1nw1 - Revision history

OCA at 07:59, 14 February 2024

OCA — Wed, 14 Feb 2024 07:59:59 GMT

←Older revision		Revision as of 07:59, 14 February 2024
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	<StructureSection load='1nw1' size='340' side='right'caption='[[1nw1]], [[Resolution\|resolution]] 2.02Å' scene=''>		<StructureSection load='1nw1' size='340' side='right'caption='[[1nw1]], [[Resolution\|resolution]] 2.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Caeel Caeel~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NW1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NW1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.02Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https://en.wikipedia.org/wiki/Choline_kinase Choline kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.32 2.7.1.32]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [https://pdbe.org/1nw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [https://www.ebi.ac.uk/pdbsum/1nw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nw1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [https://pdbe.org/1nw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [https://www.ebi.ac.uk/pdbsum/1nw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nw1 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CKA2_CAEEL CKA2_CAEEL] Catalyzes the first step in phosphatidylcholine biosynthesis. May contribute to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine but the activity is much higher with choline.<ref>PMID:12758145</ref> <ref>PMID:14960577</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nw1 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nw1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Choline kinase catalyzes the ATP-dependent phosphorylation of choline, the first committed step in the CDP-choline pathway for the biosynthesis of phosphatidylcholine. The 2.0 A crystal structure of a choline kinase from C. elegans (CKA-2) reveals that the enzyme is a homodimeric protein with each monomer organized into a two-domain fold. The structure is remarkably similar to those of protein kinases and aminoglycoside phosphotransferases, despite no significant similarity in amino acid sequence. Comparisons to the structures of other kinases suggest that ATP binds to CKA-2 in a pocket formed by highly conserved and catalytically important residues. In addition, a choline binding site is proposed to be near the ATP binding pocket and formed by several structurally flexible loops.
-
-	The crystal structure of choline kinase reveals a eukaryotic protein kinase fold.,Peisach D, Gee P, Kent C, Xu Z Structure. 2003 Jun;11(6):703-13. PMID:12791258<ref>PMID:12791258</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1nw1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caeel]]~~	+	[[Category: Caenorhabditis elegans]]
-	~~[[Category: Choline kinase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gee, P]]	+	[[Category: Gee P]]
-	[[Category: Kent, C]]	+	[[Category: Kent C]]
-	[[Category: Peisach, D]]	+	[[Category: Peisach D]]
-	[[Category: Xu, Z]]	+	[[Category: Xu Z]]
-	~~[[Category: Phospholipid synthesis]]~~	+
-	~~[[Category: Protein kinase fold]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:53, 12 May 2021

OCA — Wed, 12 May 2021 09:53:42 GMT

←Older revision		Revision as of 09:53, 12 May 2021
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	<StructureSection load='1nw1' size='340' side='right'caption='[[1nw1]], [[Resolution\|resolution]] 2.02Å' scene=''>		<StructureSection load='1nw1' size='340' side='right'caption='[[1nw1]], [[Resolution\|resolution]] 2.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nw1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1NW1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NW1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Choline_kinase Choline kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.32 2.7.1.32] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Choline_kinase Choline kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.32 2.7.1.32] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [~~http~~://pdbe.org/1nw1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1nw1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1nw1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [https://pdbe.org/1nw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [https://www.ebi.ac.uk/pdbsum/1nw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nw1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 06:45, 7 August 2019

OCA — Wed, 07 Aug 2019 06:45:32 GMT

←Older revision		Revision as of 06:45, 7 August 2019
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	==Crystal Structure of Choline Kinase==		==Crystal Structure of Choline Kinase==
-	<StructureSection load='1nw1' size='340' side='right' caption='[[1nw1]], [[Resolution\|resolution]] 2.02Å' scene=''>	+	<StructureSection load='1nw1' size='340' side='right'caption='[[1nw1]], [[Resolution\|resolution]] 2.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NW1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NW1 FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nw1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nw1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:

	==See Also==		==See Also==
		+	*[[Choline kinase 3D structures\|Choline kinase 3D structures]]
	*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]		*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
	== References ==		== References ==
Line 36:		Line 37:
	[[Category: Caeel]]		[[Category: Caeel]]
	[[Category: Choline kinase]]		[[Category: Choline kinase]]
		+	[[Category: Large Structures]]
	[[Category: Gee, P]]		[[Category: Gee, P]]
	[[Category: Kent, C]]		[[Category: Kent, C]]

OCA at 09:55, 1 November 2017

OCA — Wed, 01 Nov 2017 09:55:23 GMT

←Older revision		Revision as of 09:55, 1 November 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Choline Kinase==		==Crystal Structure of Choline Kinase==
	<StructureSection load='1nw1' size='340' side='right' caption='[[1nw1]], [[Resolution\|resolution]] 2.02Å' scene=''>		<StructureSection load='1nw1' size='340' side='right' caption='[[1nw1]], [[Resolution\|resolution]] 2.02Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_kinase Choline kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.32 2.7.1.32] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_kinase Choline kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.32 2.7.1.32] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [http://pdbe.org/1nw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [http://www.ebi.ac.uk/pdbsum/1nw1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [http://pdbe.org/1nw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [http://www.ebi.ac.uk/pdbsum/1nw1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nw1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nw1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:

	==See Also==		==See Also==
-	*[[Choline kinase\|Choline kinase]]
	*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]		*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
	== References ==		== References ==

