1mqz - Revision history

OCA at 11:49, 22 November 2023

OCA — Wed, 22 Nov 2023 11:49:36 GMT

←Older revision		Revision as of 11:49, 22 November 2023
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	==NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles==		==NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles==
-	<StructureSection load='1mqz' size='340' side='right'caption='[[1mqz~~]], [[NMR_Ensembles_of_Models \| 17 NMR models~~]]' scene=''>	+	<StructureSection load='1mqz' size='340' side='right'caption='[[1mqz]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mqz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_sp.~~_hil~~-~~y85~~/54728 Bacillus sp. ~~hil~~-~~y85~~/54728]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mqz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_sp._HIL-Y85/54728 Bacillus sp. HIL-Y85/54728]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQZ FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=~~TEE~~:~~2-AMINO-ETHENETHIOL~~'>~~TEE~~</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;~~'>~~[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1qow\|1qow]], [[1w9n\|1w9n]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=PRD_000199:Mersacidin'>PRD_000199</scene>, <scene name='pdbligand=TEE:2-AMINO-ETHENETHIOL'>TEE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqz OCA], [https://pdbe.org/1mqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mqz RCSB], [https://www.ebi.ac.uk/pdbsum/1mqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqz OCA], [https://pdbe.org/1mqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mqz RCSB], [https://www.ebi.ac.uk/pdbsum/1mqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MRSA_BACSY MRSA_BACSY]] Kills a number of Gram-positive bacteria. Acts at the level of cell wall biosynthesis by interfering with bacterial peptidoglycan biosynthesis. Specifically inhibits the conversion of the lipid II intermediate into polymeric nascent glycan strands by transglycosylation. May interact with the peptidoglycan precursor rather than with the enzyme.	+	[https://www.uniprot.org/uniprot/MRSA_BACSY MRSA_BACSY] Kills a number of Gram-positive bacteria. Acts at the level of cell wall biosynthesis by interfering with bacterial peptidoglycan biosynthesis. Specifically inhibits the conversion of the lipid II intermediate into polymeric nascent glycan strands by transglycosylation. May interact with the peptidoglycan precursor rather than with the enzyme.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus sp. ~~hil~~-~~y85~~/54728]]	+	[[Category: Bacillus sp. HIL-Y85/54728]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bierbaum, G]]	+	[[Category: Bierbaum G]]
-	[[Category: Bonvin~~, A M~~]]	+	[[Category: Bonvin AM]]
-	[[Category: Breukink, E]]	+	[[Category: Breukink E]]
-	[[Category: Hsu, S T]]	+	[[Category: Hsu S-T]]
-	[[Category: Kaptein, R]]	+	[[Category: Kaptein R]]
-	~~[[Category: Kruijff, B de]]~~	+	[[Category: Sahl H-G]]
-	~~[[Category: Nuland, N A.van~~]]	+	[[Category: De Kruijff B]]
-	[[Category: Sahl, H G]]	+	[[Category: Van Nuland NA]]
-	[[Category: ~~Antibiotic~~]]	+
-	[[Category: ~~Antimicrobial]]~~	+
-	~~[[Category: Bacteriocin]]~~	+
-	~~[[Category: Lantibiotic]]~~	+
-	~~[[Category: Methicillin resistance]]~~	+
-	~~[[Category: Peptidoglycan]]~~	+
-	~~[[Category: Thioester~~]]	+

OCA at 11:26, 16 February 2022

OCA — Wed, 16 Feb 2022 11:26:22 GMT

←Older revision		Revision as of 11:26, 16 February 2022
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	<StructureSection load='1mqz' size='340' side='right'caption='[[1mqz]], [[NMR_Ensembles_of_Models \| 17 NMR models]]' scene=''>		<StructureSection load='1mqz' size='340' side='right'caption='[[1mqz]], [[NMR_Ensembles_of_Models \| 17 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mqz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bacillus_sp._hil-y85/54728 Bacillus sp. hil-y85/54728]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1MQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mqz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_sp._hil-y85/54728 Bacillus sp. hil-y85/54728]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQZ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=TEE:2-AMINO-ETHENETHIOL'>TEE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=TEE:2-AMINO-ETHENETHIOL'>TEE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1qow\|1qow]], [[1w9n\|1w9n]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1qow\|1qow]], [[1w9n\|1w9n]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1mqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqz OCA], [~~http~~://pdbe.org/1mqz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1mqz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1mqz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqz OCA], [https://pdbe.org/1mqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mqz RCSB], [https://www.ebi.ac.uk/pdbsum/1mqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MRSA_BACSY MRSA_BACSY]] Kills a number of Gram-positive bacteria. Acts at the level of cell wall biosynthesis by interfering with bacterial peptidoglycan biosynthesis. Specifically inhibits the conversion of the lipid II intermediate into polymeric nascent glycan strands by transglycosylation. May interact with the peptidoglycan precursor rather than with the enzyme.	+	[[https://www.uniprot.org/uniprot/MRSA_BACSY MRSA_BACSY]] Kills a number of Gram-positive bacteria. Acts at the level of cell wall biosynthesis by interfering with bacterial peptidoglycan biosynthesis. Specifically inhibits the conversion of the lipid II intermediate into polymeric nascent glycan strands by transglycosylation. May interact with the peptidoglycan precursor rather than with the enzyme.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:12, 13 May 2020

