1mhz - Revision history

OCA at 06:29, 9 August 2023

OCA — Wed, 09 Aug 2023 06:29:46 GMT

←Older revision		Revision as of 06:29, 9 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mhz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylosinus_trichosporium Methylosinus trichosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MHZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mhz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylosinus_trichosporium Methylosinus trichosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MHZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhz OCA], [https://pdbe.org/1mhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mhz RCSB], [https://www.ebi.ac.uk/pdbsum/1mhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mhz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhz OCA], [https://pdbe.org/1mhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mhz RCSB], [https://www.ebi.ac.uk/pdbsum/1mhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mhz ProSAT]</span></td></tr>
	</table>		</table>
Line 30:		Line 31:

	==See Also==		==See Also==
-	*[[Methane monooxygenase\|Methane monooxygenase]]	+	*[[Methane monooxygenase 3D structures\|Methane monooxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:46, 21 December 2022

OCA — Wed, 21 Dec 2022 09:46:51 GMT

←Older revision		Revision as of 09:46, 21 December 2022
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[1mhz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylosinus_trichosporium Methylosinus trichosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MHZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mhz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylosinus_trichosporium Methylosinus trichosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MHZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methane_monooxygenase_(soluble) Methane monooxygenase (soluble)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhz OCA], [https://pdbe.org/1mhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mhz RCSB], [https://www.ebi.ac.uk/pdbsum/1mhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mhz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhz OCA], [https://pdbe.org/1mhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mhz RCSB], [https://www.ebi.ac.uk/pdbsum/1mhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mhz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MEMB_METTR MEMB_METTR]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[https://www.uniprot.org/uniprot/MEMG_METTR MEMG_METTR]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[https://www.uniprot.org/uniprot/MEMA_METTR MEMA_METTR]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.	+	[https://www.uniprot.org/uniprot/MEMB_METTR MEMB_METTR] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Methylosinus trichosporium]]		[[Category: Methylosinus trichosporium]]
-	[[Category: Earhart~~, C A~~]]	+	[[Category: Earhart CA]]
-	[[Category: Elango, N]]	+	[[Category: Elango N]]
-	[[Category: Froland~~, W A~~]]	+	[[Category: Froland WA]]
-	[[Category: Lipscomb~~, J D~~]]	+	[[Category: Lipscomb JD]]
-	[[Category: Ohlendorf~~, D H~~]]	+	[[Category: Ohlendorf DH]]
-	[[Category: Radhakrishnan, R]]	+	[[Category: Radhakrishnan R]]
-	[[Category: Waller~~, B J]]~~	+	[[Category: Waller BJ]]
-	~~[[Category: Monooxygenase]]~~	+
-	~~[[Category: Nadp]]~~	+
-	~~[[Category: One-carbon metabolism]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 06:52, 25 August 2021

OCA — Wed, 25 Aug 2021 06:52:03 GMT

←Older revision		Revision as of 06:52, 25 August 2021
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	<StructureSection load='1mhz' size='340' side='right'caption='[[1mhz]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1mhz' size='340' side='right'caption='[[1mhz]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mhz]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Methylosinus_trichosporium Methylosinus trichosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1MHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mhz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylosinus_trichosporium Methylosinus trichosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MHZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Methane_monooxygenase_(soluble) Methane monooxygenase (soluble)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methane_monooxygenase_(soluble) Methane monooxygenase (soluble)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1mhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhz OCA], [~~http~~://pdbe.org/1mhz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1mhz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1mhz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1mhz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhz OCA], [https://pdbe.org/1mhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mhz RCSB], [https://www.ebi.ac.uk/pdbsum/1mhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mhz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MEMB_METTR MEMB_METTR]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[~~http~~://www.uniprot.org/uniprot/MEMG_METTR MEMG_METTR]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[~~http~~://www.uniprot.org/uniprot/MEMA_METTR MEMA_METTR]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.	+	[[https://www.uniprot.org/uniprot/MEMB_METTR MEMB_METTR]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[https://www.uniprot.org/uniprot/MEMG_METTR MEMG_METTR]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[https://www.uniprot.org/uniprot/MEMA_METTR MEMA_METTR]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 18:45, 20 November 2019

