1lqq - Revision history

OCA at 08:26, 10 April 2024

OCA — Wed, 10 Apr 2024 08:26:25 GMT

←Older revision		Revision as of 08:26, 10 April 2024
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	==ANTI-MAMMAL AND ANTI-INSECT LQQIII SCORPION TOXIN, NMR, 15 STRUCTURES==		==ANTI-MAMMAL AND ANTI-INSECT LQQIII SCORPION TOXIN, NMR, 15 STRUCTURES==
-	<StructureSection load='1lqq' size='340' side='right'caption='[[1lqq~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='1lqq' size='340' side='right'caption='[[1lqq]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LQQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LQQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqq OCA], [https://pdbe.org/1lqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lqq RCSB], [https://www.ebi.ac.uk/pdbsum/1lqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lqq ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqq OCA], [https://pdbe.org/1lqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lqq RCSB], [https://www.ebi.ac.uk/pdbsum/1lqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lqq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SCX3_LEIQU SCX3_LEIQU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This contractive toxin is highly toxic both to mammals and insects.	+	[https://www.uniprot.org/uniprot/SCX3_LEIQU SCX3_LEIQU] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This contractive toxin is highly toxic both to mammals and insects.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lqq ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lqq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	We describe the secondary structure and the overall fold of toxin III from the venom of the scorpion Leiurus quinquestriatus quinquestriatus determined using two-dimensional-1H-NMR spectroscopy. This protein, which contains 64 amino acids and 4 disulfide bridges, belongs to the long-chain toxin category and is highly toxic to both mammals and insects. The overall fold was determined on the basis of 1208 inter-proton-distance restraints derived from NOE measurements and 90 psi, phi dihedral-angle restraints derived from NOE connectivities and 3JNH-alphaH coupling constants using the HABAS program. This fold, which mainly consists of an alpha-helix packed against a small antiparallel three-stranded beta-sheet, and of several turns and loops, is similar to that of other long-chain scorpion toxins. Aromatic and non-polar residues form several patches on the surface of the protein which alternate with patches of charged and polar residues. Such a topology should be important in the interactions of toxin III with sodium channels in membranes. Two weakly constrained loops introduce some flexibility to the structure which could be related to the activity of this toxin. The central core of toxin III is compared with the cysteine-stabilized alpha beta motif (an alpha-helix connected to a beta-sheet through two disulfide bridges) found in insect defensins and plant thionins. Defensins and thionins are small proteins (approximately 40--50 amino acid residues) containing three or four disulfide bridges, respectively. This comparison confirms that the cysteine-stabilized alpha beta motif is a common core to a number of small proteins from different origins and having different activities.
-
-	1H-NMR-derived secondary structure and the overall fold of the potent anti-mammal and anti-insect toxin III from the scorpion Leiurus quinquestriatus quinquestriatus.,Landon C, Cornet B, Bonmatin JM, Kopeyan C, Rochat H, Vovelle F, Ptak M Eur J Biochem. 1996 Mar 1;236(2):395-404. PMID:8612608<ref>PMID:8612608</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1lqq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Hemolysin 3D structures\|Hemolysin 3D structures]]		*[[Hemolysin 3D structures\|Hemolysin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Leiurus quinquestriatus quinquestriatus]]		[[Category: Leiurus quinquestriatus quinquestriatus]]
-	[[Category: Landon, C]]	+	[[Category: Landon C]]
-	[[Category: Ptak, M]]	+	[[Category: Ptak M]]
-	[[Category: Sodano, P]]	+	[[Category: Sodano P]]
-	[[Category: Vovelle, F]]	+	[[Category: Vovelle F]]
-	~~[[Category: Csalpha-beta motif]]~~	+
-	~~[[Category: Lqqiii]]~~	+
-	~~[[Category: Neurotoxin]]~~	+
-	~~[[Category: Scorpion toxin]]~~	+
-	~~[[Category: Sodium channel inhibitor~~]]	+

OCA at 06:48, 18 August 2021

OCA — Wed, 18 Aug 2021 06:48:18 GMT

←Older revision		Revision as of 06:48, 18 August 2021
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	<StructureSection load='1lqq' size='340' side='right'caption='[[1lqq]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1lqq' size='340' side='right'caption='[[1lqq]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LQQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LQQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1lqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqq OCA], [~~http~~://pdbe.org/1lqq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1lqq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1lqq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1lqq ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqq OCA], [https://pdbe.org/1lqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lqq RCSB], [https://www.ebi.ac.uk/pdbsum/1lqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lqq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SCX3_LEIQU SCX3_LEIQU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This contractive toxin is highly toxic both to mammals and insects.	+	[[https://www.uniprot.org/uniprot/SCX3_LEIQU SCX3_LEIQU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This contractive toxin is highly toxic both to mammals and insects.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:23, 13 November 2019

