1m21 - Revision history

OCA at 07:17, 25 October 2023

OCA — Wed, 25 Oct 2023 07:17:56 GMT

←Older revision		Revision as of 07:17, 25 October 2023
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	<StructureSection load='1m21' size='340' side='right'caption='[[1m21]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1m21' size='340' side='right'caption='[[1m21]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1m21]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas~~ maltophilia~~" hugh~~ and ~~ryschenkow 1961~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M21 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1m21]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia] and [https://en.wikipedia.org/wiki/Streptomyces_hygroscopicus Streptomyces hygroscopicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M21 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CSI:AMINO-(2-IMINO-HEXAHYDRO-PYRIMIDIN-4-YL)-ACETIC+ACID'>CSI</scene~~>, ~~<scene name='pdbligand=PHA:PHENYLALANINAL'>PHA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height~~: ~~3em;~~'>~~[[1m22\|1m22]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSI:AMINO-(2-IMINO-HEXAHYDRO-PYRIMIDIN-4-YL)-ACETIC+ACID'>CSI</scene>, <scene name='pdbligand=PHA:PHENYLALANINAL'>PHA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m21 OCA], [https://pdbe.org/1m21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m21 RCSB], [https://www.ebi.ac.uk/pdbsum/1m21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m21 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m21 OCA], [https://pdbe.org/1m21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m21 RCSB], [https://www.ebi.ac.uk/pdbsum/1m21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m21 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8RJN5_STEMA Q8RJN5_STEMA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Pseudomonas maltophilia hugh and ryschenkow 1961]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Buldt, G~~]]	+	[[Category: Stenotrophomonas maltophilia]]
-	[[Category: ~~Granzin, J~~]]	+	[[Category: Streptomyces hygroscopicus]]
-	[[Category: ~~Kula, M R~~]]	+	[[Category: Buldt G]]
-	[[Category: ~~Labahn,~~ J]]	+	[[Category: Granzin J]]
-	[[Category: ~~Neumann, S]]~~	+	[[Category: Kula M-R]]
-	~~[[Category: Core: eleven~~-~~stranded beta-sheet~~]]	+	[[Category: Labahn J]]
-	[[Category: ~~Covered: double layers of alpha helices on top and bottom~~]]	+	[[Category: Neumann S]]
-	[[Category: ~~Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Protein-inhibitor complex~~]]	+

OCA at 06:52, 18 August 2021

OCA — Wed, 18 Aug 2021 06:52:30 GMT

←Older revision		Revision as of 06:52, 18 August 2021
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	<StructureSection load='1m21' size='340' side='right'caption='[[1m21]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1m21' size='340' side='right'caption='[[1m21]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1m21]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas maltophilia" hugh and ryschenkow 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M21 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1M21 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1m21]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas maltophilia" hugh and ryschenkow 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M21 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSI:AMINO-(2-IMINO-HEXAHYDRO-PYRIMIDIN-4-YL)-ACETIC+ACID'>CSI</scene>, <scene name='pdbligand=PHA:PHENYLALANINAL'>PHA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSI:AMINO-(2-IMINO-HEXAHYDRO-PYRIMIDIN-4-YL)-ACETIC+ACID'>CSI</scene>, <scene name='pdbligand=PHA:PHENYLALANINAL'>PHA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m22\|1m22]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m22\|1m22]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1m21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m21 OCA], [~~http~~://pdbe.org/1m21 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1m21 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1m21 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1m21 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m21 OCA], [https://pdbe.org/1m21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m21 RCSB], [https://www.ebi.ac.uk/pdbsum/1m21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m21 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 12:07, 13 November 2019

OCA — Wed, 13 Nov 2019 12:07:55 GMT

←Older revision		Revision as of 12:07, 13 November 2019
Line 1:		Line 1:

	==Crystal structure analysis of the peptide amidase PAM in complex with the competitive inhibitor chymostatin==		==Crystal structure analysis of the peptide amidase PAM in complex with the competitive inhibitor chymostatin==
-	<StructureSection load='1m21' size='340' side='right' caption='[[1m21]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1m21' size='340' side='right'caption='[[1m21]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1m21]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas maltophilia" hugh and ryschenkow 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M21 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1m21]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas maltophilia" hugh and ryschenkow 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M21 FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Pseudomonas maltophilia hugh and ryschenkow 1961]]		[[Category: Pseudomonas maltophilia hugh and ryschenkow 1961]]
		+	[[Category: Large Structures]]
	[[Category: Buldt, G]]		[[Category: Buldt, G]]
	[[Category: Granzin, J]]		[[Category: Granzin, J]]

