1mvi - Revision history

OCA at 06:05, 31 May 2023

OCA — Wed, 31 May 2023 06:05:21 GMT

←Older revision		Revision as of 06:05, 31 May 2023
Line 1:		Line 1:

	==N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA, NMR, 15 STRUCTURES==		==N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA, NMR, 15 STRUCTURES==
-	<StructureSection load='1mvi' size='340' side='right'caption='[[1mvi~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='1mvi' size='340' side='right'caption='[[1mvi]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mvi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Conma Conma~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MVI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mvi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MVI FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvi OCA], [https://pdbe.org/1mvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mvi RCSB], [https://www.ebi.ac.uk/pdbsum/1mvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvi OCA], [https://pdbe.org/1mvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mvi RCSB], [https://www.ebi.ac.uk/pdbsum/1mvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~CO17A_CONMA CO17A_CONMA]~~] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks ~~N-type calcium channels (~~Cav2.2/CACNA1B).	+	[https://www.uniprot.org/uniprot/O17A_CONMA O17A_CONMA] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks Cav2.2/CACNA1B calcium channels (IC(50)=0.67-208 nM) (PubMed:7826361, PubMed:26344359, PubMed:34589389). It acts by neutralizing the outer electronegativity and sterically hindering the ion access path to the entrance of the channel selectivity filter (PubMed:34234349). It also shows antiproliferative effects on different glioma cell lines (M059J, U-138MG and U-251MG) (PubMed:28202361). In vivo, is lethal to fish (PubMed:26344359, PubMed:34589389). In vivo, injection into mammals induces adverse effects, such as tremor, diminution of spontaneous locomotor activity and bad coordinated locomotion (PubMed:26344359). In addition, it causes reduction of tumor area in the mouse glioma model, that is induced by the orthotopic injection of GL261 cells into the brain (PubMed:28202361).<ref>PMID:26344359</ref> <ref>PMID:34234349</ref> <ref>PMID:7826361</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Conma~~]]	+	[[Category: Conus magus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alewood~~, P F~~]]	+	[[Category: Alewood PF]]
-	[[Category: Craik~~, D J~~]]	+	[[Category: Craik DJ]]
-	[[Category: Lewis~~, R J~~]]	+	[[Category: Lewis RJ]]
-	[[Category: Nielsen~~, K J~~]]	+	[[Category: Nielsen KJ]]
-	[[Category: Thomas, L]]	+	[[Category: Thomas L]]
-	~~[[Category: Conus magus peptide specific to n-type voltage sensitive calcium channel]]~~	+
-	~~[[Category: Neurotoxin~~]]	+

OCA at 06:56, 25 August 2021

OCA — Wed, 25 Aug 2021 06:56:13 GMT

←Older revision		Revision as of 06:56, 25 August 2021
Line 3:		Line 3:
	<StructureSection load='1mvi' size='340' side='right'caption='[[1mvi]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1mvi' size='340' side='right'caption='[[1mvi]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mvi]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Conma Conma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1MVI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mvi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conma Conma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MVI FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1mvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvi OCA], [~~http~~://pdbe.org/1mvi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1mvi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1mvi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvi OCA], [https://pdbe.org/1mvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mvi RCSB], [https://www.ebi.ac.uk/pdbsum/1mvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CO17A_CONMA CO17A_CONMA]] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks N-type calcium channels (Cav2.2/CACNA1B).	+	[[https://www.uniprot.org/uniprot/CO17A_CONMA CO17A_CONMA]] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks N-type calcium channels (Cav2.2/CACNA1B).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 18:51, 20 November 2019

OCA — Wed, 20 Nov 2019 18:51:00 GMT

←Older revision		Revision as of 18:51, 20 November 2019
Line 1:		Line 1:

	==N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA, NMR, 15 STRUCTURES==		==N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA, NMR, 15 STRUCTURES==
-	<StructureSection load='1mvi' size='340' side='right' caption='[[1mvi]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='1mvi' size='340' side='right'caption='[[1mvi]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mvi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conma Conma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mvi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conma Conma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVI FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Conma]]		[[Category: Conma]]
		+	[[Category: Large Structures]]
	[[Category: Alewood, P F]]		[[Category: Alewood, P F]]
	[[Category: Craik, D J]]		[[Category: Craik, D J]]

