1m4v - Revision history

OCA at 07:39, 14 February 2024

OCA — Wed, 14 Feb 2024 07:39:40 GMT

←Older revision		Revision as of 07:39, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1m4v' size='340' side='right'caption='[[1m4v]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1m4v' size='340' side='right'caption='[[1m4v]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1m4v]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1M4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1m4v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M4V FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>SET3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1280~~ "~~Micrococcus aureus~~" ~~(Rosenbach 1884) Zopf 1885~~])</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1m4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4v OCA], [~~http~~://pdbe.org/1m4v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1m4v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1m4v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4v OCA], [https://pdbe.org/1m4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m4v RCSB], [https://www.ebi.ac.uk/pdbsum/1m4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4v ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9ZFS6_STAAU Q9ZFS6_STAAU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m4v ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m4v ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The staphylococcal enterotoxin-like toxins (SETs) are a family of proteins encoded within the Staphylococcus aureus genome that were identified by their similarity to the well described bacterial superantigens. The first crystal structure of a member of the SET family, SET3, has been determined to 1.9 A (R = 0.205, R(free) = 0.240) and reveals a fold characteristic of the superantigen family but with significant differences. The SET proteins are secreted at varying levels by staphylococcal isolates, and seroconversion studies of normal individuals indicate that they are strongly antigenic to humans. Recombinant SETs do not exhibit any of the properties expected of superantigens such as major histocompatibility complex class II binding or broad T-cell activation, suggesting they have an entirely different function. The fact that the whole gene family is clustered within the pathogenicity island SaIn2 of the S. aureus genome suggests that they are involved in host/pathogen interactions.

-	The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome.,Arcus VL, Langley R, Proft T, Fraser JD, Baker EN J Biol Chem. 2002 Aug 30;277(35):32274-81. Epub 2002 Jun 24. PMID:12082105<ref>PMID:12082105</ref>	+	==See Also==
-		+	*[[Exotoxin 3D structures\|Exotoxin 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 1m4v" style="background-color:#fffaf0;"></div>~~	+
-	== ~~References~~ ==	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arcus~~, V L~~]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: Baker~~, E N~~]]	+	[[Category: Arcus VL]]
-	[[Category: Fraser~~, J D~~]]	+	[[Category: Baker EN]]
-	[[Category: Langley, R]]	+	[[Category: Fraser JD]]
-	[[Category: Proft, T]]	+	[[Category: Langley R]]
-	~~[[Category: Beta-grasp]]~~	+	[[Category: Proft T]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Ob-fold]]~~	+
-	~~[[Category: Superantigen fold~~]]	+

OCA at 08:33, 2 December 2020

OCA — Wed, 02 Dec 2020 08:33:21 GMT

←Older revision		Revision as of 08:33, 2 December 2020
Line 1:		Line 1:

	==Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus==		==Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus==
-	<StructureSection load='1m4v' size='340' side='right' caption='[[1m4v]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1m4v' size='340' side='right'caption='[[1m4v]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1m4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1M4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1m4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1M4V FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SET3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SET3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1m4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4v OCA], [http://pdbe.org/1m4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m4v RCSB], [http://www.ebi.ac.uk/pdbsum/1m4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1m4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4v OCA], [http://pdbe.org/1m4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m4v RCSB], [http://www.ebi.ac.uk/pdbsum/1m4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4v ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m4v_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m4v_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Arcus, V L]]		[[Category: Arcus, V L]]
	[[Category: Baker, E N]]		[[Category: Baker, E N]]

OCA at 10:54, 18 October 2017

OCA — Wed, 18 Oct 2017 10:54:40 GMT

←Older revision		Revision as of 10:54, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus==		==Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus==
	<StructureSection load='1m4v' size='340' side='right' caption='[[1m4v]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1m4v' size='340' side='right' caption='[[1m4v]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1m4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[1m4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4V FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SET3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SET3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4v OCA], [http://pdbe.org/1m4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m4v RCSB], [http://www.ebi.ac.uk/pdbsum/1m4v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4v OCA], [http://pdbe.org/1m4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m4v RCSB], [http://www.ebi.ac.uk/pdbsum/1m4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4v ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m4v ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:44, 11 September 2015

