1nd0 - Revision history

OCA at 09:19, 16 August 2023

OCA — Wed, 16 Aug 2023 09:19:03 GMT

←Older revision		Revision as of 09:19, 16 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nd0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ND0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nd0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ND0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DP4:(1S,4S)-4-[DIMETHYL(PHENYL)SILYL]-1-METHYLPIPERIDINE+1-OXIDE'>DP4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ncw\|1ncw]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DP4:(1S,4S)-4-[DIMETHYL(PHENYL)SILYL]-1-METHYLPIPERIDINE+1-OXIDE'>DP4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nd0 OCA], [https://pdbe.org/1nd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nd0 RCSB], [https://www.ebi.ac.uk/pdbsum/1nd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nd0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nd0 OCA], [https://pdbe.org/1nd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nd0 RCSB], [https://www.ebi.ac.uk/pdbsum/1nd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nd0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q58EU8_MOUSE Q58EU8_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Wilson~~, I A~~]]	+	[[Category: Wilson IA]]
-	[[Category: Zhu, X]]	+	[[Category: Zhu X]]
-	~~[[Category: Catalytic antibody]]~~	+
-	~~[[Category: Cationic cyclization reaction]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin~~]]	+

OCA at 07:01, 25 August 2021

OCA — Wed, 25 Aug 2021 07:01:15 GMT

←Older revision		Revision as of 07:01, 25 August 2021
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	<StructureSection load='1nd0' size='340' side='right'caption='[[1nd0]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='1nd0' size='340' side='right'caption='[[1nd0]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nd0]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ND0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nd0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ND0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DP4:(1S,4S)-4-[DIMETHYL(PHENYL)SILYL]-1-METHYLPIPERIDINE+1-OXIDE'>DP4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DP4:(1S,4S)-4-[DIMETHYL(PHENYL)SILYL]-1-METHYLPIPERIDINE+1-OXIDE'>DP4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ncw\|1ncw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ncw\|1ncw]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1nd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nd0 OCA], [~~http~~://pdbe.org/1nd0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1nd0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1nd0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1nd0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nd0 OCA], [https://pdbe.org/1nd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nd0 RCSB], [https://www.ebi.ac.uk/pdbsum/1nd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nd0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 18:45, 20 November 2019

OCA — Wed, 20 Nov 2019 18:45:23 GMT

←Older revision		Revision as of 18:45, 20 November 2019
Line 1:		Line 1:

	==CATIONIC CYCLIZATION ANTIBODY 4C6 COMPLEX WITH TRANSITION STATE ANALOG==		==CATIONIC CYCLIZATION ANTIBODY 4C6 COMPLEX WITH TRANSITION STATE ANALOG==
-	<StructureSection load='1nd0' size='340' side='right' caption='[[1nd0]], [[Resolution\|resolution]] 2.45Å' scene=''>	+	<StructureSection load='1nd0' size='340' side='right'caption='[[1nd0]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nd0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ND0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nd0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ND0 FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1nd0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1nd0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]

OCA at 07:31, 7 February 2018

OCA — Wed, 07 Feb 2018 07:31:54 GMT

←Older revision		Revision as of 07:31, 7 February 2018
Line 1:		Line 1:
		+
	==CATIONIC CYCLIZATION ANTIBODY 4C6 COMPLEX WITH TRANSITION STATE ANALOG==		==CATIONIC CYCLIZATION ANTIBODY 4C6 COMPLEX WITH TRANSITION STATE ANALOG==
	<StructureSection load='1nd0' size='340' side='right' caption='[[1nd0]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='1nd0' size='340' side='right' caption='[[1nd0]], [[Resolution\|resolution]] 2.45Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DP4:(1S,4S)-4-[DIMETHYL(PHENYL)SILYL]-1-METHYLPIPERIDINE+1-OXIDE'>DP4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DP4:(1S,4S)-4-[DIMETHYL(PHENYL)SILYL]-1-METHYLPIPERIDINE+1-OXIDE'>DP4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ncw\|1ncw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ncw\|1ncw]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nd0 OCA], [http://pdbe.org/1nd0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nd0 RCSB], [http://www.ebi.ac.uk/pdbsum/1nd0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nd0 OCA], [http://pdbe.org/1nd0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nd0 RCSB], [http://www.ebi.ac.uk/pdbsum/1nd0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nd0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nd/1nd0_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nd/1nd0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1nd0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1nd0" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Monoclonal Antibody\|Monoclonal Antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:32, 8 February 2016

OCA — Mon, 08 Feb 2016 15:32:34 GMT

←Older revision		Revision as of 15:32, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nd0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:59, 10 September 2015

OCA — Thu, 10 Sep 2015 12:59:11 GMT

←Older revision		Revision as of 12:59, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DP4:(1S,4S)-4-[DIMETHYL(PHENYL)SILYL]-1-METHYLPIPERIDINE+1-OXIDE'>DP4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DP4:(1S,4S)-4-[DIMETHYL(PHENYL)SILYL]-1-METHYLPIPERIDINE+1-OXIDE'>DP4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ncw\|1ncw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ncw\|1ncw]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nd0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nd0 RCSB], [http://www.ebi.ac.uk/pdbsum/1nd0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nd0 OCA], [http://pdbe.org/1nd0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nd0 RCSB], [http://www.ebi.ac.uk/pdbsum/1nd0 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1nd0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:02, 5 January 2015

