1ltr - Revision history

OCA at 06:28, 9 August 2023

OCA — Wed, 09 Aug 2023 06:28:54 GMT

←Older revision		Revision as of 06:28, 9 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ltr]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LTR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ltr]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LTR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.04Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ltr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ltr OCA], [https://pdbe.org/1ltr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ltr RCSB], [https://www.ebi.ac.uk/pdbsum/1ltr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ltr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ltr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ltr OCA], [https://pdbe.org/1ltr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ltr RCSB], [https://www.ebi.ac.uk/pdbsum/1ltr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ltr ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:23, 1 February 2023

OCA — Wed, 01 Feb 2023 12:23:28 GMT

←Older revision		Revision as of 12:23, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='1ltr' size='340' side='right'caption='[[1ltr]], [[Resolution\|resolution]] 3.04Å' scene=''>		<StructureSection load='1ltr' size='340' side='right'caption='[[1ltr]], [[Resolution\|resolution]] 3.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ltr]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LTR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ltr]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LTR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ltr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ltr OCA], [https://pdbe.org/1ltr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ltr RCSB], [https://www.ebi.ac.uk/pdbsum/1ltr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ltr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ltr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ltr OCA], [https://pdbe.org/1ltr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ltr RCSB], [https://www.ebi.ac.uk/pdbsum/1ltr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ltr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ELBH_ECOLX ELBH_ECOLX] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Loreggian, A]]	+	[[Category: Loreggian A]]
-	[[Category: Matkovic-Calogovic, D]]	+	[[Category: Matkovic-Calogovic D]]
-	[[Category: Palu, G]]	+	[[Category: Palu G]]
-	[[Category: Zanotti, G]]	+	[[Category: Zanotti G]]
-	~~[[Category: Anti-hsv]]~~	+
-	~~[[Category: B subunit]]~~	+
-	~~[[Category: Enterotoxin]]~~	+
-	~~[[Category: Heat-labile enterotoxin~~]]	+

OCA at 05:56, 28 April 2021

OCA — Wed, 28 Apr 2021 05:56:14 GMT

←Older revision		Revision as of 05:56, 28 April 2021
Line 3:		Line 3:
	<StructureSection load='1ltr' size='340' side='right'caption='[[1ltr]], [[Resolution\|resolution]] 3.04Å' scene=''>		<StructureSection load='1ltr' size='340' side='right'caption='[[1ltr]], [[Resolution\|resolution]] 3.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ltr]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LTR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ltr]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LTR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ltr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ltr OCA], [~~http~~://pdbe.org/1ltr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ltr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ltr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ltr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ltr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ltr OCA], [https://pdbe.org/1ltr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ltr RCSB], [https://www.ebi.ac.uk/pdbsum/1ltr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ltr ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:52, 24 July 2019

OCA — Wed, 24 Jul 2019 08:52:11 GMT

←Older revision		Revision as of 08:52, 24 July 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE B SUBUNIT OF HUMAN HEAT-LABILE ENTEROTOXIN FROM E. COLI CARRYING A PEPTIDE WITH ANTI-HSV ACTIVITY==		==CRYSTAL STRUCTURE OF THE B SUBUNIT OF HUMAN HEAT-LABILE ENTEROTOXIN FROM E. COLI CARRYING A PEPTIDE WITH ANTI-HSV ACTIVITY==
-	<StructureSection load='1ltr' size='340' side='right' caption='[[1ltr]], [[Resolution\|resolution]] 3.04Å' scene=''>	+	<StructureSection load='1ltr' size='340' side='right'caption='[[1ltr]], [[Resolution\|resolution]] 3.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ltr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ltr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTR FirstGlance]. <br>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Loreggian, A]]		[[Category: Loreggian, A]]
	[[Category: Matkovic-Calogovic, D]]		[[Category: Matkovic-Calogovic, D]]

