1nqx - Revision history

OCA at 07:59, 14 February 2024

OCA — Wed, 14 Feb 2024 07:59:02 GMT

←Older revision

Revision as of 07:59, 14 February 2024

OCA at 07:05, 25 August 2021

OCA — Wed, 25 Aug 2021 07:05:30 GMT

←Older revision		Revision as of 07:05, 25 August 2021
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	<StructureSection load='1nqx' size='340' side='right'caption='[[1nqx]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='1nqx' size='340' side='right'caption='[[1nqx]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nqx]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1NQX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nqx]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NQX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RLP:3-(7-HYDROXY-8-RIBITYLLUMAZINE-6-YL)+PROPIONIC+ACID'>RLP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RLP:3-(7-HYDROXY-8-RIBITYLLUMAZINE-6-YL)+PROPIONIC+ACID'>RLP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nqv\|1nqv]], [[1nqu\|1nqu]], [[1nqw\|1nqw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nqv\|1nqv]], [[1nqu\|1nqu]], [[1nqw\|1nqw]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/6,7-dimethyl-8-ribityllumazine_synthase 6,7-dimethyl-8-ribityllumazine synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.78 2.5.1.78] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/6,7-dimethyl-8-ribityllumazine_synthase 6,7-dimethyl-8-ribityllumazine synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.78 2.5.1.78] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1nqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqx OCA], [~~http~~://pdbe.org/1nqx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1nqx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1nqx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1nqx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqx OCA], [https://pdbe.org/1nqx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nqx RCSB], [https://www.ebi.ac.uk/pdbsum/1nqx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nqx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RISB_AQUAE RISB_AQUAE]] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.<ref>PMID:12603336</ref> <ref>PMID:11237620</ref>	+	[[https://www.uniprot.org/uniprot/RISB_AQUAE RISB_AQUAE]] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.<ref>PMID:12603336</ref> <ref>PMID:11237620</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 18:14, 20 November 2019

OCA — Wed, 20 Nov 2019 18:14:44 GMT

←Older revision		Revision as of 18:14, 20 November 2019
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	==Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 3-(7-hydroxy-8-ribityllumazine-6-yl)propionic acid==		==Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 3-(7-hydroxy-8-ribityllumazine-6-yl)propionic acid==
-	<StructureSection load='1nqx' size='340' side='right' caption='[[1nqx]], [[Resolution\|resolution]] 1.82Å' scene=''>	+	<StructureSection load='1nqx' size='340' side='right'caption='[[1nqx]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nqx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NQX FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nqx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NQX FirstGlance]. <br>
Line 36:		Line 36:
	[[Category: Aquifex aeolicus huber and stetter 2001]]		[[Category: Aquifex aeolicus huber and stetter 2001]]
	[[Category: 6,7-dimethyl-8-ribityllumazine synthase]]		[[Category: 6,7-dimethyl-8-ribityllumazine synthase]]
		+	[[Category: Large Structures]]
	[[Category: Bacher, A]]		[[Category: Bacher, A]]
	[[Category: Cushman, M]]		[[Category: Cushman, M]]

OCA at 07:03, 7 February 2018

OCA — Wed, 07 Feb 2018 07:03:53 GMT

←Older revision		Revision as of 07:03, 7 February 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 3-(7-hydroxy-8-ribityllumazine-6-yl)propionic acid==		==Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 3-(7-hydroxy-8-ribityllumazine-6-yl)propionic acid==
	<StructureSection load='1nqx' size='340' side='right' caption='[[1nqx]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='1nqx' size='340' side='right' caption='[[1nqx]], [[Resolution\|resolution]] 1.82Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nqv\|1nqv]], [[1nqu\|1nqu]], [[1nqw\|1nqw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nqv\|1nqv]], [[1nqu\|1nqu]], [[1nqw\|1nqw]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6,7-dimethyl-8-ribityllumazine_synthase 6,7-dimethyl-8-ribityllumazine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.78 2.5.1.78] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6,7-dimethyl-8-ribityllumazine_synthase 6,7-dimethyl-8-ribityllumazine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.78 2.5.1.78] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqx OCA], [http://pdbe.org/1nqx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nqx RCSB], [http://www.ebi.ac.uk/pdbsum/1nqx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqx OCA], [http://pdbe.org/1nqx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nqx RCSB], [http://www.ebi.ac.uk/pdbsum/1nqx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nqx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/1nqx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/1nqx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:16, 7 February 2016

