1ms1 - Revision history

OCA at 08:40, 10 April 2024

OCA — Wed, 10 Apr 2024 08:40:31 GMT

←Older revision		Revision as of 08:40, 10 April 2024
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	<StructureSection load='1ms1' size='340' side='right'caption='[[1ms1]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ms1' size='340' side='right'caption='[[1ms1]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ms1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Trycr Trycr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MS1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ms1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MS1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DAN:2~~-~~DEOXY-2~~,~~3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1mr5\|1mr5]], [[1ms0\|1ms0]], [[1ms3\|1ms3]], [[1ms4\|1ms4]], [[1ms5\|1ms5]], [[1ms8\|1ms8]], [[1ms9\|1ms9]], [[1mz5\|1mz5]], [[1mz6\|1mz6]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ms1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms1 OCA], [https://pdbe.org/1ms1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ms1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ms1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ms1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ms1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms1 OCA], [https://pdbe.org/1ms1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ms1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ms1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ms1 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q26966_TRYCR Q26966_TRYCR]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ms1 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ms1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Trans-sialidases (TS) are GPI-anchored surface enzymes expressed in specific developmental stages of trypanosome parasites like Trypanosoma cruzi, the etiologic agent of Chagas disease, and T. brucei, the causative agent of sleeping sickness. TS catalyzes the transfer of sialic acid residues from host to parasite glycoconjugates through a transglycosidase reaction that appears to be critical for T. cruzi survival and cell invasion capability. We report here the structure of the T. cruzi trans-sialidase, alone and in complex with sugar ligands. Sialic acid binding is shown to trigger a conformational switch that modulates the affinity for the acceptor substrate and concomitantly creates the conditions for efficient transglycosylation. The structure provides a framework for the structure-based design of novel inhibitors with potential therapeutic applications.
-
-	The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis.,Buschiazzo A, Amaya MF, Cremona ML, Frasch AC, Alzari PM Mol Cell. 2002 Oct;10(4):757-68. PMID:12419220<ref>PMID:12419220</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1ms1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]		*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Exo-alpha-sialidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Trycr~~]]	+	[[Category: Trypanosoma cruzi]]
-	[[Category: Alzari~~, P M~~]]	+	[[Category: Alzari PM]]
-	[[Category: Amaya~~, M F~~]]	+	[[Category: Amaya MF]]
-	[[Category: Buschiazzo, A]]	+	[[Category: Buschiazzo A]]
-	[[Category: Cremona~~, M L~~]]	+	[[Category: Cremona ML]]
-	[[Category: Frasch~~, A C]]~~	+	[[Category: Frasch AC]]
-	~~[[Category: Beta-propeller]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Protein-carbohydrate interaction]]~~	+
-	~~[[Category: Sialidase]]~~	+
-	~~[[Category: Transglycosylation~~]]	+

OCA at 06:55, 25 August 2021

OCA — Wed, 25 Aug 2021 06:55:03 GMT

←Older revision		Revision as of 06:55, 25 August 2021
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	<StructureSection load='1ms1' size='340' side='right'caption='[[1ms1]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ms1' size='340' side='right'caption='[[1ms1]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ms1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1MS1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ms1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MS1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mr5\|1mr5]], [[1ms0\|1ms0]], [[1ms3\|1ms3]], [[1ms4\|1ms4]], [[1ms5\|1ms5]], [[1ms8\|1ms8]], [[1ms9\|1ms9]], [[1mz5\|1mz5]], [[1mz6\|1mz6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mr5\|1mr5]], [[1ms0\|1ms0]], [[1ms3\|1ms3]], [[1ms4\|1ms4]], [[1ms5\|1ms5]], [[1ms8\|1ms8]], [[1ms9\|1ms9]], [[1mz5\|1mz5]], [[1mz6\|1mz6]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ms1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms1 OCA], [~~http~~://pdbe.org/1ms1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ms1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ms1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ms1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ms1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms1 OCA], [https://pdbe.org/1ms1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ms1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ms1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ms1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 18:11, 20 November 2019

