1ntn - Revision history

OCA at 08:53, 10 April 2024

OCA — Wed, 10 Apr 2024 08:53:08 GMT

←Older revision		Revision as of 08:53, 10 April 2024
Line 3:		Line 3:
	<StructureSection load='1ntn' size='340' side='right'caption='[[1ntn]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1ntn' size='340' side='right'caption='[[1ntn]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ntn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Central_asian_cobra Central asian cobra~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NTN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ntn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NTN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ntn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntn OCA], [https://pdbe.org/1ntn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ntn RCSB], [https://www.ebi.ac.uk/pdbsum/1ntn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ntn ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ntn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntn OCA], [https://pdbe.org/1ntn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ntn RCSB], [https://www.ebi.ac.uk/pdbsum/1ntn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ntn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~NXL1_NAJOX NXL1_NAJOX]~~] Binds with high affinity to muscular and neuronal alpha-7 nicotinic acetylcholine receptors (~~nAChRs~~).<ref>PMID:9305882</ref>	+	[https://www.uniprot.org/uniprot/3L21_NAJOX 3L21_NAJOX] Binds with high affinity to muscular (tested on Torpedo marmorata AChR, Kd=0.38 nM) and neuronal (tested on chimeric alpha-7/CHRNA7, Kd=12 nM) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission (PubMed:9305882). The toxin also shows a very weak inhibition of GABA(A) receptors composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (PubMed:26221036).<ref>PMID:26221036</ref> <ref>PMID:9305882</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ntn ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ntn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Neurotoxin-1 from Naja naja oxiana venom (NTX-1) has been crystallized by vapor diffusion in sitting drops. The crystals have cell dimensions of a = 25.2 A, b = 75.6 A, c = 35.9 A, and are in space group P2(1)2(1)2(1). Three-dimensional data to 1.9 A have been recorded by a Syntex P2(1) automatic diffractometer. The atomic structure of the toxin has been determined by molecular replacement using the alpha-cobratoxin (alpha-CTX) as the search model. The position of 534 non-hydrogen protein atoms have been determined. The model contains 65 water molecules. Refinement has led to an R-factor of 19.3% at 1.9 A resolution. The secondary and tertiary structures of NTX-1 have been analyzed and a comparison with structure of the alpha-CTX has been made.
-
-	Three-dimensional structure of neurotoxin-1 from Naja naja oxiana venom at 1.9 A resolution.,Nickitenko AV, Michailov AM, Betzel C, Wilson KS FEBS Lett. 1993 Apr 5;320(2):111-7. PMID:8458425<ref>PMID:8458425</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1ntn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Central asian cobra]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Betzel, C]]	+	[[Category: Naja oxiana]]
-	[[Category: Mikhailov~~, A M~~]]	+	[[Category: Betzel C]]
-	[[Category: Nickitenko~~, A V~~]]	+	[[Category: Mikhailov AM]]
-	[[Category: Vainshtein~~, B K~~]]	+	[[Category: Nickitenko AV]]
-	[[Category: Wilson, K]]	+	[[Category: Vainshtein BK]]
-	~~[[Category: Postsynaptic neurotoxin~~]]	+	[[Category: Wilson K]]

OCA at 07:06, 25 August 2021

OCA — Wed, 25 Aug 2021 07:06:06 GMT

←Older revision		Revision as of 07:06, 25 August 2021
Line 3:		Line 3:
	<StructureSection load='1ntn' size='340' side='right'caption='[[1ntn]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1ntn' size='340' side='right'caption='[[1ntn]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ntn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Central_asian_cobra Central asian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1NTN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ntn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Central_asian_cobra Central asian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NTN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ntn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntn OCA], [~~http~~://pdbe.org/1ntn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ntn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ntn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ntn ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ntn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntn OCA], [https://pdbe.org/1ntn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ntn RCSB], [https://www.ebi.ac.uk/pdbsum/1ntn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ntn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NXL1_NAJOX NXL1_NAJOX]] Binds with high affinity to muscular and neuronal alpha-7 nicotinic acetylcholine receptors (nAChRs).<ref>PMID:9305882</ref>	+	[[https://www.uniprot.org/uniprot/NXL1_NAJOX NXL1_NAJOX]] Binds with high affinity to muscular and neuronal alpha-7 nicotinic acetylcholine receptors (nAChRs).<ref>PMID:9305882</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 18:24, 20 November 2019

OCA — Wed, 20 Nov 2019 18:24:37 GMT

←Older revision		Revision as of 18:24, 20 November 2019
Line 1:		Line 1:

	==THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION==		==THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION==
-	<StructureSection load='1ntn' size='340' side='right' caption='[[1ntn]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1ntn' size='340' side='right'caption='[[1ntn]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ntn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Central_asian_cobra Central asian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NTN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ntn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Central_asian_cobra Central asian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NTN FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/1ntn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/1ntn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Central asian cobra]]		[[Category: Central asian cobra]]
		+	[[Category: Large Structures]]
	[[Category: Betzel, C]]		[[Category: Betzel, C]]
	[[Category: Mikhailov, A M]]		[[Category: Mikhailov, A M]]

OCA at 06:49, 29 November 2017

OCA — Wed, 29 Nov 2017 06:49:29 GMT

←Older revision		Revision as of 06:49, 29 November 2017
Line 1:		Line 1:
		+
	==THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION==		==THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION==
	<StructureSection load='1ntn' size='340' side='right' caption='[[1ntn]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1ntn' size='340' side='right' caption='[[1ntn]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ntn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Central_asian_cobra Central asian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NTN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ntn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Central_asian_cobra Central asian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NTN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ntn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntn OCA], [http://pdbe.org/1ntn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ntn RCSB], [http://www.ebi.ac.uk/pdbsum/1ntn PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ntn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntn OCA], [http://pdbe.org/1ntn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ntn RCSB], [http://www.ebi.ac.uk/pdbsum/1ntn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ntn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:54, 10 February 2016

