1mqs - Revision history

OCA at 08:40, 10 April 2024

OCA — Wed, 10 Apr 2024 08:40:05 GMT

←Older revision		Revision as of 08:40, 10 April 2024
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	<StructureSection load='1mqs' size='340' side='right'caption='[[1mqs]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1mqs' size='340' side='right'caption='[[1mqs]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQS FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1dn1\|1dn1]], [[1epu\|1epu]], [[1fvf\|1fvf]], [[1fvh\|1fvh]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqs OCA], [https://pdbe.org/1mqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mqs RCSB], [https://www.ebi.ac.uk/pdbsum/1mqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqs OCA], [https://pdbe.org/1mqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mqs RCSB], [https://www.ebi.ac.uk/pdbsum/1mqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SLY1_YEAST SLY1_YEAST]] Able to suppress the functional loss of YPT1. SLY1 is essential for cell viability. May interact indirectly, or directly with YPT1. [[https://www.uniprot.org/uniprot/SED5_YEAST SED5_YEAST]] Required for vesicular transport between the endoplasmic reticulum and the Golgi complex. Acts as a target organelle soluble NSF attachment protein receptor (t-SNARE).	+	[https://www.uniprot.org/uniprot/SLY1_YEAST SLY1_YEAST] Able to suppress the functional loss of YPT1. SLY1 is essential for cell viability. May interact indirectly, or directly with YPT1.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mqs ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mqs ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Cytosolic Sec1/munc18-like proteins (SM proteins) are recruited to membrane fusion sites by interaction with syntaxin-type SNARE proteins, constituting indispensable positive regulators of intracellular membrane fusion. Here we present the crystal structure of the yeast SM protein Sly1p in complex with a short N-terminal peptide derived from the Golgi-resident syntaxin Sed5p. Sly1p folds, similarly to neuronal Sec1, into a three-domain arch-shaped assembly, and Sed5p interacts in a helical conformation predominantly with domain I of Sly1p on the opposite site of the nSec1/syntaxin-1-binding site. Sequence conservation of the major interactions suggests that homologues of Sly1p as well as the paralogous Vps45p group bind their respective syntaxins in the same way. Furthermore, we present indirect evidence that nSec1 might be able to contact syntaxin 1 in a similar fashion. The observed Sly1p-Sed5p interaction mode therefore indicates how SM proteins can stay associated with the assembling fusion machinery in order to participate in late fusion steps.
-
-	Structural basis for the Golgi membrane recruitment of Sly1p by Sed5p.,Bracher A, Weissenhorn W EMBO J. 2002 Nov 15;21(22):6114-24. PMID:12426383<ref>PMID:12426383</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1mqs" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Bracher, A~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Weissenhorn, W~~]]	+	[[Category: Bracher A]]
-	[[Category: ~~Endocytosis-exocytosis complex]]~~	+	[[Category: Weissenhorn W]]
-	~~[[Category: Sm-protein]]~~	+
-	~~[[Category: Snare]]~~	+
-	~~[[Category: Syntaxin~~]]	+

OCA at 08:54, 21 April 2021

OCA — Wed, 21 Apr 2021 08:54:56 GMT

←Older revision		Revision as of 08:54, 21 April 2021
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	<StructureSection load='1mqs' size='340' side='right'caption='[[1mqs]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1mqs' size='340' side='right'caption='[[1mqs]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mqs]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1MQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQS FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dn1\|1dn1]], [[1epu\|1epu]], [[1fvf\|1fvf]], [[1fvh\|1fvh]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dn1\|1dn1]], [[1epu\|1epu]], [[1fvf\|1fvf]], [[1fvh\|1fvh]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1mqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqs OCA], [~~http~~://pdbe.org/1mqs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1mqs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1mqs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqs OCA], [https://pdbe.org/1mqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mqs RCSB], [https://www.ebi.ac.uk/pdbsum/1mqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SLY1_YEAST SLY1_YEAST]] Able to suppress the functional loss of YPT1. SLY1 is essential for cell viability. May interact indirectly, or directly with YPT1. [[~~http~~://www.uniprot.org/uniprot/SED5_YEAST SED5_YEAST]] Required for vesicular transport between the endoplasmic reticulum and the Golgi complex. Acts as a target organelle soluble NSF attachment protein receptor (t-SNARE).	+	[[https://www.uniprot.org/uniprot/SLY1_YEAST SLY1_YEAST]] Able to suppress the functional loss of YPT1. SLY1 is essential for cell viability. May interact indirectly, or directly with YPT1. [[https://www.uniprot.org/uniprot/SED5_YEAST SED5_YEAST]] Required for vesicular transport between the endoplasmic reticulum and the Golgi complex. Acts as a target organelle soluble NSF attachment protein receptor (t-SNARE).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:24, 17 July 2019