OCA at 10:22, 25 October 2017

OCA — Wed, 25 Oct 2017 10:22:49 GMT

←Older revision		Revision as of 10:22, 25 October 2017
Line 1:		Line 1:
		+
	==N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA, NMR, 15 STRUCTURES==		==N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA, NMR, 15 STRUCTURES==
	<StructureSection load='1mvi' size='340' side='right' caption='[[1mvi]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1mvi' size='340' side='right' caption='[[1mvi]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1mvi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conma Conma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mvi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conma Conma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVI FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvi OCA], [http://pdbe.org/1mvi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mvi RCSB], [http://www.ebi.ac.uk/pdbsum/1mvi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvi OCA], [http://pdbe.org/1mvi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mvi RCSB], [http://www.ebi.ac.uk/pdbsum/1mvi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 21:26, 9 September 2015

OCA — Wed, 09 Sep 2015 21:26:32 GMT

←Older revision		Revision as of 21:26, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1mvi' size='340' side='right' caption='[[1mvi]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1mvi' size='340' side='right' caption='[[1mvi]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mvi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Conus_magus Conus magus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mvi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conma Conma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVI FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mvi RCSB], [http://www.ebi.ac.uk/pdbsum/1mvi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvi OCA], [http://pdbe.org/1mvi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mvi RCSB], [http://www.ebi.ac.uk/pdbsum/1mvi PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~CXO7A_CONMA CXO7A_CONMA~~]] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks N-type calcium channels (Cav2.2/CACNA1B).	+	[[http://www.uniprot.org/uniprot/CO17A_CONMA CO17A_CONMA]] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks N-type calcium channels (Cav2.2/CACNA1B).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1mvi" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Conus magus~~]]	+	[[Category: Conma]]
	[[Category: Alewood, P F]]		[[Category: Alewood, P F]]
	[[Category: Craik, D J]]		[[Category: Craik, D J]]

OCA at 07:35, 24 December 2014

OCA — Wed, 24 Dec 2014 07:35:50 GMT

←Older revision		Revision as of 07:35, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mvi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mvi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mvi RCSB], [http://www.ebi.ac.uk/pdbsum/1mvi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mvi RCSB], [http://www.ebi.ac.uk/pdbsum/1mvi PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CXO7A_CONMA CXO7A_CONMA]] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks N-type calcium channels (Cav2.2/CACNA1B).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Conus magus]]		[[Category: Conus magus]]
-	[[Category: Alewood, P F.]]	+	[[Category: Alewood, P F]]
-	[[Category: Craik, D J.]]	+	[[Category: Craik, D J]]
-	[[Category: Lewis, R J.]]	+	[[Category: Lewis, R J]]
-	[[Category: Nielsen, K J.]]	+	[[Category: Nielsen, K J]]
-	[[Category: Thomas, L.]]	+	[[Category: Thomas, L]]
	[[Category: Conus magus peptide specific to n-type voltage sensitive calcium channel]]		[[Category: Conus magus peptide specific to n-type voltage sensitive calcium channel]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]

OCA at 07:11, 9 June 2014

OCA — Mon, 09 Jun 2014 07:11:23 GMT

←Older revision		Revision as of 07:11, 9 June 2014
Line 1:		Line 1:
-	[[~~Image:~~1mvi.~~png~~\|~~left\|200px~~]]	+	==N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA, NMR, 15 STRUCTURES==
		+	<StructureSection load='1mvi' size='340' side='right' caption='[[1mvi]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1mvi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mvi RCSB], [http://www.ebi.ac.uk/pdbsum/1mvi PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The omega-conotoxins are a set of structurally related peptides that have a wide range of specificities for different subtypes of the voltage-sensitive calcium channel (VSCC). To understand their VSCC subtype differentiation we studied the structure of two naturally occurring omega-conotoxins, MVIIA (specific to N-type) and SVIB (specific to P/Q-type) and a synthetic hybrid, SNX-202, which has altered specificities to both VSCC subtypes. The secondary structures of the three peptides are almost identical, consisting of a triple-stranded beta-sheet and several turns. A comparison of NMR data emphasizes the structural similarities between the peptides and highlights some minor structural differences. In the three-dimensional structures of SVIB and MVIIA these are manifested as orientational differences between two key loops. The structural rigidity of MVIIA was also examined. H alpha shifts are similar in a range of solvents, indicating that there are no solvent-induced changes in structure. The omega-conotoxins form a consensus structure despite differences in sequence and VSCC subtype specificity. This indicates that the omega-conotoxin macrosites for the N/P/Q-subfamily of VSCCs are related, with specificity for receptor targets being conferred by the positions of functional side-chains on the surface of the peptides.

