1mzu - Revision history

OCA at 08:44, 10 April 2024

OCA — Wed, 10 Apr 2024 08:44:02 GMT

←Older revision		Revision as of 08:44, 10 April 2024
Line 3:		Line 3:
	<StructureSection load='1mzu' size='340' side='right'caption='[[1mzu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1mzu' size='340' side='right'caption='[[1mzu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mzu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_43720 Atcc 43720~~]. The March 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phototropin'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_3 10.2210/rcsb_pdb/mom_2015_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MZU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mzu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodospirillum_centenum Rhodospirillum centenum]. The March 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phototropin'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_3 10.2210/rcsb_pdb/mom_2015_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MZU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HC4:4~~-~~HYDROXYCINNAMIC+ACID'>HC4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2phy\|2phy]], [[1gsv\|1gsv]], [[1g28\|1g28]], [[2pyp\|2pyp]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HC4:4-HYDROXYCINNAMIC+ACID'>HC4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzu OCA], [https://pdbe.org/1mzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mzu RCSB], [https://www.ebi.ac.uk/pdbsum/1mzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mzu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzu OCA], [https://pdbe.org/1mzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mzu RCSB], [https://www.ebi.ac.uk/pdbsum/1mzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mzu ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9X2W8_RHOCE Q9X2W8_RHOCE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mzu ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mzu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Photoactive yellow protein (E-PYP) is a blue light photoreceptor, implicated in a negative phototactic response in Ectothiorhodospira halophila, that also serves as a model for the Per-Arnt-Sim superfamily of signaling molecules. Because no biological signaling partner for E-PYP has been identified, it has not been possible to correlate any of its photocycle intermediates with a relevant signaling state. However, the PYP domain (Ppr-PYP) from the sensor histidine kinase Ppr in Rhodospirillum centenum, which regulates the catalytic activity of Ppr by blue light absorption, may allow such issues to be addressed. Here we report the crystal structure of Ppr-PYP at 2 A resolution. This domain has the same absorption spectrum and similar photocycle kinetics as full length Ppr, but a blue-shifted absorbance and considerably slower photocycle than E-PYP. Although the overall fold of Ppr-PYP resembles that of E-PYP, a novel conformation of the beta 4-beta 5 loop results in inaccessibility of Met-100, thought to catalyze chromophore reisomerization, to the chromophore. This conformation also exposes a highly conserved molecular surface that could interact with downstream signaling partners. Other structural differences in the alpha 3-alpha 4 and beta 4-beta 5 loops are consistent with these regions playing significant roles in the control of photocycle dynamics and, by comparison to other sensory Per-Arnt-Sim domains, in signal transduction. Because of its direct linkage to a measurable biological output, Ppr-PYP serves as an excellent system for understanding how changes in photocycle dynamics affect signaling by PYPs.
-
-	Crystal structure of a photoactive yellow protein from a sensor histidine kinase: conformational variability and signal transduction.,Rajagopal S, Moffat K Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1649-54. Epub 2003 Jan 31. PMID:12563032<ref>PMID:12563032</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1mzu" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 43720]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Phototropin]]		[[Category: Phototropin]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
-	[[Category: ~~Moffat, K~~]]	+	[[Category: Rhodospirillum centenum]]
-	[[Category: ~~Rajagopal, S~~]]	+	[[Category: Moffat K]]
-	[[Category: ~~Pa]]~~	+	[[Category: Rajagopal S]]
-	~~[[Category: Photoactive yellow protein]]~~	+
-	~~[[Category: Ppr]]~~	+
-	~~[[Category: Pyp]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 06:57, 25 August 2021

OCA — Wed, 25 Aug 2021 06:57:31 GMT

←Older revision		Revision as of 06:57, 25 August 2021
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	<StructureSection load='1mzu' size='340' side='right'caption='[[1mzu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1mzu' size='340' side='right'caption='[[1mzu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mzu]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_43720 Atcc 43720]. The March 2015 RCSB PDB [~~http~~://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phototropin'' by David Goodsell is [~~http~~://dx.doi.org/10.2210/rcsb_pdb/mom_2015_3 10.2210/rcsb_pdb/mom_2015_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1MZU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mzu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43720 Atcc 43720]. The March 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phototropin'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_3 10.2210/rcsb_pdb/mom_2015_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MZU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC4:4-HYDROXYCINNAMIC+ACID'>HC4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HC4:4-HYDROXYCINNAMIC+ACID'>HC4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2phy\|2phy]], [[1gsv\|1gsv]], [[1g28\|1g28]], [[2pyp\|2pyp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2phy\|2phy]], [[1gsv\|1gsv]], [[1g28\|1g28]], [[2pyp\|2pyp]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzu OCA], [~~http~~://pdbe.org/1mzu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1mzu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1mzu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1mzu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzu OCA], [https://pdbe.org/1mzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mzu RCSB], [https://www.ebi.ac.uk/pdbsum/1mzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mzu ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 18:22, 20 November 2019