OCA — Wed, 13 May 2020 06:12:38 GMT

←Older revision		Revision as of 06:12, 13 May 2020
Line 1:		Line 1:

	==NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles==		==NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles==
-	<StructureSection load='1mqz' size='340' side='right' caption='[[1mqz]], [[NMR_Ensembles_of_Models \| 17 NMR models]]' scene=''>	+	<StructureSection load='1mqz' size='340' side='right'caption='[[1mqz]], [[NMR_Ensembles_of_Models \| 17 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_sp._hil-y85/54728 Bacillus sp. hil-y85/54728]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1MQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_sp._hil-y85/54728 Bacillus sp. hil-y85/54728]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1MQZ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=TEE:2-AMINO-ETHENETHIOL'>TEE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=TEE:2-AMINO-ETHENETHIOL'>TEE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1qow\|1qow]], [[1w9n\|1w9n]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1qow\|1qow]], [[1w9n\|1w9n]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1mqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqz OCA], [http://pdbe.org/1mqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mqz RCSB], [http://www.ebi.ac.uk/pdbsum/1mqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1mqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqz OCA], [http://pdbe.org/1mqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mqz RCSB], [http://www.ebi.ac.uk/pdbsum/1mqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus sp. hil-y85/54728]]		[[Category: Bacillus sp. hil-y85/54728]]
		+	[[Category: Large Structures]]
	[[Category: Bierbaum, G]]		[[Category: Bierbaum, G]]
	[[Category: Bonvin, A M]]		[[Category: Bonvin, A M]]

OCA at 10:06, 25 October 2017

OCA — Wed, 25 Oct 2017 10:06:54 GMT

←Older revision		Revision as of 10:06, 25 October 2017
Line 1:		Line 1:
		+
	==NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles==		==NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles==
	<StructureSection load='1mqz' size='340' side='right' caption='[[1mqz]], [[NMR_Ensembles_of_Models \| 17 NMR models]]' scene=''>		<StructureSection load='1mqz' size='340' side='right' caption='[[1mqz]], [[NMR_Ensembles_of_Models \| 17 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacsy Bacsy~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_sp._hil-y85/54728 Bacillus sp. hil-y85/54728]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQZ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=TEE:2-AMINO-ETHENETHIOL'>TEE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=TEE:2-AMINO-ETHENETHIOL'>TEE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1qow\|1qow]], [[1w9n\|1w9n]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1qow\|1qow]], [[1w9n\|1w9n]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqz OCA], [http://pdbe.org/1mqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mqz RCSB], [http://www.ebi.ac.uk/pdbsum/1mqz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqz OCA], [http://pdbe.org/1mqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mqz RCSB], [http://www.ebi.ac.uk/pdbsum/1mqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacsy~~]]	+	[[Category: Bacillus sp. hil-y85/54728]]
	[[Category: Bierbaum, G]]		[[Category: Bierbaum, G]]
	[[Category: Bonvin, A M]]		[[Category: Bonvin, A M]]

OCA at 11:51, 11 September 2015

OCA — Fri, 11 Sep 2015 11:51:16 GMT

←Older revision		Revision as of 11:51, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1mqz' size='340' side='right' caption='[[1mqz]], [[NMR_Ensembles_of_Models \| 17 NMR models]]' scene=''>		<StructureSection load='1mqz' size='340' side='right' caption='[[1mqz]], [[NMR_Ensembles_of_Models \| 17 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_sp._hil-y85/54728 Bacillus sp. hil-y85/54728~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsy Bacsy]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQZ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=TEE:2-AMINO-ETHENETHIOL'>TEE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=TEE:2-AMINO-ETHENETHIOL'>TEE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1qow\|1qow]], [[1w9n\|1w9n]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1qow\|1qow]], [[1w9n\|1w9n]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mqz RCSB], [http://www.ebi.ac.uk/pdbsum/1mqz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqz OCA], [http://pdbe.org/1mqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mqz RCSB], [http://www.ebi.ac.uk/pdbsum/1mqz PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MRSA_BACSY MRSA_BACSY]] Kills a number of Gram-positive bacteria. Acts at the level of cell wall biosynthesis by interfering with bacterial peptidoglycan biosynthesis. Specifically inhibits the conversion of the lipid II intermediate into polymeric nascent glycan strands by transglycosylation. May interact with the peptidoglycan precursor rather than with the enzyme.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1mqz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus sp. hil-y85/54728~~]]	+	[[Category: Bacsy]]
	[[Category: Bierbaum, G]]		[[Category: Bierbaum, G]]
	[[Category: Bonvin, A M]]		[[Category: Bonvin, A M]]

