe.org/1lo6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lo6 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo6 OCA], [http://pdbe.org/1lo6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lo6 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1lo6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1lo6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lo6 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lo6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-
-	==See Also==
-	*[[Kallikrein\|Kallikrein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:46, 9 February 2016

OCA — Tue, 09 Feb 2016 11:46:26 GMT

←Older revision		Revision as of 11:46, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lo6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 21:54, 10 September 2015

OCA — Thu, 10 Sep 2015 21:54:54 GMT

←Older revision		Revision as of 21:54, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1lo6' size='340' side='right' caption='[[1lo6]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='1lo6' size='340' side='right' caption='[[1lo6]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lo6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lo6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l2e\|1l2e]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l2e\|1l2e]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lo6 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo6 OCA], [http://pdbe.org/1lo6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lo6 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo6 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Kallikrein\|Kallikrein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bernett, M J]]		[[Category: Bernett, M J]]
	[[Category: Blaber, M]]		[[Category: Blaber, M]]

OCA at 06:35, 25 December 2014

OCA — Thu, 25 Dec 2014 06:35:54 GMT

←Older revision		Revision as of 06:35, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lo6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lo6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l2e\|1l2e]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l2e\|1l2e]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lo6 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lo6 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo6 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KLK6_HUMAN KLK6_HUMAN]] Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.<ref>PMID:12878203</ref> <ref>PMID:12928483</ref> <ref>PMID:15557757</ref> <ref>PMID:16987227</ref> <ref>PMID:16321973</ref> <ref>PMID:11983703</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bernett, M J.]]	+	[[Category: Bernett, M J]]
-	[[Category: Blaber, M.]]	+	[[Category: Blaber, M]]
-	[[Category: Blaber, S I.]]	+	[[Category: Blaber, S I]]
-	[[Category: Dhanarajan, P.]]	+	[[Category: Dhanarajan, P]]
-	[[Category: Scarisbrick, I A.]]	+	[[Category: Scarisbrick, I A]]
-	[[Category: Thompson, S M.]]	+	[[Category: Thompson, S M]]
	[[Category: Benzamidine]]		[[Category: Benzamidine]]
	[[Category: Brain serine protease]]		[[Category: Brain serine protease]]

OCA at 18:14, 28 September 2014

OCA — Sun, 28 Sep 2014 18:14:27 GMT

←Older revision		Revision as of 18:14, 28 September 2014
Line 1:		Line 1:
-	~~[[Image:1lo6.png\|left\|200px]]~~	+	==Human Kallikrein 6 (hK6) active form with benzamidine inhibitor at 1.56 A resolution==
-		+	<StructureSection load='1lo6' size='340' side='right' caption='[[1lo6]], [[Resolution\|resolution]] 1.56Å' scene=''>
-	~~{{STRUCTURE_1lo6\| PDB=1lo6 \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1lo6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO6 FirstGlance]. <br>
-	===Human Kallikrein 6 (hK6) active form with benzamidine inhibitor at 1.56 A resolution===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l2e\|1l2e]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lo6 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo6 PDBsum]</span></td></tr>
-	==~~About this Structure~~==	+	<table>
-	[[1lo6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA].	+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1lo6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bernett, M J.]]		[[Category: Bernett, M J.]]

OCA: Protected "1lo6" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 21:06:17 GMT

Protected "1lo6" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:06, 5 December 2012

OCA at 21:06, 5 December 2012

OCA — Wed, 05 Dec 2012 21:06:14 GMT

←Older revision		Revision as of 21:06, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1lo6.png\|left\|200px]]		[[Image:1lo6.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1lo6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1lo6\| PDB=1lo6 \| SCENE= }}		{{STRUCTURE_1lo6\| PDB=1lo6 \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~1LO6~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA].	+	[[1lo6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bernett, M J.]]		[[Category: Bernett, M J.]]
Line 26:		Line 19:
	[[Category: Hk6]]		[[Category: Hk6]]
	[[Category: Human kallikrein 6]]		[[Category: Human kallikrein 6]]
		+	[[Category: Hydrolase]]
	[[Category: Kallikrein]]		[[Category: Kallikrein]]
	[[Category: Msp]]		[[Category: Msp]]
Line 34:		Line 28:
	[[Category: Serine protease]]		[[Category: Serine protease]]
	[[Category: Zyme]]		[[Category: Zyme]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:31:46 2009''