1lzl - Revision history

OCA at 07:37, 14 February 2024

OCA — Wed, 14 Feb 2024 07:37:44 GMT

←Older revision		Revision as of 07:37, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1lzl' size='340' side='right'caption='[[1lzl]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='1lzl' size='340' side='right'caption='[[1lzl]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lzl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Rhoso Rhoso~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lzl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp. Rhodococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LZL FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~1lzk~~\|~~1lzk~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzl OCA], [https://pdbe.org/1lzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lzl RCSB], [https://www.ebi.ac.uk/pdbsum/1lzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lzl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzl OCA], [https://pdbe.org/1lzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lzl RCSB], [https://www.ebi.ac.uk/pdbsum/1lzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lzl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O06441_RHOSO O06441_RHOSO]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lzl ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lzl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The crystal structures of an acetyl esterase, HerE, and its complex with an inhibitor dimethylarsinic acid have been determined at 1.30- and 1.45-A resolution, respectively. Although the natural substrate for the enzyme is unknown, HerE hydrolyzes the acetyl groups from heroin to yield morphine and from phenyl acetate to yield phenol. Recently, the activity of the enzyme toward heroin has been exploited to develop a heroin biosensor, which affords higher sensitivity than other currently available detection methods. The crystal structure reveals a single domain with the canonical alpha/beta hydrolase fold with an acyl binding pocket that snugly accommodates the acetyl substituent of the substrate and three backbone amides that form a tripartite oxyanion hole. In addition, a covalent adduct was observed between the active site serine and dimethylarsinic acid, which inhibits the enzyme. This crystal structure provides the first example of an As-containing compound in a serine esterase active site and the first example of covalent modification of serine by arsenic. Thus, the HerE complex reveals the structural basis for the broad scope inhibition of serine hydrolases by As(V)-containing organic compounds.
-
-	Observation of an arsenic adduct in an acetyl esterase crystal structure.,Zhu X, Larsen NA, Basran A, Bruce NC, Wilson IA J Biol Chem. 2003 Jan 17;278(3):2008-14. Epub 2002 Nov 5. PMID:12421810<ref>PMID:12421810</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1lzl" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Rhoso~~]]	+	[[Category: Rhodococcus sp]]
-	[[Category: Basran, A]]	+	[[Category: Basran A]]
-	[[Category: Bruce~~, N C~~]]	+	[[Category: Bruce NC]]
-	[[Category: Larsen~~, N A~~]]	+	[[Category: Larsen NA]]
-	[[Category: Wilson~~, I A~~]]	+	[[Category: Wilson IA]]
-	[[Category: Zhu, X]]	+	[[Category: Zhu X]]
-	~~[[Category: Alpha/beta hydrolase]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 05:57, 28 April 2021

OCA — Wed, 28 Apr 2021 05:57:12 GMT

←Older revision		Revision as of 05:57, 28 April 2021
Line 3:		Line 3:
	<StructureSection load='1lzl' size='340' side='right'caption='[[1lzl]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='1lzl' size='340' side='right'caption='[[1lzl]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lzl]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Rhoso Rhoso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lzl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhoso Rhoso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LZL FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzk\|1lzk]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lzk\|1lzk]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzl OCA], [~~http~~://pdbe.org/1lzl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1lzl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1lzl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1lzl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzl OCA], [https://pdbe.org/1lzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lzl RCSB], [https://www.ebi.ac.uk/pdbsum/1lzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lzl ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 06:50, 24 July 2019

OCA — Wed, 24 Jul 2019 06:50:10 GMT

←Older revision		Revision as of 06:50, 24 July 2019
Line 1:		Line 1:

	==Bacterial Heroin Esterase==		==Bacterial Heroin Esterase==
-	<StructureSection load='1lzl' size='340' side='right' caption='[[1lzl]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='1lzl' size='340' side='right'caption='[[1lzl]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhoso Rhoso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhoso Rhoso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZL FirstGlance]. <br>
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Rhoso]]		[[Category: Rhoso]]
	[[Category: Basran, A]]		[[Category: Basran, A]]

OCA at 07:55, 31 January 2018

OCA — Wed, 31 Jan 2018 07:55:39 GMT

←Older revision		Revision as of 07:55, 31 January 2018
Line 1:		Line 1:
		+
	==Bacterial Heroin Esterase==		==Bacterial Heroin Esterase==
	<StructureSection load='1lzl' size='340' side='right' caption='[[1lzl]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='1lzl' size='340' side='right' caption='[[1lzl]], [[Resolution\|resolution]] 1.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1lzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhoso Rhoso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhoso Rhoso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZL FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzk\|1lzk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzk\|1lzk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzl OCA], [http://pdbe.org/1lzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lzl RCSB], [http://www.ebi.ac.uk/pdbsum/1lzl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzl OCA], [http://pdbe.org/1lzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lzl RCSB], [http://www.ebi.ac.uk/pdbsum/1lzl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lzl ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lz/1lzl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lz/1lzl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:33, 8 February 2016

OCA — Mon, 08 Feb 2016 09:33:35 GMT

←Older revision		Revision as of 09:33, 8 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lzl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:15, 10 September 2015

