1n81 - Revision history

OCA at 07:53, 14 February 2024

OCA — Wed, 14 Feb 2024 07:53:54 GMT

←Older revision		Revision as of 07:53, 14 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1n81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N81 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1n81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N81 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n81 OCA], [https://pdbe.org/1n81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n81 RCSB], [https://www.ebi.ac.uk/pdbsum/1n81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n81 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n81 OCA], [https://pdbe.org/1n81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n81 RCSB], [https://www.ebi.ac.uk/pdbsum/1n81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n81 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q8IEU2_PLAF7 Q8IEU2_PLAF7]]	+	[https://www.uniprot.org/uniprot/Q8IEU2_PLAF7 Q8IEU2_PLAF7]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:00, 7 September 2022

OCA — Wed, 07 Sep 2022 17:00:57 GMT

←Older revision		Revision as of 17:00, 7 September 2022
Line 3:		Line 3:
	<StructureSection load='1n81' size='340' side='right'caption='[[1n81]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1n81' size='340' side='right'caption='[[1n81]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1n81]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1N81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1n81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N81 FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pfg27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n81 OCA], [https://pdbe.org/1n81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n81 RCSB], [https://www.ebi.ac.uk/pdbsum/1n81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n81 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n81 OCA], [~~http~~://pdbe.org/1n81 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1n81 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1n81 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1n81 ProSAT]</span></td></tr>	+
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[[https://www.uniprot.org/uniprot/Q8IEU2_PLAF7 Q8IEU2_PLAF7]]
-	Malaria transmission is dependent on the development of sexual forms of Plasmodium falciparum, called gametocytes, in the vertebrate host. Pfg27 is an abundantly expressed sexual stage-specific protein that is essential for gametocytogenesis in P. falciparum. We describe the crystal structure of Pfg27, which reveals a novel fold composed of two pseudo dyad-related repeats of the helix-turn-helix motif. Structurally equivalent helices of each repeat either form a dimer interface or interact with RNA in vitro. One side of the dimer presents an unprecedented juxtaposition of four polyproline (PXXP) motifs. Preliminary binding data indicate that these sites are capable of binding Src homology-3 (SH3) modules. Molecular modeling suggests that the dimer can accommodate two SH3 modules simultaneously, potentially enabling molecular crosstalk between SH3-containing proteins. The structural and initial biochemical evidence suggests that Pfg27 may serve as a platform for RNA and SH3 binding.	+
-		+
-	~~Structure of a gametocyte protein essential for sexual development in Plasmodium falciparum.,Sharma A, Sharma I, Kogkasuriyachai D, Kumar N Nat Struct Biol. 2003 Mar;10(3)~~:~~197-203. PMID:12577051<ref>PMID:12577051<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 1n81" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plaf7~~]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: Kogkasuriyachai, D]]	+	[[Category: Kogkasuriyachai D]]
-	[[Category: Kumar, N]]	+	[[Category: Kumar N]]
-	[[Category: Sharma, A]]	+	[[Category: Sharma A]]
-	[[Category: Sharma, I]]	+	[[Category: Sharma I]]
-	~~[[Category: Gametocyte]]~~	+
-	~~[[Category: Helical]]~~	+
-	~~[[Category: Helix-turn-helix]]~~	+
-	~~[[Category: Pxxp]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 08:46, 2 December 2020

OCA — Wed, 02 Dec 2020 08:46:57 GMT

←Older revision		Revision as of 08:46, 2 December 2020
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	==Crystal structure of Pfg27 from Plasmodium falciparum==		==Crystal structure of Pfg27 from Plasmodium falciparum==
-	<StructureSection load='1n81' size='340' side='right' caption='[[1n81]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1n81' size='340' side='right'caption='[[1n81]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1n81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1N81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1n81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1N81 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pfg27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pfg27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n81 OCA], [http://pdbe.org/1n81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n81 RCSB], [http://www.ebi.ac.uk/pdbsum/1n81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1n81 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n81 OCA], [http://pdbe.org/1n81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n81 RCSB], [http://www.ebi.ac.uk/pdbsum/1n81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1n81 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Plaf7]]		[[Category: Plaf7]]
	[[Category: Kogkasuriyachai, D]]		[[Category: Kogkasuriyachai, D]]

