1naa - Revision history

OCA at 09:17, 16 August 2023

OCA — Wed, 16 Aug 2023 09:17:54 GMT

←Older revision		Revision as of 09:17, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1naa' size='340' side='right'caption='[[1naa]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1naa' size='340' side='right'caption='[[1naa]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1naa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Phanerochaete_chrysosporium Phanerochaete~~ chrysosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NAA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1naa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Phanerodontia_chrysosporium Phanerodontia chrysosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NAA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6FA:6-HYDROXY-FLAVIN-ADENINE+DINUCLEOTIDE'>6FA</scene>, <scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1kdg\|1kdg]], [[1d7b\|1d7b]], [[1d7c\|1d7c]], [[1d7d\|1d7d]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6FA:6-HYDROXY-FLAVIN-ADENINE+DINUCLEOTIDE'>6FA</scene>, <scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.99.18 1.1.99.18] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1naa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1naa OCA], [https://pdbe.org/1naa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1naa RCSB], [https://www.ebi.ac.uk/pdbsum/1naa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1naa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1naa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1naa OCA], [https://pdbe.org/1naa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1naa RCSB], [https://www.ebi.ac.uk/pdbsum/1naa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1naa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CDH_PHACH CDH_PHACH]] Degrades both lignin and cellulose. Oxidizes cellobiose to cellobionolactone.	+	[https://www.uniprot.org/uniprot/CDH_PHACH CDH_PHACH] Degrades both lignin and cellulose. Oxidizes cellobiose to cellobionolactone.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Oxidoreductase]]~~	+	[[Category: Phanerodontia chrysosporium]]
-	~~[[Category: Phanerochaete~~ chrysosporium]]	+	[[Category: Divne C]]
-	[[Category: Divne, C]]	+	[[Category: Hallberg BM]]
-	[[Category: Hallberg~~, B M~~]]	+	[[Category: Henriksson G]]
-	[[Category: Henriksson, G]]	+	[[Category: Pettersson G]]
-	[[Category: Pettersson, G]]	+	[[Category: Vasella A]]
-	[[Category: Vasella, A]]	+
-	~~[[Category: 6-hydroxylated fad]]~~	+
-	~~[[Category: Alpha/beta structure]]~~	+
-	~~[[Category: Gmc oxidoreductase]]~~	+
-	~~[[Category: Phbh fold]]~~	+
-	~~[[Category: Product analogue complex]]~~	+
-	~~[[Category: Rossmann fold~~]]	+

OCA at 05:59, 28 April 2021

OCA — Wed, 28 Apr 2021 05:59:43 GMT

←Older revision		Revision as of 05:59, 28 April 2021
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	<StructureSection load='1naa' size='340' side='right'caption='[[1naa]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1naa' size='340' side='right'caption='[[1naa]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1naa]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Phanerochaete_chrysosporium Phanerochaete chrysosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1NAA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1naa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Phanerochaete_chrysosporium Phanerochaete chrysosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NAA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6FA:6-HYDROXY-FLAVIN-ADENINE+DINUCLEOTIDE'>6FA</scene>, <scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6FA:6-HYDROXY-FLAVIN-ADENINE+DINUCLEOTIDE'>6FA</scene>, <scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kdg\|1kdg]], [[1d7b\|1d7b]], [[1d7c\|1d7c]], [[1d7d\|1d7d]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1kdg\|1kdg]], [[1d7b\|1d7b]], [[1d7c\|1d7c]], [[1d7d\|1d7d]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.99.18 1.1.99.18] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.99.18 1.1.99.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1naa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1naa OCA], [~~http~~://pdbe.org/1naa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1naa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1naa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1naa ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1naa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1naa OCA], [https://pdbe.org/1naa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1naa RCSB], [https://www.ebi.ac.uk/pdbsum/1naa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1naa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CDH_PHACH CDH_PHACH]] Degrades both lignin and cellulose. Oxidizes cellobiose to cellobionolactone.	+	[[https://www.uniprot.org/uniprot/CDH_PHACH CDH_PHACH]] Degrades both lignin and cellulose. Oxidizes cellobiose to cellobionolactone.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:52, 24 July 2019

OCA — Wed, 24 Jul 2019 06:52:07 GMT

←Older revision		Revision as of 06:52, 24 July 2019
Line 1:		Line 1:

	==Cellobiose Dehydrogenase Flavoprotein Fragment in Complex with Cellobionolactam==		==Cellobiose Dehydrogenase Flavoprotein Fragment in Complex with Cellobionolactam==
-	<StructureSection load='1naa' size='340' side='right' caption='[[1naa]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1naa' size='340' side='right'caption='[[1naa]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1naa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Phanerochaete_chrysosporium Phanerochaete chrysosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NAA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1naa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Phanerochaete_chrysosporium Phanerochaete chrysosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NAA FirstGlance]. <br>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Phanerochaete chrysosporium]]		[[Category: Phanerochaete chrysosporium]]

