1ml0 - Revision history

OCA at 08:37, 10 April 2024

OCA — Wed, 10 Apr 2024 08:37:51 GMT

←Older revision		Revision as of 08:37, 10 April 2024
Line 3:		Line 3:
	<StructureSection load='1ml0' size='340' side='right'caption='[[1ml0]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1ml0' size='340' side='right'caption='[[1ml0]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ml0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~] and [https://en.wikipedia.org/wiki/~~Mhv68 Mhv68~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ML0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ml0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Murid_gammaherpesvirus_4 Murid gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ML0 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1mkf\|1mkf]], [[1dok\|1dok]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">M3 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=33708 MHV68]), MONOCYTE CHEMOATTRACTANT PROTEIN 1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ml0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml0 OCA], [https://pdbe.org/1ml0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ml0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ml0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ml0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ml0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml0 OCA], [https://pdbe.org/1ml0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ml0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ml0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ml0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~CCL2_HUMAN CCL2_HUMAN~~]] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.	+	[https://www.uniprot.org/uniprot/O41925_MHV68 O41925_MHV68]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ml0 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ml0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The M3 protein encoded by murine gamma herpesvirus68 (gamma HV68) functions as an immune system saboteur by the engagement of chemoattractant cytokines, thereby altering host antiviral inflammatory responses. Here we report the crystal structures of M3 both alone and in complex with the CC chemokine MCP-1. M3 is a two-domain beta sandwich protein with a unique sequence and topology, forming a tightly packed anti-parallel dimer. The stoichiometry of the MCP-1:M3 complex is 2:2, with two monomeric chemokines embedded at distal ends of the preassociated M3 dimer. Conformational flexibility and electrostatic complementation are both used by M3 to achieve high-affinity and broad-spectrum chemokine engagement. M3 also employs structural mimicry to promiscuously sequester chemokines, engaging conservative structural elements associated with both chemokine homodimerization and binding to G protein-coupled receptors.
-
-	Structural basis of chemokine sequestration by a herpesvirus decoy receptor.,Alexander JM, Nelson CA, van Berkel V, Lau EK, Studts JM, Brett TJ, Speck SH, Handel TM, Virgin HW, Fremont DH Cell. 2002 Nov 1;111(3):343-56. PMID:12419245<ref>PMID:12419245</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1ml0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Monocyte chemoattractant protein\|Monocyte chemoattractant protein]]		*[[Monocyte chemoattractant protein\|Monocyte chemoattractant protein]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mhv68~~]]	+	[[Category: Murid gammaherpesvirus 4]]
-	[[Category: Alexander~~, J M~~]]	+	[[Category: Alexander JM]]
-	[[Category: Fremont~~, D H]]~~	+	[[Category: Fremont DH]]
-	~~[[Category: Chemokine binding protein]]~~	+
-	~~[[Category: Decoy receptor]]~~	+
-	~~[[Category: Herpesvirus]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Viral immune evasion~~]]	+

OCA at 14:55, 27 October 2021

OCA — Wed, 27 Oct 2021 14:55:43 GMT

←Older revision		Revision as of 14:55, 27 October 2021
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	<StructureSection load='1ml0' size='340' side='right'caption='[[1ml0]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1ml0' size='340' side='right'caption='[[1ml0]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ml0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Mhv68 Mhv68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1ML0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ml0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Mhv68 Mhv68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ML0 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mkf\|1mkf]], [[1dok\|1dok]]</div></td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mkf\|1mkf]], [[1dok\|1dok]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33708 MHV68]), MONOCYTE CHEMOATTRACTANT PROTEIN 1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33708 MHV68]), MONOCYTE CHEMOATTRACTANT PROTEIN 1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1ml0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml0 OCA], [~~http~~://pdbe.org/1ml0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ml0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ml0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ml0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ml0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml0 OCA], [https://pdbe.org/1ml0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ml0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ml0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ml0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CCL2_HUMAN CCL2_HUMAN]] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.	+	[[https://www.uniprot.org/uniprot/CCL2_HUMAN CCL2_HUMAN]] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	==See Also==		==See Also==
	*[[Monocyte chemoattractant protein\|Monocyte chemoattractant protein]]		*[[Monocyte chemoattractant protein\|Monocyte chemoattractant protein]]
-	*[[User:Coline Perrin/CCL2\|User:Coline Perrin/CCL2]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:38, 2 December 2020