OCA — Wed, 13 Nov 2019 12:23:10 GMT

←Older revision		Revision as of 12:23, 13 November 2019
Line 1:		Line 1:

	==ANTI-MAMMAL AND ANTI-INSECT LQQIII SCORPION TOXIN, NMR, 15 STRUCTURES==		==ANTI-MAMMAL AND ANTI-INSECT LQQIII SCORPION TOXIN, NMR, 15 STRUCTURES==
-	<StructureSection load='1lqq' size='340' side='right' caption='[[1lqq]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='1lqq' size='340' side='right'caption='[[1lqq]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LQQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LQQ FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1lqq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1lqq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hemolysin 3D structures\|Hemolysin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Leiurus quinquestriatus quinquestriatus]]		[[Category: Leiurus quinquestriatus quinquestriatus]]
	[[Category: Landon, C]]		[[Category: Landon, C]]

OCA at 07:58, 31 January 2018

OCA — Wed, 31 Jan 2018 07:58:46 GMT

←Older revision		Revision as of 07:58, 31 January 2018
Line 1:		Line 1:
		+
	==ANTI-MAMMAL AND ANTI-INSECT LQQIII SCORPION TOXIN, NMR, 15 STRUCTURES==		==ANTI-MAMMAL AND ANTI-INSECT LQQIII SCORPION TOXIN, NMR, 15 STRUCTURES==
	<StructureSection load='1lqq' size='340' side='right' caption='[[1lqq]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1lqq' size='340' side='right' caption='[[1lqq]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Deathstalker_scorpion Deathstalker scorpion~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LQQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LQQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqq OCA], [http://pdbe.org/1lqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lqq RCSB], [http://www.ebi.ac.uk/pdbsum/1lqq PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqq OCA], [http://pdbe.org/1lqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lqq RCSB], [http://www.ebi.ac.uk/pdbsum/1lqq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lqq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lq/1lqq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lq/1lqq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Deathstalker scorpion~~]]	+	[[Category: Leiurus quinquestriatus quinquestriatus]]
	[[Category: Landon, C]]		[[Category: Landon, C]]
	[[Category: Ptak, M]]		[[Category: Ptak, M]]

OCA at 07:06, 7 February 2016

OCA — Sun, 07 Feb 2016 07:06:42 GMT

←Older revision		Revision as of 07:06, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lqq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:00, 9 September 2015

OCA — Wed, 09 Sep 2015 23:00:25 GMT

←Older revision		Revision as of 23:00, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1lqq' size='340' side='right' caption='[[1lqq]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1lqq' size='340' side='right' caption='[[1lqq]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LQQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Deathstalker_scorpion Deathstalker scorpion]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LQQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lqq RCSB], [http://www.ebi.ac.uk/pdbsum/1lqq PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqq OCA], [http://pdbe.org/1lqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lqq RCSB], [http://www.ebi.ac.uk/pdbsum/1lqq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1lqq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Leiurus quinquestriatus quinquestriatus~~]]	+	[[Category: Deathstalker scorpion]]
	[[Category: Landon, C]]		[[Category: Landon, C]]
	[[Category: Ptak, M]]		[[Category: Ptak, M]]

OCA at 08:51, 24 December 2014

OCA — Wed, 24 Dec 2014 08:51:23 GMT

←Older revision		Revision as of 08:51, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LQQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LQQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lqq RCSB], [http://www.ebi.ac.uk/pdbsum/1lqq PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lqq RCSB], [http://www.ebi.ac.uk/pdbsum/1lqq PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SCX3_LEIQU SCX3_LEIQU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This contractive toxin is highly toxic both to mammals and insects.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Leiurus quinquestriatus quinquestriatus]]		[[Category: Leiurus quinquestriatus quinquestriatus]]
-	[[Category: Landon, C.]]	+	[[Category: Landon, C]]
-	[[Category: Ptak, M.]]	+	[[Category: Ptak, M]]
-	[[Category: Sodano, P.]]	+	[[Category: Sodano, P]]
-	[[Category: Vovelle, F.]]	+	[[Category: Vovelle, F]]
	[[Category: Csalpha-beta motif]]		[[Category: Csalpha-beta motif]]
	[[Category: Lqqiii]]		[[Category: Lqqiii]]

