1n4k - Revision history

OCA at 07:52, 14 February 2024

OCA — Wed, 14 Feb 2024 07:52:29 GMT

←Older revision		Revision as of 07:52, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1n4k' size='340' side='right'caption='[[1n4k]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1n4k' size='340' side='right'caption='[[1n4k]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1n4k]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1N4K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1n4k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4K FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=I3P:D~~-~~MYO-INOSITOL-1~~,~~4,5-TRIPHOSPHATE'>I3P</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ITPR1 OR INSP3R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1n4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4k OCA], [~~http~~://pdbe.org/1n4k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1n4k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1n4k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4k OCA], [https://pdbe.org/1n4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4k RCSB], [https://www.ebi.ac.uk/pdbsum/1n4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ITPR1_MOUSE ITPR1_MOUSE]] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.<ref>PMID:2554142</ref> <ref>PMID:19752026</ref> <ref>PMID:20813840</ref>	+	[https://www.uniprot.org/uniprot/ITPR1_MOUSE ITPR1_MOUSE] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.<ref>PMID:2554142</ref> <ref>PMID:19752026</ref> <ref>PMID:20813840</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4k ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4k ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	In a variety of cells, the Ca2+ signalling process is mediated by the endoplasmic-reticulum-membrane-associated Ca2+ release channel, inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R). Being ubiquitous and present in organisms ranging from humans to Caenorhabditis elegans, InsP3R has a vital role in the control of cellular and physiological processes as diverse as cell division, cell proliferation, apoptosis, fertilization, development, behaviour, memory and learning. Mouse type I InsP3R (InsP3R1), found in high abundance in cerebellar Purkinje cells, is a polypeptide with three major functionally distinct regions: the amino-terminal InsP3-binding region, the central modulatory region and the carboxy-terminal channel region. Here we present a 2.2-A crystal structure of the InsP3-binding core of mouse InsP3R1 in complex with InsP3. The asymmetric, boomerang-like structure consists of an N-terminal beta-trefoil domain and a C-terminal alpha-helical domain containing an 'armadillo repeat'-like fold. The cleft formed by the two domains exposes a cluster of arginine and lysine residues that coordinate the three phosphoryl groups of InsP3. Putative Ca2+-binding sites are identified in two separate locations within the InsP3-binding core.
-
-	Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand.,Bosanac I, Alattia JR, Mal TK, Chan J, Talarico S, Tong FK, Tong KI, Yoshikawa F, Furuichi T, Iwai M, Michikawa T, Mikoshiba K, Ikura M Nature. 2002 Dec 12;420(6916):696-700. Epub 2002 Nov 17. PMID:12442173<ref>PMID:12442173</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1n4k" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Alattia~~, J R~~]]	+	[[Category: Alattia JR]]
-	[[Category: Bosanac, I]]	+	[[Category: Bosanac I]]
-	[[Category: Chan, J]]	+	[[Category: Chan J]]
-	[[Category: Furuichi, T]]	+	[[Category: Furuichi T]]
-	[[Category: Ikura, M]]	+	[[Category: Ikura M]]
-	[[Category: Iwai, M]]	+	[[Category: Iwai M]]
-	[[Category: Mal~~, T K~~]]	+	[[Category: Mal TK]]
-	[[Category: Michikawa, T]]	+	[[Category: Michikawa T]]
-	[[Category: Mikoshiba, K]]	+	[[Category: Mikoshiba K]]
-	[[Category: Talarico, S]]	+	[[Category: Talarico S]]
-	[[Category: Tong~~, F K~~]]	+	[[Category: Tong FK]]
-	[[Category: Tong~~, K I~~]]	+	[[Category: Tong KI]]
-	[[Category: Yoshikawa, F]]	+	[[Category: Yoshikawa F]]
-	~~[[Category: Armadillo-like fold]]~~	+
-	~~[[Category: B-trefoil fold]]~~	+
-	~~[[Category: Calcium channel]]~~	+
-	~~[[Category: Ip3 receptor]]~~	+
-	~~[[Category: Ip3-binding core]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Protein-ligand complex~~]]	+

OCA at 08:45, 2 December 2020

OCA — Wed, 02 Dec 2020 08:45:18 GMT

←Older revision		Revision as of 08:45, 2 December 2020
Line 1:		Line 1:

	==Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3==		==Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3==
-	<StructureSection load='1n4k' size='340' side='right' caption='[[1n4k]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1n4k' size='340' side='right'caption='[[1n4k]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1n4k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1N4K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1n4k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1N4K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITPR1 OR INSP3R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITPR1 OR INSP3R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1n4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4k OCA], [http://pdbe.org/1n4k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n4k RCSB], [http://www.ebi.ac.uk/pdbsum/1n4k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1n4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4k OCA], [http://pdbe.org/1n4k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n4k RCSB], [http://www.ebi.ac.uk/pdbsum/1n4k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1n4k" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1n4k" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Inositol 1%2C4%2C5-Trisphosphate Receptor\|Inositol 1%2C4%2C5-Trisphosphate Receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Alattia, J R]]		[[Category: Alattia, J R]]

OCA at 07:37, 7 February 2018

OCA — Wed, 07 Feb 2018 07:37:50 GMT

←Older revision		Revision as of 07:37, 7 February 2018
Line 1:		Line 1:
		+
	==Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3==		==Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3==
	<StructureSection load='1n4k' size='340' side='right' caption='[[1n4k]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1n4k' size='340' side='right' caption='[[1n4k]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITPR1 OR INSP3R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITPR1 OR INSP3R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4k OCA], [http://pdbe.org/1n4k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n4k RCSB], [http://www.ebi.ac.uk/pdbsum/1n4k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4k OCA], [http://pdbe.org/1n4k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n4k RCSB], [http://www.ebi.ac.uk/pdbsum/1n4k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/1n4k_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/1n4k_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1n4k" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1n4k" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Inositol 1%2C4%2C5-Trisphosphate Receptor\|Inositol 1%2C4%2C5-Trisphosphate Receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:52, 7 February 2016

OCA — Sun, 07 Feb 2016 05:52:41 GMT

←Older revision		Revision as of 05:52, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4k ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:29, 9 September 2015

OCA — Wed, 09 Sep 2015 22:29:00 GMT

←Older revision		Revision as of 22:29, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1n4k' size='340' side='right' caption='[[1n4k]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1n4k' size='340' side='right' caption='[[1n4k]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1n4k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N4K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1n4k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N4K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITPR1 OR INSP3R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITPR1 OR INSP3R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n4k RCSB], [http://www.ebi.ac.uk/pdbsum/1n4k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4k OCA], [http://pdbe.org/1n4k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n4k RCSB], [http://www.ebi.ac.uk/pdbsum/1n4k PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1n4k" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Alattia, J R]]		[[Category: Alattia, J R]]
	[[Category: Bosanac, I]]		[[Category: Bosanac, I]]

OCA at 08:23, 24 December 2014

OCA — Wed, 24 Dec 2014 08:23:38 GMT

←Older revision		Revision as of 08:23, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1n4k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N4K FirstGlance]. <br>		<table><tr><td colspan='2'>[[1n4k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N4K FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITPR1 OR INSP3R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITPR1 OR INSP3R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n4k RCSB], [http://www.ebi.ac.uk/pdbsum/1n4k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n4k RCSB], [http://www.ebi.ac.uk/pdbsum/1n4k PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ITPR1_MOUSE ITPR1_MOUSE]] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.<ref>PMID:2554142</ref> <ref>PMID:19752026</ref> <ref>PMID:20813840</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Alattia, J R.]]	+	[[Category: Alattia, J R]]
-	[[Category: Bosanac, I.]]	+	[[Category: Bosanac, I]]
-	[[Category: Chan, J.]]	+	[[Category: Chan, J]]
-	[[Category: Furuichi, T.]]	+	[[Category: Furuichi, T]]
-	[[Category: Ikura, M.]]	+	[[Category: Ikura, M]]
-	[[Category: Iwai, M.]]	+	[[Category: Iwai, M]]
-	[[Category: Mal, T K.]]	+	[[Category: Mal, T K]]
-	[[Category: Michikawa, T.]]	+	[[Category: Michikawa, T]]
-	[[Category: Mikoshiba, K.]]	+	[[Category: Mikoshiba, K]]
-	[[Category: Talarico, S.]]	+	[[Category: Talarico, S]]
-	[[Category: Tong, F K.]]	+	[[Category: Tong, F K]]
-	[[Category: Tong, K I.]]	+	[[Category: Tong, K I]]
-	[[Category: Yoshikawa, F.]]	+	[[Category: Yoshikawa, F]]
	[[Category: Armadillo-like fold]]		[[Category: Armadillo-like fold]]
	[[Category: B-trefoil fold]]		[[Category: B-trefoil fold]]