OCA — Wed, 20 Nov 2019 18:22:13 GMT

←Older revision		Revision as of 18:22, 20 November 2019
Line 1:		Line 1:

	==Crystal Structure of the Photoactive Yellow Protein Domain from the Sensor Histidine Kinase Ppr from Rhodospirillum centenum==		==Crystal Structure of the Photoactive Yellow Protein Domain from the Sensor Histidine Kinase Ppr from Rhodospirillum centenum==
-	<StructureSection load='1mzu' size='340' side='right' caption='[[1mzu]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1mzu' size='340' side='right'caption='[[1mzu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mzu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43720 Atcc 43720]. The March 2015 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phototropin'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2015_3 10.2210/rcsb_pdb/mom_2015_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MZU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mzu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43720 Atcc 43720]. The March 2015 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phototropin'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2015_3 10.2210/rcsb_pdb/mom_2015_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MZU FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 43720]]		[[Category: Atcc 43720]]
		+	[[Category: Large Structures]]
	[[Category: Phototropin]]		[[Category: Phototropin]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]

OCA at 07:49, 31 January 2018

OCA — Wed, 31 Jan 2018 07:49:16 GMT

←Older revision		Revision as of 07:49, 31 January 2018
Line 1:		Line 1:
		+
	==Crystal Structure of the Photoactive Yellow Protein Domain from the Sensor Histidine Kinase Ppr from Rhodospirillum centenum==		==Crystal Structure of the Photoactive Yellow Protein Domain from the Sensor Histidine Kinase Ppr from Rhodospirillum centenum==
	<StructureSection load='1mzu' size='340' side='right' caption='[[1mzu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1mzu' size='340' side='right' caption='[[1mzu]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC4:4-HYDROXYCINNAMIC+ACID'>HC4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC4:4-HYDROXYCINNAMIC+ACID'>HC4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2phy\|2phy]], [[1gsv\|1gsv]], [[1g28\|1g28]], [[2pyp\|2pyp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2phy\|2phy]], [[1gsv\|1gsv]], [[1g28\|1g28]], [[2pyp\|2pyp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzu OCA], [http://pdbe.org/1mzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mzu RCSB], [http://www.ebi.ac.uk/pdbsum/1mzu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzu OCA], [http://pdbe.org/1mzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mzu RCSB], [http://www.ebi.ac.uk/pdbsum/1mzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mzu ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mz/1mzu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mz/1mzu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:59, 9 February 2016

OCA — Tue, 09 Feb 2016 12:59:01 GMT

←Older revision		Revision as of 12:59, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mzu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:29, 10 September 2015

OCA — Thu, 10 Sep 2015 22:29:29 GMT

←Older revision		Revision as of 22:29, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1mzu' size='340' side='right' caption='[[1mzu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1mzu' size='340' side='right' caption='[[1mzu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mzu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rhodospirillum_centenum Rhodospirillum centenum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MZU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mzu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43720 Atcc 43720]. The March 2015 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phototropin'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2015_3 10.2210/rcsb_pdb/mom_2015_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MZU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC4:4-HYDROXYCINNAMIC+ACID'>HC4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC4:4-HYDROXYCINNAMIC+ACID'>HC4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2phy\|2phy]], [[1gsv\|1gsv]], [[1g28\|1g28]], [[2pyp\|2pyp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2phy\|2phy]], [[1gsv\|1gsv]], [[1g28\|1g28]], [[2pyp\|2pyp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mzu RCSB], [http://www.ebi.ac.uk/pdbsum/1mzu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzu OCA], [http://pdbe.org/1mzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mzu RCSB], [http://www.ebi.ac.uk/pdbsum/1mzu PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1mzu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rhodospirillum centenum~~]]	+	[[Category: Atcc 43720]]
		+	[[Category: Phototropin]]
		+	[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Moffat, K]]		[[Category: Moffat, K]]
	[[Category: Rajagopal, S]]		[[Category: Rajagopal, S]]

OCA at 15:33, 5 January 2015

OCA — Mon, 05 Jan 2015 15:33:49 GMT

←Older revision		Revision as of 15:33, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mzu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodospirillum_centenum Rhodospirillum centenum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MZU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mzu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodospirillum_centenum Rhodospirillum centenum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MZU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC4:4-HYDROXYCINNAMIC+ACID'>HC4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC4:4-HYDROXYCINNAMIC+ACID'>HC4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2phy\|2phy]], [[1gsv\|1gsv]], [[1g28\|1g28]], [[2pyp\|2pyp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2phy\|2phy]], [[1gsv\|1gsv]], [[1g28\|1g28]], [[2pyp\|2pyp]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mzu RCSB], [http://www.ebi.ac.uk/pdbsum/1mzu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mzu RCSB], [http://www.ebi.ac.uk/pdbsum/1mzu PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Rhodospirillum centenum]]		[[Category: Rhodospirillum centenum]]
-	[[Category: Moffat, K.]]	+	[[Category: Moffat, K]]
-	[[Category: Rajagopal, S.]]	+	[[Category: Rajagopal, S]]
	[[Category: Pa]]		[[Category: Pa]]
	[[Category: Photoactive yellow protein]]		[[Category: Photoactive yellow protein]]