OCA at 07:44, 31 January 2018

OCA — Wed, 31 Jan 2018 07:44:44 GMT

←Older revision		Revision as of 07:44, 31 January 2018
Line 1:		Line 1:
		+
	==Crystal structure analysis of the peptide amidase PAM in complex with the competitive inhibitor chymostatin==		==Crystal structure analysis of the peptide amidase PAM in complex with the competitive inhibitor chymostatin==
	<StructureSection load='1m21' size='340' side='right' caption='[[1m21]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1m21' size='340' side='right' caption='[[1m21]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSI:AMINO-(2-IMINO-HEXAHYDRO-PYRIMIDIN-4-YL)-ACETIC+ACID'>CSI</scene>, <scene name='pdbligand=PHA:PHENYLALANINAL'>PHA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSI:AMINO-(2-IMINO-HEXAHYDRO-PYRIMIDIN-4-YL)-ACETIC+ACID'>CSI</scene>, <scene name='pdbligand=PHA:PHENYLALANINAL'>PHA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m22\|1m22]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m22\|1m22]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m21 OCA], [http://pdbe.org/1m21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m21 RCSB], [http://www.ebi.ac.uk/pdbsum/1m21 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m21 OCA], [http://pdbe.org/1m21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m21 RCSB], [http://www.ebi.ac.uk/pdbsum/1m21 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1m21 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m2/1m21_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m2/1m21_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:46, 9 February 2016

OCA — Tue, 09 Feb 2016 12:46:45 GMT

←Older revision		Revision as of 12:46, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m21 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:23, 10 September 2015

OCA — Thu, 10 Sep 2015 22:23:46 GMT

←Older revision		Revision as of 22:23, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1m21' size='340' side='right' caption='[[1m21]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1m21' size='340' side='right' caption='[[1m21]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1m21]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Stenotrophomonas_maltophilia Stenotrophomonas~~ maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M21 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1m21]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas maltophilia" hugh and ryschenkow 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M21 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSI:AMINO-(2-IMINO-HEXAHYDRO-PYRIMIDIN-4-YL)-ACETIC+ACID'>CSI</scene>, <scene name='pdbligand=PHA:PHENYLALANINAL'>PHA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSI:AMINO-(2-IMINO-HEXAHYDRO-PYRIMIDIN-4-YL)-ACETIC+ACID'>CSI</scene>, <scene name='pdbligand=PHA:PHENYLALANINAL'>PHA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m22\|1m22]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m22\|1m22]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m21 RCSB], [http://www.ebi.ac.uk/pdbsum/1m21 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m21 OCA], [http://pdbe.org/1m21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m21 RCSB], [http://www.ebi.ac.uk/pdbsum/1m21 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1m21" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Stenotrophomonas~~ maltophilia]]	+	[[Category: Pseudomonas maltophilia hugh and ryschenkow 1961]]
	[[Category: Buldt, G]]		[[Category: Buldt, G]]
	[[Category: Granzin, J]]		[[Category: Granzin, J]]

OCA at 15:26, 5 January 2015

OCA — Mon, 05 Jan 2015 15:26:35 GMT

←Older revision		Revision as of 15:26, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1m21]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M21 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1m21]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M21 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSI:AMINO-(2-IMINO-HEXAHYDRO-PYRIMIDIN-4-YL)-ACETIC+ACID'>CSI</scene>, <scene name='pdbligand=PHA:PHENYLALANINAL'>PHA</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSI:AMINO-(2-IMINO-HEXAHYDRO-PYRIMIDIN-4-YL)-ACETIC+ACID'>CSI</scene>, <scene name='pdbligand=PHA:PHENYLALANINAL'>PHA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m22\|1m22]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m22\|1m22]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m21 RCSB], [http://www.ebi.ac.uk/pdbsum/1m21 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m21 RCSB], [http://www.ebi.ac.uk/pdbsum/1m21 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Stenotrophomonas maltophilia]]		[[Category: Stenotrophomonas maltophilia]]
-	[[Category: Buldt, G.]]	+	[[Category: Buldt, G]]
-	[[Category: Granzin, J.]]	+	[[Category: Granzin, J]]
-	[[Category: Kula, M R.]]	+	[[Category: Kula, M R]]
-	[[Category: Labahn, J.]]	+	[[Category: Labahn, J]]
-	[[Category: Neumann, S.]]	+	[[Category: Neumann, S]]
	[[Category: Core: eleven-stranded beta-sheet]]		[[Category: Core: eleven-stranded beta-sheet]]
	[[Category: Covered: double layers of alpha helices on top and bottom]]		[[Category: Covered: double layers of alpha helices on top and bottom]]