OCA — Wed, 17 Jul 2019 13:24:27 GMT

←Older revision		Revision as of 13:24, 17 July 2019
Line 1:		Line 1:

	==Crystal structure of Sly1p in complex with an N-terminal peptide of Sed5p==		==Crystal structure of Sly1p in complex with an N-terminal peptide of Sed5p==
-	<StructureSection load='1mqs' size='340' side='right' caption='[[1mqs]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='1mqs' size='340' side='right'caption='[[1mqs]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQS FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/1mqs_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/1mqs_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Bracher, A]]		[[Category: Bracher, A]]
	[[Category: Weissenhorn, W]]		[[Category: Weissenhorn, W]]

OCA at 09:10, 12 October 2017

OCA — Thu, 12 Oct 2017 09:10:41 GMT

←Older revision		Revision as of 09:10, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of Sly1p in complex with an N-terminal peptide of Sed5p==		==Crystal structure of Sly1p in complex with an N-terminal peptide of Sed5p==
	<StructureSection load='1mqs' size='340' side='right' caption='[[1mqs]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1mqs' size='340' side='right' caption='[[1mqs]], [[Resolution\|resolution]] 3.00Å' scene=''>
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dn1\|1dn1]], [[1epu\|1epu]], [[1fvf\|1fvf]], [[1fvh\|1fvh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dn1\|1dn1]], [[1epu\|1epu]], [[1fvf\|1fvf]], [[1fvh\|1fvh]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqs OCA], [http://pdbe.org/1mqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mqs RCSB], [http://www.ebi.ac.uk/pdbsum/1mqs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqs OCA], [http://pdbe.org/1mqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mqs RCSB], [http://www.ebi.ac.uk/pdbsum/1mqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 06:24, 9 February 2016

OCA — Tue, 09 Feb 2016 06:24:54 GMT

←Older revision		Revision as of 06:24, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mqs ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:28, 10 September 2015

OCA — Thu, 10 Sep 2015 19:28:55 GMT

←Older revision		Revision as of 19:28, 10 September 2015
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	<StructureSection load='1mqs' size='340' side='right' caption='[[1mqs]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1mqs' size='340' side='right' caption='[[1mqs]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQS FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dn1\|1dn1]], [[1epu\|1epu]], [[1fvf\|1fvf]], [[1fvh\|1fvh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dn1\|1dn1]], [[1epu\|1epu]], [[1fvf\|1fvf]], [[1fvh\|1fvh]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mqs RCSB], [http://www.ebi.ac.uk/pdbsum/1mqs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqs OCA], [http://pdbe.org/1mqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mqs RCSB], [http://www.ebi.ac.uk/pdbsum/1mqs PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1mqs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Bracher, A]]		[[Category: Bracher, A]]
	[[Category: Weissenhorn, W]]		[[Category: Weissenhorn, W]]

OCA at 05:01, 25 December 2014

OCA — Thu, 25 Dec 2014 05:01:04 GMT

←Older revision		Revision as of 05:01, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dn1\|1dn1]], [[1epu\|1epu]], [[1fvf\|1fvf]], [[1fvh\|1fvh]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dn1\|1dn1]], [[1epu\|1epu]], [[1fvf\|1fvf]], [[1fvh\|1fvh]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mqs RCSB], [http://www.ebi.ac.uk/pdbsum/1mqs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mqs RCSB], [http://www.ebi.ac.uk/pdbsum/1mqs PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SLY1_YEAST SLY1_YEAST]] Able to suppress the functional loss of YPT1. SLY1 is essential for cell viability. May interact indirectly, or directly with YPT1. [[http://www.uniprot.org/uniprot/SED5_YEAST SED5_YEAST]] Required for vesicular transport between the endoplasmic reticulum and the Golgi complex. Acts as a target organelle soluble NSF attachment protein receptor (t-SNARE).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Bracher, A.]]	+	[[Category: Bracher, A]]
-	[[Category: Weissenhorn, W.]]	+	[[Category: Weissenhorn, W]]
	[[Category: Endocytosis-exocytosis complex]]		[[Category: Endocytosis-exocytosis complex]]
	[[Category: Sm-protein]]		[[Category: Sm-protein]]
	[[Category: Snare]]		[[Category: Snare]]
	[[Category: Syntaxin]]		[[Category: Syntaxin]]

