1myl - Revision history

OCA at 07:50, 14 February 2024

OCA — Wed, 14 Feb 2024 07:50:07 GMT

←Older revision		Revision as of 07:50, 14 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1myl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_virus_P22 Salmonella virus P22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MYL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1myl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_virus_P22 Salmonella virus P22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MYL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1myl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myl OCA], [https://pdbe.org/1myl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1myl RCSB], [https://www.ebi.ac.uk/pdbsum/1myl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1myl ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1myl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myl OCA], [https://pdbe.org/1myl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1myl RCSB], [https://www.ebi.ac.uk/pdbsum/1myl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1myl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RARC_BPP22 RARC_BPP22]] This protein acts as a transcriptional repressor of its own gene arc and of gene ant.	+	[https://www.uniprot.org/uniprot/RARC_BPP22 RARC_BPP22] This protein acts as a transcriptional repressor of its own gene arc and of gene ant.

	==See Also==		==See Also==

OCA at 17:00, 7 September 2022

OCA — Wed, 07 Sep 2022 17:00:47 GMT

←Older revision		Revision as of 17:00, 7 September 2022
Line 3:		Line 3:
	<StructureSection load='1myl' size='340' side='right'caption='[[1myl]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1myl' size='340' side='right'caption='[[1myl]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1myl]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bpp22 Bpp22~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1MYL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1myl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_virus_P22 Salmonella virus P22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MYL FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MUTATED ARC GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10754 BPP22])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1myl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myl OCA], [https://pdbe.org/1myl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1myl RCSB], [https://www.ebi.ac.uk/pdbsum/1myl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1myl ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1myl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myl OCA], [~~http~~://pdbe.org/1myl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1myl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1myl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1myl ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RARC_BPP22 RARC_BPP22]] This protein acts as a transcriptional repressor of its own gene arc and of gene ant.	+	[[https://www.uniprot.org/uniprot/RARC_BPP22 RARC_BPP22]] This protein acts as a transcriptional repressor of its own gene arc and of gene ant.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The side chains of Arg 31, Glu 36 and Arg 40 in Arc repressor form a buried salt-bridge triad. The entire salt-bridge network can be replaced by hydrophobic residues in combinatorial randomization experiments resulting in active mutants that are significantly more stable than wild type. The crystal structure of one mutant reveals that the mutant side chains pack against each other in an otherwise wild-type fold. Thus, simple hydrophobic interactions provide more stabilizing energy than the buried salt bridge and confer comparable conformational specificity.	+
-		+
-	~~Are buried salt bridges important for protein stability and conformational specificity?,Waldburger CD, Schildbach JF, Sauer RT Nat Struct Biol. 1995 Feb;2(2):122-8. PMID:7749916<ref>PMID:7749916</ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 1myl" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Myosin 3D Structures\|Myosin 3D Structures]]		*[[Myosin 3D Structures\|Myosin 3D Structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bpp22]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Sauer, R T~~]]	+	[[Category: Salmonella virus P22]]
-	[[Category: ~~Schildbach, J F~~]]	+	[[Category: Sauer RT]]
-	[[Category: ~~Waldburger, C D~~]]	+	[[Category: Schildbach JF]]
-	[[Category: ~~Hyperstable mutant]]~~	+	[[Category: Waldburger CD]]
-	~~[[Category: Transcription regulation~~]]	+

OCA at 08:42, 2 December 2020

OCA — Wed, 02 Dec 2020 08:42:49 GMT

←Older revision		Revision as of 08:42, 2 December 2020
Line 1:		Line 1:

	==SUBSTITUTING HYDROPHOBIC RESIDUES FOR A BURIED SALT BRIDGE ENHANCES PROTEIN STABILITY BUT DOES NOT REDUCE CONFORMATIONAL SPECIFICITY==		==SUBSTITUTING HYDROPHOBIC RESIDUES FOR A BURIED SALT BRIDGE ENHANCES PROTEIN STABILITY BUT DOES NOT REDUCE CONFORMATIONAL SPECIFICITY==
-	<StructureSection load='1myl' size='340' side='right' caption='[[1myl]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1myl' size='340' side='right'caption='[[1myl]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1myl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpp22 Bpp22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1MYL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1myl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpp22 Bpp22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1MYL FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MUTATED ARC GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10754 BPP22])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MUTATED ARC GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10754 BPP22])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1myl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myl OCA], [http://pdbe.org/1myl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1myl RCSB], [http://www.ebi.ac.uk/pdbsum/1myl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1myl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1myl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myl OCA], [http://pdbe.org/1myl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1myl RCSB], [http://www.ebi.ac.uk/pdbsum/1myl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1myl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 1myl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1myl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Bpp22]]		[[Category: Bpp22]]
		+	[[Category: Large Structures]]
	[[Category: Sauer, R T]]		[[Category: Sauer, R T]]
	[[Category: Schildbach, J F]]		[[Category: Schildbach, J F]]

OCA at 10:21, 25 October 2017

OCA — Wed, 25 Oct 2017 10:21:18 GMT

←Older revision		Revision as of 10:21, 25 October 2017
Line 1:		Line 1:
		+
	==SUBSTITUTING HYDROPHOBIC RESIDUES FOR A BURIED SALT BRIDGE ENHANCES PROTEIN STABILITY BUT DOES NOT REDUCE CONFORMATIONAL SPECIFICITY==		==SUBSTITUTING HYDROPHOBIC RESIDUES FOR A BURIED SALT BRIDGE ENHANCES PROTEIN STABILITY BUT DOES NOT REDUCE CONFORMATIONAL SPECIFICITY==
	<StructureSection load='1myl' size='340' side='right' caption='[[1myl]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1myl' size='340' side='right' caption='[[1myl]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1myl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpp22 Bpp22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MYL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1myl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpp22 Bpp22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MYL FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MUTATED ARC GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10754 BPP22])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MUTATED ARC GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10754 BPP22])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1myl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myl OCA], [http://pdbe.org/1myl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1myl RCSB], [http://www.ebi.ac.uk/pdbsum/1myl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1myl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myl OCA], [http://pdbe.org/1myl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1myl RCSB], [http://www.ebi.ac.uk/pdbsum/1myl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1myl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 1myl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1myl" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Myosin\|Myosin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:15, 12 September 2015

OCA — Sat, 12 Sep 2015 00:15:48 GMT

←Older revision		Revision as of 00:15, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1myl' size='340' side='right' caption='[[1myl]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1myl' size='340' side='right' caption='[[1myl]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1myl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterobacteria_phage_p22 Enterobacteria phage p22~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MYL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1myl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpp22 Bpp22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MYL FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MUTATED ARC GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10754 ~~Enterobacteria phage P22~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MUTATED ARC GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10754 BPP22])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1myl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1myl RCSB], [http://www.ebi.ac.uk/pdbsum/1myl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1myl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myl OCA], [http://pdbe.org/1myl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1myl RCSB], [http://www.ebi.ac.uk/pdbsum/1myl PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1myl" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Enterobacteria phage p22~~]]	+	[[Category: Bpp22]]
	[[Category: Sauer, R T]]		[[Category: Sauer, R T]]
	[[Category: Schildbach, J F]]		[[Category: Schildbach, J F]]

OCA at 21:17, 25 December 2014

OCA — Thu, 25 Dec 2014 21:17:00 GMT

←Older revision		Revision as of 21:17, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1myl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MYL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1myl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MYL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MUTATED ARC GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10754 Enterobacteria phage P22])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MUTATED ARC GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10754 Enterobacteria phage P22])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1myl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1myl RCSB], [http://www.ebi.ac.uk/pdbsum/1myl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1myl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1myl RCSB], [http://www.ebi.ac.uk/pdbsum/1myl PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RARC_BPP22 RARC_BPP22]] This protein acts as a transcriptional repressor of its own gene arc and of gene ant.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Enterobacteria phage p22]]		[[Category: Enterobacteria phage p22]]
-	[[Category: Sauer, R T.]]	+	[[Category: Sauer, R T]]
-	[[Category: Schildbach, J F.]]	+	[[Category: Schildbach, J F]]
-	[[Category: Waldburger, C D.]]	+	[[Category: Waldburger, C D]]
	[[Category: Hyperstable mutant]]		[[Category: Hyperstable mutant]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