OCA at 13:08, 28 September 2014

OCA — Sun, 28 Sep 2014 13:08:24 GMT

←Older revision		Revision as of 13:08, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1m21.~~png~~\|~~left~~\|200px]]	+	==Crystal structure analysis of the peptide amidase PAM in complex with the competitive inhibitor chymostatin==
		+	<StructureSection load='1m21' size='340' side='right' caption='[[1m21]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1m21]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M21 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSI:AMINO-(2-IMINO-HEXAHYDRO-PYRIMIDIN-4-YL)-ACETIC+ACID'>CSI</scene>, <scene name='pdbligand=PHA:PHENYLALANINAL'>PHA</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m22\|1m22]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m21 RCSB], [http://www.ebi.ac.uk/pdbsum/1m21 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m2/1m21_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The peptide amidase from Stenotrophomonas maltophilia catalyses predominantly the hydrolysis of the C-terminal amide bond in peptide amides. Peptide bonds or amide functions in amino acid side-chains are not hydrolysed. This specificity makes peptide amidase (Pam) interesting for different biotechnological applications. Pam belongs to the amidase signature (AS) family. It is the first protein within this family whose tertiary structure has been solved. The structure of the native Pam has been determined with a resolution of 1.4A and in complex with the competitive inhibitor chymostatin at a resolution of 1.8A. Chymostatin, which forms acyl adducts with many serine proteases, binds non-covalently to this enzyme.Pam folds as a very compact single-domain protein. The AS sequence represents a core domain that is covered by alpha-helices. This AS domain contains the catalytic residues. It is topologically homologous to the phosphoinositol phosphatase domain.The structural data do not support the recently proposed Ser-Lys catalytic dyad mechanism for AS enzymes. Our results are in agreement with the role of Ser226 as the primary nucleophile but differ concerning the roles of Ser202 and Lys123: Ser202, with direct contact both to the substrate molecule and to Ser226, presumably serves as an acid/bases catalyst. Lys123, with direct contact to Ser202 but no contact to Ser226 or the substrate molecule, most likely acts as an acid catalyst.

-	~~{{STRUCTURE_1m21\| PDB=1m21 \| SCENE= }}~~	+	An alternative mechanism for amidase signature enzymes.,Labahn J, Neumann S, Buldt G, Kula MR, Granzin J J Mol Biol. 2002 Oct 4;322(5):1053-64. PMID:12367528<ref>PMID:12367528</ref>

-	~~===Crystal structure analysis~~ of the ~~peptide amidase PAM in complex with the competitive inhibitor chymostatin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12367528}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1m21]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1M21 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012367528<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Stenotrophomonas maltophilia]]		[[Category: Stenotrophomonas maltophilia]]
	[[Category: Buldt, G.]]		[[Category: Buldt, G.]]

OCA: Protected "1m21" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 19:42:19 GMT

Protected "1m21" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:42, 5 December 2012

OCA at 19:42, 5 December 2012

OCA — Wed, 05 Dec 2012 19:42:15 GMT

←Older revision		Revision as of 19:42, 5 December 2012
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-	{{Seed}}
	[[Image:1m21.png\|left\|200px]]		[[Image:1m21.png\|left\|200px]]

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	{{STRUCTURE_1m21\| PDB=1m21 \| SCENE= }}		{{STRUCTURE_1m21\| PDB=1m21 \| SCENE= }}

	===Crystal structure analysis of the peptide amidase PAM in complex with the competitive inhibitor chymostatin===		===Crystal structure analysis of the peptide amidase PAM in complex with the competitive inhibitor chymostatin===

-
-	<!--
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	{{ABSTRACT_PUBMED_12367528}}		{{ABSTRACT_PUBMED_12367528}}

	==About this Structure==		==About this Structure==
-	~~1M21~~ is a ~~2 chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M21 OCA].	+	[[1m21]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M21 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12367528~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012367528</ref><references group="xtra"/>
	[[Category: Stenotrophomonas maltophilia]]		[[Category: Stenotrophomonas maltophilia]]
	[[Category: Buldt, G.]]		[[Category: Buldt, G.]]
Line 32:		Line 20:
	[[Category: Core: eleven-stranded beta-sheet]]		[[Category: Core: eleven-stranded beta-sheet]]
	[[Category: Covered: double layers of alpha helices on top and bottom]]		[[Category: Covered: double layers of alpha helices on top and bottom]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Protein-inhibitor complex]]		[[Category: Protein-inhibitor complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:54:01 2009''