1np9 - Revision history

OCA at 18:53, 29 November 2023

OCA — Wed, 29 Nov 2023 18:53:40 GMT

←Older revision		Revision as of 18:53, 29 November 2023
Line 1:		Line 1:

	==Structure of the parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat==		==Structure of the parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat==
-	<StructureSection load='1np9' size='340' side='right'caption='[[1np9~~]], [[NMR_Ensembles_of_Models \| 11 NMR models~~]]' scene=''>	+	<StructureSection load='1np9' size='340' side='right'caption='[[1np9]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1np9]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NP9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1np9]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NP9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1np9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1np9 OCA], [https://pdbe.org/1np9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1np9 RCSB], [https://www.ebi.ac.uk/pdbsum/1np9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1np9 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1np9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1np9 OCA], [https://pdbe.org/1np9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1np9 RCSB], [https://www.ebi.ac.uk/pdbsum/1np9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1np9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gavathiotis, E]]	+	[[Category: Gavathiotis E]]
-	[[Category: Searle~~, M S]]~~	+	[[Category: Searle MS]]
-	~~[[Category: A-tetrad]]~~	+
-	~~[[Category: Dna]]~~	+
-	~~[[Category: Parallel-stranded quadruplex dna]]~~	+
-	~~[[Category: Ttagggt repeat~~]]	+

OCA at 09:52, 12 May 2021

OCA — Wed, 12 May 2021 09:52:49 GMT

←Older revision		Revision as of 09:52, 12 May 2021
Line 3:		Line 3:
	<StructureSection load='1np9' size='340' side='right'caption='[[1np9]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>		<StructureSection load='1np9' size='340' side='right'caption='[[1np9]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1np9]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1NP9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1np9]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NP9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1np9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1np9 OCA], [~~http~~://pdbe.org/1np9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1np9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1np9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1np9 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1np9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1np9 OCA], [https://pdbe.org/1np9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1np9 RCSB], [https://www.ebi.ac.uk/pdbsum/1np9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1np9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:42, 7 August 2019

OCA — Wed, 07 Aug 2019 06:42:26 GMT

←Older revision		Revision as of 06:42, 7 August 2019
Line 1:		Line 1:

	==Structure of the parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat==		==Structure of the parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat==
-	<StructureSection load='1np9' size='340' side='right' caption='[[1np9]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>	+	<StructureSection load='1np9' size='340' side='right'caption='[[1np9]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1np9]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NP9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1np9]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NP9 FirstGlance]. <br>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gavathiotis, E]]		[[Category: Gavathiotis, E]]
	[[Category: Searle, M S]]		[[Category: Searle, M S]]

OCA at 09:52, 1 November 2017

OCA — Wed, 01 Nov 2017 09:52:20 GMT

←Older revision		Revision as of 09:52, 1 November 2017
Line 1:		Line 1:
		+
	==Structure of the parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat==		==Structure of the parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat==
	<StructureSection load='1np9' size='340' side='right' caption='[[1np9]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>		<StructureSection load='1np9' size='340' side='right' caption='[[1np9]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1np9]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NP9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1np9]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NP9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1np9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1np9 OCA], [http://pdbe.org/1np9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1np9 RCSB], [http://www.ebi.ac.uk/pdbsum/1np9 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1np9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1np9 OCA], [http://pdbe.org/1np9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1np9 RCSB], [http://www.ebi.ac.uk/pdbsum/1np9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1np9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:08, 10 September 2015

OCA — Thu, 10 Sep 2015 06:08:31 GMT

←Older revision		Revision as of 06:08, 10 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1np9]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NP9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1np9]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NP9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1np9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1np9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1np9 RCSB], [http://www.ebi.ac.uk/pdbsum/1np9 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1np9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1np9 OCA], [http://pdbe.org/1np9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1np9 RCSB], [http://www.ebi.ac.uk/pdbsum/1np9 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1np9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:26, 5 January 2015

OCA — Mon, 05 Jan 2015 16:26:08 GMT

←Older revision		Revision as of 16:26, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1np9]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NP9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1np9]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NP9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1np9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1np9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1np9 RCSB], [http://www.ebi.ac.uk/pdbsum/1np9 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1np9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1np9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1np9 RCSB], [http://www.ebi.ac.uk/pdbsum/1np9 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Gavathiotis, E.]]	+	[[Category: Gavathiotis, E]]
-	[[Category: Searle, M S.]]	+	[[Category: Searle, M S]]
	[[Category: A-tetrad]]		[[Category: A-tetrad]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Parallel-stranded quadruplex dna]]		[[Category: Parallel-stranded quadruplex dna]]
	[[Category: Ttagggt repeat]]		[[Category: Ttagggt repeat]]