OCA — Wed, 20 Nov 2019 18:11:54 GMT

←Older revision		Revision as of 18:11, 20 November 2019
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	==Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA)==		==Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA)==
-	<StructureSection load='1ms1' size='340' side='right' caption='[[1ms1]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1ms1' size='340' side='right'caption='[[1ms1]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ms1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MS1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ms1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MS1 FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1ms1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1ms1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
		+	[[Category: Large Structures]]
	[[Category: Trycr]]		[[Category: Trycr]]
	[[Category: Alzari, P M]]		[[Category: Alzari, P M]]

OCA at 07:41, 31 January 2018

OCA — Wed, 31 Jan 2018 07:41:01 GMT

←Older revision		Revision as of 07:41, 31 January 2018
Line 1:		Line 1:
		+
	==Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA)==		==Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA)==
	<StructureSection load='1ms1' size='340' side='right' caption='[[1ms1]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ms1' size='340' side='right' caption='[[1ms1]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mr5\|1mr5]], [[1ms0\|1ms0]], [[1ms3\|1ms3]], [[1ms4\|1ms4]], [[1ms5\|1ms5]], [[1ms8\|1ms8]], [[1ms9\|1ms9]], [[1mz5\|1mz5]], [[1mz6\|1mz6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mr5\|1mr5]], [[1ms0\|1ms0]], [[1ms3\|1ms3]], [[1ms4\|1ms4]], [[1ms5\|1ms5]], [[1ms8\|1ms8]], [[1ms9\|1ms9]], [[1mz5\|1mz5]], [[1mz6\|1mz6]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ms1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms1 OCA], [http://pdbe.org/1ms1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ms1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ms1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ms1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms1 OCA], [http://pdbe.org/1ms1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ms1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ms1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ms1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/1ms1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/1ms1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1ms1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1ms1" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Neuraminidase\|Neuraminidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:35, 9 February 2016

OCA — Tue, 09 Feb 2016 12:35:59 GMT

←Older revision		Revision as of 12:35, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ms1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:18, 10 September 2015

OCA — Thu, 10 Sep 2015 22:18:47 GMT

←Older revision		Revision as of 22:18, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1ms1' size='340' side='right' caption='[[1ms1]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ms1' size='340' side='right' caption='[[1ms1]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ms1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_cruzi Trypanosoma cruzi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MS1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ms1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MS1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mr5\|1mr5]], [[1ms0\|1ms0]], [[1ms3\|1ms3]], [[1ms4\|1ms4]], [[1ms5\|1ms5]], [[1ms8\|1ms8]], [[1ms9\|1ms9]], [[1mz5\|1mz5]], [[1mz6\|1mz6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mr5\|1mr5]], [[1ms0\|1ms0]], [[1ms3\|1ms3]], [[1ms4\|1ms4]], [[1ms5\|1ms5]], [[1ms8\|1ms8]], [[1ms9\|1ms9]], [[1mz5\|1mz5]], [[1mz6\|1mz6]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ms1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ms1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ms1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ms1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms1 OCA], [http://pdbe.org/1ms1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ms1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ms1 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ms1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Neuraminidase\|Neuraminidase]]
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
-	[[Category: ~~Trypanosoma cruzi~~]]	+	[[Category: Trycr]]
	[[Category: Alzari, P M]]		[[Category: Alzari, P M]]
	[[Category: Amaya, M F]]		[[Category: Amaya, M F]]

