1mbk - Revision history

OCA at 08:33, 10 April 2024

OCA — Wed, 10 Apr 2024 08:33:49 GMT

←Older revision		Revision as of 08:33, 10 April 2024
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	==MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3==		==MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3==
-	<StructureSection load='1mbk' size='340' side='right'caption='[[1mbk~~]], [[NMR_Ensembles_of_Models \| 50 NMR models~~]]' scene=''>	+	<StructureSection load='1mbk' size='340' side='right'caption='[[1mbk]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mbk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MBK FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mbk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MBK FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1mbj\|1mbj]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mbk OCA], [https://pdbe.org/1mbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mbk RCSB], [https://www.ebi.ac.uk/pdbsum/1mbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mbk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mbk OCA], [https://pdbe.org/1mbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mbk RCSB], [https://www.ebi.ac.uk/pdbsum/1mbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mbk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MYB_MOUSE MYB_MOUSE]] Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.	+	[https://www.uniprot.org/uniprot/MYB_MOUSE MYB_MOUSE] Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mbk ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mbk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The DNA-binding domain of c-Myb consists of three imperfect tandem repeats (R1, R2 and R3). The three repeats have similar overall architectures, each containing a helix-turn-helix variation motif. The three conserved tryptophans in each repeat participate in forming a hydrophobic core. Comparison of the three repeat structures indicated that cavities are found in the hydrophobic core of R2, which is thermally unstable. On complexation with DNA, the orientations of R2 and R3 are fixed by tight binding and their conformations are slightly changed. No significant changes occur in the chemical shifts of R1 consistent with its loose interaction with DNA.
-
-	Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb.,Ogata K, Morikawa S, Nakamura H, Hojo H, Yoshimura S, Zhang R, Aimoto S, Ametani Y, Hirata Z, Sarai A, et al. Nat Struct Biol. 1995 Apr;2(4):309-20. PMID:7796266<ref>PMID:7796266</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1mbk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]		*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Aimoto, S]]	+	[[Category: Aimoto S]]
-	[[Category: Ametani, Y]]	+	[[Category: Ametani Y]]
-	[[Category: Hirata, Z]]	+	[[Category: Hirata Z]]
-	[[Category: Hojo, H]]	+	[[Category: Hojo H]]
-	[[Category: Ishii, S]]	+	[[Category: Ishii S]]
-	[[Category: Morikawa, S]]	+	[[Category: Morikawa S]]
-	[[Category: Nakamura, H]]	+	[[Category: Nakamura H]]
-	[[Category: Nishimura, Y]]	+	[[Category: Nishimura Y]]
-	[[Category: Ogata, K]]	+	[[Category: Ogata K]]
-	[[Category: Sarai, A]]	+	[[Category: Sarai A]]
-	[[Category: Yoshimura, S]]	+	[[Category: Yoshimura S]]
-	[[Category: Zhang, R]]	+	[[Category: Zhang R]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Protooncogene product~~]]	+

OCA at 06:55, 18 August 2021

OCA — Wed, 18 Aug 2021 06:55:12 GMT

←Older revision		Revision as of 06:55, 18 August 2021
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	<StructureSection load='1mbk' size='340' side='right'caption='[[1mbk]], [[NMR_Ensembles_of_Models \| 50 NMR models]]' scene=''>		<StructureSection load='1mbk' size='340' side='right'caption='[[1mbk]], [[NMR_Ensembles_of_Models \| 50 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mbk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1MBK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mbk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MBK FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mbj\|1mbj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mbj\|1mbj]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1mbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mbk OCA], [~~http~~://pdbe.org/1mbk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1mbk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1mbk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1mbk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mbk OCA], [https://pdbe.org/1mbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mbk RCSB], [https://www.ebi.ac.uk/pdbsum/1mbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mbk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MYB_MOUSE MYB_MOUSE]] Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.	+	[[https://www.uniprot.org/uniprot/MYB_MOUSE MYB_MOUSE]] Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Transcriptional activator\|Transcriptional activator]]	+	*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:36, 13 November 2019

OCA — Wed, 13 Nov 2019 12:36:53 GMT

←Older revision		Revision as of 12:36, 13 November 2019
Line 1:		Line 1:

	==MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3==		==MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3==
-	<StructureSection load='1mbk' size='340' side='right' caption='[[1mbk]], [[NMR_Ensembles_of_Models \| 50 NMR models]]' scene=''>	+	<StructureSection load='1mbk' size='340' side='right'caption='[[1mbk]], [[NMR_Ensembles_of_Models \| 50 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mbk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MBK FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mbk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MBK FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1mbk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1mbk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transcriptional activator\|Transcriptional activator]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Aimoto, S]]		[[Category: Aimoto, S]]

OCA at 08:11, 31 January 2018

OCA — Wed, 31 Jan 2018 08:11:07 GMT

←Older revision		Revision as of 08:11, 31 January 2018
Line 1:		Line 1:
		+
	==MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3==		==MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3==
	<StructureSection load='1mbk' size='340' side='right' caption='[[1mbk]], [[NMR_Ensembles_of_Models \| 50 NMR models]]' scene=''>		<StructureSection load='1mbk' size='340' side='right' caption='[[1mbk]], [[NMR_Ensembles_of_Models \| 50 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mbj\|1mbj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mbj\|1mbj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mbk OCA], [http://pdbe.org/1mbk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mbk RCSB], [http://www.ebi.ac.uk/pdbsum/1mbk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mbk OCA], [http://pdbe.org/1mbk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mbk RCSB], [http://www.ebi.ac.uk/pdbsum/1mbk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mbk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mb/1mbk_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mb/1mbk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1mbk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1mbk" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Transcriptional activator\|Transcriptional activator]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:52, 9 February 2016