OCA at 07:29, 7 February 2018

OCA — Wed, 07 Feb 2018 07:29:38 GMT

←Older revision		Revision as of 07:29, 7 February 2018
Line 1:		Line 1:
		+
	==Cellobiose Dehydrogenase Flavoprotein Fragment in Complex with Cellobionolactam==		==Cellobiose Dehydrogenase Flavoprotein Fragment in Complex with Cellobionolactam==
	<StructureSection load='1naa' size='340' side='right' caption='[[1naa]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1naa' size='340' side='right' caption='[[1naa]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kdg\|1kdg]], [[1d7b\|1d7b]], [[1d7c\|1d7c]], [[1d7d\|1d7d]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kdg\|1kdg]], [[1d7b\|1d7b]], [[1d7c\|1d7c]], [[1d7d\|1d7d]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.99.18 1.1.99.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.99.18 1.1.99.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1naa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1naa OCA], [http://pdbe.org/1naa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1naa RCSB], [http://www.ebi.ac.uk/pdbsum/1naa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1naa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1naa OCA], [http://pdbe.org/1naa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1naa RCSB], [http://www.ebi.ac.uk/pdbsum/1naa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1naa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/na/1naa_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/na/1naa_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:39, 9 February 2016

OCA — Tue, 09 Feb 2016 15:39:26 GMT

←Older revision		Revision as of 15:39, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1naa ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:39, 10 September 2015

OCA — Thu, 10 Sep 2015 23:39:52 GMT

←Older revision		Revision as of 23:39, 10 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kdg\|1kdg]], [[1d7b\|1d7b]], [[1d7c\|1d7c]], [[1d7d\|1d7d]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kdg\|1kdg]], [[1d7b\|1d7b]], [[1d7c\|1d7c]], [[1d7d\|1d7d]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.99.18 1.1.99.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.99.18 1.1.99.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1naa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1naa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1naa RCSB], [http://www.ebi.ac.uk/pdbsum/1naa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1naa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1naa OCA], [http://pdbe.org/1naa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1naa RCSB], [http://www.ebi.ac.uk/pdbsum/1naa PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1naa" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:48, 25 December 2014

OCA — Thu, 25 Dec 2014 07:48:16 GMT

←Older revision		Revision as of 07:48, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1naa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1naa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1naa RCSB], [http://www.ebi.ac.uk/pdbsum/1naa PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1naa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1naa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1naa RCSB], [http://www.ebi.ac.uk/pdbsum/1naa PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CDH_PHACH CDH_PHACH]] Degrades both lignin and cellulose. Oxidizes cellobiose to cellobionolactone.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:12, 12 November 2014

OCA — Wed, 12 Nov 2014 07:12:16 GMT

←Older revision		Revision as of 07:12, 12 November 2014
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6FA:6-HYDROXY-FLAVIN-ADENINE+DINUCLEOTIDE'>6FA</scene>, <scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6FA:6-HYDROXY-FLAVIN-ADENINE+DINUCLEOTIDE'>6FA</scene>, <scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kdg\|1kdg]], [[1d7b\|1d7b]], [[1d7c\|1d7c]], [[1d7d\|1d7d]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kdg\|1kdg]], [[1d7b\|1d7b]], [[1d7c\|1d7c]], [[1d7d\|1d7d]]</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Cellobiose_dehydrogenase_(acceptor) Cellobiose dehydrogenase (acceptor)~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.99.18 1.1.99.18] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.99.18 1.1.99.18] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1naa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1naa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1naa RCSB], [http://www.ebi.ac.uk/pdbsum/1naa PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1naa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1naa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1naa RCSB], [http://www.ebi.ac.uk/pdbsum/1naa PDBsum]</span></td></tr>
	</table>		</table>
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Oxidoreductase]]
	[[Category: Phanerochaete chrysosporium]]		[[Category: Phanerochaete chrysosporium]]
-	[[Category: Divne, C.]]	+	[[Category: Divne, C]]
-	[[Category: Hallberg, B M.]]	+	[[Category: Hallberg, B M]]
-	[[Category: Henriksson, G.]]	+	[[Category: Henriksson, G]]
-	[[Category: Pettersson, G.]]	+	[[Category: Pettersson, G]]
-	[[Category: Vasella, A.]]	+	[[Category: Vasella, A]]
	[[Category: 6-hydroxylated fad]]		[[Category: 6-hydroxylated fad]]
	[[Category: Alpha/beta structure]]		[[Category: Alpha/beta structure]]
	[[Category: Gmc oxidoreductase]]		[[Category: Gmc oxidoreductase]]
-	[[Category: Oxidoreductase]]
	[[Category: Phbh fold]]		[[Category: Phbh fold]]
	[[Category: Product analogue complex]]		[[Category: Product analogue complex]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]

