1loi - Revision history

OCA at 18:48, 29 November 2023

OCA — Wed, 29 Nov 2023 18:48:35 GMT

←Older revision		Revision as of 18:48, 29 November 2023
Line 1:		Line 1:

	==N-TERMINAL SPLICE REGION OF RAT C-AMP PHOSPHODIESTERASE, NMR, 7 STRUCTURES==		==N-TERMINAL SPLICE REGION OF RAT C-AMP PHOSPHODIESTERASE, NMR, 7 STRUCTURES==
-	<StructureSection load='1loi' size='340' side='right'caption='[[1loi~~]], [[NMR_Ensembles_of_Models \| 7 NMR models~~]]' scene=''>	+	<StructureSection load='1loi' size='340' side='right'caption='[[1loi]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1loi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LOI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1loi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LOI FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>[https://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1loi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loi OCA], [https://pdbe.org/1loi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1loi RCSB], [https://www.ebi.ac.uk/pdbsum/1loi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1loi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1loi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loi OCA], [https://pdbe.org/1loi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1loi RCSB], [https://www.ebi.ac.uk/pdbsum/1loi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1loi ProSAT]</span></td></tr>
	</table>		</table>
-	== Function ==
-	[[https://www.uniprot.org/uniprot/PDE4A_RAT PDE4A_RAT]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Beattie, J]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Houslay~~, M D~~]]	+	[[Category: Beattie J]]
-	[[Category: Scotland, G]]	+	[[Category: Houslay MD]]
-	[[Category: Smith~~, K J~~]]	+	[[Category: Scotland G]]
-	[[Category: Trayer~~, I P]]~~	+	[[Category: Smith KJ]]
-	~~[[Category: C-amp phosphodiesterase]]~~	+	[[Category: Trayer IP]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 05:55, 28 April 2021

OCA — Wed, 28 Apr 2021 05:55:10 GMT

←Older revision		Revision as of 05:55, 28 April 2021
Line 3:		Line 3:
	<StructureSection load='1loi' size='340' side='right'caption='[[1loi]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='1loi' size='340' side='right'caption='[[1loi]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1loi]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LOI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1loi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LOI FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1loi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loi OCA], [~~http~~://pdbe.org/1loi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1loi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1loi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1loi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1loi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loi OCA], [https://pdbe.org/1loi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1loi RCSB], [https://www.ebi.ac.uk/pdbsum/1loi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1loi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PDE4A_RAT PDE4A_RAT]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity).	+	[[https://www.uniprot.org/uniprot/PDE4A_RAT PDE4A_RAT]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Phosphodiesterase\|Phosphodiesterase]]	+	*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:27, 24 July 2019

OCA — Wed, 24 Jul 2019 09:27:54 GMT

←Older revision		Revision as of 09:27, 24 July 2019
Line 1:		Line 1:

	==N-TERMINAL SPLICE REGION OF RAT C-AMP PHOSPHODIESTERASE, NMR, 7 STRUCTURES==		==N-TERMINAL SPLICE REGION OF RAT C-AMP PHOSPHODIESTERASE, NMR, 7 STRUCTURES==
-	<StructureSection load='1loi' size='340' side='right' caption='[[1loi]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>	+	<StructureSection load='1loi' size='340' side='right'caption='[[1loi]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1loi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1loi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOI FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 1loi" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1loi" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphodiesterase\|Phosphodiesterase]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]		[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Beattie, J]]		[[Category: Beattie, J]]
	[[Category: Houslay, M D]]		[[Category: Houslay, M D]]

OCA at 10:41, 18 October 2017

OCA — Wed, 18 Oct 2017 10:41:49 GMT

←Older revision		Revision as of 10:41, 18 October 2017
Line 1:		Line 1:
		+
	==N-TERMINAL SPLICE REGION OF RAT C-AMP PHOSPHODIESTERASE, NMR, 7 STRUCTURES==		==N-TERMINAL SPLICE REGION OF RAT C-AMP PHOSPHODIESTERASE, NMR, 7 STRUCTURES==
	<StructureSection load='1loi' size='340' side='right' caption='[[1loi]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='1loi' size='340' side='right' caption='[[1loi]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1loi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loi OCA], [http://pdbe.org/1loi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1loi RCSB], [http://www.ebi.ac.uk/pdbsum/1loi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1loi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loi OCA], [http://pdbe.org/1loi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1loi RCSB], [http://www.ebi.ac.uk/pdbsum/1loi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1loi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 1loi" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1loi" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Phosphodiesterase\|Phosphodiesterase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:15, 11 September 2015

OCA — Fri, 11 Sep 2015 01:15:57 GMT

←Older revision		Revision as of 01:15, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1loi' size='340' side='right' caption='[[1loi]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='1loi' size='340' side='right' caption='[[1loi]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1loi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1loi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOI FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1loi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1loi RCSB], [http://www.ebi.ac.uk/pdbsum/1loi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1loi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loi OCA], [http://pdbe.org/1loi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1loi RCSB], [http://www.ebi.ac.uk/pdbsum/1loi PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1loi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]		[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Beattie, J]]		[[Category: Beattie, J]]
	[[Category: Houslay, M D]]		[[Category: Houslay, M D]]

OCA at 08:57, 25 December 2014

OCA — Thu, 25 Dec 2014 08:57:45 GMT

←Older revision		Revision as of 08:57, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1loi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1loi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1loi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1loi RCSB], [http://www.ebi.ac.uk/pdbsum/1loi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1loi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1loi RCSB], [http://www.ebi.ac.uk/pdbsum/1loi PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDE4A_RAT PDE4A_RAT]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 26:
	[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]		[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Beattie, J.]]	+	[[Category: Beattie, J]]
-	[[Category: Houslay, M D.]]	+	[[Category: Houslay, M D]]
-	[[Category: Scotland, G.]]	+	[[Category: Scotland, G]]
-	[[Category: Smith, K J.]]	+	[[Category: Smith, K J]]
-	[[Category: Trayer, I P.]]	+	[[Category: Trayer, I P]]
	[[Category: C-amp phosphodiesterase]]		[[Category: C-amp phosphodiesterase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 15:11, 28 September 2014

