1lti - Revision history

OCA at 08:27, 10 April 2024

OCA — Wed, 10 Apr 2024 08:27:43 GMT

←Older revision		Revision as of 08:27, 10 April 2024
Line 3:		Line 3:
	<StructureSection load='1lti' size='340' side='right'caption='[[1lti]], [[Resolution\|resolution]] 2.13Å' scene=''>		<StructureSection load='1lti' size='340' side='right'caption='[[1lti]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lti]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LTI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lti]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LTI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=~~A2G~~:N-~~ACETYL-2-DEOXY-2-AMINO-GALACTOSE~~'>~~A2G~~</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.13Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900084:Thomsen-Friedenreich+antigen'>PRD_900084</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lti OCA], [https://pdbe.org/1lti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lti RCSB], [https://www.ebi.ac.uk/pdbsum/1lti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lti ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lti OCA], [https://pdbe.org/1lti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lti RCSB], [https://www.ebi.ac.uk/pdbsum/1lti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lti ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ELBP_ECOLX ELBP_ECOLX~~]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase. [[https://www.uniprot.org/uniprot/ELAP_ECOLX ELAP_ECOLX]~~] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.	+	[https://www.uniprot.org/uniprot/ELBP_ECOLX ELBP_ECOLX] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lti ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lti ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Heat-labile enterotoxin (LT) is part of the cholera toxin (CT) family and consists of a catalytic A subunit and a B pentamer that serves to recognize the oligosaccharide part of the GM1 ganglioside receptor. We report here the crystal structure of heat-labile enterotoxin in complex with the disaccharide portion of the Thomsen-Friedenreich (T-antigen) tumor marker. The toxin:carbohydrate complex is determined to 2.13 A resolution, yielding an R-factor of 18.5%. The T-antigen disaccharide, D-Gal-beta 1,3-GalNAc-Ser/Thr, is present in more than 85% of human carcinomas and monitoring its autoimmune response is used for the early detection of tumors. Insight into the molecular recognition of this tumor antigen by sugar binding proteins can benefit the development of a diagnostic tool for human carcinomas as well as a T-antigen directed anticancer drug delivery system.
-
-	Tumor marker disaccharide D-Gal-beta 1, 3-GalNAc complexed to heat-labile enterotoxin from Escherichia coli.,van den Akker F, Steensma E, Hol WG Protein Sci. 1996 Jun;5(6):1184-8. PMID:8762150<ref>PMID:8762150</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1lti" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Akker, F Van Den]]~~	+	[[Category: Hol WGJ]]
-	[[Category: Hol~~, W G.J~~]]	+	[[Category: Van Den Akker F]]
-	[[Category: ~~Adp-ribosyl transferase]]~~	+
-	~~[[Category: Enterotoxin~~]]	+

OCA at 06:49, 18 August 2021

OCA — Wed, 18 Aug 2021 06:49:06 GMT

←Older revision		Revision as of 06:49, 18 August 2021
Line 3:		Line 3:
	<StructureSection load='1lti' size='340' side='right'caption='[[1lti]], [[Resolution\|resolution]] 2.13Å' scene=''>		<StructureSection load='1lti' size='340' side='right'caption='[[1lti]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lti]] is a 7 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LTI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lti]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LTI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~A2G~~:N-~~ACETYL-2-DEOXY-2-AMINO~~-GALACTOSE'>~~A2G~~</scene>, <scene name='pdbligand=~~GAL~~:~~BETA~~-D-GALACTOSE'>~~GAL~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1lti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lti OCA], [~~http~~://pdbe.org/1lti PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1lti RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1lti PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1lti ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lti OCA], [https://pdbe.org/1lti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lti RCSB], [https://www.ebi.ac.uk/pdbsum/1lti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lti ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ELBP_ECOLX ELBP_ECOLX]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase. [[~~http~~://www.uniprot.org/uniprot/ELAP_ECOLX ELAP_ECOLX]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.	+	[[https://www.uniprot.org/uniprot/ELBP_ECOLX ELBP_ECOLX]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase. [[https://www.uniprot.org/uniprot/ELAP_ECOLX ELAP_ECOLX]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:10, 13 November 2019

OCA — Wed, 13 Nov 2019 12:10:05 GMT

←Older revision		Revision as of 12:10, 13 November 2019
Line 1:		Line 1:

	==HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN==		==HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN==
-	<StructureSection load='1lti' size='340' side='right' caption='[[1lti]], [[Resolution\|resolution]] 2.13Å' scene=''>	+	<StructureSection load='1lti' size='340' side='right'caption='[[1lti]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lti]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lti]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTI FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Akker, F Van Den]]		[[Category: Akker, F Van Den]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]
	[[Category: Adp-ribosyl transferase]]		[[Category: Adp-ribosyl transferase]]
	[[Category: Enterotoxin]]		[[Category: Enterotoxin]]

OCA at 07:46, 31 January 2018

OCA — Wed, 31 Jan 2018 07:46:34 GMT

←Older revision		Revision as of 07:46, 31 January 2018
Line 1:		Line 1:
		+
	==HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN==		==HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN==
	<StructureSection load='1lti' size='340' side='right' caption='[[1lti]], [[Resolution\|resolution]] 2.13Å' scene=''>		<StructureSection load='1lti' size='340' side='right' caption='[[1lti]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lti]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lti]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~GAL~~:~~BETA~~-D-GALACTOSE'>~~GAL~~</scene>, <scene name='pdbligand=~~A2G~~:N-~~ACETYL-2-DEOXY-2-AMINO~~-GALACTOSE'>~~A2G~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lti OCA], [http://pdbe.org/1lti PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lti RCSB], [http://www.ebi.ac.uk/pdbsum/1lti PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lti OCA], [http://pdbe.org/1lti PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lti RCSB], [http://www.ebi.ac.uk/pdbsum/1lti PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lti ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lt/1lti_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lt/1lti_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 14:41, 9 February 2016