OCA at 14:09, 3 November 2014

OCA — Mon, 03 Nov 2014 14:09:19 GMT

←Older revision		Revision as of 14:09, 3 November 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1naa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Phanerochaete_chrysosporium Phanerochaete chrysosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NAA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1naa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Phanerochaete_chrysosporium Phanerochaete chrysosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NAA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6FA:6-HYDROXY-FLAVIN-ADENINE+DINUCLEOTIDE'>6FA</scene>, <scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6FA:6-HYDROXY-FLAVIN-ADENINE+DINUCLEOTIDE'>6FA</scene>, <scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kdg\|1kdg]], [[1d7b\|1d7b]], [[1d7c\|1d7c]], [[1d7d\|1d7d]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kdg\|1kdg]], [[1d7b\|1d7b]], [[1d7c\|1d7c]], [[1d7d\|1d7d]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellobiose_dehydrogenase_(acceptor) Cellobiose dehydrogenase (acceptor)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.99.18 1.1.99.18] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellobiose_dehydrogenase_(acceptor) Cellobiose dehydrogenase (acceptor)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.99.18 1.1.99.18] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1naa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1naa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1naa RCSB], [http://www.ebi.ac.uk/pdbsum/1naa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1naa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1naa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1naa RCSB], [http://www.ebi.ac.uk/pdbsum/1naa PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 42:		Line 42:
	[[Category: Phbh fold]]		[[Category: Phbh fold]]
	[[Category: Product analogue complex]]		[[Category: Product analogue complex]]
-	[[Category: ~~Rossman~~ fold]]	+	[[Category: Rossmann fold]]

OCA at 14:02, 28 September 2014

OCA — Sun, 28 Sep 2014 14:02:25 GMT

←Older revision		Revision as of 14:02, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1naa.~~png~~\|~~left~~\|200px]]	+	==Cellobiose Dehydrogenase Flavoprotein Fragment in Complex with Cellobionolactam==
		+	<StructureSection load='1naa' size='340' side='right' caption='[[1naa]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1naa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Phanerochaete_chrysosporium Phanerochaete chrysosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NAA FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6FA:6-HYDROXY-FLAVIN-ADENINE+DINUCLEOTIDE'>6FA</scene>, <scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kdg\|1kdg]], [[1d7b\|1d7b]], [[1d7c\|1d7c]], [[1d7d\|1d7d]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellobiose_dehydrogenase_(acceptor) Cellobiose dehydrogenase (acceptor)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.99.18 1.1.99.18] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1naa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1naa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1naa RCSB], [http://www.ebi.ac.uk/pdbsum/1naa PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/na/1naa_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The extracellular flavocytochrome cellobiose dehydrogenase (CDH; EC ) participates in lignocellulose degradation by white-rot fungi with a proposed role in the early events of wood degradation. The complete hemoflavoenzyme consists of a catalytically active dehydrogenase fragment (DH(cdh)) connected to a b-type cytochrome domain via a linker peptide. In the reductive half-reaction, DH(cdh) catalyzes the oxidation of cellobiose to yield cellobiono-1,5-lactone. The active site of DH(cdh) is structurally similar to that of glucose oxidase and cholesterol oxidase, with a conserved histidine residue positioned at the re face of the flavin ring close to the N5 atom. The mechanisms of oxidation in glucose oxidase and cholesterol oxidase are still poorly understood, partly because of lack of experimental structure data or difficulties in interpreting existing data for enzyme-ligand complexes. Here we report the crystal structure of the Phanerochaete chrysosporium DH(cdh) with a bound inhibitor, cellobiono-1,5-lactam, at 1.8-A resolution. The distance between the lactam C1 and the flavin N5 is only 2.9 A, implying that in an approximately planar transition state, the maximum distance for the axial 1-hydrogen to travel for covalent addition to N5 is 0.8-0.9 A. The lactam O1 interacts intimately with the side chains of His-689 and Asn-732. Our data lend substantial structural support to a reaction mechanism where His-689 acts as a general base by abstracting the O1 hydroxyl proton in concert with transfer of the C1 hydrogen as hydride to the re face of the flavin N5.

-	~~{{STRUCTURE_1naa\| PDB=1naa \| SCENE= }}~~	+	Mechanism of the reductive half-reaction in cellobiose dehydrogenase.,Hallberg BM, Henriksson G, Pettersson G, Vasella A, Divne C J Biol Chem. 2003 Feb 28;278(9):7160-6. Epub 2002 Dec 19. PMID:12493734<ref>PMID:12493734</ref>

-	~~===Cellobiose Dehydrogenase Flavoprotein Fragment in Complex with Cellobionolactam===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12493734}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1naa]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Phanerochaete_chrysosporium Phanerochaete chrysosporium]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1NAA OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012493734<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Phanerochaete chrysosporium]]		[[Category: Phanerochaete chrysosporium]]
	[[Category: Divne, C.]]		[[Category: Divne, C.]]