OCA — Wed, 20 Nov 2019 18:45:53 GMT

←Older revision		Revision as of 18:45, 20 November 2019
Line 1:		Line 1:

	==METHANE MONOOXYGENASE HYDROXYLASE==		==METHANE MONOOXYGENASE HYDROXYLASE==
-	<StructureSection load='1mhz' size='340' side='right' caption='[[1mhz]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='1mhz' size='340' side='right'caption='[[1mhz]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mhz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylosinus_trichosporium Methylosinus trichosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MHZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mhz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylosinus_trichosporium Methylosinus trichosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MHZ FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mh/1mhz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mh/1mhz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1mhz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1mhz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Methane monooxygenase\|Methane monooxygenase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Methylosinus trichosporium]]		[[Category: Methylosinus trichosporium]]
	[[Category: Earhart, C A]]		[[Category: Earhart, C A]]

OCA at 06:47, 29 November 2017

OCA — Wed, 29 Nov 2017 06:47:46 GMT

←Older revision		Revision as of 06:47, 29 November 2017
Line 1:		Line 1:
		+
	==METHANE MONOOXYGENASE HYDROXYLASE==		==METHANE MONOOXYGENASE HYDROXYLASE==
	<StructureSection load='1mhz' size='340' side='right' caption='[[1mhz]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1mhz' size='340' side='right' caption='[[1mhz]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase_(soluble) Methane monooxygenase (soluble)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase_(soluble) Methane monooxygenase (soluble)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhz OCA], [http://pdbe.org/1mhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mhz RCSB], [http://www.ebi.ac.uk/pdbsum/1mhz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhz OCA], [http://pdbe.org/1mhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mhz RCSB], [http://www.ebi.ac.uk/pdbsum/1mhz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mhz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1mhz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1mhz" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Methane monooxygenase\|Methane monooxygenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:30, 8 February 2016

OCA — Mon, 08 Feb 2016 01:30:37 GMT

←Older revision		Revision as of 01:30, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mhz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:37, 10 September 2015

OCA — Thu, 10 Sep 2015 06:37:02 GMT

←Older revision		Revision as of 06:37, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1mhz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylosinus_trichosporium Methylosinus trichosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MHZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mhz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylosinus_trichosporium Methylosinus trichosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MHZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Methane_monooxygenase~~ Methane monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase_(soluble) Methane monooxygenase (soluble)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mhz RCSB], [http://www.ebi.ac.uk/pdbsum/1mhz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhz OCA], [http://pdbe.org/1mhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mhz RCSB], [http://www.ebi.ac.uk/pdbsum/1mhz PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1mhz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Methane monooxygenase]]
	[[Category: Methylosinus trichosporium]]		[[Category: Methylosinus trichosporium]]
	[[Category: Earhart, C A]]		[[Category: Earhart, C A]]

OCA at 19:34, 24 December 2014

OCA — Wed, 24 Dec 2014 19:34:10 GMT

←Older revision		Revision as of 19:34, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mhz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylosinus_trichosporium Methylosinus trichosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MHZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mhz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylosinus_trichosporium Methylosinus trichosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MHZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase Methane monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase Methane monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mhz RCSB], [http://www.ebi.ac.uk/pdbsum/1mhz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mhz RCSB], [http://www.ebi.ac.uk/pdbsum/1mhz PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MEMB_METTR MEMB_METTR]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[http://www.uniprot.org/uniprot/MEMG_METTR MEMG_METTR]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[http://www.uniprot.org/uniprot/MEMA_METTR MEMA_METTR]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Methane monooxygenase]]		[[Category: Methane monooxygenase]]
	[[Category: Methylosinus trichosporium]]		[[Category: Methylosinus trichosporium]]
-	[[Category: Earhart, C A.]]	+	[[Category: Earhart, C A]]
-	[[Category: Elango, N.]]	+	[[Category: Elango, N]]
-	[[Category: Froland, W A.]]	+	[[Category: Froland, W A]]
-	[[Category: Lipscomb, J D.]]	+	[[Category: Lipscomb, J D]]
-	[[Category: Ohlendorf, D H.]]	+	[[Category: Ohlendorf, D H]]
-	[[Category: Radhakrishnan, R.]]	+	[[Category: Radhakrishnan, R]]
-	[[Category: Waller, B J.]]	+	[[Category: Waller, B J]]
	[[Category: Monooxygenase]]		[[Category: Monooxygenase]]
	[[Category: Nadp]]		[[Category: Nadp]]
	[[Category: One-carbon metabolism]]		[[Category: One-carbon metabolism]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 15:14, 28 September 2014

