1mvd - Revision history

OCA at 06:56, 25 August 2021

OCA — Wed, 25 Aug 2021 06:56:10 GMT

←Older revision		Revision as of 06:56, 25 August 2021
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	<StructureSection load='1mvd' size='340' side='right'caption='[[1mvd]]' scene=''>		<StructureSection load='1mvd' size='340' side='right'caption='[[1mvd]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1MVD FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MVD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1mvd FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1mvd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvd ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mvd FirstGlance], [https://www.ebi.ac.uk/pdbsum/1mvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:41, 20 November 2019

OCA — Wed, 20 Nov 2019 18:41:21 GMT

←Older revision		Revision as of 18:41, 20 November 2019
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	==IMPROVED MODEL OF A LEXA REPRESSOR DIMER BOUND TO RECA OPERATOR==		==IMPROVED MODEL OF A LEXA REPRESSOR DIMER BOUND TO RECA OPERATOR==
-	<StructureSection load='1mvd' size='340' side='right' caption='[[1mvd]]' scene=''>	+	<StructureSection load='1mvd' size='340' side='right'caption='[[1mvd]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVD FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVD FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Chattopadhyaya, R]]		[[Category: Chattopadhyaya, R]]

OCA at 08:06, 31 January 2018

OCA — Wed, 31 Jan 2018 08:06:07 GMT

←Older revision		Revision as of 08:06, 31 January 2018
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVD FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mvd FirstGlance], [http://www.ebi.ac.uk/pdbsum/1mvd PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mvd FirstGlance], [http://www.ebi.ac.uk/pdbsum/1mvd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:28, 11 February 2016

OCA — Thu, 11 Feb 2016 09:28:43 GMT

←Older revision		Revision as of 09:28, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==IMPROVED MODEL OF A LEXA REPRESSOR DIMER BOUND TO RECA OPERATOR==		==IMPROVED MODEL OF A LEXA REPRESSOR DIMER BOUND TO RECA OPERATOR==
	<StructureSection load='1mvd' size='340' side='right' caption='[[1mvd]]' scene=''>		<StructureSection load='1mvd' size='340' side='right' caption='[[1mvd]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Chattopadhyaya, R]]		[[Category: Chattopadhyaya, R]]

OCA at 00:08, 12 September 2015

OCA — Sat, 12 Sep 2015 00:08:13 GMT

←Older revision		Revision as of 00:08, 12 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1mvd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:00, 5 January 2015

OCA — Mon, 05 Jan 2015 16:00:59 GMT

←Older revision		Revision as of 16:00, 5 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVD FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mvd FirstGlance], [http://www.ebi.ac.uk/pdbsum/1mvd PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mvd FirstGlance], [http://www.ebi.ac.uk/pdbsum/1mvd PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:43, 28 September 2014

OCA — Sun, 28 Sep 2014 15:43:04 GMT

←Older revision		Revision as of 15:43, 28 September 2014
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-	~~{{Theoretical_model}}~~	+	==IMPROVED MODEL OF A LEXA REPRESSOR DIMER BOUND TO RECA OPERATOR==
		+	<StructureSection load='1mvd' size='340' side='right' caption='[[1mvd]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mvd FirstGlance], [http://www.ebi.ac.uk/pdbsum/1mvd PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A complete three dimensional model for the LexA repressor dimer bound to the recA operator site consistent with relevant biochemical and biophysical data for the repressor was proposed from our laboratory when no crystal structure of LexA was available. Subsequently, the crystal structures of four LexA mutants Delta(1-67) S119A, S119A, G85D and Delta(1-67) quadruple mutant in the absence of operator were reported. It is examined in this paper to what extent our previous model was correct and how, using the crystal structure of the operator-free LexA dimer we can predict an improved model of LexA dimer bound to recA operator. In our improved model, the C-domain dimerization observed repeatedly in the mutant operator-free crystals is retained but the relative orientation between the two domains within a LexA molecule changes. The crystal structure of wild type LexA with or without the recA operator cannot be solved as it autocleaves itself. We argue that the 'cleavable' cleavage site region found in the crystal structures is actually the more relevant form of the region in wild-type LexA since it agrees with the value of the pre-exponential Arrhenius factor for its autocleavage, absence of various types of trans-cleavages, difficulty in modifying the catalytic serine by diisopropyl flourophosphate and lack of cleavage at Arg 81 by trypsin; hence the concept of a 'conformational switch' inferred from the crystal structures is meaningless.

-	~~[[Image~~:~~1mvd~~.~~png\|left\|200px]]~~	+	Improved model of a LexA repressor dimer bound to recA operator.,Chattopadhyaya R, Pal A J Biomol Struct Dyn. 2004 Apr;21(5):681-9. PMID:14769061<ref>PMID:14769061</ref>

-	~~{{STRUCTURE_1mvd\| PDB=1mvd \| SCENE= }}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	==~~=IMPROVED MODEL OF A LEXA REPRESSOR DIMER BOUND TO RECA OPERATOR===~~	+	== References ==
-		+	<references/>
-	~~{{ABSTRACT_PUBMED_14769061}}~~	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:014769061<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Chattopadhyaya, R]]		[[Category: Chattopadhyaya, R]]

OCA: Protected "1mvd" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 09:11:54 GMT

Protected "1mvd" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:11, 21 October 2012

OCA at 09:11, 21 October 2012

OCA — Sun, 21 Oct 2012 09:11:52 GMT

←Older revision		Revision as of 09:11, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1mvd.png\|left\|200px]]		[[Image:1mvd.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1mvd\| PDB=1mvd \| SCENE= }}		{{STRUCTURE_1mvd\| PDB=1mvd \| SCENE= }}

	===IMPROVED MODEL OF A LEXA REPRESSOR DIMER BOUND TO RECA OPERATOR===		===IMPROVED MODEL OF A LEXA REPRESSOR DIMER BOUND TO RECA OPERATOR===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14769061}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14769061 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_14769061}}		{{ABSTRACT_PUBMED_14769061}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVD OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14769061~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014769061</ref><references group="xtra"/>
	[[Category: Chattopadhyaya, R]]		[[Category: Chattopadhyaya, R]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:52:06 2010''

OCA at 04:52, 8 April 2010

OCA — Thu, 08 Apr 2010 04:52:06 GMT

←Older revision		Revision as of 04:52, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1mvd.png\|left\|200px]]

-	The ~~entry 1MVD~~ is ~~a Theoretical Model titled 'Improved Model of a LEXA Repressor Dimer Bound to RECA Operator'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1mvd", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1mvd\| PDB=1mvd \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===IMPROVED MODEL OF A LEXA REPRESSOR DIMER BOUND TO RECA OPERATOR===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:51:~~53 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_14769061}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 14769061 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_14769061}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVD OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:14769061</ref><references group="xtra"/>
		+	[[Category: Chattopadhyaya, R]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:52:06 2010''