OCA at 14:31, 28 September 2014

OCA — Sun, 28 Sep 2014 14:31:57 GMT

←Older revision		Revision as of 14:31, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1lqq.~~png\|left~~\|200px]]	+	==ANTI-MAMMAL AND ANTI-INSECT LQQIII SCORPION TOXIN, NMR, 15 STRUCTURES==
		+	<StructureSection load='1lqq' size='340' side='right' caption='[[1lqq]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LQQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lqq RCSB], [http://www.ebi.ac.uk/pdbsum/1lqq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lq/1lqq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We describe the secondary structure and the overall fold of toxin III from the venom of the scorpion Leiurus quinquestriatus quinquestriatus determined using two-dimensional-1H-NMR spectroscopy. This protein, which contains 64 amino acids and 4 disulfide bridges, belongs to the long-chain toxin category and is highly toxic to both mammals and insects. The overall fold was determined on the basis of 1208 inter-proton-distance restraints derived from NOE measurements and 90 psi, phi dihedral-angle restraints derived from NOE connectivities and 3JNH-alphaH coupling constants using the HABAS program. This fold, which mainly consists of an alpha-helix packed against a small antiparallel three-stranded beta-sheet, and of several turns and loops, is similar to that of other long-chain scorpion toxins. Aromatic and non-polar residues form several patches on the surface of the protein which alternate with patches of charged and polar residues. Such a topology should be important in the interactions of toxin III with sodium channels in membranes. Two weakly constrained loops introduce some flexibility to the structure which could be related to the activity of this toxin. The central core of toxin III is compared with the cysteine-stabilized alpha beta motif (an alpha-helix connected to a beta-sheet through two disulfide bridges) found in insect defensins and plant thionins. Defensins and thionins are small proteins (approximately 40--50 amino acid residues) containing three or four disulfide bridges, respectively. This comparison confirms that the cysteine-stabilized alpha beta motif is a common core to a number of small proteins from different origins and having different activities.

-	~~{{STRUCTURE_1lqq\| PDB=1lqq \| SCENE= }}~~	+	1H-NMR-derived secondary structure and the overall fold of the potent anti-mammal and anti-insect toxin III from the scorpion Leiurus quinquestriatus quinquestriatus.,Landon C, Cornet B, Bonmatin JM, Kopeyan C, Rochat H, Vovelle F, Ptak M Eur J Biochem. 1996 Mar 1;236(2):395-404. PMID:8612608<ref>PMID:8612608</ref>

-	~~===ANTI-MAMMAL AND ANTI-INSECT LQQIII SCORPION TOXIN~~, ~~NMR, 15 STRUCTURES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8612608}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1lqq]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:008612608<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Leiurus quinquestriatus quinquestriatus]]		[[Category: Leiurus quinquestriatus quinquestriatus]]
	[[Category: Landon, C.]]		[[Category: Landon, C.]]

OCA: Protected "1lqq" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 20:04:56 GMT

Protected "1lqq" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:04, 5 December 2012

OCA at 20:04, 5 December 2012

OCA — Wed, 05 Dec 2012 20:04:54 GMT

←Older revision		Revision as of 20:04, 5 December 2012
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-	{{Seed}}
	[[Image:1lqq.png\|left\|200px]]		[[Image:1lqq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1lqq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1lqq\| PDB=1lqq \| SCENE= }}		{{STRUCTURE_1lqq\| PDB=1lqq \| SCENE= }}

	===ANTI-MAMMAL AND ANTI-INSECT LQQIII SCORPION TOXIN, NMR, 15 STRUCTURES===		===ANTI-MAMMAL AND ANTI-INSECT LQQIII SCORPION TOXIN, NMR, 15 STRUCTURES===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8612608}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8612608 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_8612608}}		{{ABSTRACT_PUBMED_8612608}}

	==About this Structure==		==About this Structure==
-	~~1LQQ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA].	+	[[1lqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8612608~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008612608</ref><references group="xtra"/>
	[[Category: Leiurus quinquestriatus quinquestriatus]]		[[Category: Leiurus quinquestriatus quinquestriatus]]
	[[Category: Landon, C.]]		[[Category: Landon, C.]]
Line 34:		Line 22:
	[[Category: Scorpion toxin]]		[[Category: Scorpion toxin]]
	[[Category: Sodium channel inhibitor]]		[[Category: Sodium channel inhibitor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:09:40 2009''