1lzw - Revision history

OCA at 07:37, 14 February 2024

OCA — Wed, 14 Feb 2024 07:37:49 GMT

←Older revision		Revision as of 07:37, 14 February 2024
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	<StructureSection load='1lzw' size='340' side='right'caption='[[1lzw]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1lzw' size='340' side='right'caption='[[1lzw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lzw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lzw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LZW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzw OCA], [https://pdbe.org/1lzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lzw RCSB], [https://www.ebi.ac.uk/pdbsum/1lzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lzw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzw OCA], [https://pdbe.org/1lzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lzw RCSB], [https://www.ebi.ac.uk/pdbsum/1lzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lzw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CLPS_ECOLI CLPS_ECOLI]] Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. [[https://www.uniprot.org/uniprot/CLPA_ECOLI CLPA_ECOLI]] ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific substrates. It has unfoldase activity. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins.	+	[https://www.uniprot.org/uniprot/CLPS_ECOLI CLPS_ECOLI] Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lzw ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lzw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	In Escherichia coli, protein degradation is performed by several proteolytic machines, including ClpAP. Generally, the substrate specificity of these machines is determined by chaperone components, such as ClpA. In some cases, however, the specificity is modified by adaptor proteins, such as ClpS. Here we report the 2.5 A resolution crystal structure of ClpS in complex with the N-terminal domain of ClpA. Using mutagenesis, we demonstrate that two contact residues (Glu79 and Lys 84) are essential not only for ClpAS complex formation but also for ClpAPS-mediated substrate degradation. The corresponding residues are absent in the chaperone ClpB, providing a structural rationale for the unique specificity shown by ClpS despite the high overall similarity between ClpA and ClpB. To determine the location of ClpS within the ClpA hexamer, we modeled the N-terminal domain of ClpA onto a structurally defined, homologous AAA+ protein. From this model, we proposed a molecular mechanism to explain the ClpS-mediated switch in ClpA substrate specificity.
-
-	Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA.,Zeth K, Ravelli RB, Paal K, Cusack S, Bukau B, Dougan DA Nat Struct Biol. 2002 Dec;9(12):906-11. PMID:12426582<ref>PMID:12426582</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1lzw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]		*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bukau, B]]	+	[[Category: Bukau B]]
-	[[Category: Cusack, S]]	+	[[Category: Cusack S]]
-	[[Category: Dougan~~, D A~~]]	+	[[Category: Dougan DA]]
-	[[Category: Paal, K]]	+	[[Category: Paal K]]
-	[[Category: Ravelli~~, R B~~]]	+	[[Category: Ravelli RB]]
-	[[Category: Zeth, K]]	+	[[Category: Zeth K]]
-	~~[[Category: Chaperone~~]]	+

OCA at 06:51, 18 August 2021

OCA — Wed, 18 Aug 2021 06:51:39 GMT

←Older revision		Revision as of 06:51, 18 August 2021
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	<StructureSection load='1lzw' size='340' side='right'caption='[[1lzw]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1lzw' size='340' side='right'caption='[[1lzw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lzw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lzw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LZW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzw OCA], [~~http~~://pdbe.org/1lzw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1lzw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1lzw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1lzw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzw OCA], [https://pdbe.org/1lzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lzw RCSB], [https://www.ebi.ac.uk/pdbsum/1lzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lzw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CLPS_ECOLI CLPS_ECOLI]] Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. [[~~http~~://www.uniprot.org/uniprot/CLPA_ECOLI CLPA_ECOLI]] ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific substrates. It has unfoldase activity. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins.	+	[[https://www.uniprot.org/uniprot/CLPS_ECOLI CLPS_ECOLI]] Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. [[https://www.uniprot.org/uniprot/CLPA_ECOLI CLPA_ECOLI]] ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific substrates. It has unfoldase activity. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:17, 13 November 2019

OCA — Wed, 13 Nov 2019 12:17:46 GMT

←Older revision		Revision as of 12:17, 13 November 2019
Line 1:		Line 1:

	==Structural basis of ClpS-mediated switch in ClpA substrate recognition==		==Structural basis of ClpS-mediated switch in ClpA substrate recognition==
-	<StructureSection load='1lzw' size='340' side='right' caption='[[1lzw]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1lzw' size='340' side='right'caption='[[1lzw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lzw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lzw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZW FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1lzw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1lzw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Bukau, B]]		[[Category: Bukau, B]]
	[[Category: Cusack, S]]		[[Category: Cusack, S]]

OCA at 06:23, 31 January 2018

OCA — Wed, 31 Jan 2018 06:23:54 GMT

←Older revision		Revision as of 06:23, 31 January 2018
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lz/1lzw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lz/1lzw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:53, 18 October 2017

OCA — Wed, 18 Oct 2017 10:53:05 GMT

←Older revision		Revision as of 10:53, 18 October 2017
Line 1:		Line 1:
		+
	==Structural basis of ClpS-mediated switch in ClpA substrate recognition==		==Structural basis of ClpS-mediated switch in ClpA substrate recognition==
	<StructureSection load='1lzw' size='340' side='right' caption='[[1lzw]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1lzw' size='340' side='right' caption='[[1lzw]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1lzw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lzw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzw OCA], [http://pdbe.org/1lzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lzw RCSB], [http://www.ebi.ac.uk/pdbsum/1lzw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzw OCA], [http://pdbe.org/1lzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lzw RCSB], [http://www.ebi.ac.uk/pdbsum/1lzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lzw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lzw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1lzw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1lzw" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Clp Protease\|Clp Protease]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:39, 12 September 2015

