1m4m - Revision history

OCA at 08:31, 10 April 2024

OCA — Wed, 10 Apr 2024 08:31:25 GMT

←Older revision		Revision as of 08:31, 10 April 2024
Line 3:		Line 3:
	<StructureSection load='1m4m' size='340' side='right'caption='[[1m4m]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1m4m' size='340' side='right'caption='[[1m4m]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1m4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M4M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1m4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M4M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4m OCA], [https://pdbe.org/1m4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m4m RCSB], [https://www.ebi.ac.uk/pdbsum/1m4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4m OCA], [https://pdbe.org/1m4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m4m RCSB], [https://www.ebi.ac.uk/pdbsum/1m4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BIRC5_MOUSE BIRC5_MOUSE]] Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity).	+	[https://www.uniprot.org/uniprot/BIRC5_MOUSE BIRC5_MOUSE] Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m4m ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m4m ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The coupling of apoptosis (programmed cell death) to the cell division cycle is essential for homeostasis and genomic integrity. Here, we report the crystal structure of survivin, an inhibitor of apoptosis, which has been implicated in both control of cell death and regulation of cell division. In addition to a conserved N-terminal Zn finger baculovirus IAP repeat, survivin forms a dimer through a symmetric interaction with an intermolecularly bound Zn atom located along the molecular dyad axis. The interaction of the dimer-related C-terminal alpha helices forms an extended surface of approximately 70 A in length. Mutagenesis analysis revealed that survivin dimerization and an extended negatively charged surface surrounding Asp-71 are required to counteract apoptosis and preserve ploidy. These findings may provide a structural basis for a dual role of survivin in inhibition of apoptosis and regulation of cell division.
-
-	Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin.,Muchmore SW, Chen J, Jakob C, Zakula D, Matayoshi ED, Wu W, Zhang H, Li F, Ng SC, Altieri DC Mol Cell. 2000 Jul;6(1):173-82. PMID:10949038<ref>PMID:10949038</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1m4m" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Survivin\|Survivin]]		*[[Survivin\|Survivin]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Altieri~~, D C~~]]	+	[[Category: Altieri DC]]
-	[[Category: Chen, J]]	+	[[Category: Chen J]]
-	[[Category: Jakob, C]]	+	[[Category: Jakob C]]
-	[[Category: Li, F]]	+	[[Category: Li F]]
-	[[Category: Matayoshi~~, E D~~]]	+	[[Category: Matayoshi ED]]
-	[[Category: Muchmore~~, S W~~]]	+	[[Category: Muchmore SW]]
-	[[Category: Ng~~, S C~~]]	+	[[Category: Ng SC]]
-	[[Category: Wu, W]]	+	[[Category: Wu W]]
-	[[Category: Zakula, D]]	+	[[Category: Zakula D]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Zn finger baculovirus iap repeat~~]]	+

OCA at 06:53, 18 August 2021

OCA — Wed, 18 Aug 2021 06:53:03 GMT

←Older revision		Revision as of 06:53, 18 August 2021
Line 3:		Line 3:
	<StructureSection load='1m4m' size='340' side='right'caption='[[1m4m]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1m4m' size='340' side='right'caption='[[1m4m]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1m4m]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1M4M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1m4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M4M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1m4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4m OCA], [~~http~~://pdbe.org/1m4m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1m4m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1m4m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4m OCA], [https://pdbe.org/1m4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m4m RCSB], [https://www.ebi.ac.uk/pdbsum/1m4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BIRC5_MOUSE BIRC5_MOUSE]] Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity).	+	[[https://www.uniprot.org/uniprot/BIRC5_MOUSE BIRC5_MOUSE]] Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:34, 13 November 2019

OCA — Wed, 13 Nov 2019 12:34:18 GMT

←Older revision		Revision as of 12:34, 13 November 2019
Line 1:		Line 1:

	==Mouse Survivin==		==Mouse Survivin==
-	<StructureSection load='1m4m' size='340' side='right' caption='[[1m4m]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='1m4m' size='340' side='right'caption='[[1m4m]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1m4m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4M FirstGlance]. <br>		<table><tr><td colspan='2'>[[1m4m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4M FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1m4m" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1m4m" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Survivin\|Survivin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Altieri, D C]]		[[Category: Altieri, D C]]

OCA at 08:09, 31 January 2018

OCA — Wed, 31 Jan 2018 08:09:17 GMT

←Older revision		Revision as of 08:09, 31 January 2018
Line 1:		Line 1:
		+
	==Mouse Survivin==		==Mouse Survivin==
	<StructureSection load='1m4m' size='340' side='right' caption='[[1m4m]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1m4m' size='340' side='right' caption='[[1m4m]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1m4m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4M FirstGlance]. <br>		<table><tr><td colspan='2'>[[1m4m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4m OCA], [http://pdbe.org/1m4m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m4m RCSB], [http://www.ebi.ac.uk/pdbsum/1m4m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4m OCA], [http://pdbe.org/1m4m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m4m RCSB], [http://www.ebi.ac.uk/pdbsum/1m4m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m4m_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m4m_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1m4m" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1m4m" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Survivin\|Survivin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:55, 8 February 2016

