1n1g - Revision history

OCA at 07:51, 14 February 2024

OCA — Wed, 14 Feb 2024 07:51:13 GMT

←Older revision		Revision as of 07:51, 14 February 2024
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	<StructureSection load='1n1g' size='340' side='right'caption='[[1n1g]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1n1g' size='340' side='right'caption='[[1n1g]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1n1g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Leime Leime~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N1G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1n1g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N1G FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BCP:2~~-~~BROMO-6-CHLORO-PURINE'>BCP</scene>~~, ~~<scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1m66\|1m66]], [[1m67\|1m67]], [[1jdj\|1jdj]], [[1n1e\|1n1e]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCP:2-BROMO-6-CHLORO-PURINE'>BCP</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/Glycerol-3-phosphate_dehydrogenase_(NAD(+)) Glycerol-3-phosphate dehydrogenase (NAD(+))], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.8 1.1.1.8] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1g OCA], [https://pdbe.org/1n1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n1g RCSB], [https://www.ebi.ac.uk/pdbsum/1n1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n1g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1g OCA], [https://pdbe.org/1n1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n1g RCSB], [https://www.ebi.ac.uk/pdbsum/1n1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n1g ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GPDA_LEIME GPDA_LEIME]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n1g ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n1g ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Pathogenic protozoa such as Trypanosome and Leishmania species cause tremendous suffering worldwide. Because of their dependence on glycolysis for energy, the glycolytic enzymes of these organisms, including glycerol-3-phosphate dehydrogenase (GPDH), are considered attractive drug targets. Using the adenine part of NAD as a lead compound, several 2,6-disubstituted purines were synthesized as inhibitors of Leishmania mexicana GPDH (LmGPDH). The electron densities for the inhibitor 2-bromo-6-chloro-purine bound to LmGPDH using a "conventional" wavelength around 1 A displayed a quasisymmetric shape. The anomalous signals from data collected at 1.77 A clearly indicated the positions of the halogen atoms and revealed the multiple binding modes of this inhibitor. Intriguing differences in the observed binding modes of the inhibitor between very similarly prepared crystals illustrate the possibility of crystal-to-crystal variations in protein-ligand complex structures.
-
-	Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase.,Choe J, Suresh S, Wisedchaisri G, Kennedy KJ, Gelb MH, Hol WG Chem Biol. 2002 Nov;9(11):1189-97. PMID:12445769<ref>PMID:12445769</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1n1g" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Glycerol-3-phosphate dehydrogenase 3D structures\|Glycerol-3-phosphate dehydrogenase 3D structures]]		*[[Glycerol-3-phosphate dehydrogenase 3D structures\|Glycerol-3-phosphate dehydrogenase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Leime~~]]	+	[[Category: Leishmania mexicana]]
-	[[Category: Choe, J]]	+	[[Category: Choe J]]
-	[[Category: Hol~~, W G]]~~	+	[[Category: Hol WG]]
-	~~[[Category: Nad binding domain]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 06:57, 25 August 2021

OCA — Wed, 25 Aug 2021 06:57:55 GMT

←Older revision		Revision as of 06:57, 25 August 2021
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	<StructureSection load='1n1g' size='340' side='right'caption='[[1n1g]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1n1g' size='340' side='right'caption='[[1n1g]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1n1g]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Leime Leime]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1N1G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1n1g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leime Leime]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N1G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCP:2-BROMO-6-CHLORO-PURINE'>BCP</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCP:2-BROMO-6-CHLORO-PURINE'>BCP</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m66\|1m66]], [[1m67\|1m67]], [[1jdj\|1jdj]], [[1n1e\|1n1e]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m66\|1m66]], [[1m67\|1m67]], [[1jdj\|1jdj]], [[1n1e\|1n1e]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glycerol-3-phosphate_dehydrogenase_(NAD(+)) Glycerol-3-phosphate dehydrogenase (NAD(+))], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.8 1.1.1.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycerol-3-phosphate_dehydrogenase_(NAD(+)) Glycerol-3-phosphate dehydrogenase (NAD(+))], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.8 1.1.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1n1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1g OCA], [~~http~~://pdbe.org/1n1g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1n1g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1n1g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1n1g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1g OCA], [https://pdbe.org/1n1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n1g RCSB], [https://www.ebi.ac.uk/pdbsum/1n1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n1g ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 18:13, 20 November 2019

OCA — Wed, 20 Nov 2019 18:13:06 GMT

←Older revision		Revision as of 18:13, 20 November 2019
Line 1:		Line 1:

	==Crystal structure of Leishmania mexicana Glycerol-3-phosphate dehydrogenase with inhibitor BCP==		==Crystal structure of Leishmania mexicana Glycerol-3-phosphate dehydrogenase with inhibitor BCP==
-	<StructureSection load='1n1g' size='340' side='right' caption='[[1n1g]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1n1g' size='340' side='right'caption='[[1n1g]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1n1g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leime Leime]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N1G FirstGlance]. <br>		<table><tr><td colspan='2'>[[1n1g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leime Leime]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N1G FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1n1g" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1n1g" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glycerol-3-phosphate dehydrogenase 3D structures\|Glycerol-3-phosphate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Leime]]		[[Category: Leime]]
	[[Category: Choe, J]]		[[Category: Choe, J]]

OCA at 07:41, 31 January 2018

OCA — Wed, 31 Jan 2018 07:41:57 GMT

←Older revision		Revision as of 07:41, 31 January 2018
Line 1:		Line 1:
		+
	==Crystal structure of Leishmania mexicana Glycerol-3-phosphate dehydrogenase with inhibitor BCP==		==Crystal structure of Leishmania mexicana Glycerol-3-phosphate dehydrogenase with inhibitor BCP==
	<StructureSection load='1n1g' size='340' side='right' caption='[[1n1g]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1n1g' size='340' side='right' caption='[[1n1g]], [[Resolution\|resolution]] 2.50Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m66\|1m66]], [[1m67\|1m67]], [[1jdj\|1jdj]], [[1n1e\|1n1e]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m66\|1m66]], [[1m67\|1m67]], [[1jdj\|1jdj]], [[1n1e\|1n1e]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol-3-phosphate_dehydrogenase_(NAD(+)) Glycerol-3-phosphate dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.8 1.1.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol-3-phosphate_dehydrogenase_(NAD(+)) Glycerol-3-phosphate dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.8 1.1.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1g OCA], [http://pdbe.org/1n1g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n1g RCSB], [http://www.ebi.ac.uk/pdbsum/1n1g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1g OCA], [http://pdbe.org/1n1g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n1g RCSB], [http://www.ebi.ac.uk/pdbsum/1n1g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1n1g ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/1n1g_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/1n1g_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1n1g" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1n1g" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Glycerol-3-Phosphate Dehydrogenase\|Glycerol-3-Phosphate Dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:05, 8 February 2016

OCA — Mon, 08 Feb 2016 16:05:28 GMT

←Older revision		Revision as of 16:05, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n1g ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:13, 10 September 2015

OCA — Thu, 10 Sep 2015 13:13:24 GMT

←Older revision		Revision as of 13:13, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1n1g' size='340' side='right' caption='[[1n1g]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1n1g' size='340' side='right' caption='[[1n1g]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1n1g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Leishmania_mexicana Leishmania mexicana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N1G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1n1g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leime Leime]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N1G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCP:2-BROMO-6-CHLORO-PURINE'>BCP</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCP:2-BROMO-6-CHLORO-PURINE'>BCP</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m66\|1m66]], [[1m67\|1m67]], [[1jdj\|1jdj]], [[1n1e\|1n1e]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m66\|1m66]], [[1m67\|1m67]], [[1jdj\|1jdj]], [[1n1e\|1n1e]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol-3-phosphate_dehydrogenase_(NAD(+)) Glycerol-3-phosphate dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.8 1.1.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol-3-phosphate_dehydrogenase_(NAD(+)) Glycerol-3-phosphate dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.8 1.1.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n1g RCSB], [http://www.ebi.ac.uk/pdbsum/1n1g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1g OCA], [http://pdbe.org/1n1g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n1g RCSB], [http://www.ebi.ac.uk/pdbsum/1n1g PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1n1g" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Leishmania mexicana~~]]	+	[[Category: Leime]]
	[[Category: Choe, J]]		[[Category: Choe, J]]
	[[Category: Hol, W G]]		[[Category: Hol, W G]]
	[[Category: Nad binding domain]]		[[Category: Nad binding domain]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 15:21, 5 January 2015