OCA at 15:19, 5 January 2015

OCA — Mon, 05 Jan 2015 15:19:15 GMT

←Older revision		Revision as of 15:19, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ms1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MS1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ms1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MS1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mr5\|1mr5]], [[1ms0\|1ms0]], [[1ms3\|1ms3]], [[1ms4\|1ms4]], [[1ms5\|1ms5]], [[1ms8\|1ms8]], [[1ms9\|1ms9]], [[1mz5\|1mz5]], [[1mz6\|1mz6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mr5\|1mr5]], [[1ms0\|1ms0]], [[1ms3\|1ms3]], [[1ms4\|1ms4]], [[1ms5\|1ms5]], [[1ms8\|1ms8]], [[1ms9\|1ms9]], [[1mz5\|1mz5]], [[1mz6\|1mz6]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ms1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ms1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ms1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ms1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ms1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ms1 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]
-	[[Category: Alzari, P M.]]	+	[[Category: Alzari, P M]]
-	[[Category: Amaya, M F.]]	+	[[Category: Amaya, M F]]
-	[[Category: Buschiazzo, A.]]	+	[[Category: Buschiazzo, A]]
-	[[Category: Cremona, M L.]]	+	[[Category: Cremona, M L]]
-	[[Category: Frasch, A C.]]	+	[[Category: Frasch, A C]]
	[[Category: Beta-propeller]]		[[Category: Beta-propeller]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 08:21, 3 October 2014

OCA — Fri, 03 Oct 2014 08:21:17 GMT

←Older revision		Revision as of 08:21, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1ms1\| PDB=1ms1 \| SCENE= }}~~	+	==Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA)==
-	===Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA)===	+	<StructureSection load='1ms1' size='340' side='right' caption='[[1ms1]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_12419220}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ms1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MS1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mr5\|1mr5]], [[1ms0\|1ms0]], [[1ms3\|1ms3]], [[1ms4\|1ms4]], [[1ms5\|1ms5]], [[1ms8\|1ms8]], [[1ms9\|1ms9]], [[1mz5\|1mz5]], [[1mz6\|1mz6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ms1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ms1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ms1 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/1ms1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Trans-sialidases (TS) are GPI-anchored surface enzymes expressed in specific developmental stages of trypanosome parasites like Trypanosoma cruzi, the etiologic agent of Chagas disease, and T. brucei, the causative agent of sleeping sickness. TS catalyzes the transfer of sialic acid residues from host to parasite glycoconjugates through a transglycosidase reaction that appears to be critical for T. cruzi survival and cell invasion capability. We report here the structure of the T. cruzi trans-sialidase, alone and in complex with sugar ligands. Sialic acid binding is shown to trigger a conformational switch that modulates the affinity for the acceptor substrate and concomitantly creates the conditions for efficient transglycosylation. The structure provides a framework for the structure-based design of novel inhibitors with potential therapeutic applications.

-	~~==About this Structure==~~	+	The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis.,Buschiazzo A, Amaya MF, Cremona ML, Frasch AC, Alzari PM Mol Cell. 2002 Oct;10(4):757-68. PMID:12419220<ref>PMID:12419220</ref>
-	~~[[1ms1]] is~~ a ~~2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi~~ Trypanosoma cruzi]. ~~Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann.ac.il~~/~~oca-bin/ocashort?id=1MS1 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:012419220</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]

OCA at 10:34, 16 April 2014

OCA — Wed, 16 Apr 2014 10:34:09 GMT

←Older revision		Revision as of 10:34, 16 April 2014
Line 1:		Line 1:
-	[[Image:1ms1.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ms1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ms1\| PDB=1ms1 \| SCENE= }}		{{STRUCTURE_1ms1\| PDB=1ms1 \| SCENE= }}
-
	===Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA)===		===Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA)===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12419220}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12419220 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12419220}}		{{ABSTRACT_PUBMED_12419220}}

Line 22:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:012419220</ref><~~ref~~ group="xtra"~~>PMID:019216574<~~/~~ref~~><references ~~group="xtra"~~/>	+	<ref group="xtra">PMID:012419220</ref><references group="xtra"/><references/>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]

OCA: Protected "1ms1" [edit=sysop:move=sysop]

OCA — Sat, 02 Jun 2012 09:00:48 GMT

Protected "1ms1" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:00, 2 June 2012