OCA — Tue, 09 Feb 2016 15:52:22 GMT

←Older revision		Revision as of 15:52, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mbk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:45, 10 September 2015

OCA — Thu, 10 Sep 2015 23:45:19 GMT

←Older revision		Revision as of 23:45, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mbj\|1mbj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mbj\|1mbj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mbk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mbk RCSB], [http://www.ebi.ac.uk/pdbsum/1mbk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mbk OCA], [http://pdbe.org/1mbk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mbk RCSB], [http://www.ebi.ac.uk/pdbsum/1mbk PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1mbk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:53, 25 December 2014

OCA — Thu, 25 Dec 2014 07:53:19 GMT

←Older revision		Revision as of 07:53, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mbk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MBK FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mbk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MBK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mbj\|1mbj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mbj\|1mbj]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mbk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mbk RCSB], [http://www.ebi.ac.uk/pdbsum/1mbk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mbk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mbk RCSB], [http://www.ebi.ac.uk/pdbsum/1mbk PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYB_MOUSE MYB_MOUSE]] Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Aimoto, S.]]	+	[[Category: Aimoto, S]]
-	[[Category: Ametani, Y.]]	+	[[Category: Ametani, Y]]
-	[[Category: Hirata, Z.]]	+	[[Category: Hirata, Z]]
-	[[Category: Hojo, H.]]	+	[[Category: Hojo, H]]
-	[[Category: Ishii, S.]]	+	[[Category: Ishii, S]]
-	[[Category: Morikawa, S.]]	+	[[Category: Morikawa, S]]
-	[[Category: Nakamura, H.]]	+	[[Category: Nakamura, H]]
-	[[Category: Nishimura, Y.]]	+	[[Category: Nishimura, Y]]
-	[[Category: Ogata, K.]]	+	[[Category: Ogata, K]]
-	[[Category: Sarai, A.]]	+	[[Category: Sarai, A]]
-	[[Category: Yoshimura, S.]]	+	[[Category: Yoshimura, S]]
-	[[Category: Zhang, R.]]	+	[[Category: Zhang, R]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Protooncogene product]]		[[Category: Protooncogene product]]

OCA at 09:07, 3 October 2014

OCA — Fri, 03 Oct 2014 09:07:47 GMT

←Older revision		Revision as of 09:07, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1mbk\| PDB=1mbk \| SCENE= }}~~	+	==MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3==
-	===MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3===	+	<StructureSection load='1mbk' size='340' side='right' caption='[[1mbk]], [[NMR_Ensembles_of_Models \| 50 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_7796266}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1mbk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MBK FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mbj\|1mbj]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mbk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mbk RCSB], [http://www.ebi.ac.uk/pdbsum/1mbk PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mb/1mbk_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The DNA-binding domain of c-Myb consists of three imperfect tandem repeats (R1, R2 and R3). The three repeats have similar overall architectures, each containing a helix-turn-helix variation motif. The three conserved tryptophans in each repeat participate in forming a hydrophobic core. Comparison of the three repeat structures indicated that cavities are found in the hydrophobic core of R2, which is thermally unstable. On complexation with DNA, the orientations of R2 and R3 are fixed by tight binding and their conformations are slightly changed. No significant changes occur in the chemical shifts of R1 consistent with its loose interaction with DNA.

-	~~==Function==~~	+	Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb.,Ogata K, Morikawa S, Nakamura H, Hojo H, Yoshimura S, Zhang R, Aimoto S, Ametani Y, Hirata Z, Sarai A, et al. Nat Struct Biol. 1995 Apr;2(4):309-20. PMID:7796266<ref>PMID:7796266</ref>
-	~~[[http://www.uniprot.org/uniprot/MYB_MOUSE MYB_MOUSE]] Transcriptional activator;~~ DNA-~~binding protein that specifically recognize~~ the ~~sequence 5'~~-~~YAAC[GT]G~~-3'. ~~Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1mbk]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1MBK OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Transcriptional activator\|Transcriptional activator]]		*[[Transcriptional activator\|Transcriptional activator]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:007796266</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Aimoto, S.]]		[[Category: Aimoto, S.]]

OCA at 10:56, 16 April 2014

OCA — Wed, 16 Apr 2014 10:56:14 GMT

←Older revision		Revision as of 10:56, 16 April 2014
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-	[[Image:1mbk.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1mbk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1mbk\| PDB=1mbk \| SCENE= }}		{{STRUCTURE_1mbk\| PDB=1mbk \| SCENE= }}
-
	===MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3===		===MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3===
		+	{{ABSTRACT_PUBMED_7796266}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/MYB_MOUSE MYB_MOUSE]] Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_7796266}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 7796266 is~~ the ~~PubMed ID number.~~	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_7796266}}~~	+

	==About this Structure==		==About this Structure==
	[[1mbk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBK OCA].		[[1mbk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBK OCA].
		+
		+	==See Also==
		+	*[[Transcriptional activator\|Transcriptional activator]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:007796266</ref><references group="xtra"/>	+	<ref group="xtra">PMID:007796266</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Aimoto, S.]]		[[Category: Aimoto, S.]]

OCA: Protected "1mbk" [edit=sysop:move=sysop]

OCA — Wed, 29 Feb 2012 07:55:49 GMT

Protected "1mbk" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:55, 29 February 2012