OCA — Sun, 07 Feb 2016 06:16:31 GMT

←Older revision		Revision as of 06:16, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nqx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:38, 9 September 2015

OCA — Wed, 09 Sep 2015 22:38:37 GMT

←Older revision		Revision as of 22:38, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1nqx' size='340' side='right' caption='[[1nqx]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='1nqx' size='340' side='right' caption='[[1nqx]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nqx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aquifex_aeolicus Aquifex~~ aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NQX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nqx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NQX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RLP:3-(7-HYDROXY-8-RIBITYLLUMAZINE-6-YL)+PROPIONIC+ACID'>RLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RLP:3-(7-HYDROXY-8-RIBITYLLUMAZINE-6-YL)+PROPIONIC+ACID'>RLP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nqv\|1nqv]], [[1nqu\|1nqu]], [[1nqw\|1nqw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nqv\|1nqv]], [[1nqu\|1nqu]], [[1nqw\|1nqw]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6,7-dimethyl-8-ribityllumazine_synthase 6,7-dimethyl-8-ribityllumazine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.78 2.5.1.78] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6,7-dimethyl-8-ribityllumazine_synthase 6,7-dimethyl-8-ribityllumazine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.78 2.5.1.78] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nqx RCSB], [http://www.ebi.ac.uk/pdbsum/1nqx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqx OCA], [http://pdbe.org/1nqx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nqx RCSB], [http://www.ebi.ac.uk/pdbsum/1nqx PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1nqx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aquifex aeolicus huber and stetter 2001]]
	[[Category: 6,7-dimethyl-8-ribityllumazine synthase]]		[[Category: 6,7-dimethyl-8-ribityllumazine synthase]]
-	[[Category: Aquifex aeolicus]]
	[[Category: Bacher, A]]		[[Category: Bacher, A]]
	[[Category: Cushman, M]]		[[Category: Cushman, M]]
Line 41:		Line 42:
	[[Category: Meining, W]]		[[Category: Meining, W]]
	[[Category: Zhang, X]]		[[Category: Zhang, X]]
		+	[[Category: Aquifex aeolicus]]
	[[Category: Catalytic mechanism]]		[[Category: Catalytic mechanism]]
	[[Category: Inhibitor complex]]		[[Category: Inhibitor complex]]

OCA at 08:33, 24 December 2014

OCA — Wed, 24 Dec 2014 08:33:54 GMT

←Older revision		Revision as of 08:33, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nqx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NQX FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nqx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NQX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RLP:3-(7-HYDROXY-8-RIBITYLLUMAZINE-6-YL)+PROPIONIC+ACID'>RLP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RLP:3-(7-HYDROXY-8-RIBITYLLUMAZINE-6-YL)+PROPIONIC+ACID'>RLP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nqv\|1nqv]], [[1nqu\|1nqu]], [[1nqw\|1nqw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nqv\|1nqv]], [[1nqu\|1nqu]], [[1nqw\|1nqw]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6,7-dimethyl-8-ribityllumazine_synthase 6,7-dimethyl-8-ribityllumazine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.78 2.5.1.78] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6,7-dimethyl-8-ribityllumazine_synthase 6,7-dimethyl-8-ribityllumazine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.78 2.5.1.78] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nqx RCSB], [http://www.ebi.ac.uk/pdbsum/1nqx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nqx RCSB], [http://www.ebi.ac.uk/pdbsum/1nqx PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RISB_AQUAE RISB_AQUAE]] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.<ref>PMID:12603336</ref> <ref>PMID:11237620</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	[[Category: 6,7-dimethyl-8-ribityllumazine synthase]]		[[Category: 6,7-dimethyl-8-ribityllumazine synthase]]
	[[Category: Aquifex aeolicus]]		[[Category: Aquifex aeolicus]]
-	[[Category: Bacher, A.]]	+	[[Category: Bacher, A]]
-	[[Category: Cushman, M.]]	+	[[Category: Cushman, M]]
-	[[Category: Fischer, M.]]	+	[[Category: Fischer, M]]
-	[[Category: Haase, I.]]	+	[[Category: Haase, I]]
-	[[Category: Ladenstein, R.]]	+	[[Category: Ladenstein, R]]
-	[[Category: Meining, W.]]	+	[[Category: Meining, W]]
-	[[Category: Zhang, X~~.]]~~	+	[[Category: Zhang, X]]
-	~~[[Category: Aquifex aeolicus~~]]	+
	[[Category: Catalytic mechanism]]		[[Category: Catalytic mechanism]]
	[[Category: Inhibitor complex]]		[[Category: Inhibitor complex]]