OCA at 14:08, 28 September 2014

OCA — Sun, 28 Sep 2014 14:08:55 GMT

←Older revision		Revision as of 14:08, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1n4k.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3==
		+	<StructureSection load='1n4k' size='340' side='right' caption='[[1n4k]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1n4k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N4K FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITPR1 OR INSP3R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n4k RCSB], [http://www.ebi.ac.uk/pdbsum/1n4k PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/1n4k_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In a variety of cells, the Ca2+ signalling process is mediated by the endoplasmic-reticulum-membrane-associated Ca2+ release channel, inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R). Being ubiquitous and present in organisms ranging from humans to Caenorhabditis elegans, InsP3R has a vital role in the control of cellular and physiological processes as diverse as cell division, cell proliferation, apoptosis, fertilization, development, behaviour, memory and learning. Mouse type I InsP3R (InsP3R1), found in high abundance in cerebellar Purkinje cells, is a polypeptide with three major functionally distinct regions: the amino-terminal InsP3-binding region, the central modulatory region and the carboxy-terminal channel region. Here we present a 2.2-A crystal structure of the InsP3-binding core of mouse InsP3R1 in complex with InsP3. The asymmetric, boomerang-like structure consists of an N-terminal beta-trefoil domain and a C-terminal alpha-helical domain containing an 'armadillo repeat'-like fold. The cleft formed by the two domains exposes a cluster of arginine and lysine residues that coordinate the three phosphoryl groups of InsP3. Putative Ca2+-binding sites are identified in two separate locations within the InsP3-binding core.

-	~~{{STRUCTURE_1n4k\| PDB=1n4k \| SCENE= }}~~	+	Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand.,Bosanac I, Alattia JR, Mal TK, Chan J, Talarico S, Tong FK, Tong KI, Yoshikawa F, Furuichi T, Iwai M, Michikawa T, Mikoshiba K, Ikura M Nature. 2002 Dec 12;420(6916):696-700. Epub 2002 Nov 17. PMID:12442173<ref>PMID:12442173</ref>

-	~~===Crystal structure~~ of the ~~inositol 1,4,5-trisphosphate receptor binding core in complex with IP3===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12442173}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1n4k]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA].~~	+

	==See Also==		==See Also==
	*[[Inositol 1%2C4%2C5-Trisphosphate Receptor\|Inositol 1%2C4%2C5-Trisphosphate Receptor]]		*[[Inositol 1%2C4%2C5-Trisphosphate Receptor\|Inositol 1%2C4%2C5-Trisphosphate Receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012442173<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Alattia, J R.]]		[[Category: Alattia, J R.]]

OCA at 05:46, 20 October 2012

OCA — Sat, 20 Oct 2012 05:46:19 GMT

←Older revision		Revision as of 05:46, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1n4k]] is a 1 chain structure ~~of [[Inositol 1%2C4%2C5-Trisphosphate Receptor]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA].	+	[[1n4k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA].

	==See Also==		==See Also==

OCA at 11:04, 25 July 2012

OCA — Wed, 25 Jul 2012 11:04:19 GMT

←Older revision		Revision as of 11:04, 25 July 2012
Line 1:		Line 1:
	[[Image:1n4k.png\|left\|200px]]		[[Image:1n4k.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1n4k", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1n4k\| PDB=1n4k \| SCENE= }}		{{STRUCTURE_1n4k\| PDB=1n4k \| SCENE= }}

	===Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3===		===Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12442173}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12442173 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12442173}}		{{ABSTRACT_PUBMED_12442173}}

	==About this Structure==		==About this Structure==
-	[[1n4k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA].	+	[[1n4k]] is a 1 chain structure of [[Inositol 1%2C4%2C5-Trisphosphate Receptor]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA].

	==See Also==		==See Also==
-	*[[Inositol 1%2C4%2C5-Trisphosphate Receptor]]	+	*[[Inositol 1%2C4%2C5-Trisphosphate Receptor\|Inositol 1%2C4%2C5-Trisphosphate Receptor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12442173~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012442173</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Alattia, J R.]]		[[Category: Alattia, J R.]]

OCA: Protected "1n4k" [edit=sysop:move=sysop]

OCA — Thu, 06 Jan 2011 04:10:29 GMT

Protected "1n4k" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:10, 6 January 2011