OCA — Mon, 05 Jan 2015 17:02:42 GMT

←Older revision		Revision as of 17:02, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nd0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ND0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nd0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ND0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DP4:(1S,4S)-4-[DIMETHYL(PHENYL)SILYL]-1-METHYLPIPERIDINE+1-OXIDE'>DP4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DP4:(1S,4S)-4-[DIMETHYL(PHENYL)SILYL]-1-METHYLPIPERIDINE+1-OXIDE'>DP4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ncw\|1ncw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ncw\|1ncw]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nd0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nd0 RCSB], [http://www.ebi.ac.uk/pdbsum/1nd0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nd0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nd0 RCSB], [http://www.ebi.ac.uk/pdbsum/1nd0 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
-	[[Category: Zhu, X.]]	+	[[Category: Zhu, X]]
	[[Category: Catalytic antibody]]		[[Category: Catalytic antibody]]
	[[Category: Cationic cyclization reaction]]		[[Category: Cationic cyclization reaction]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

OCA at 15:13, 28 September 2014

OCA — Sun, 28 Sep 2014 15:13:50 GMT

←Older revision		Revision as of 15:13, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1nd0.~~png~~\|~~left~~\|200px]]	+	==CATIONIC CYCLIZATION ANTIBODY 4C6 COMPLEX WITH TRANSITION STATE ANALOG==
		+	<StructureSection load='1nd0' size='340' side='right' caption='[[1nd0]], [[Resolution\|resolution]] 2.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1nd0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ND0 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DP4:(1S,4S)-4-[DIMETHYL(PHENYL)SILYL]-1-METHYLPIPERIDINE+1-OXIDE'>DP4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ncw\|1ncw]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nd0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nd0 RCSB], [http://www.ebi.ac.uk/pdbsum/1nd0 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nd/1nd0_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antibody 4C6 efficiently catalyzes a cationic cyclization reaction. Crystal structures of the antibody 4C6 Fab in complex with benzoic acid and in complex with its eliciting hapten were determined to 1.30A and 2.45A resolution, respectively. These crystal structures, together with computational analysis, have elucidated a possible mechanism for the monocyclization reaction. The hapten complex revealed a combining site pocket with high shape complementarity to the hapten. This active site cleft is dominated by aromatic residues that shield the highly reactive carbocation intermediates from solvent and stabilize the carbocation intermediates through cation-pi interactions. Modeling of an acyclic olefinic sulfonate ester substrate and the transition state (TS) structures shows that the chair-like transition state is favored, and trapping by water directly produces trans-2-(dimethylphenylsilyl)-cyclohexanol, whereas the less favored boat-like transition state leads to cyclohexene. The only significant change observed upon hapten binding is a side-chain rotation of Trp(L89), which reorients to form the base of the combining site. Intriguingly, a benzoic acid molecule was sequestered in the combining site of the unliganded antibody. The 4C6 active site was compared to that observed in a previously reported tandem cyclization antibody 19A4 hapten complex. These cationic cyclization antibodies exhibit convergent structural features with terpenoid cyclases that appear to be important for catalysis.

-	~~{{STRUCTURE_1nd0\| PDB=1nd0 \| SCENE= }}~~	+	Structural basis for antibody catalysis of a cationic cyclization reaction.,Zhu X, Heine A, Monnat F, Houk KN, Janda KD, Wilson IA J Mol Biol. 2003 May 23;329(1):69-83. PMID:12742019<ref>PMID:12742019</ref>

-	~~===CATIONIC CYCLIZATION ANTIBODY 4C6 COMPLEX WITH TRANSITION STATE ANALOG===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_12742019}}~~	+	==See Also==
-		+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1nd0~~]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND0 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:012742019<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Wilson, I A.]]		[[Category: Wilson, I A.]]

OCA: Protected "1nd0" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 21:20:06 GMT

Protected "1nd0" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:20, 5 December 2012

OCA at 21:20, 5 December 2012

OCA — Wed, 05 Dec 2012 21:20:04 GMT

←Older revision		Revision as of 21:20, 5 December 2012
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-	{{Seed}}
	[[Image:1nd0.png\|left\|200px]]		[[Image:1nd0.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1nd0\| PDB=1nd0 \| SCENE= }}		{{STRUCTURE_1nd0\| PDB=1nd0 \| SCENE= }}

	===CATIONIC CYCLIZATION ANTIBODY 4C6 COMPLEX WITH TRANSITION STATE ANALOG===		===CATIONIC CYCLIZATION ANTIBODY 4C6 COMPLEX WITH TRANSITION STATE ANALOG===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12742019}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_12742019}}		{{ABSTRACT_PUBMED_12742019}}

	==About this Structure==		==About this Structure==
-	~~1ND0~~ is a 8 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND0 OCA].	+	[[1nd0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND0 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12742019~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012742019</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Wilson, I A.]]		[[Category: Wilson, I A.]]
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	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 10 10:51:53 2010''