OCA at 10:14, 25 October 2017

OCA — Wed, 25 Oct 2017 10:14:44 GMT

←Older revision		Revision as of 10:14, 25 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of Pfg27 from Plasmodium falciparum==		==Crystal structure of Pfg27 from Plasmodium falciparum==
	<StructureSection load='1n81' size='340' side='right' caption='[[1n81]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1n81' size='340' side='right' caption='[[1n81]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1n81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N81 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1n81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N81 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pfg27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pfg27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n81 OCA], [http://pdbe.org/1n81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n81 RCSB], [http://www.ebi.ac.uk/pdbsum/1n81 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n81 OCA], [http://pdbe.org/1n81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n81 RCSB], [http://www.ebi.ac.uk/pdbsum/1n81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1n81 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:48, 10 September 2015

OCA — Thu, 10 Sep 2015 20:48:00 GMT

←Older revision		Revision as of 20:48, 10 September 2015
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	<StructureSection load='1n81' size='340' side='right' caption='[[1n81]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1n81' size='340' side='right' caption='[[1n81]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1n81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1n81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N81 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pfg27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~5833 Plasmodium falciparum~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pfg27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n81 RCSB], [http://www.ebi.ac.uk/pdbsum/1n81 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n81 OCA], [http://pdbe.org/1n81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n81 RCSB], [http://www.ebi.ac.uk/pdbsum/1n81 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1n81" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plaf7]]
	[[Category: Kogkasuriyachai, D]]		[[Category: Kogkasuriyachai, D]]
	[[Category: Kumar, N]]		[[Category: Kumar, N]]

OCA at 05:57, 25 December 2014

OCA — Thu, 25 Dec 2014 05:57:48 GMT

←Older revision		Revision as of 05:57, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1n81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N81 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1n81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N81 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pfg27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pfg27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n81 RCSB], [http://www.ebi.ac.uk/pdbsum/1n81 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n81 RCSB], [http://www.ebi.ac.uk/pdbsum/1n81 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Kogkasuriyachai, D.]]	+	[[Category: Kogkasuriyachai, D]]
-	[[Category: Kumar, N.]]	+	[[Category: Kumar, N]]
-	[[Category: Sharma, A.]]	+	[[Category: Sharma, A]]
-	[[Category: Sharma, I.]]	+	[[Category: Sharma, I]]
	[[Category: Gametocyte]]		[[Category: Gametocyte]]
	[[Category: Helical]]		[[Category: Helical]]

OCA at 16:39, 28 September 2014

OCA — Sun, 28 Sep 2014 16:39:26 GMT

←Older revision		Revision as of 16:39, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1n81.~~png~~\|~~left\|200px~~]]	+	==Crystal structure of Pfg27 from Plasmodium falciparum==
		+	<StructureSection load='1n81' size='340' side='right' caption='[[1n81]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1n81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N81 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pfg27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n81 RCSB], [http://www.ebi.ac.uk/pdbsum/1n81 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Malaria transmission is dependent on the development of sexual forms of Plasmodium falciparum, called gametocytes, in the vertebrate host. Pfg27 is an abundantly expressed sexual stage-specific protein that is essential for gametocytogenesis in P. falciparum. We describe the crystal structure of Pfg27, which reveals a novel fold composed of two pseudo dyad-related repeats of the helix-turn-helix motif. Structurally equivalent helices of each repeat either form a dimer interface or interact with RNA in vitro. One side of the dimer presents an unprecedented juxtaposition of four polyproline (PXXP) motifs. Preliminary binding data indicate that these sites are capable of binding Src homology-3 (SH3) modules. Molecular modeling suggests that the dimer can accommodate two SH3 modules simultaneously, potentially enabling molecular crosstalk between SH3-containing proteins. The structural and initial biochemical evidence suggests that Pfg27 may serve as a platform for RNA and SH3 binding.