OCA at 10:31, 18 October 2017

OCA — Wed, 18 Oct 2017 10:31:16 GMT

←Older revision		Revision as of 10:31, 18 October 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE B SUBUNIT OF HUMAN HEAT-LABILE ENTEROTOXIN FROM E. COLI CARRYING A PEPTIDE WITH ANTI-HSV ACTIVITY==		==CRYSTAL STRUCTURE OF THE B SUBUNIT OF HUMAN HEAT-LABILE ENTEROTOXIN FROM E. COLI CARRYING A PEPTIDE WITH ANTI-HSV ACTIVITY==
	<StructureSection load='1ltr' size='340' side='right' caption='[[1ltr]], [[Resolution\|resolution]] 3.04Å' scene=''>		<StructureSection load='1ltr' size='340' side='right' caption='[[1ltr]], [[Resolution\|resolution]] 3.04Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1ltr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ltr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ltr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ltr OCA], [http://pdbe.org/1ltr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ltr RCSB], [http://www.ebi.ac.uk/pdbsum/1ltr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ltr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ltr OCA], [http://pdbe.org/1ltr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ltr RCSB], [http://www.ebi.ac.uk/pdbsum/1ltr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ltr ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:32, 9 September 2015

OCA — Wed, 09 Sep 2015 21:32:17 GMT

←Older revision		Revision as of 21:32, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1ltr' size='340' side='right' caption='[[1ltr]], [[Resolution\|resolution]] 3.04Å' scene=''>		<StructureSection load='1ltr' size='340' side='right' caption='[[1ltr]], [[Resolution\|resolution]] 3.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ltr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ltr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ltr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ltr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ltr RCSB], [http://www.ebi.ac.uk/pdbsum/1ltr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ltr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ltr OCA], [http://pdbe.org/1ltr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ltr RCSB], [http://www.ebi.ac.uk/pdbsum/1ltr PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ltr" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Loreggian, A]]		[[Category: Loreggian, A]]
	[[Category: Matkovic-Calogovic, D]]		[[Category: Matkovic-Calogovic, D]]

OCA at 07:39, 24 December 2014

OCA — Wed, 24 Dec 2014 07:39:25 GMT

←Older revision		Revision as of 07:39, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ltr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ltr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ltr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ltr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ltr RCSB], [http://www.ebi.ac.uk/pdbsum/1ltr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ltr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ltr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ltr RCSB], [http://www.ebi.ac.uk/pdbsum/1ltr PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Loreggian, A.]]	+	[[Category: Loreggian, A]]
-	[[Category: Matkovic-Calogovic, D.]]	+	[[Category: Matkovic-Calogovic, D]]
-	[[Category: Palu, G.]]	+	[[Category: Palu, G]]
-	[[Category: Zanotti, G.]]	+	[[Category: Zanotti, G]]
	[[Category: Anti-hsv]]		[[Category: Anti-hsv]]
	[[Category: B subunit]]		[[Category: B subunit]]
	[[Category: Enterotoxin]]		[[Category: Enterotoxin]]
	[[Category: Heat-labile enterotoxin]]		[[Category: Heat-labile enterotoxin]]

OCA at 05:24, 8 June 2014

OCA — Sun, 08 Jun 2014 05:24:16 GMT

←Older revision		Revision as of 05:24, 8 June 2014
Line 1:		Line 1:
-	[[~~Image:~~1ltr.~~png~~\|~~left\|200px~~]]	+	==CRYSTAL STRUCTURE OF THE B SUBUNIT OF HUMAN HEAT-LABILE ENTEROTOXIN FROM E. COLI CARRYING A PEPTIDE WITH ANTI-HSV ACTIVITY==
		+	<StructureSection load='1ltr' size='340' side='right' caption='[[1ltr]], [[Resolution\|resolution]] 3.04Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ltr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ltr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ltr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ltr RCSB], [http://www.ebi.ac.uk/pdbsum/1ltr PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Two chimeric proteins, consisting of the B subunit of Escherichia coli heat-labile enterotoxin with different peptides fused to the COOH-terminal ends, have been crystallized and their three-dimensional structure determined. The two extensions correspond to (a) a nonapeptide representing the COOH-terminal sequence of the small subunit of herpes simplex virus type 1 ribonucleotide reductase and (b) a 27-amino acid long peptide, corresponding to the COOH-terminal end of the catalytic subunit (POL) of DNA polymerase from the same virus. Both proteins crystallize in the P41212 space group with one pentameric molecule per asymmetric unit, corresponding to a solvent content of about 75%. The overall conformation of the B subunit pentamer in the two chimeric proteins, which consists of five identical polypeptide chains, is very similar to that in the native AB complex and conforms strictly to 5-fold symmetry. On the contrary, the peptide extensions are essentially disordered: in the case of the nonapeptide, only 5 and 6 amino acids were, respectively, positioned in two monomers, while in the other three only 2 residues are ordered. The extension is fully confined to the surface of the pentamer opposite to the face that interacts with the membrane and consequently it does not interfere with the ability of the B subunit to interact with membrane receptors. Moreover, the conformational flexibility of the two peptide extensions could be correlated to their propensity for proteolytic processing and consequent release of a biologically active molecule into cultured cells.