OCA — Wed, 10 Feb 2016 07:54:00 GMT

←Older revision		Revision as of 07:54, 10 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ntn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:52, 11 September 2015

OCA — Fri, 11 Sep 2015 06:52:48 GMT

←Older revision		Revision as of 06:52, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1ntn' size='340' side='right' caption='[[1ntn]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1ntn' size='340' side='right' caption='[[1ntn]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ntn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Naja_oxiana Naja oxiana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NTN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ntn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Central_asian_cobra Central asian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NTN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ntn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ntn RCSB], [http://www.ebi.ac.uk/pdbsum/1ntn PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ntn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntn OCA], [http://pdbe.org/1ntn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ntn RCSB], [http://www.ebi.ac.uk/pdbsum/1ntn PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ntn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Naja oxiana~~]]	+	[[Category: Central asian cobra]]
	[[Category: Betzel, C]]		[[Category: Betzel, C]]
	[[Category: Mikhailov, A M]]		[[Category: Mikhailov, A M]]

OCA at 12:50, 25 December 2014

OCA — Thu, 25 Dec 2014 12:50:24 GMT

←Older revision		Revision as of 12:50, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ntn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NTN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ntn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NTN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ntn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ntn RCSB], [http://www.ebi.ac.uk/pdbsum/1ntn PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ntn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ntn RCSB], [http://www.ebi.ac.uk/pdbsum/1ntn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NXL1_NAJOX NXL1_NAJOX]] Binds with high affinity to muscular and neuronal alpha-7 nicotinic acetylcholine receptors (nAChRs).<ref>PMID:9305882</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Naja oxiana]]		[[Category: Naja oxiana]]
-	[[Category: Betzel, C.]]	+	[[Category: Betzel, C]]
-	[[Category: Mikhailov, A M.]]	+	[[Category: Mikhailov, A M]]
-	[[Category: Nickitenko, A V.]]	+	[[Category: Nickitenko, A V]]
-	[[Category: Vainshtein, B K.]]	+	[[Category: Vainshtein, B K]]
-	[[Category: Wilson, K.]]	+	[[Category: Wilson, K]]
	[[Category: Postsynaptic neurotoxin]]		[[Category: Postsynaptic neurotoxin]]

OCA at 14:59, 28 September 2014

OCA — Sun, 28 Sep 2014 14:59:23 GMT

←Older revision		Revision as of 14:59, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1ntn.~~png\|left~~\|200px]]	+	==THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION==
		+	<StructureSection load='1ntn' size='340' side='right' caption='[[1ntn]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ntn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NTN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ntn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ntn RCSB], [http://www.ebi.ac.uk/pdbsum/1ntn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/1ntn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Neurotoxin-1 from Naja naja oxiana venom (NTX-1) has been crystallized by vapor diffusion in sitting drops. The crystals have cell dimensions of a = 25.2 A, b = 75.6 A, c = 35.9 A, and are in space group P2(1)2(1)2(1). Three-dimensional data to 1.9 A have been recorded by a Syntex P2(1) automatic diffractometer. The atomic structure of the toxin has been determined by molecular replacement using the alpha-cobratoxin (alpha-CTX) as the search model. The position of 534 non-hydrogen protein atoms have been determined. The model contains 65 water molecules. Refinement has led to an R-factor of 19.3% at 1.9 A resolution. The secondary and tertiary structures of NTX-1 have been analyzed and a comparison with structure of the alpha-CTX has been made.

-	~~{{STRUCTURE_1ntn\| PDB=1ntn \| SCENE= }}~~	+	Three-dimensional structure of neurotoxin-1 from Naja naja oxiana venom at 1.9 A resolution.,Nickitenko AV, Michailov AM, Betzel C, Wilson KS FEBS Lett. 1993 Apr 5;320(2):111-7. PMID:8458425<ref>PMID:8458425</ref>

-	~~===THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8458425}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1ntn]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Naja_oxiana Naja oxiana]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:008458425<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Naja oxiana]]		[[Category: Naja oxiana]]
	[[Category: Betzel, C.]]		[[Category: Betzel, C.]]

OCA: Protected "1ntn" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 20:52:24 GMT

Protected "1ntn" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:52, 5 December 2012

OCA at 20:52, 5 December 2012

OCA — Wed, 05 Dec 2012 20:52:21 GMT

←Older revision		Revision as of 20:52, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1ntn.png\|left\|200px]]		[[Image:1ntn.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ntn", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ntn\| PDB=1ntn \| SCENE= }}		{{STRUCTURE_1ntn\| PDB=1ntn \| SCENE= }}

	===THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION===		===THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8458425}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8458425 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8458425}}		{{ABSTRACT_PUBMED_8458425}}

	==About this Structure==		==About this Structure==
-	~~1NTN~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA].	+	[[1ntn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8458425~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008458425</ref><references group="xtra"/>
	[[Category: Naja oxiana]]		[[Category: Naja oxiana]]
	[[Category: Betzel, C.]]		[[Category: Betzel, C.]]
Line 31:		Line 19:
	[[Category: Wilson, K.]]		[[Category: Wilson, K.]]
	[[Category: Postsynaptic neurotoxin]]		[[Category: Postsynaptic neurotoxin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:39:14 2009''