OCA — Tue, 09 Feb 2016 14:41:01 GMT

←Older revision		Revision as of 14:41, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lti ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:14, 10 September 2015

OCA — Thu, 10 Sep 2015 23:14:35 GMT

←Older revision		Revision as of 23:14, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1lti' size='340' side='right' caption='[[1lti]], [[Resolution\|resolution]] 2.13Å' scene=''>		<StructureSection load='1lti' size='340' side='right' caption='[[1lti]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lti]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lti]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lti OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lti RCSB], [http://www.ebi.ac.uk/pdbsum/1lti PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lti OCA], [http://pdbe.org/1lti PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lti RCSB], [http://www.ebi.ac.uk/pdbsum/1lti PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~ELBP_ECOLI ELBP_ECOLI~~]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase. [[http://www.uniprot.org/uniprot/~~ELAP_ECOLI ELAP_ECOLI~~]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.	+	[[http://www.uniprot.org/uniprot/ELBP_ECOLX ELBP_ECOLX]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase. [[http://www.uniprot.org/uniprot/ELAP_ECOLX ELAP_ECOLX]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1lti" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Akker, F Van Den]]		[[Category: Akker, F Van Den]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]
	[[Category: Adp-ribosyl transferase]]		[[Category: Adp-ribosyl transferase]]
	[[Category: Enterotoxin]]		[[Category: Enterotoxin]]

OCA at 07:27, 25 December 2014

OCA — Thu, 25 Dec 2014 07:27:27 GMT

←Older revision		Revision as of 07:27, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lti]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lti]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lti OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lti RCSB], [http://www.ebi.ac.uk/pdbsum/1lti PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lti OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lti RCSB], [http://www.ebi.ac.uk/pdbsum/1lti PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ELBP_ECOLI ELBP_ECOLI]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase. [[http://www.uniprot.org/uniprot/ELAP_ECOLI ELAP_ECOLI]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Akker, F Van Den.]]	+	[[Category: Akker, F Van Den]]
-	[[Category: Hol, W G.J.]]	+	[[Category: Hol, W G.J]]
	[[Category: Adp-ribosyl transferase]]		[[Category: Adp-ribosyl transferase]]
	[[Category: Enterotoxin]]		[[Category: Enterotoxin]]

OCA at 13:42, 28 September 2014

OCA — Sun, 28 Sep 2014 13:42:49 GMT

←Older revision		Revision as of 13:42, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1lti.~~png\|left~~\|200px]]	+	==HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN==
		+	<StructureSection load='1lti' size='340' side='right' caption='[[1lti]], [[Resolution\|resolution]] 2.13Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1lti]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lti OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lti RCSB], [http://www.ebi.ac.uk/pdbsum/1lti PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lt/1lti_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heat-labile enterotoxin (LT) is part of the cholera toxin (CT) family and consists of a catalytic A subunit and a B pentamer that serves to recognize the oligosaccharide part of the GM1 ganglioside receptor. We report here the crystal structure of heat-labile enterotoxin in complex with the disaccharide portion of the Thomsen-Friedenreich (T-antigen) tumor marker. The toxin:carbohydrate complex is determined to 2.13 A resolution, yielding an R-factor of 18.5%. The T-antigen disaccharide, D-Gal-beta 1,3-GalNAc-Ser/Thr, is present in more than 85% of human carcinomas and monitoring its autoimmune response is used for the early detection of tumors. Insight into the molecular recognition of this tumor antigen by sugar binding proteins can benefit the development of a diagnostic tool for human carcinomas as well as a T-antigen directed anticancer drug delivery system.

-	~~{{STRUCTURE_1lti\| PDB=1lti \| SCENE= }}~~	+	Tumor marker disaccharide D-Gal-beta 1, 3-GalNAc complexed to heat-labile enterotoxin from Escherichia coli.,van den Akker F, Steensma E, Hol WG Protein Sci. 1996 Jun;5(6):1184-8. PMID:8762150<ref>PMID:8762150</ref>

-	~~===HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8762150}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1lti]] is~~ a ~~7 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:008762150<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Akker, F Van Den.]]		[[Category: Akker, F Van Den.]]

OCA: Protected "1lti" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 20:45:07 GMT

Protected "1lti" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:45, 5 December 2012

OCA at 20:45, 5 December 2012

OCA — Wed, 05 Dec 2012 20:45:04 GMT

←Older revision		Revision as of 20:45, 5 December 2012
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-	{{Seed}}
	[[Image:1lti.png\|left\|200px]]		[[Image:1lti.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1lti", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1lti\| PDB=1lti \| SCENE= }}		{{STRUCTURE_1lti\| PDB=1lti \| SCENE= }}

	===HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN===		===HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8762150}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8762150 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8762150}}		{{ABSTRACT_PUBMED_8762150}}

	==About this Structure==		==About this Structure==
-	~~1LTI~~ is a 7 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA].	+	[[1lti]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8762150~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008762150</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Akker, F Van Den.]]		[[Category: Akker, F Van Den.]]
Line 29:		Line 17:
	[[Category: Adp-ribosyl transferase]]		[[Category: Adp-ribosyl transferase]]
	[[Category: Enterotoxin]]		[[Category: Enterotoxin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:33:24 2009''