OCA — Fri, 11 Sep 2015 07:44:30 GMT

←Older revision		Revision as of 07:44, 11 September 2015
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	<StructureSection load='1m4v' size='340' side='right' caption='[[1m4v]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1m4v' size='340' side='right' caption='[[1m4v]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1m4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1m4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4V FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SET3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 ~~Staphylococcus~~ aureus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SET3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m4v RCSB], [http://www.ebi.ac.uk/pdbsum/1m4v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4v OCA], [http://pdbe.org/1m4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m4v RCSB], [http://www.ebi.ac.uk/pdbsum/1m4v PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1m4v" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Staphylococcus aureus]]
	[[Category: Arcus, V L]]		[[Category: Arcus, V L]]
	[[Category: Baker, E N]]		[[Category: Baker, E N]]

OCA at 15:41, 5 January 2015

OCA — Mon, 05 Jan 2015 15:41:57 GMT

←Older revision		Revision as of 15:41, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1m4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[1m4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4V FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SET3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SET3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m4v RCSB], [http://www.ebi.ac.uk/pdbsum/1m4v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m4v RCSB], [http://www.ebi.ac.uk/pdbsum/1m4v PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Arcus, V L.]]	+	[[Category: Arcus, V L]]
-	[[Category: Baker, E N.]]	+	[[Category: Baker, E N]]
-	[[Category: Fraser, J D.]]	+	[[Category: Fraser, J D]]
-	[[Category: Langley, R.]]	+	[[Category: Langley, R]]
-	[[Category: Proft, T.]]	+	[[Category: Proft, T]]
	[[Category: Beta-grasp]]		[[Category: Beta-grasp]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Ob-fold]]		[[Category: Ob-fold]]
	[[Category: Superantigen fold]]		[[Category: Superantigen fold]]

OCA at 15:33, 28 September 2014

OCA — Sun, 28 Sep 2014 15:33:47 GMT

←Older revision		Revision as of 15:33, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1m4v.~~png\|left~~\|200px]]	+	==Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus==
		+	<StructureSection load='1m4v' size='340' side='right' caption='[[1m4v]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1m4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4V FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SET3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m4v RCSB], [http://www.ebi.ac.uk/pdbsum/1m4v PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m4v_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The staphylococcal enterotoxin-like toxins (SETs) are a family of proteins encoded within the Staphylococcus aureus genome that were identified by their similarity to the well described bacterial superantigens. The first crystal structure of a member of the SET family, SET3, has been determined to 1.9 A (R = 0.205, R(free) = 0.240) and reveals a fold characteristic of the superantigen family but with significant differences. The SET proteins are secreted at varying levels by staphylococcal isolates, and seroconversion studies of normal individuals indicate that they are strongly antigenic to humans. Recombinant SETs do not exhibit any of the properties expected of superantigens such as major histocompatibility complex class II binding or broad T-cell activation, suggesting they have an entirely different function. The fact that the whole gene family is clustered within the pathogenicity island SaIn2 of the S. aureus genome suggests that they are involved in host/pathogen interactions.

-	~~{{STRUCTURE_1m4v\| PDB=1m4v \| SCENE= }}~~	+	The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome.,Arcus VL, Langley R, Proft T, Fraser JD, Baker EN J Biol Chem. 2002 Aug 30;277(35):32274-81. Epub 2002 Jun 24. PMID:12082105<ref>PMID:12082105</ref>

-	~~===Crystal structure of SET3~~, a ~~superantigen-like protein from Staphylococcus aureus===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12082105}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1m4v]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus Staphylococcus aureus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012082105<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Arcus, V L.]]		[[Category: Arcus, V L.]]