OCA at 15:48, 28 September 2014

OCA — Sun, 28 Sep 2014 15:48:52 GMT

←Older revision		Revision as of 15:48, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1myl.~~png~~\|~~left\|200px~~]]	+	==SUBSTITUTING HYDROPHOBIC RESIDUES FOR A BURIED SALT BRIDGE ENHANCES PROTEIN STABILITY BUT DOES NOT REDUCE CONFORMATIONAL SPECIFICITY==
		+	<StructureSection load='1myl' size='340' side='right' caption='[[1myl]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1myl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MYL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MUTATED ARC GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10754 Enterobacteria phage P22])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1myl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1myl RCSB], [http://www.ebi.ac.uk/pdbsum/1myl PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The side chains of Arg 31, Glu 36 and Arg 40 in Arc repressor form a buried salt-bridge triad. The entire salt-bridge network can be replaced by hydrophobic residues in combinatorial randomization experiments resulting in active mutants that are significantly more stable than wild type. The crystal structure of one mutant reveals that the mutant side chains pack against each other in an otherwise wild-type fold. Thus, simple hydrophobic interactions provide more stabilizing energy than the buried salt bridge and confer comparable conformational specificity.

-	~~{{STRUCTURE_1myl\| PDB=1myl \| SCENE= }}~~	+	Are buried salt bridges important for protein stability and conformational specificity?,Waldburger CD, Schildbach JF, Sauer RT Nat Struct Biol. 1995 Feb;2(2):122-8. PMID:7749916<ref>PMID:7749916</ref>

-	~~===SUBSTITUTING HYDROPHOBIC RESIDUES FOR A BURIED SALT BRIDGE ENHANCES PROTEIN STABILITY BUT DOES NOT REDUCE CONFORMATIONAL SPECIFICITY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_7749916}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1myl]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA].~~	+

	==See Also==		==See Also==
	*[[Myosin\|Myosin]]		*[[Myosin\|Myosin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:007749916<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Enterobacteria phage p22]]		[[Category: Enterobacteria phage p22]]
	[[Category: Sauer, R T.]]		[[Category: Sauer, R T.]]

OCA at 21:46, 20 October 2012

OCA — Sat, 20 Oct 2012 21:46:03 GMT

←Older revision		Revision as of 21:46, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1myl]] is a 6 chain structure ~~of [[Myosin]]~~ with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA].	+	[[1myl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYL OCA].

	==See Also==		==See Also==

OCA at 14:13, 27 July 2012

OCA — Fri, 27 Jul 2012 14:13:03 GMT

←Older revision		Revision as of 14:13, 27 July 2012
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	[[Image:1myl.png\|left\|200px]]		[[Image:1myl.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1myl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_1myl\| PDB=1myl \| SCENE= }}		{{STRUCTURE_1myl\| PDB=1myl \| SCENE= }}

	===SUBSTITUTING HYDROPHOBIC RESIDUES FOR A BURIED SALT BRIDGE ENHANCES PROTEIN STABILITY BUT DOES NOT REDUCE CONFORMATIONAL SPECIFICITY===		===SUBSTITUTING HYDROPHOBIC RESIDUES FOR A BURIED SALT BRIDGE ENHANCES PROTEIN STABILITY BUT DOES NOT REDUCE CONFORMATIONAL SPECIFICITY===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_7749916}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 7749916 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_7749916}}		{{ABSTRACT_PUBMED_7749916}}

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	==See Also==		==See Also==
-	*[[Myosin]]	+	*[[Myosin\|Myosin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~7749916~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:007749916</ref><references group="xtra"/>
	[[Category: Enterobacteria phage p22]]		[[Category: Enterobacteria phage p22]]
	[[Category: Sauer, R T.]]		[[Category: Sauer, R T.]]

OCA: Protected "1myl" [edit=sysop:move=sysop]

OCA — Mon, 27 Dec 2010 00:40:25 GMT

Protected "1myl" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:40, 27 December 2010