OCA — Mon, 08 Feb 2016 04:55:29 GMT

←Older revision		Revision as of 04:55, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m4m ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:05, 10 September 2015

OCA — Thu, 10 Sep 2015 08:05:03 GMT

←Older revision		Revision as of 08:05, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1m4m' size='340' side='right' caption='[[1m4m]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1m4m' size='340' side='right' caption='[[1m4m]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1m4m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1m4m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m4m RCSB], [http://www.ebi.ac.uk/pdbsum/1m4m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4m OCA], [http://pdbe.org/1m4m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m4m RCSB], [http://www.ebi.ac.uk/pdbsum/1m4m PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1m4m" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Altieri, D C]]		[[Category: Altieri, D C]]
	[[Category: Chen, J]]		[[Category: Chen, J]]

OCA at 20:47, 24 December 2014

OCA — Wed, 24 Dec 2014 20:47:34 GMT

←Older revision		Revision as of 20:47, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1m4m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4M FirstGlance]. <br>		<table><tr><td colspan='2'>[[1m4m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4M FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m4m RCSB], [http://www.ebi.ac.uk/pdbsum/1m4m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m4m RCSB], [http://www.ebi.ac.uk/pdbsum/1m4m PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BIRC5_MOUSE BIRC5_MOUSE]] Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Altieri, D C.]]	+	[[Category: Altieri, D C]]
-	[[Category: Chen, J.]]	+	[[Category: Chen, J]]
-	[[Category: Jakob, C.]]	+	[[Category: Jakob, C]]
-	[[Category: Li, F.]]	+	[[Category: Li, F]]
-	[[Category: Matayoshi, E D.]]	+	[[Category: Matayoshi, E D]]
-	[[Category: Muchmore, S W.]]	+	[[Category: Muchmore, S W]]
-	[[Category: Ng, S C.]]	+	[[Category: Ng, S C]]
-	[[Category: Wu, W.]]	+	[[Category: Wu, W]]
-	[[Category: Zakula, D.]]	+	[[Category: Zakula, D]]
-	[[Category: Zhang, H.]]	+	[[Category: Zhang, H]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Zn finger baculovirus iap repeat]]		[[Category: Zn finger baculovirus iap repeat]]

OCA at 16:14, 28 September 2014

OCA — Sun, 28 Sep 2014 16:14:45 GMT

←Older revision		Revision as of 16:14, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1m4m.~~png\|left~~\|200px]]	+	==Mouse Survivin==
		+	<StructureSection load='1m4m' size='340' side='right' caption='[[1m4m]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1m4m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4M FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m4m RCSB], [http://www.ebi.ac.uk/pdbsum/1m4m PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m4m_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The coupling of apoptosis (programmed cell death) to the cell division cycle is essential for homeostasis and genomic integrity. Here, we report the crystal structure of survivin, an inhibitor of apoptosis, which has been implicated in both control of cell death and regulation of cell division. In addition to a conserved N-terminal Zn finger baculovirus IAP repeat, survivin forms a dimer through a symmetric interaction with an intermolecularly bound Zn atom located along the molecular dyad axis. The interaction of the dimer-related C-terminal alpha helices forms an extended surface of approximately 70 A in length. Mutagenesis analysis revealed that survivin dimerization and an extended negatively charged surface surrounding Asp-71 are required to counteract apoptosis and preserve ploidy. These findings may provide a structural basis for a dual role of survivin in inhibition of apoptosis and regulation of cell division.

-	~~{{STRUCTURE_1m4m\| PDB=1m4m \| SCENE= }}~~	+	Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin.,Muchmore SW, Chen J, Jakob C, Zakula D, Matayoshi ED, Wu W, Zhang H, Li F, Ng SC, Altieri DC Mol Cell. 2000 Jul;6(1):173-82. PMID:10949038<ref>PMID:10949038</ref>

-	~~===Mouse Survivin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_10949038}}~~	+	==See Also==
-		+	*[[Survivin\|Survivin]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1m4m~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:010949038<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Altieri, D C.]]		[[Category: Altieri, D C.]]

OCA: Protected "1m4m" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 21:20:12 GMT

Protected "1m4m" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:20, 5 December 2012

OCA at 21:20, 5 December 2012

OCA — Wed, 05 Dec 2012 21:20:09 GMT

←Older revision		Revision as of 21:20, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1m4m.png\|left\|200px]]		[[Image:1m4m.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1m4m", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1m4m\| PDB=1m4m \| SCENE= }}		{{STRUCTURE_1m4m\| PDB=1m4m \| SCENE= }}

	===Mouse Survivin===		===Mouse Survivin===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10949038}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10949038 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10949038}}		{{ABSTRACT_PUBMED_10949038}}

	==About this Structure==		==About this Structure==
-	~~1M4M~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA].	+	[[1m4m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10949038~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010949038</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Altieri, D C.]]		[[Category: Altieri, D C.]]
Line 35:		Line 23:
	[[Category: Zakula, D.]]		[[Category: Zakula, D.]]
	[[Category: Zhang, H.]]		[[Category: Zhang, H.]]
		+	[[Category: Apoptosis]]
	[[Category: Zn finger baculovirus iap repeat]]		[[Category: Zn finger baculovirus iap repeat]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:57:45 2009''