OCA — Wed, 02 Dec 2020 08:38:33 GMT

←Older revision		Revision as of 08:38, 2 December 2020
Line 1:		Line 1:

	==VIRAL CHEMOKINE BINDING PROTEIN M3 FROM MURINE GAMMAHERPESVIRUS68 IN COMPLEX WITH THE P8A VARIANT OF CC-CHEMOKINE MCP-1==		==VIRAL CHEMOKINE BINDING PROTEIN M3 FROM MURINE GAMMAHERPESVIRUS68 IN COMPLEX WITH THE P8A VARIANT OF CC-CHEMOKINE MCP-1==
-	<StructureSection load='1ml0' size='340' side='right' caption='[[1ml0]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='1ml0' size='340' side='right'caption='[[1ml0]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ml0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Mhv68 Mhv68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ML0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ml0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Mhv68 Mhv68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1ML0 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mkf\|1mkf]], [[1dok\|1dok]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mkf\|1mkf]], [[1dok\|1dok]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33708 MHV68]), MONOCYTE CHEMOATTRACTANT PROTEIN 1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33708 MHV68]), MONOCYTE CHEMOATTRACTANT PROTEIN 1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ml0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml0 OCA], [http://pdbe.org/1ml0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ml0 RCSB], [http://www.ebi.ac.uk/pdbsum/1ml0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ml0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ml0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml0 OCA], [http://pdbe.org/1ml0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ml0 RCSB], [http://www.ebi.ac.uk/pdbsum/1ml0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ml0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
		+	*[[Monocyte chemoattractant protein\|Monocyte chemoattractant protein]]
	*[[User:Coline Perrin/CCL2\|User:Coline Perrin/CCL2]]		*[[User:Coline Perrin/CCL2\|User:Coline Perrin/CCL2]]
	== References ==		== References ==
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Mhv68]]		[[Category: Mhv68]]
	[[Category: Alexander, J M]]		[[Category: Alexander, J M]]

OCA at 08:10, 31 January 2018

OCA — Wed, 31 Jan 2018 08:10:59 GMT

←Older revision		Revision as of 08:10, 31 January 2018
Line 1:		Line 1:
		+
	==VIRAL CHEMOKINE BINDING PROTEIN M3 FROM MURINE GAMMAHERPESVIRUS68 IN COMPLEX WITH THE P8A VARIANT OF CC-CHEMOKINE MCP-1==		==VIRAL CHEMOKINE BINDING PROTEIN M3 FROM MURINE GAMMAHERPESVIRUS68 IN COMPLEX WITH THE P8A VARIANT OF CC-CHEMOKINE MCP-1==
	<StructureSection load='1ml0' size='340' side='right' caption='[[1ml0]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1ml0' size='340' side='right' caption='[[1ml0]], [[Resolution\|resolution]] 2.80Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mkf\|1mkf]], [[1dok\|1dok]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mkf\|1mkf]], [[1dok\|1dok]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33708 MHV68]), MONOCYTE CHEMOATTRACTANT PROTEIN 1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33708 MHV68]), MONOCYTE CHEMOATTRACTANT PROTEIN 1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ml0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml0 OCA], [http://pdbe.org/1ml0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ml0 RCSB], [http://www.ebi.ac.uk/pdbsum/1ml0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ml0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml0 OCA], [http://pdbe.org/1ml0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ml0 RCSB], [http://www.ebi.ac.uk/pdbsum/1ml0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ml0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ml/1ml0_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ml/1ml0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:

	==See Also==		==See Also==
-	*[[Monocyte chemoattractant protein\|Monocyte chemoattractant protein]]
	*[[User:Coline Perrin/CCL2\|User:Coline Perrin/CCL2]]		*[[User:Coline Perrin/CCL2\|User:Coline Perrin/CCL2]]
-	*[[Viral chemokine binding protein M3\|Viral chemokine binding protein M3]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:45, 7 February 2016

OCA — Sun, 07 Feb 2016 07:45:34 GMT

←Older revision		Revision as of 07:45, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ml0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 30:

	==See Also==		==See Also==
		+	*[[Monocyte chemoattractant protein\|Monocyte chemoattractant protein]]
		+	*[[User:Coline Perrin/CCL2\|User:Coline Perrin/CCL2]]
	*[[Viral chemokine binding protein M3\|Viral chemokine binding protein M3]]		*[[Viral chemokine binding protein M3\|Viral chemokine binding protein M3]]
	== References ==		== References ==

OCA at 23:19, 9 September 2015

OCA — Wed, 09 Sep 2015 23:19:38 GMT

←Older revision		Revision as of 23:19, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1ml0' size='340' side='right' caption='[[1ml0]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1ml0' size='340' side='right' caption='[[1ml0]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ml0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Murid_herpesvirus_4 Murid herpesvirus 4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ML0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ml0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Mhv68 Mhv68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ML0 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mkf\|1mkf]], [[1dok\|1dok]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mkf\|1mkf]], [[1dok\|1dok]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33708 ~~Murid herpesvirus 4~~]), MONOCYTE CHEMOATTRACTANT PROTEIN 1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33708 MHV68]), MONOCYTE CHEMOATTRACTANT PROTEIN 1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ml0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ml0 RCSB], [http://www.ebi.ac.uk/pdbsum/1ml0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ml0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml0 OCA], [http://pdbe.org/1ml0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ml0 RCSB], [http://www.ebi.ac.uk/pdbsum/1ml0 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ml0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Murid herpesvirus 4~~]]	+	[[Category: Mhv68]]
	[[Category: Alexander, J M]]		[[Category: Alexander, J M]]
	[[Category: Fremont, D H]]		[[Category: Fremont, D H]]

OCA at 09:04, 24 December 2014

OCA — Wed, 24 Dec 2014 09:04:40 GMT

←Older revision		Revision as of 09:04, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ml0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Murid_herpesvirus_4 Murid herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ML0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ml0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Murid_herpesvirus_4 Murid herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ML0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mkf\|1mkf]], [[1dok\|1dok]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mkf\|1mkf]], [[1dok\|1dok]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33708 Murid herpesvirus 4]), MONOCYTE CHEMOATTRACTANT PROTEIN 1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33708 Murid herpesvirus 4]), MONOCYTE CHEMOATTRACTANT PROTEIN 1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ml0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ml0 RCSB], [http://www.ebi.ac.uk/pdbsum/1ml0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ml0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ml0 RCSB], [http://www.ebi.ac.uk/pdbsum/1ml0 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CCL2_HUMAN CCL2_HUMAN]] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Murid herpesvirus 4]]		[[Category: Murid herpesvirus 4]]
-	[[Category: Alexander, J M.]]	+	[[Category: Alexander, J M]]
-	[[Category: Fremont, D H.]]	+	[[Category: Fremont, D H]]
	[[Category: Chemokine binding protein]]		[[Category: Chemokine binding protein]]
	[[Category: Decoy receptor]]		[[Category: Decoy receptor]]