OCA: Protected "1m4v" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 19:57:01 GMT

Protected "1m4v" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:57, 5 December 2012

OCA at 19:56, 5 December 2012

OCA — Wed, 05 Dec 2012 19:56:59 GMT

←Older revision		Revision as of 19:56, 5 December 2012
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-	{{Seed}}
	[[Image:1m4v.png\|left\|200px]]		[[Image:1m4v.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1m4v", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1m4v\| PDB=1m4v \| SCENE= }}		{{STRUCTURE_1m4v\| PDB=1m4v \| SCENE= }}

	===Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus===		===Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12082105}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12082105 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12082105}}		{{ABSTRACT_PUBMED_12082105}}

	==About this Structure==		==About this Structure==
-	~~1M4V~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA].	+	[[1m4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12082105~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012082105</ref><references group="xtra"/>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Arcus, V L.]]		[[Category: Arcus, V L.]]
Line 31:		Line 19:
	[[Category: Proft, T.]]		[[Category: Proft, T.]]
	[[Category: Beta-grasp]]		[[Category: Beta-grasp]]
		+	[[Category: Immune system]]
	[[Category: Ob-fold]]		[[Category: Ob-fold]]
	[[Category: Superantigen fold]]		[[Category: Superantigen fold]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:20:25 2009''

OCA at 15:20, 17 February 2009

OCA — Tue, 17 Feb 2009 15:20:26 GMT

←Older revision		Revision as of 15:20, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1M4V is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA].	+	1M4V is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA].

	==Reference==		==Reference==
-	The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome., Arcus VL, Langley R, Proft T, Fraser JD, Baker EN, J Biol Chem. 2002 Aug 30;277(35):32274-81. Epub 2002 Jun 24. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12082105 12082105]~~	+	<ref group="xtra">PMID:12082105</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Arcus, V L.]]		[[Category: Arcus, V L.]]
Line 35:		Line 34:
	[[Category: Superantigen fold]]		[[Category: Superantigen fold]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 2 23~~:12:~~48 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:20:25 2009''

OCA at 20:12, 2 July 2008

OCA — Wed, 02 Jul 2008 20:12:52 GMT

←Older revision		Revision as of 20:12, 2 July 2008
Line 1:		Line 1:
-	[[Image:1m4v.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1m4v.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1m4v\| PDB=1m4v \| SCENE= }}		{{STRUCTURE_1m4v\| PDB=1m4v \| SCENE= }}

-	~~'''~~Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus~~'''~~	+	===Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus===


-	~~==Overview==~~	+	<!--
-	The ~~staphylococcal enterotoxin-like toxins (SETs) are a family of proteins encoded within~~ the ~~Staphylococcus aureus genome that were identified by their similarity~~ to the ~~well described bacterial superantigens. The first crystal structure of a member of the SET family, SET3, has been determined to 1.9 A~~ (~~R = 0~~.~~205, R(free) = 0~~.~~240~~) ~~and reveals a fold characteristic of the superantigen family but with significant differences. The SET proteins are secreted at varying levels by staphylococcal isolates~~, and seroconversion studies of normal individuals indicate that they are strongly antigenic to humans. Recombinant SETs do not exhibit any of the properties expected of superantigens such as major histocompatibility complex class II binding or broad T-cell activation, suggesting they have an entirely different function. The fact that the whole gene family is ~~clustered within~~ the ~~pathogenicity island SaIn2 of the S. aureus genome suggests that they are involved in host/pathogen interactions~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_12082105}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 12082105 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_12082105}}

	==About this Structure==		==About this Structure==
Line 30:		Line 34:
	[[Category: Ob-fold]]		[[Category: Ob-fold]]
	[[Category: Superantigen fold]]		[[Category: Superantigen fold]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May~~ ~~3 00~~:37:57 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:12:48 2008''