OCA — Sat, 12 Sep 2015 00:39:40 GMT

←Older revision		Revision as of 00:39, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1lzw' size='340' side='right' caption='[[1lzw]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1lzw' size='340' side='right' caption='[[1lzw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lzw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lzw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lzw RCSB], [http://www.ebi.ac.uk/pdbsum/1lzw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzw OCA], [http://pdbe.org/1lzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lzw RCSB], [http://www.ebi.ac.uk/pdbsum/1lzw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1lzw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Bukau, B]]		[[Category: Bukau, B]]
	[[Category: Cusack, S]]		[[Category: Cusack, S]]

OCA at 21:32, 25 December 2014

OCA — Thu, 25 Dec 2014 21:32:17 GMT

←Older revision		Revision as of 21:32, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lzw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lzw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lzw RCSB], [http://www.ebi.ac.uk/pdbsum/1lzw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lzw RCSB], [http://www.ebi.ac.uk/pdbsum/1lzw PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CLPS_ECOLI CLPS_ECOLI]] Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. [[http://www.uniprot.org/uniprot/CLPA_ECOLI CLPA_ECOLI]] ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific substrates. It has unfoldase activity. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Bukau, B.]]	+	[[Category: Bukau, B]]
-	[[Category: Cusack, S.]]	+	[[Category: Cusack, S]]
-	[[Category: Dougan, D A.]]	+	[[Category: Dougan, D A]]
-	[[Category: Paal, K.]]	+	[[Category: Paal, K]]
-	[[Category: Ravelli, R B.]]	+	[[Category: Ravelli, R B]]
-	[[Category: Zeth, K.]]	+	[[Category: Zeth, K]]
	[[Category: Chaperone]]		[[Category: Chaperone]]

OCA at 16:02, 28 September 2014

OCA — Sun, 28 Sep 2014 16:02:37 GMT

←Older revision		Revision as of 16:02, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1lzw.~~png\|left~~\|200px]]	+	==Structural basis of ClpS-mediated switch in ClpA substrate recognition==
		+	<StructureSection load='1lzw' size='340' side='right' caption='[[1lzw]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1lzw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LZW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lzw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lzw RCSB], [http://www.ebi.ac.uk/pdbsum/1lzw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lz/1lzw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In Escherichia coli, protein degradation is performed by several proteolytic machines, including ClpAP. Generally, the substrate specificity of these machines is determined by chaperone components, such as ClpA. In some cases, however, the specificity is modified by adaptor proteins, such as ClpS. Here we report the 2.5 A resolution crystal structure of ClpS in complex with the N-terminal domain of ClpA. Using mutagenesis, we demonstrate that two contact residues (Glu79 and Lys 84) are essential not only for ClpAS complex formation but also for ClpAPS-mediated substrate degradation. The corresponding residues are absent in the chaperone ClpB, providing a structural rationale for the unique specificity shown by ClpS despite the high overall similarity between ClpA and ClpB. To determine the location of ClpS within the ClpA hexamer, we modeled the N-terminal domain of ClpA onto a structurally defined, homologous AAA+ protein. From this model, we proposed a molecular mechanism to explain the ClpS-mediated switch in ClpA substrate specificity.

-	~~{{STRUCTURE_1lzw\| PDB=1lzw \| SCENE= }}~~	+	Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA.,Zeth K, Ravelli RB, Paal K, Cusack S, Bukau B, Dougan DA Nat Struct Biol. 2002 Dec;9(12):906-11. PMID:12426582<ref>PMID:12426582</ref>

-	~~===Structural basis~~ of ~~ClpS-mediated switch in ClpA substrate recognition===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12426582}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1lzw]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA].~~	+

	==See Also==		==See Also==
	*[[Clp Protease\|Clp Protease]]		*[[Clp Protease\|Clp Protease]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012426582<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Bukau, B.]]		[[Category: Bukau, B.]]

OCA: Protected "1lzw" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 21:54:35 GMT

Protected "1lzw" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:54, 20 October 2012

OCA at 21:54, 20 October 2012

OCA — Sat, 20 Oct 2012 21:54:33 GMT

←Older revision		Revision as of 21:54, 20 October 2012
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-	{{Seed}}
	[[Image:1lzw.png\|left\|200px]]		[[Image:1lzw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1lzw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1lzw\| PDB=1lzw \| SCENE= }}		{{STRUCTURE_1lzw\| PDB=1lzw \| SCENE= }}

	===Structural basis of ClpS-mediated switch in ClpA substrate recognition===		===Structural basis of ClpS-mediated switch in ClpA substrate recognition===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12426582}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12426582 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12426582}}		{{ABSTRACT_PUBMED_12426582}}

	==About this Structure==		==About this Structure==
-	~~1LZW~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA].	+	[[1lzw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LZW OCA].
		+
		+	==See Also==
		+	*[[Clp Protease\|Clp Protease]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12426582~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012426582</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Bukau, B.]]		[[Category: Bukau, B.]]
Line 31:		Line 22:
	[[Category: Ravelli, R B.]]		[[Category: Ravelli, R B.]]
	[[Category: Zeth, K.]]		[[Category: Zeth, K.]]
-		+	[[Category: Chaperone]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 08:24:06 2009''~~	+