OCA at 14:41, 28 September 2014

OCA — Sun, 28 Sep 2014 14:41:33 GMT

←Older revision		Revision as of 14:41, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ml0.~~png~~\|~~left~~\|200px]]	+	==VIRAL CHEMOKINE BINDING PROTEIN M3 FROM MURINE GAMMAHERPESVIRUS68 IN COMPLEX WITH THE P8A VARIANT OF CC-CHEMOKINE MCP-1==
		+	<StructureSection load='1ml0' size='340' side='right' caption='[[1ml0]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ml0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Murid_herpesvirus_4 Murid herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ML0 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mkf\|1mkf]], [[1dok\|1dok]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33708 Murid herpesvirus 4]), MONOCYTE CHEMOATTRACTANT PROTEIN 1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ml0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ml0 RCSB], [http://www.ebi.ac.uk/pdbsum/1ml0 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ml/1ml0_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The M3 protein encoded by murine gamma herpesvirus68 (gamma HV68) functions as an immune system saboteur by the engagement of chemoattractant cytokines, thereby altering host antiviral inflammatory responses. Here we report the crystal structures of M3 both alone and in complex with the CC chemokine MCP-1. M3 is a two-domain beta sandwich protein with a unique sequence and topology, forming a tightly packed anti-parallel dimer. The stoichiometry of the MCP-1:M3 complex is 2:2, with two monomeric chemokines embedded at distal ends of the preassociated M3 dimer. Conformational flexibility and electrostatic complementation are both used by M3 to achieve high-affinity and broad-spectrum chemokine engagement. M3 also employs structural mimicry to promiscuously sequester chemokines, engaging conservative structural elements associated with both chemokine homodimerization and binding to G protein-coupled receptors.

-	~~{{STRUCTURE_1ml0\| PDB=1ml0 \| SCENE= }}~~	+	Structural basis of chemokine sequestration by a herpesvirus decoy receptor.,Alexander JM, Nelson CA, van Berkel V, Lau EK, Studts JM, Brett TJ, Speck SH, Handel TM, Virgin HW, Fremont DH Cell. 2002 Nov 1;111(3):343-56. PMID:12419245<ref>PMID:12419245</ref>

-	~~===VIRAL CHEMOKINE BINDING PROTEIN M3 FROM MURINE GAMMAHERPESVIRUS68 IN COMPLEX WITH THE P8A VARIANT OF CC-CHEMOKINE MCP-1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12419245}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1ml0]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Murid_herpesvirus_4 Murid herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA].~~	+

	==See Also==		==See Also==
	*[[Viral chemokine binding protein M3\|Viral chemokine binding protein M3]]		*[[Viral chemokine binding protein M3\|Viral chemokine binding protein M3]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012419245<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Murid herpesvirus 4]]		[[Category: Murid herpesvirus 4]]

OCA at 06:01, 20 October 2012

OCA — Sat, 20 Oct 2012 06:01:37 GMT

←Older revision		Revision as of 06:01, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1ml0]] is a 2 chain structure ~~of [[Viral chemokine binding protein M3]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Murid_herpesvirus_4 Murid herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA].	+	[[1ml0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Murid_herpesvirus_4 Murid herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA].

	==See Also==		==See Also==

OCA at 11:52, 25 July 2012

OCA — Wed, 25 Jul 2012 11:52:21 GMT

←Older revision		Revision as of 11:52, 25 July 2012
Line 1:		Line 1:
	[[Image:1ml0.png\|left\|200px]]		[[Image:1ml0.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1ml0\| PDB=1ml0 \| SCENE= }}		{{STRUCTURE_1ml0\| PDB=1ml0 \| SCENE= }}

	===VIRAL CHEMOKINE BINDING PROTEIN M3 FROM MURINE GAMMAHERPESVIRUS68 IN COMPLEX WITH THE P8A VARIANT OF CC-CHEMOKINE MCP-1===		===VIRAL CHEMOKINE BINDING PROTEIN M3 FROM MURINE GAMMAHERPESVIRUS68 IN COMPLEX WITH THE P8A VARIANT OF CC-CHEMOKINE MCP-1===

-
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