OCA at 08:33, 8 December 2014

OCA — Mon, 08 Dec 2014 08:33:22 GMT

←Older revision		Revision as of 08:33, 8 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1mqz\| PDB=1mqz \| SCENE= }}~~	+	==NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles==
-	===NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles===	+	<StructureSection load='1mqz' size='340' side='right' caption='[[1mqz]], [[NMR_Ensembles_of_Models \| 17 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_12562773}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1mqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_sp._hil-y85/54728 Bacillus sp. hil-y85/54728]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQZ FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=TEE:2-AMINO-ETHENETHIOL'>TEE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1qow\|1qow]], [[1w9n\|1w9n]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mqz RCSB], [http://www.ebi.ac.uk/pdbsum/1mqz PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mersacidin belongs to the type B lantibiotics (lanthionine-containing antibiotics) that contain post-translationally modified amino acids and cyclic ring structures. It targets the cell wall precursor lipid II and thereby inhibits cell wall synthesis. In light of the emerging antibiotics resistance problem, the understanding of the antibacterial activity on a structural basis provides a key to circumvent this issue. Here we present solution NMR studies of mersacidin-lipid II interaction in dodecylphosphocholine (DPC) micelles. Distinct solution structures of mersacidin were determined in three different states: in water/methanol solution and in DPC micelles with and without lipid II. The structures in various sample conditions reveal remarkable conformational changes in which the junction between Ala-12 and Abu-13 (where Abu is aminobutyric acid) effectively serves as the hinge for the opening and closure of the ring structures. The DPC micelle-bound form resembles the previously determined NMR and x-ray crystal structures of mersacidin in pure methanol but substantially deviates from the other two states in our current report. The structural changes delineate the large chemical shift perturbations observed during the course of a two-step (15)N-(1)H heteronuclear single quantum coherence titration. They also modulate the surface charge distribution of mersacidin suggesting that electrostatics play a central role in the mersacidin-lipid II interaction. The observed conformational adaptability of mersacidin might be a general feature of lipid II-interacting antibiotics/peptides.

-	~~==About this Structure==~~	+	NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles. Conformational changes are a key to antimicrobial activity.,Hsu ST, Breukink E, Bierbaum G, Sahl HG, de Kruijff B, Kaptein R, van Nuland NA, Bonvin AM J Biol Chem. 2003 Apr 11;278(15):13110-7. Epub 2003 Jan 31. PMID:12562773<ref>PMID:12562773</ref>
-	~~[[1mqz]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_sp._hil~~-~~y85/54728 Bacillus sp~~. ~~hil-y85/54728]~~. ~~Full experimental information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:012562773</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus sp. hil-y85/54728]]		[[Category: Bacillus sp. hil-y85/54728]]
-	[[Category: Bierbaum, G.]]	+	[[Category: Bierbaum, G]]
-	[[Category: Bonvin, A M.]]	+	[[Category: Bonvin, A M]]
-	[[Category: Breukink, E.]]	+	[[Category: Breukink, E]]
-	[[Category: Hsu, S T.]]	+	[[Category: Hsu, S T]]
-	[[Category: Kaptein, R.]]	+	[[Category: Kaptein, R]]
-	[[Category: Kruijff, B de.]]	+	[[Category: Kruijff, B de]]
-	[[Category: Nuland, N A.van.]]	+	[[Category: Nuland, N A.van]]
-	[[Category: Sahl, H G.]]	+	[[Category: Sahl, H G]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
	[[Category: Antimicrobial]]		[[Category: Antimicrobial]]

OCA at 10:33, 16 April 2014

OCA — Wed, 16 Apr 2014 10:33:16 GMT

←Older revision		Revision as of 10:33, 16 April 2014
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-	[[Image:1mqz.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1mqz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1mqz\| PDB=1mqz \| SCENE= }}		{{STRUCTURE_1mqz\| PDB=1mqz \| SCENE= }}
-
	===NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles===		===NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12562773}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12562773 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12562773}}		{{ABSTRACT_PUBMED_12562773}}

	==About this Structure==		==About this Structure==
-	[[1mqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacteria Bacteria~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA].	+	[[1mqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_sp._hil-y85/54728 Bacillus sp. hil-y85/54728]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:012562773</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012562773</ref><references group="xtra"/><references/>
-	[[Category: ~~Bacteria~~]]	+	[[Category: Bacillus sp. hil-y85/54728]]
	[[Category: Bierbaum, G.]]		[[Category: Bierbaum, G.]]
	[[Category: Bonvin, A M.]]		[[Category: Bonvin, A M.]]