-	~~{{STRUCTURE_1n81\| PDB=1n81 \| SCENE= }}~~	+	Structure of a gametocyte protein essential for sexual development in Plasmodium falciparum.,Sharma A, Sharma I, Kogkasuriyachai D, Kumar N Nat Struct Biol. 2003 Mar;10(3):197-203. PMID:12577051<ref>PMID:12577051</ref>

-	~~===Crystal structure~~ of ~~Pfg27 from Plasmodium falciparum===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12577051}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[1n81]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA].~~	+	</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Kogkasuriyachai, D.]]		[[Category: Kogkasuriyachai, D.]]

OCA: Protected "1n81" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 19:46:09 GMT

Protected "1n81" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:46, 5 December 2012

OCA at 19:46, 5 December 2012

OCA — Wed, 05 Dec 2012 19:46:05 GMT

←Older revision		Revision as of 19:46, 5 December 2012
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-	{{Seed}}
	[[Image:1n81.png\|left\|200px]]		[[Image:1n81.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1n81", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1n81\| PDB=1n81 \| SCENE= }}		{{STRUCTURE_1n81\| PDB=1n81 \| SCENE= }}

	===Crystal structure of Pfg27 from Plasmodium falciparum===		===Crystal structure of Pfg27 from Plasmodium falciparum===

-
-	<!--
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	{{ABSTRACT_PUBMED_12577051}}		{{ABSTRACT_PUBMED_12577051}}

	==About this Structure==		==About this Structure==
-	~~1N81 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum_3d7~~ Plasmodium falciparum ~~3d7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA].	+	[[1n81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA].
-		+	[[Category: Plasmodium falciparum]]
-	~~==Reference==~~	+
-	Structure of a gametocyte protein essential for sexual development in Plasmodium falciparum., Sharma A, Sharma I, Kogkasuriyachai D, Kumar N, Nat Struct Biol. 2003 Mar;10(3):197-203. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12577051 12577051]	+
-	[[Category: Plasmodium falciparum ~~3d7]]~~	+
-	~~[[Category: Single protein~~]]	+
	[[Category: Kogkasuriyachai, D.]]		[[Category: Kogkasuriyachai, D.]]
	[[Category: Kumar, N.]]		[[Category: Kumar, N.]]
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	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Pxxp]]		[[Category: Pxxp]]
-		+	[[Category: Unknown function]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Jul 28 12:06:59 2008''~~	+

OCA at 09:07, 28 July 2008

OCA — Mon, 28 Jul 2008 09:07:03 GMT

←Older revision		Revision as of 09:07, 28 July 2008
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-	[[Image:1n81.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1n81.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1n81\| PDB=1n81 \| SCENE= }}		{{STRUCTURE_1n81\| PDB=1n81 \| SCENE= }}

-	~~'''~~Crystal structure of Pfg27 from Plasmodium falciparum~~'''~~	+	===Crystal structure of Pfg27 from Plasmodium falciparum===


-	~~==Overview==~~	+	<!--
-	~~Malaria transmission is dependent on the development of sexual forms of Plasmodium falciparum~~, ~~called gametocytes~~, in the ~~vertebrate host~~. ~~Pfg27 is an abundantly expressed sexual stage-specific protein that is essential for gametocytogenesis in P~~. ~~falciparum. We describe the crystal structure of Pfg27~~, ~~which reveals a novel fold composed of two pseudo dyad-related repeats of~~ the ~~helix-turn-helix motif~~. Structurally equivalent helices of each repeat either form a dimer interface or interact with RNA in vitro. One side of the dimer presents an unprecedented juxtaposition of four polyproline (PXXP) motifs. Preliminary binding data indicate that these sites are capable of binding Src homology-~~3 (SH3) modules. Molecular modeling suggests that the dimer can accommodate two SH3 modules simultaneously, potentially enabling molecular crosstalk between SH3~~-~~containing proteins. The structural and initial biochemical evidence suggests that Pfg27 may serve as a platform for RNA and SH3 binding.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_12577051}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 12577051 is the PubMed ID number.
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		+	{{ABSTRACT_PUBMED_12577051}}

	==About this Structure==		==About this Structure==
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	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Pxxp]]		[[Category: Pxxp]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 02:~~12:40 2008''	+
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