OCA at 14:52, 28 September 2014

OCA — Sun, 28 Sep 2014 14:52:59 GMT

←Older revision		Revision as of 14:52, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1np9.~~png\|left\|200px~~]]	+	==Structure of the parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat==
		+	<StructureSection load='1np9' size='340' side='right' caption='[[1np9]], [[NMR_Ensembles_of_Models \| 11 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1np9]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NP9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1np9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1np9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1np9 RCSB], [http://www.ebi.ac.uk/pdbsum/1np9 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of the intermolecular DNA quadruplex d(TTAGGGT)4, based on the human telomeric DNA sequence d(TTAGGG), has been determined in solution by NMR and restrained molecular dynamics simultations. The core GGG region forms a highly stable quadruplex with G-tetrads likely stabilised by K+ ions bound between tetrad plains. However, we have focused on the conformation of the adenines which differ considerably in base alignment, stability and dynamics from those in previously reported structures of d(AGGGT)4 and d(TAGGGT)4. We show unambiguously that the adenines of d(TTAGGGT)4 are involved in the formation of a relatively stable A-tetrad with well-defined glycosidic torsion angles (anti), hydrogen bonding network (adenine 6-NH2-adenine N1) defined by interbase NOEs, and base stacking interactions with the neighbouring G-tetrad. All of these structural features are apparent from NOE data involving both exchangeable and non-exchangeable protons. Thus, context-dependent effects appear to play some role in dictating preferred conformation, stability and dynamics. The structure of d(TTAGGGT)4 provides us with a model system for exploiting in the design of novel telomerase inhibitors that bind to and stabilise G-quadruplex structures.

-	~~{{STRUCTURE_1np9\| PDB=1np9 \| SCENE= }}~~	+	Structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat: evidence for A-tetrad formation from NMR and molecular dynamics simulations.,Gavathiotis E, Searle MS Org Biomol Chem. 2003 May 21;1(10):1650-6. PMID:12926351<ref>PMID:12926351</ref>

-	~~===Structure~~ of the ~~parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12926351}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1np9]] is a 4 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1NP9 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018998644<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Gavathiotis, E.]]		[[Category: Gavathiotis, E.]]
	[[Category: Searle, M S.]]		[[Category: Searle, M S.]]

OCA: Protected "1np9" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 20:40:47 GMT

Protected "1np9" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:40, 5 December 2012

OCA at 20:40, 5 December 2012

OCA — Wed, 05 Dec 2012 20:40:42 GMT

←Older revision		Revision as of 20:40, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1np9.png\|left\|200px]]		[[Image:1np9.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1np9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1np9\| PDB=1np9 \| SCENE= }}		{{STRUCTURE_1np9\| PDB=1np9 \| SCENE= }}

	===Structure of the parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat===		===Structure of the parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12926351}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12926351 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12926351}}		{{ABSTRACT_PUBMED_12926351}}

	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA].	+	[[1np9]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA].

	==Reference==		==Reference==
-	Structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat: evidence for A-tetrad formation from NMR and molecular dynamics simulations., Gavathiotis E, Searle MS, Org Biomol Chem. 2003 May 21;1(10):1650-6. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~12926351 12926351]~~	+	<ref group="xtra">PMID:018998644</ref><references group="xtra"/>
	[[Category: Gavathiotis, E.]]		[[Category: Gavathiotis, E.]]
	[[Category: Searle, M S.]]		[[Category: Searle, M S.]]
	[[Category: A-tetrad]]		[[Category: A-tetrad]]
		+	[[Category: Dna]]
	[[Category: Parallel-stranded quadruplex dna]]		[[Category: Parallel-stranded quadruplex dna]]
	[[Category: Ttagggt repeat]]		[[Category: Ttagggt repeat]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:50:34 2008''

OCA at 17:50, 27 July 2008

OCA — Sun, 27 Jul 2008 17:50:36 GMT

←Older revision		Revision as of 17:50, 27 July 2008
Line 1:		Line 1:
-	[[Image:1np9.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1np9.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1np9\| PDB=1np9 \| SCENE= }}		{{STRUCTURE_1np9\| PDB=1np9 \| SCENE= }}

-	~~'''~~Structure of the parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat~~'''~~	+	===Structure of the parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat===


-	~~==Overview==~~	+	<!--
-	The ~~structure of the intermolecular DNA quadruplex d(TTAGGGT)4~~, ~~based on the human telomeric DNA sequence d(TTAGGG)~~, has been determined in solution by NMR and restrained molecular dynamics simultations. The core GGG region forms a highly stable quadruplex with G-tetrads likely stabilised by K+ ions bound between tetrad plains. However, we have focused on the ~~conformation of~~ the ~~adenines which differ considerably in base alignment, stability and dynamics from those in previously reported structures of d~~(~~AGGGT)4 and d(TAGGGT)4~~. We show unambiguously that the adenines of d(TTAGGGT)4 are involved in the formation of a relatively stable A-tetrad with well-defined glycosidic torsion angles (anti), hydrogen bonding network (adenine 6-NH2-adenine N1) ~~defined by interbase NOEs~~, ~~and base stacking interactions with~~ the ~~neighbouring G-tetrad~~. ~~All of these structural features are apparent from NOE data involving both exchangeable and non~~-~~exchangeable protons. Thus, context~~-dependent effects appear to play some role in dictating preferred conformation, stability and dynamics. The structure of d(TTAGGGT)4 provides us with a model system for exploiting in the design of novel telomerase inhibitors that bind to and stabilise G-quadruplex structures.	+	The line below this paragraph, {{ABSTRACT_PUBMED_12926351}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 12926351 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_12926351}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA].

	==Reference==		==Reference==
Line 25:		Line 29:
	[[Category: Parallel-stranded quadruplex dna]]		[[Category: Parallel-stranded quadruplex dna]]
	[[Category: Ttagggt repeat]]		[[Category: Ttagggt repeat]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 02~~:48:36 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:50:34 2008''