OCA — Thu, 10 Sep 2015 10:15:00 GMT

←Older revision		Revision as of 10:15, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1lzl' size='340' side='right' caption='[[1lzl]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='1lzl' size='340' side='right' caption='[[1lzl]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rhodococcus_sp. Rhodococcus sp.~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhoso Rhoso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZL FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzk\|1lzk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzk\|1lzk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lzl RCSB], [http://www.ebi.ac.uk/pdbsum/1lzl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzl OCA], [http://pdbe.org/1lzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lzl RCSB], [http://www.ebi.ac.uk/pdbsum/1lzl PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1lzl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rhodococcus sp~~]]	+	[[Category: Rhoso]]
	[[Category: Basran, A]]		[[Category: Basran, A]]
	[[Category: Bruce, N C]]		[[Category: Bruce, N C]]

OCA at 15:45, 5 January 2015

OCA — Mon, 05 Jan 2015 15:45:11 GMT

←Older revision		Revision as of 15:45, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp. Rhodococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp. Rhodococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzk\|1lzk]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzk\|1lzk]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lzl RCSB], [http://www.ebi.ac.uk/pdbsum/1lzl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lzl RCSB], [http://www.ebi.ac.uk/pdbsum/1lzl PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Rhodococcus sp.]]	+	[[Category: Rhodococcus sp]]
-	[[Category: Basran, A.]]	+	[[Category: Basran, A]]
-	[[Category: Bruce, N C.]]	+	[[Category: Bruce, N C]]
-	[[Category: Larsen, N A.]]	+	[[Category: Larsen, N A]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
-	[[Category: Zhu, X.]]	+	[[Category: Zhu, X]]
	[[Category: Alpha/beta hydrolase]]		[[Category: Alpha/beta hydrolase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 13:18, 28 September 2014

OCA — Sun, 28 Sep 2014 13:18:35 GMT

←Older revision		Revision as of 13:18, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1lzl.~~png~~\|~~left~~\|200px]]	+	==Bacterial Heroin Esterase==
		+	<StructureSection load='1lzl' size='340' side='right' caption='[[1lzl]], [[Resolution\|resolution]] 1.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1lzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp. Rhodococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzk\|1lzk]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lzl RCSB], [http://www.ebi.ac.uk/pdbsum/1lzl PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lz/1lzl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structures of an acetyl esterase, HerE, and its complex with an inhibitor dimethylarsinic acid have been determined at 1.30- and 1.45-A resolution, respectively. Although the natural substrate for the enzyme is unknown, HerE hydrolyzes the acetyl groups from heroin to yield morphine and from phenyl acetate to yield phenol. Recently, the activity of the enzyme toward heroin has been exploited to develop a heroin biosensor, which affords higher sensitivity than other currently available detection methods. The crystal structure reveals a single domain with the canonical alpha/beta hydrolase fold with an acyl binding pocket that snugly accommodates the acetyl substituent of the substrate and three backbone amides that form a tripartite oxyanion hole. In addition, a covalent adduct was observed between the active site serine and dimethylarsinic acid, which inhibits the enzyme. This crystal structure provides the first example of an As-containing compound in a serine esterase active site and the first example of covalent modification of serine by arsenic. Thus, the HerE complex reveals the structural basis for the broad scope inhibition of serine hydrolases by As(V)-containing organic compounds.

-	~~{{STRUCTURE_1lzl\| PDB=1lzl \| SCENE= }}~~	+	Observation of an arsenic adduct in an acetyl esterase crystal structure.,Zhu X, Larsen NA, Basran A, Bruce NC, Wilson IA J Biol Chem. 2003 Jan 17;278(3):2008-14. Epub 2002 Nov 5. PMID:12421810<ref>PMID:12421810</ref>

-	~~===Bacterial Heroin Esterase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12421810}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1lzl]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rhodococcus_sp~~. ~~Rhodococcus sp.]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012421810<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rhodococcus sp.]]		[[Category: Rhodococcus sp.]]
	[[Category: Basran, A.]]		[[Category: Basran, A.]]

OCA: Protected "1lzl" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 19:59:34 GMT

Protected "1lzl" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:59, 5 December 2012

OCA at 19:59, 5 December 2012

OCA — Wed, 05 Dec 2012 19:59:32 GMT

←Older revision		Revision as of 19:59, 5 December 2012
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-	{{Seed}}
	[[Image:1lzl.png\|left\|200px]]		[[Image:1lzl.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1lzl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1lzl\| PDB=1lzl \| SCENE= }}		{{STRUCTURE_1lzl\| PDB=1lzl \| SCENE= }}

	===Bacterial Heroin Esterase===		===Bacterial Heroin Esterase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12421810}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12421810 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12421810}}		{{ABSTRACT_PUBMED_12421810}}

	==About this Structure==		==About this Structure==
-	~~1LZL~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp. Rhodococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA].	+	[[1lzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp. Rhodococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZL OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12421810~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012421810</ref><references group="xtra"/>
	[[Category: Rhodococcus sp.]]		[[Category: Rhodococcus sp.]]
	[[Category: Basran, A.]]		[[Category: Basran, A.]]
Line 31:		Line 19:
	[[Category: Zhu, X.]]		[[Category: Zhu, X.]]
	[[Category: Alpha/beta hydrolase]]		[[Category: Alpha/beta hydrolase]]
-		+	[[Category: Hydrolase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 21:00:44 2009''~~	+