OCA at 13:11, 28 September 2014

OCA — Sun, 28 Sep 2014 13:11:54 GMT

←Older revision		Revision as of 13:11, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1mzu.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the Photoactive Yellow Protein Domain from the Sensor Histidine Kinase Ppr from Rhodospirillum centenum==
		+	<StructureSection load='1mzu' size='340' side='right' caption='[[1mzu]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1mzu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodospirillum_centenum Rhodospirillum centenum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MZU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC4:4-HYDROXYCINNAMIC+ACID'>HC4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2phy\|2phy]], [[1gsv\|1gsv]], [[1g28\|1g28]], [[2pyp\|2pyp]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mzu RCSB], [http://www.ebi.ac.uk/pdbsum/1mzu PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mz/1mzu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Photoactive yellow protein (E-PYP) is a blue light photoreceptor, implicated in a negative phototactic response in Ectothiorhodospira halophila, that also serves as a model for the Per-Arnt-Sim superfamily of signaling molecules. Because no biological signaling partner for E-PYP has been identified, it has not been possible to correlate any of its photocycle intermediates with a relevant signaling state. However, the PYP domain (Ppr-PYP) from the sensor histidine kinase Ppr in Rhodospirillum centenum, which regulates the catalytic activity of Ppr by blue light absorption, may allow such issues to be addressed. Here we report the crystal structure of Ppr-PYP at 2 A resolution. This domain has the same absorption spectrum and similar photocycle kinetics as full length Ppr, but a blue-shifted absorbance and considerably slower photocycle than E-PYP. Although the overall fold of Ppr-PYP resembles that of E-PYP, a novel conformation of the beta 4-beta 5 loop results in inaccessibility of Met-100, thought to catalyze chromophore reisomerization, to the chromophore. This conformation also exposes a highly conserved molecular surface that could interact with downstream signaling partners. Other structural differences in the alpha 3-alpha 4 and beta 4-beta 5 loops are consistent with these regions playing significant roles in the control of photocycle dynamics and, by comparison to other sensory Per-Arnt-Sim domains, in signal transduction. Because of its direct linkage to a measurable biological output, Ppr-PYP serves as an excellent system for understanding how changes in photocycle dynamics affect signaling by PYPs.

-	~~{{STRUCTURE_1mzu\| PDB=1mzu \| SCENE= }}~~	+	Crystal structure of a photoactive yellow protein from a sensor histidine kinase: conformational variability and signal transduction.,Rajagopal S, Moffat K Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1649-54. Epub 2003 Jan 31. PMID:12563032<ref>PMID:12563032</ref>

-	~~===Crystal Structure~~ of the ~~Photoactive Yellow Protein Domain from the Sensor Histidine Kinase Ppr from Rhodospirillum centenum===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12563032}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1mzu]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rhodospirillum_centenum Rhodospirillum centenum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1MZU OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012563032<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rhodospirillum centenum]]		[[Category: Rhodospirillum centenum]]
	[[Category: Moffat, K.]]		[[Category: Moffat, K.]]

OCA: Protected "1mzu" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 19:49:50 GMT

Protected "1mzu" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:49, 5 December 2012

OCA at 19:49, 5 December 2012

OCA — Wed, 05 Dec 2012 19:49:46 GMT

←Older revision		Revision as of 19:49, 5 December 2012
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-	{{Seed}}
	[[Image:1mzu.png\|left\|200px]]		[[Image:1mzu.png\|left\|200px]]

-	<!--
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1mzu\| PDB=1mzu \| SCENE= }}		{{STRUCTURE_1mzu\| PDB=1mzu \| SCENE= }}

	===Crystal Structure of the Photoactive Yellow Protein Domain from the Sensor Histidine Kinase Ppr from Rhodospirillum centenum===		===Crystal Structure of the Photoactive Yellow Protein Domain from the Sensor Histidine Kinase Ppr from Rhodospirillum centenum===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12563032}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12563032 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12563032}}		{{ABSTRACT_PUBMED_12563032}}

	==About this Structure==		==About this Structure==
-	~~1MZU~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Rhodospirillum_centenum Rhodospirillum centenum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZU OCA].	+	[[1mzu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodospirillum_centenum Rhodospirillum centenum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZU OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12563032~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012563032</ref><references group="xtra"/>
	[[Category: Rhodospirillum centenum]]		[[Category: Rhodospirillum centenum]]
	[[Category: Moffat, K.]]		[[Category: Moffat, K.]]
Line 31:		Line 19:
	[[Category: Ppr]]		[[Category: Ppr]]
	[[Category: Pyp]]		[[Category: Pyp]]
-		+	[[Category: Signaling protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 09:58:27 2009''~~	+