1n8y - Revision history

OCA at 09:17, 16 August 2023

OCA — Wed, 16 Aug 2023 09:17:16 GMT

←Older revision		Revision as of 09:17, 16 August 2023
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	<StructureSection load='1n8y' size='340' side='right'caption='[[1n8y]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1n8y' size='340' side='right'caption='[[1n8y]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1n8y]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1N8Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1n8y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N8Y FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NAG:N~~-~~ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1m6b\|1m6b]]~~</~~div~~>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">neu ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8y OCA], [https://pdbe.org/1n8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n8y RCSB], [https://www.ebi.ac.uk/pdbsum/1n8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n8y ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8y OCA], [~~http~~://pdbe.org/1n8y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1n8y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1n8y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1n8y ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ERBB2_RAT ERBB2_RAT] Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).<ref>PMID:7945309</ref> In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth (By similarity).<ref>PMID:7945309</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cho, H S]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Denney~~, D W~~]]	+	[[Category: Cho H-S]]
-	[[Category: Gabelli~~, S B~~]]	+	[[Category: Denney Jr DW]]
-	[[Category: Leahy~~, D J~~]]	+	[[Category: Gabelli SB]]
-	[[Category: Mason, K]]	+	[[Category: Leahy DJ]]
-	[[Category: Ramyar~~, K X~~]]	+	[[Category: Mason K]]
-	[[Category: Stanley~~, A M]]~~	+	[[Category: Ramyar KX]]
-	~~[[Category: Cell surface receptor]]~~	+	[[Category: Stanley AM]]
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Tyrosin kinase receptor~~]]	+

OCA at 08:47, 2 December 2020

OCA — Wed, 02 Dec 2020 08:47:19 GMT

←Older revision		Revision as of 08:47, 2 December 2020
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	==Crystal structure of the extracellular region of rat HER2==		==Crystal structure of the extracellular region of rat HER2==
-	<StructureSection load='1n8y' size='340' side='right' caption='[[1n8y]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1n8y' size='340' side='right'caption='[[1n8y]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1n8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1N8Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1n8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1N8Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m6b\|1m6b]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m6b\|1m6b]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">neu ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">neu ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8y OCA], [http://pdbe.org/1n8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n8y RCSB], [http://www.ebi.ac.uk/pdbsum/1n8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1n8y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8y OCA], [http://pdbe.org/1n8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n8y RCSB], [http://www.ebi.ac.uk/pdbsum/1n8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1n8y ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Cho, H S]]		[[Category: Cho, H S]]
	[[Category: Denney, D W]]		[[Category: Denney, D W]]

OCA at 07:02, 7 February 2018

OCA — Wed, 07 Feb 2018 07:02:43 GMT

←Older revision		Revision as of 07:02, 7 February 2018
Line 1:		Line 1:
		+
	==Crystal structure of the extracellular region of rat HER2==		==Crystal structure of the extracellular region of rat HER2==
	<StructureSection load='1n8y' size='340' side='right' caption='[[1n8y]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1n8y' size='340' side='right' caption='[[1n8y]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m6b\|1m6b]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m6b\|1m6b]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">neu ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">neu ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8y OCA], [http://pdbe.org/1n8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n8y RCSB], [http://www.ebi.ac.uk/pdbsum/1n8y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8y OCA], [http://pdbe.org/1n8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n8y RCSB], [http://www.ebi.ac.uk/pdbsum/1n8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1n8y ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n8/1n8y_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n8/1n8y_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:10, 7 February 2016

OCA — Sun, 07 Feb 2016 22:10:50 GMT

←Older revision		Revision as of 22:10, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n8y ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:23, 10 September 2015

OCA — Thu, 10 Sep 2015 05:23:08 GMT

←Older revision		Revision as of 05:23, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1n8y' size='340' side='right' caption='[[1n8y]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1n8y' size='340' side='right' caption='[[1n8y]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1n8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N8Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1n8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N8Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m6b\|1m6b]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m6b\|1m6b]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">neu ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">neu ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n8y RCSB], [http://www.ebi.ac.uk/pdbsum/1n8y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8y OCA], [http://pdbe.org/1n8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n8y RCSB], [http://www.ebi.ac.uk/pdbsum/1n8y PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1n8y" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Cho, H S]]		[[Category: Cho, H S]]
	[[Category: Denney, D W]]		[[Category: Denney, D W]]

OCA at 15:21, 5 January 2015

OCA — Mon, 05 Jan 2015 15:21:39 GMT

←Older revision		Revision as of 15:21, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1n8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N8Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[1n8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N8Y FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m6b\|1m6b]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m6b\|1m6b]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">neu ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">neu ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n8y RCSB], [http://www.ebi.ac.uk/pdbsum/1n8y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n8y RCSB], [http://www.ebi.ac.uk/pdbsum/1n8y PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Cho, H S.]]	+	[[Category: Cho, H S]]
-	[[Category: Denney, D W.]]	+	[[Category: Denney, D W]]
-	[[Category: Gabelli, S B.]]	+	[[Category: Gabelli, S B]]
-	[[Category: Leahy, D J.]]	+	[[Category: Leahy, D J]]
-	[[Category: Mason, K.]]	+	[[Category: Mason, K]]
-	[[Category: Ramyar, K X.]]	+	[[Category: Ramyar, K X]]
-	[[Category: Stanley, A M.]]	+	[[Category: Stanley, A M]]
	[[Category: Cell surface receptor]]		[[Category: Cell surface receptor]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Tyrosin kinase receptor]]		[[Category: Tyrosin kinase receptor]]