OCA — Sun, 28 Sep 2014 15:14:20 GMT

←Older revision		Revision as of 15:14, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1mhz.~~png\|left~~\|200px]]	+	==METHANE MONOOXYGENASE HYDROXYLASE==
		+	<StructureSection load='1mhz' size='340' side='right' caption='[[1mhz]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1mhz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylosinus_trichosporium Methylosinus trichosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MHZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase Methane monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mhz RCSB], [http://www.ebi.ac.uk/pdbsum/1mhz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mh/1mhz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Methane monooxygenase (MMO), found in aerobic methanotrophic bacteria, catalyzes the O2-dependent conversion of methane to methanol. The soluble form of the enzyme (sMMO) consists of three components: a reductase, a regulatory "B" component (MMOB), and a hydroxylase component (MMOH), which contains a hydroxo-bridged dinuclear iron cluster. Two genera of methanotrophs, termed Type X and Type II, which differ markedly in cellular and metabolic characteristics, are known to produce the sMMO. The structure of MMOH from the Type X methanotroph Methylococcus capsulatus Bath (MMO Bath) has been reported recently. Two different structures were found for the essential diiron cluster, depending upon the temperature at which the diffraction data were collected. In order to extend the structural studies to the Type II methanotrophs and to determine whether one of the two known MMOH structures is generally applicable to the MMOH family, we have determined the crystal structure of the MMOH from Type II Methylosinus trichosporium OB3b (MMO OB3b) in two crystal forms to 2.0 A resolution, respectively, both determined at 18 degrees C. The crystal forms differ in that MMOB was present during crystallization of the second form. Both crystal forms, however, yielded very similar results for the structure of the MMOH. Most of the major structural features of the MMOH Bath were also maintained with high fidelity. The two irons of the active site cluster of MMOH OB3b are bridged by two OH (or one OH and one H2O), as well as both carboxylate oxygens of Glu alpha 144. This bis-mu-hydroxo-bridged "diamond core" structure, with a short Fe-Fe distance of 2.99 A, is unique for the resting state of proteins containing analogous diiron clusters, and is very similar to the structure reported for the cluster from flash frozen (-160 degrees C) crystals of MMOH Bath, suggesting a common active site structure for the soluble MMOHs. The high-resolution structure of MMOH OB3b indicates 26 consecutive amino acid sequence differences in the beta chain when compared to the previously reported sequence inferred from the cloned gene. Fifteen additional sequence differences distributed randomly over the three chains were also observed, including D alpha 209E, a ligand of one of the irons.

-	~~{{STRUCTURE_1mhz\| PDB=1mhz \| SCENE= }}~~	+	Crystal structure of the hydroxylase component of methane monooxygenase from Methylosinus trichosporium OB3b.,Elango N, Radhakrishnan R, Froland WA, Wallar BJ, Earhart CA, Lipscomb JD, Ohlendorf DH Protein Sci. 1997 Mar;6(3):556-68. PMID:9070438<ref>PMID:9070438</ref>

-	~~===METHANE MONOOXYGENASE HYDROXYLASE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_9070438}}~~	+	==See Also==
-		+	*[[Methane monooxygenase\|Methane monooxygenase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1mhz~~]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylosinus_trichosporium Methylosinus trichosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHZ OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:009070438<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Methane monooxygenase]]		[[Category: Methane monooxygenase]]
	[[Category: Methylosinus trichosporium]]		[[Category: Methylosinus trichosporium]]

OCA: Protected "1mhz" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 21:21:06 GMT

Protected "1mhz" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:21, 5 December 2012