OCA — Mon, 05 Jan 2015 15:21:04 GMT

←Older revision		Revision as of 15:21, 5 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1n1g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N1G FirstGlance]. <br>		<table><tr><td colspan='2'>[[1n1g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N1G FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCP:2-BROMO-6-CHLORO-PURINE'>BCP</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCP:2-BROMO-6-CHLORO-PURINE'>BCP</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m66\|1m66]], [[1m67\|1m67]], [[1jdj\|1jdj]], [[1n1e\|1n1e]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m66\|1m66]], [[1m67\|1m67]], [[1jdj\|1jdj]], [[1n1e\|1n1e]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol-3-phosphate_dehydrogenase_(NAD(+)) Glycerol-3-phosphate dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.8 1.1.1.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol-3-phosphate_dehydrogenase_(NAD(+)) Glycerol-3-phosphate dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.8 1.1.1.8] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n1g RCSB], [http://www.ebi.ac.uk/pdbsum/1n1g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n1g RCSB], [http://www.ebi.ac.uk/pdbsum/1n1g PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Leishmania mexicana]]		[[Category: Leishmania mexicana]]
-	[[Category: Choe, J.]]	+	[[Category: Choe, J]]
-	[[Category: Hol, W G.]]	+	[[Category: Hol, W G]]
	[[Category: Nad binding domain]]		[[Category: Nad binding domain]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 15:24, 28 September 2014

OCA — Sun, 28 Sep 2014 15:24:03 GMT

←Older revision		Revision as of 15:24, 28 September 2014
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-	[[~~Image:~~1n1g.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Leishmania mexicana Glycerol-3-phosphate dehydrogenase with inhibitor BCP==
		+	<StructureSection load='1n1g' size='340' side='right' caption='[[1n1g]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1n1g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N1G FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCP:2-BROMO-6-CHLORO-PURINE'>BCP</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m66\|1m66]], [[1m67\|1m67]], [[1jdj\|1jdj]], [[1n1e\|1n1e]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol-3-phosphate_dehydrogenase_(NAD(+)) Glycerol-3-phosphate dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.8 1.1.1.8] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n1g RCSB], [http://www.ebi.ac.uk/pdbsum/1n1g PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/1n1g_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pathogenic protozoa such as Trypanosome and Leishmania species cause tremendous suffering worldwide. Because of their dependence on glycolysis for energy, the glycolytic enzymes of these organisms, including glycerol-3-phosphate dehydrogenase (GPDH), are considered attractive drug targets. Using the adenine part of NAD as a lead compound, several 2,6-disubstituted purines were synthesized as inhibitors of Leishmania mexicana GPDH (LmGPDH). The electron densities for the inhibitor 2-bromo-6-chloro-purine bound to LmGPDH using a "conventional" wavelength around 1 A displayed a quasisymmetric shape. The anomalous signals from data collected at 1.77 A clearly indicated the positions of the halogen atoms and revealed the multiple binding modes of this inhibitor. Intriguing differences in the observed binding modes of the inhibitor between very similarly prepared crystals illustrate the possibility of crystal-to-crystal variations in protein-ligand complex structures.

-	~~{{STRUCTURE_1n1g\| PDB=1n1g \| SCENE= }}~~	+	Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase.,Choe J, Suresh S, Wisedchaisri G, Kennedy KJ, Gelb MH, Hol WG Chem Biol. 2002 Nov;9(11):1189-97. PMID:12445769<ref>PMID:12445769</ref>

-	~~===Crystal structure~~ of ~~Leishmania mexicana Glycerol-3-phosphate dehydrogenase with inhibitor BCP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12445769}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1n1g]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Leishmania_mexicana Leishmania mexicana]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1N1G OCA].~~	+

	==See Also==		==See Also==
	*[[Glycerol-3-Phosphate Dehydrogenase\|Glycerol-3-Phosphate Dehydrogenase]]		*[[Glycerol-3-Phosphate Dehydrogenase\|Glycerol-3-Phosphate Dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012445769<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Leishmania mexicana]]		[[Category: Leishmania mexicana]]
	[[Category: Choe, J.]]		[[Category: Choe, J.]]

OCA at 10:41, 20 October 2012

OCA — Sat, 20 Oct 2012 10:41:59 GMT

←Older revision		Revision as of 10:41, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1n1g]] is a 1 chain structure ~~of [[Glycerol-3-Phosphate Dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1G OCA].	+	[[1n1g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1G OCA].

	==See Also==		==See Also==

OCA at 02:58, 26 July 2012

OCA — Thu, 26 Jul 2012 02:58:12 GMT

←Older revision		Revision as of 02:58, 26 July 2012
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	[[Image:1n1g.png\|left\|200px]]		[[Image:1n1g.png\|left\|200px]]

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	===Crystal structure of Leishmania mexicana Glycerol-3-phosphate dehydrogenase with inhibitor BCP===		===Crystal structure of Leishmania mexicana Glycerol-3-phosphate dehydrogenase with inhibitor BCP===

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