OCA at 14:14, 28 September 2014

OCA — Sun, 28 Sep 2014 14:14:15 GMT

←Older revision		Revision as of 14:14, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1n8y.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the extracellular region of rat HER2==
		+	<StructureSection load='1n8y' size='340' side='right' caption='[[1n8y]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1n8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N8Y FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m6b\|1m6b]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">neu ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n8y RCSB], [http://www.ebi.ac.uk/pdbsum/1n8y PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n8/1n8y_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	HER2 (also known as Neu, ErbB2) is a member of the epidermal growth factor receptor (EGFR; also known as ErbB) family of receptor tyrosine kinases, which in humans includes HER1 (EGFR, ERBB1), HER2, HER3 (ERBB3) and HER4 (ERBB4). ErbB receptors are essential mediators of cell proliferation and differentiation in the developing embryo and in adult tissues, and their inappropriate activation is associated with the development and severity of many cancers. Overexpression of HER2 is found in 20-30% of human breast cancers, and correlates with more aggressive tumours and a poorer prognosis. Anticancer therapies targeting ErbB receptors have shown promise, and a monoclonal antibody against HER2, Herceptin (also known as trastuzumab), is currently in use as a treatment for breast cancer. Here we report crystal structures of the entire extracellular regions of rat HER2 at 2.4 A and human HER2 complexed with the Herceptin antigen-binding fragment (Fab) at 2.5 A. These structures reveal a fixed conformation for HER2 that resembles a ligand-activated state, and show HER2 poised to interact with other ErbB receptors in the absence of direct ligand binding. Herceptin binds to the juxtamembrane region of HER2, identifying this site as a target for anticancer therapies.

-	~~{{STRUCTURE_1n8y\| PDB=1n8y \| SCENE= }}~~	+	Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab.,Cho HS, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney DW Jr, Leahy DJ Nature. 2003 Feb 13;421(6924):756-60. PMID:12610629<ref>PMID:12610629</ref>

-	~~===Crystal structure~~ of the ~~extracellular region of rat HER2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12610629}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1n8y]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1N8Y OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012610629<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Cho, H S.]]		[[Category: Cho, H S.]]

OCA: Protected "1n8y" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 19:37:25 GMT

Protected "1n8y" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:37, 5 December 2012

OCA at 19:37, 5 December 2012

OCA — Wed, 05 Dec 2012 19:37:23 GMT

←Older revision		Revision as of 19:37, 5 December 2012
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-	{{Seed}}
	[[Image:1n8y.png\|left\|200px]]		[[Image:1n8y.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1n8y", creates the "Structure Box" on the page.
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	{{STRUCTURE_1n8y\| PDB=1n8y \| SCENE= }}		{{STRUCTURE_1n8y\| PDB=1n8y \| SCENE= }}

	===Crystal structure of the extracellular region of rat HER2===		===Crystal structure of the extracellular region of rat HER2===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12610629}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12610629 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_12610629}}		{{ABSTRACT_PUBMED_12610629}}

	==About this Structure==		==About this Structure==
-	~~1N8Y~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8Y OCA].	+	[[1n8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8Y OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12610629~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012610629</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Cho, H S.]]		[[Category: Cho, H S.]]
		+	[[Category: Denney, D W.]]
	[[Category: Gabelli, S B.]]		[[Category: Gabelli, S B.]]
-	[[Category: Jr., D W.Denney.]]
	[[Category: Leahy, D J.]]		[[Category: Leahy, D J.]]
	[[Category: Mason, K.]]		[[Category: Mason, K.]]
Line 33:		Line 21:
	[[Category: Stanley, A M.]]		[[Category: Stanley, A M.]]
	[[Category: Cell surface receptor]]		[[Category: Cell surface receptor]]
		+	[[Category: Transferase]]
	[[Category: Tyrosin kinase receptor]]		[[Category: Tyrosin kinase receptor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:49:56 2009''

OCA at 14:49, 16 February 2009

OCA — Mon, 16 Feb 2009 14:49:57 GMT

←Older revision		Revision as of 14:49, 16 February 2009
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	==About this Structure==		==About this Structure==
-	1N8Y is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8Y OCA].	+	1N8Y is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8Y OCA].

	==Reference==		==Reference==
-	Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab., Cho HS, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney DW Jr, Leahy DJ, Nature. 2003 Feb 13;421(6924):756-60. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12610629 12610629]~~	+	<ref group="xtra">PMID:12610629</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Single protein]]
	[[Category: Cho, H S.]]		[[Category: Cho, H S.]]
	[[Category: Gabelli, S B.]]		[[Category: Gabelli, S B.]]
Line 36:		Line 35:
	[[Category: Tyrosin kinase receptor]]		[[Category: Tyrosin kinase receptor]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 20~~:05:~~31 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:49:56 2009''