OCA at 15:38, 28 September 2014

OCA — Sun, 28 Sep 2014 15:38:49 GMT

←Older revision		Revision as of 15:38, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1mqs.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Sly1p in complex with an N-terminal peptide of Sed5p==
		+	<StructureSection load='1mqs' size='340' side='right' caption='[[1mqs]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1mqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQS FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dn1\|1dn1]], [[1epu\|1epu]], [[1fvf\|1fvf]], [[1fvh\|1fvh]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mqs RCSB], [http://www.ebi.ac.uk/pdbsum/1mqs PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/1mqs_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytosolic Sec1/munc18-like proteins (SM proteins) are recruited to membrane fusion sites by interaction with syntaxin-type SNARE proteins, constituting indispensable positive regulators of intracellular membrane fusion. Here we present the crystal structure of the yeast SM protein Sly1p in complex with a short N-terminal peptide derived from the Golgi-resident syntaxin Sed5p. Sly1p folds, similarly to neuronal Sec1, into a three-domain arch-shaped assembly, and Sed5p interacts in a helical conformation predominantly with domain I of Sly1p on the opposite site of the nSec1/syntaxin-1-binding site. Sequence conservation of the major interactions suggests that homologues of Sly1p as well as the paralogous Vps45p group bind their respective syntaxins in the same way. Furthermore, we present indirect evidence that nSec1 might be able to contact syntaxin 1 in a similar fashion. The observed Sly1p-Sed5p interaction mode therefore indicates how SM proteins can stay associated with the assembling fusion machinery in order to participate in late fusion steps.

-	~~{{STRUCTURE_1mqs\| PDB=1mqs \| SCENE= }}~~	+	Structural basis for the Golgi membrane recruitment of Sly1p by Sed5p.,Bracher A, Weissenhorn W EMBO J. 2002 Nov 15;21(22):6114-24. PMID:12426383<ref>PMID:12426383</ref>

-	~~===Crystal structure~~ of ~~Sly1p in complex with an N-terminal peptide of Sed5p===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12426383}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1mqs]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1MQS OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012426383<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Bracher, A.]]		[[Category: Bracher, A.]]

OCA: Protected "1mqs" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 20:07:09 GMT

Protected "1mqs" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:07, 5 December 2012

OCA at 20:07, 5 December 2012

OCA — Wed, 05 Dec 2012 20:07:06 GMT

←Older revision		Revision as of 20:07, 5 December 2012
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-	{{Seed}}
	[[Image:1mqs.png\|left\|200px]]		[[Image:1mqs.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1mqs", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1mqs\| PDB=1mqs \| SCENE= }}		{{STRUCTURE_1mqs\| PDB=1mqs \| SCENE= }}

	===Crystal structure of Sly1p in complex with an N-terminal peptide of Sed5p===		===Crystal structure of Sly1p in complex with an N-terminal peptide of Sed5p===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12426383}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12426383 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12426383}}		{{ABSTRACT_PUBMED_12426383}}

	==About this Structure==		==About this Structure==
-	~~1MQS~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQS OCA].	+	[[1mqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQS OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12426383~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012426383</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Bracher, A.]]		[[Category: Bracher, A.]]
	[[Category: Weissenhorn, W.]]		[[Category: Weissenhorn, W.]]
		+	[[Category: Endocytosis-exocytosis complex]]
	[[Category: Sm-protein]]		[[Category: Sm-protein]]
	[[Category: Snare]]		[[Category: Snare]]
	[[Category: Syntaxin]]		[[Category: Syntaxin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:12:18 2009''