-	~~{{STRUCTURE_1mvi\| PDB=1mvi \| SCENE= }}~~	+	A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202.,Nielsen KJ, Thomas L, Lewis RJ, Alewood PF, Craik DJ J Mol Biol. 1996 Oct 25;263(2):297-310. PMID:8913308<ref>PMID:8913308</ref>

-	~~===N-TYPE CALCIUM CHANNEL BLOCKER~~, ~~OMEGA-CONOTOXIN MVIIA, NMR, 15 STRUCTURES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8913308}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1mvi]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Conus_magus Conus magus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:008913308<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Conus magus]]		[[Category: Conus magus]]
	[[Category: Alewood, P F.]]		[[Category: Alewood, P F.]]

OCA: Protected "1mvi" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 16:55:41 GMT

Protected "1mvi" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:55, 14 August 2012

OCA at 16:55, 14 August 2012

OCA — Tue, 14 Aug 2012 16:55:39 GMT

←Older revision		Revision as of 16:55, 14 August 2012
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-	{{Seed}}
	[[Image:1mvi.png\|left\|200px]]		[[Image:1mvi.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1mvi\| PDB=1mvi \| SCENE= }}		{{STRUCTURE_1mvi\| PDB=1mvi \| SCENE= }}

	===N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA, NMR, 15 STRUCTURES===		===N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA, NMR, 15 STRUCTURES===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8913308}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_8913308}}		{{ABSTRACT_PUBMED_8913308}}

	==About this Structure==		==About this Structure==
-	~~1MVI is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA].	+	[[1mvi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA].

	==Reference==		==Reference==
-	A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202., Nielsen KJ, Thomas L, Lewis RJ, Alewood PF, Craik DJ, J Mol Biol. 1996 Oct 25;263(2):297-310. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~8913308 8913308]~~	+	<ref group="xtra">PMID:008913308</ref><references group="xtra"/>
	[[Category: Conus magus]]		[[Category: Conus magus]]
-	[[Category: Single protein]]
	[[Category: Alewood, P F.]]		[[Category: Alewood, P F.]]
	[[Category: Craik, D J.]]		[[Category: Craik, D J.]]
Line 33:		Line 20:
	[[Category: Conus magus peptide specific to n-type voltage sensitive calcium channel]]		[[Category: Conus magus peptide specific to n-type voltage sensitive calcium channel]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:04:05 2008''

OCA at 10:04, 27 July 2008

OCA — Sun, 27 Jul 2008 10:04:06 GMT

←Older revision		Revision as of 10:04, 27 July 2008
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-	[[Image:1mvi.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1mvi.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1mvi\| PDB=1mvi \| SCENE= }}		{{STRUCTURE_1mvi\| PDB=1mvi \| SCENE= }}

-	~~'''~~N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA, NMR, 15 STRUCTURES~~'''~~	+	===N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA, NMR, 15 STRUCTURES===


-	~~==Overview==~~	+	<!--
-	The omega-conotoxins are a set of structurally related peptides that have a wide range of specificities for different subtypes of the voltage-sensitive calcium channel (VSCC). To understand their VSCC subtype differentiation we studied the structure of two naturally occurring omega-conotoxins, ~~MVIIA (specific to N-type) and SVIB (specific to P/Q-type) and a synthetic hybrid~~, ~~SNX-202, which has altered specificities~~ to ~~both VSCC subtypes. The secondary structures of~~ the three peptides are almost identical, consisting of a triple-stranded beta-sheet and several turns. A comparison of NMR data emphasizes the structural similarities between the peptides and highlights some minor structural differences. In the three-dimensional structures of SVIB and MVIIA these are manifested as ~~orientational differences between two key loops~~. ~~The structural rigidity of MVIIA was also examined~~. ~~H alpha shifts are similar in a range of solvents~~, ~~indicating that there are no solvent-induced changes in structure~~. ~~The omega~~-~~conotoxins form a consensus structure despite differences in sequence and VSCC subtype specificity. This indicates that the omega~~-~~conotoxin macrosites for the N/P/Q-subfamily of VSCCs are related, with specificity for receptor targets being conferred by the positions of functional side-chains on the surface of the peptides.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_8913308}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 8913308 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_8913308}}

	==About this Structure==		==About this Structure==
-	1MVI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA].	+	1MVI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVI OCA].

	==Reference==		==Reference==
Line 29:		Line 33:
	[[Category: Conus magus peptide specific to n-type voltage sensitive calcium channel]]		[[Category: Conus magus peptide specific to n-type voltage sensitive calcium channel]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 01~~:46:10 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:04:05 2008''