OCA: Protected "1mqz" [edit=sysop:move=sysop]

OCA — Wed, 27 Jul 2011 04:44:08 GMT

Protected "1mqz" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:44, 27 July 2011

OCA at 04:44, 27 July 2011

OCA — Wed, 27 Jul 2011 04:44:07 GMT

←Older revision		Revision as of 04:44, 27 July 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1mqz.png\|left\|200px]]		[[Image:1mqz.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~1MQZ is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/~~Bacillus_sp. Bacillus sp.~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA].	+	[[1mqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA].

	==Reference==		==Reference==
-	NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles. Conformational changes are a key to antimicrobial activity., Hsu ST, Breukink E, Bierbaum G, Sahl HG, de Kruijff B, Kaptein R, van Nuland NA, Bonvin AM, J Biol Chem. 2003 Apr 11;278(15):13110-7. Epub 2003 Jan 31. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12562773 12562773]~~	+	<ref group="xtra">PMID:012562773</ref><references group="xtra"/>
-	~~[[Category: Bacillus sp.]]~~	+	[[Category: Bacteria]]
-	[[Category: ~~Single protein~~]]	+
	[[Category: Bierbaum, G.]]		[[Category: Bierbaum, G.]]
	[[Category: Bonvin, A M.]]		[[Category: Bonvin, A M.]]
Line 35:		Line 33:
	[[Category: Sahl, H G.]]		[[Category: Sahl, H G.]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
-		+	[[Category: Antimicrobial]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Jul 29 05~~:20:~~07 2008''~~	+	[[Category: Bacteriocin]]
		+	[[Category: Lantibiotic]]
		+	[[Category: Methicillin resistance]]
		+	[[Category: Peptidoglycan]]
		+	[[Category: Thioester]]

OCA at 02:20, 29 July 2008

OCA — Tue, 29 Jul 2008 02:20:11 GMT

←Older revision		Revision as of 02:20, 29 July 2008
Line 1:		Line 1:
-	[[Image:1mqz.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1mqz.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1mqz\| PDB=1mqz \| SCENE= }}		{{STRUCTURE_1mqz\| PDB=1mqz \| SCENE= }}

-	~~'''~~NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles~~'''~~	+	===NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles===


-	~~==Overview==~~	+	<!--
-	~~Mersacidin belongs to the type B lantibiotics (lanthionine~~-~~containing antibiotics) that contain post~~-translationally modified amino acids and cyclic ring structures. It targets the cell wall precursor lipid II and thereby inhibits cell wall synthesis. In light of the emerging antibiotics resistance problem, the ~~understanding of~~ the ~~antibacterial activity~~ on a structural basis provides a key to circumvent this issue. Here we present solution NMR studies of mersacidin-lipid II interaction in dodecylphosphocholine (DPC) micelles. Distinct solution structures of mersacidin were determined in three different states: ~~in water~~/~~methanol solution and in DPC micelles with and without lipid II~~. ~~The structures in various sample conditions reveal remarkable conformational changes in which the junction between Ala-12 and Abu-13 (~~where ~~Abu~~ is ~~aminobutyric acid) effectively serves as~~ the ~~hinge for the opening and closure of the ring structures~~. ~~The DPC micelle~~-~~bound form resembles the previously determined NMR and x~~-ray crystal structures of mersacidin in pure methanol but substantially deviates from the other two states in our current report. The structural changes delineate the large chemical shift perturbations observed during the course of a two-step (15)N-(1)H heteronuclear single quantum coherence titration. They also modulate the surface charge distribution of mersacidin suggesting that electrostatics play a central role in the mersacidin-lipid II interaction. The observed conformational adaptability of mersacidin might be a general feature of lipid II-interacting antibiotics/peptides.	+	The line below this paragraph, {{ABSTRACT_PUBMED_12562773}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 12562773 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_12562773}}

	==About this Structure==		==About this Structure==
-	1MQZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_sp. Bacillus sp.]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA].	+	1MQZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_sp. Bacillus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQZ OCA].

	==Reference==		==Reference==
Line 31:		Line 35:
	[[Category: Sahl, H G.]]		[[Category: Sahl, H G.]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 01~~:36:59 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:20:07 2008''