OCA — Sun, 28 Sep 2014 15:11:08 GMT

←Older revision		Revision as of 15:11, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1loi.~~png~~\|~~left\|200px~~]]	+	==N-TERMINAL SPLICE REGION OF RAT C-AMP PHOSPHODIESTERASE, NMR, 7 STRUCTURES==
		+	<StructureSection load='1loi' size='340' side='right' caption='[[1loi]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1loi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1loi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1loi RCSB], [http://www.ebi.ac.uk/pdbsum/1loi PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A 25-residue peptide representing the membrane targeting N-terminal splice region of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1) was synthesized, and its structure was determined by 1H NMR. Two independently folding helical regions were identified, separated by a highly mobile "hinge" region. The first helical region was formed by an N-terminal amphipathic alpha-helix, and the second consisted of multiple overlapping turns and contained a distinct compact, hydrophobic, tryptophan-rich domain (residues 14-20). Chimeric molecules, formed between the N-terminal region of RD1 and the soluble bacterial protein chloramphenicol acetyltransferase, were used in an in vitro system to determine the features within the splice region that were required for membrane association. The ability of RD1-chloramphenicol acetyltransferase chimera to become membrane-associated was not affected by deletion of any of the following regions: the apolar section (residues 2-7) of the first helical region, the polar part of this region together with the hinge region (residues 8-13), or the polar end of the C-terminal helical region (residues 21-25). In marked contrast, deletion of the compact, hydrophobic tryptophan-rich domain (residues 14-20) found in the second helical region obliterated membrane association. Replacement of this domain with a hydrophobic cassette of seven alanine residues also abolished membrane association, indicating that membrane-association occurred by virtue of specific hydrophobic interactions with residues within the compact, tryptophan-rich domain. The structure of this domain is well defined in the peptide, and although the region is helical, both the backbone and the distribution of side chains are somewhat distorted as compared with an ideal alpha-helix. Hydrophobic interactions, such as the "stacked" rings of residues Pro14 and Trp15, stabilize this domain with the side chain of residue Leu16 adopting a central position, interacting with the side chains of all three tryptophan residues 15, 19, and 20. These bulky side chains thus form a hydrophobic cluster. In contrast, the side chain of residue Val17 is relatively exposed, pointing out from the opposite "face" of the peptide. Although it appears that this compact, tryptophan-rich domain is responsible for membrane association, at present the target site and hence the specific interactions involved in membrane targeting by the RD1 splice region remain unidentified.

-	~~{{STRUCTURE_1loi\| PDB=1loi \| SCENE= }}~~	+	Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs.,Smith KJ, Scotland G, Beattie J, Trayer IP, Houslay MD J Biol Chem. 1996 Jul 12;271(28):16703-11. PMID:8663181<ref>PMID:8663181</ref>

-	~~===N-TERMINAL SPLICE REGION OF RAT C-AMP PHOSPHODIESTERASE~~, ~~NMR, 7 STRUCTURES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8663181}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1loi]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA].~~	+

	==See Also==		==See Also==
	*[[Phosphodiesterase\|Phosphodiesterase]]		*[[Phosphodiesterase\|Phosphodiesterase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:008663181<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]		[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]

OCA at 14:51, 20 October 2012

OCA — Sat, 20 Oct 2012 14:51:44 GMT

←Older revision		Revision as of 14:51, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1loi]] is a 1 chain structure ~~of [[Phosphodiesterase]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA].	+	[[1loi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA].

	==See Also==		==See Also==

OCA: Protected "1loi" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 16:32:03 GMT

Protected "1loi" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:32, 26 July 2012

OCA at 16:32, 26 July 2012

OCA — Thu, 26 Jul 2012 16:32:00 GMT

←Older revision		Revision as of 16:32, 26 July 2012
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-	{{Seed}}
	[[Image:1loi.png\|left\|200px]]		[[Image:1loi.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1loi\| PDB=1loi \| SCENE= }}		{{STRUCTURE_1loi\| PDB=1loi \| SCENE= }}

	===N-TERMINAL SPLICE REGION OF RAT C-AMP PHOSPHODIESTERASE, NMR, 7 STRUCTURES===		===N-TERMINAL SPLICE REGION OF RAT C-AMP PHOSPHODIESTERASE, NMR, 7 STRUCTURES===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8663181}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_8663181}}		{{ABSTRACT_PUBMED_8663181}}

	==About this Structure==		==About this Structure==
-	~~1LOI is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA].	+	[[1loi]] is a 1 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOI OCA].
		+
		+	==See Also==
		+	*[[Phosphodiesterase\|Phosphodiesterase]]

	==Reference==		==Reference==
-	Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs., Smith KJ, Scotland G, Beattie J, Trayer IP, Houslay MD, J Biol Chem. 1996 Jul 12;271(28):16703-11. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~8663181 8663181]~~	+	<ref group="xtra">PMID:008663181</ref><references group="xtra"/>
	[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]		[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Single protein]]
	[[Category: Beattie, J.]]		[[Category: Beattie, J.]]
	[[Category: Houslay, M D.]]		[[Category: Houslay, M D.]]
Line 34:		Line 24:
	[[Category: C-amp phosphodiesterase]]		[[Category: C-amp phosphodiesterase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:35:39 2008''