-	~~{{STRUCTURE_1ltr\| PDB=1ltr \| SCENE= }}~~	+	Crystal structure of the B subunit of Escherichia coli heat-labile enterotoxin carrying peptides with anti-herpes simplex virus type 1 activity.,Matkovic-Calogovic D, Loregian A, D'Acunto MR, Battistutta R, Tossi A, Palu G, Zanotti G J Biol Chem. 1999 Mar 26;274(13):8764-9. PMID:10085117<ref>PMID:10085117</ref>

-	~~===CRYSTAL STRUCTURE OF THE B SUBUNIT OF HUMAN HEAT-LABILE ENTEROTOXIN FROM E. COLI CARRYING A PEPTIDE WITH ANTI-HSV ACTIVITY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10085117}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1ltr]] is~~ a ~~5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010085117<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Loreggian, A.]]		[[Category: Loreggian, A.]]

OCA: Protected "1ltr" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 17:07:26 GMT

Protected "1ltr" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:07, 14 August 2012

OCA at 17:07, 14 August 2012

OCA — Tue, 14 Aug 2012 17:07:24 GMT

←Older revision		Revision as of 17:07, 14 August 2012
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-	{{Seed}}
	[[Image:1ltr.png\|left\|200px]]		[[Image:1ltr.png\|left\|200px]]

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	{{STRUCTURE_1ltr\| PDB=1ltr \| SCENE= }}		{{STRUCTURE_1ltr\| PDB=1ltr \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE B SUBUNIT OF HUMAN HEAT-LABILE ENTEROTOXIN FROM E. COLI CARRYING A PEPTIDE WITH ANTI-HSV ACTIVITY===		===CRYSTAL STRUCTURE OF THE B SUBUNIT OF HUMAN HEAT-LABILE ENTEROTOXIN FROM E. COLI CARRYING A PEPTIDE WITH ANTI-HSV ACTIVITY===

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	{{ABSTRACT_PUBMED_10085117}}		{{ABSTRACT_PUBMED_10085117}}

	==About this Structure==		==About this Structure==
-	~~1LTR is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA].	+	[[1ltr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTR OCA].

	==Reference==		==Reference==
-	Crystal structure of the B subunit of Escherichia coli heat-labile enterotoxin carrying peptides with anti-herpes simplex virus type 1 activity., Matkovic-Calogovic D, Loregian A, D'Acunto MR, Battistutta R, Tossi A, Palu G, Zanotti G, J Biol Chem. 1999 Mar 26;274(13):8764-9. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~10085117 10085117]~~	+	<ref group="xtra">PMID:010085117</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Single protein]]
	[[Category: Loreggian, A.]]		[[Category: Loreggian, A.]]
	[[Category: Matkovic-Calogovic, D.]]		[[Category: Matkovic-Calogovic, D.]]
Line 32:		Line 19:
	[[Category: Anti-hsv]]		[[Category: Anti-hsv]]
	[[Category: B subunit]]		[[Category: B subunit]]
		+	[[Category: Enterotoxin]]
	[[Category: Heat-labile enterotoxin]]		[[Category: Heat-labile enterotoxin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:12:32 2008''