OCA at 14:56, 29 September 2014

OCA — Mon, 29 Sep 2014 14:56:00 GMT

←Older revision		Revision as of 14:56, 29 September 2014
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-	[[~~Image:~~1nqx.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 3-(7-hydroxy-8-ribityllumazine-6-yl)propionic acid==
		+	<StructureSection load='1nqx' size='340' side='right' caption='[[1nqx]], [[Resolution\|resolution]] 1.82Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1nqx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NQX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RLP:3-(7-HYDROXY-8-RIBITYLLUMAZINE-6-YL)+PROPIONIC+ACID'>RLP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nqv\|1nqv]], [[1nqu\|1nqu]], [[1nqw\|1nqw]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6,7-dimethyl-8-ribityllumazine_synthase 6,7-dimethyl-8-ribityllumazine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.78 2.5.1.78] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nqx RCSB], [http://www.ebi.ac.uk/pdbsum/1nqx PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/1nqx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	6,7-Dimethyl-8-ribityllumazine is the biosynthetic precursor of riboflavin, which, as a coenzyme, plays a vital role in the electron transfer process for energy production in all cellular organisms. The enzymes involved in lumazine biosynthesis have been studied in considerable detail. However, the conclusive mechanism of the reaction catalyzed by lumazine synthase has remained unclear. Here, we report four crystal structures of the enzyme from the hyperthermophilic bacterium Aquifex aeolicus in complex with different inhibitor compounds. The structures were refined at resolutions of 1.72 A, 1.85 A, 2.05 A and 2.2 A, respectively. The inhibitors have been designed in order to mimic the substrate, the putative reaction intermediates and the final product. Structural comparisons of the native enzyme and the inhibitor complexes as well as the kinetic data of single-site mutants of lumazine synthase from Bacillus subtilis showed that several highly conserved residues at the active site, namely Phe22, His88, Arg127, Lys135 and Glu138 are most likely involved in catalysis. A structural model of the catalytic process, which illustrates binding of substrates, enantiomer specificity, proton abstraction/donation, inorganic phosphate elimination, formation of the Schiff base and cyclization is proposed.

-	~~{{STRUCTURE_1nqx\| PDB=1nqx \| SCENE= }}~~	+	A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus.,Zhang X, Meining W, Cushman M, Haase I, Fischer M, Bacher A, Ladenstein R J Mol Biol. 2003 Apr 18;328(1):167-82. PMID:12684006<ref>PMID:12684006</ref>

-	~~===Crystal Structure~~ of ~~Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 3-(7-hydroxy-8-ribityllumazine-6-yl)propionic acid===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12684006}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1nqx]] is a 5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aquifex_aeolicus Aquifex aeolicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1NQX OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012684006<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: 6,7-dimethyl-8-ribityllumazine synthase]]		[[Category: 6,7-dimethyl-8-ribityllumazine synthase]]
	[[Category: Aquifex aeolicus]]		[[Category: Aquifex aeolicus]]

OCA at 09:15, 16 January 2013

OCA — Wed, 16 Jan 2013 09:15:44 GMT

←Older revision		Revision as of 09:15, 16 January 2013
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	==Reference==		==Reference==
	<ref group="xtra">PMID:012684006</ref><references group="xtra"/>		<ref group="xtra">PMID:012684006</ref><references group="xtra"/>
		+	[[Category: 6,7-dimethyl-8-ribityllumazine synthase]]
	[[Category: Aquifex aeolicus]]		[[Category: Aquifex aeolicus]]
-	[[Category: Riboflavin synthase]]
	[[Category: Bacher, A.]]		[[Category: Bacher, A.]]
	[[Category: Cushman, M.]]		[[Category: Cushman, M.]]

OCA: Protected "1nqx" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 19:39:01 GMT

Protected "1nqx" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:39, 5 December 2012