OCA at 00:30, 12 September 2015

OCA — Sat, 12 Sep 2015 00:30:34 GMT

←Older revision		Revision as of 00:30, 12 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_kinase Choline kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.32 2.7.1.32] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_kinase Choline kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.32 2.7.1.32] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [http://www.ebi.ac.uk/pdbsum/1nw1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [http://pdbe.org/1nw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [http://www.ebi.ac.uk/pdbsum/1nw1 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1nw1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
		+	*[[Choline kinase\|Choline kinase]]
	*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]		*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
	== References ==		== References ==

OCA at 16:29, 5 January 2015

OCA — Mon, 05 Jan 2015 16:29:30 GMT

←Older revision		Revision as of 16:29, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NW1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NW1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_kinase Choline kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.32 2.7.1.32] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_kinase Choline kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.32 2.7.1.32] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [http://www.ebi.ac.uk/pdbsum/1nw1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [http://www.ebi.ac.uk/pdbsum/1nw1 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Caeel]]		[[Category: Caeel]]
	[[Category: Choline kinase]]		[[Category: Choline kinase]]
-	[[Category: Gee, P.]]	+	[[Category: Gee, P]]
-	[[Category: Kent, C.]]	+	[[Category: Kent, C]]
-	[[Category: Peisach, D.]]	+	[[Category: Peisach, D]]
-	[[Category: Xu, Z~~.]]~~	+	[[Category: Xu, Z]]
-	~~[[Category: Choline kinase~~]]	+
	[[Category: Phospholipid synthesis]]		[[Category: Phospholipid synthesis]]
	[[Category: Protein kinase fold]]		[[Category: Protein kinase fold]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:42, 3 October 2014

OCA — Fri, 03 Oct 2014 10:42:09 GMT

←Older revision		Revision as of 10:42, 3 October 2014
Line 2:		Line 2:
	<StructureSection load='1nw1' size='340' side='right' caption='[[1nw1]], [[Resolution\|resolution]] 2.02Å' scene=''>		<StructureSection load='1nw1' size='340' side='right' caption='[[1nw1]], [[Resolution\|resolution]] 2.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. <br>	+	<table><tr><td colspan='2'>[[1nw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NW1 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Glucokinase Glucokinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_kinase Choline kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.32 2.7.1.32] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [http://www.ebi.ac.uk/pdbsum/1nw1 PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [http://www.ebi.ac.uk/pdbsum/1nw1 PDBsum]</span></td></tr>
	<table>		<table>
Line 23:		Line 23:
	The crystal structure of choline kinase reveals a eukaryotic protein kinase fold.,Peisach D, Gee P, Kent C, Xu Z Structure. 2003 Jun;11(6):703-13. PMID:12791258<ref>PMID:12791258</ref>		The crystal structure of choline kinase reveals a eukaryotic protein kinase fold.,Peisach D, Gee P, Kent C, Xu Z Structure. 2003 Jun;11(6):703-13. PMID:12791258<ref>PMID:12791258</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:32, 1 May 2014

OCA — Thu, 01 May 2014 09:32:07 GMT

←Older revision		Revision as of 09:32, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='1nw1' size='340' side='right' caption='[[1nw1]], [[Resolution\|resolution]] 2.02Å' scene=''>		<StructureSection load='1nw1' size='340' side='right' caption='[[1nw1]], [[Resolution\|resolution]] 2.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	[[1nw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. <br>	+	<table><tr><td colspan='2'>[[1nw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. <br>
-	<b>[[Ligand\|Ligands:]]</b> <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
-	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
-	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [http://www.ebi.ac.uk/pdbsum/1nw1 PDBsum]</span><br>	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [http://www.ebi.ac.uk/pdbsum/1nw1 PDBsum]</span></td></tr>
		+	<table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
-	[[Image:Consurf_key_small.gif\|right]]	+	[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
Line 16:		Line 17:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	Choline kinase catalyzes the ATP-dependent phosphorylation of choline, the first committed step in the CDP-choline pathway for the biosynthesis of phosphatidylcholine. The 2.0 A crystal structure of a choline kinase from C. elegans (CKA-2) reveals that the enzyme is a homodimeric protein with each monomer organized into a two-domain fold. The structure is remarkably similar to those of protein kinases and aminoglycoside phosphotransferases, despite no significant similarity in amino acid sequence. Comparisons to the structures of other kinases suggest that ATP binds to CKA-2 in a pocket formed by highly conserved and catalytically important residues. In addition, a choline binding site is proposed to be near the ATP binding pocket and formed by several structurally flexible loops.		Choline kinase catalyzes the ATP-dependent phosphorylation of choline, the first committed step in the CDP-choline pathway for the biosynthesis of phosphatidylcholine. The 2.0 A crystal structure of a choline kinase from C. elegans (CKA-2) reveals that the enzyme is a homodimeric protein with each monomer organized into a two-domain fold. The structure is remarkably similar to those of protein kinases and aminoglycoside phosphotransferases, despite no significant similarity in amino acid sequence. Comparisons to the structures of other kinases suggest that ATP binds to CKA-2 in a pocket formed by highly conserved and catalytically important residues. In addition, a choline binding site is proposed to be near the ATP binding pocket and formed by several structurally flexible loops.
Line 22:		Line 24:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:07, 30 April 2014

OCA — Wed, 30 Apr 2014 10:07:48 GMT

←Older revision		Revision as of 10:07, 30 April 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	[[1nw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. <br>		[[1nw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. <br>
		+	<b>[[Ligand\|Ligands:]]</b> <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [http://www.ebi.ac.uk/pdbsum/1nw1 PDBsum]</span><br>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|right]]		[[Image:Consurf_key_small.gif\|right]]

OCA at 05:31, 30 April 2014

OCA — Wed, 30 Apr 2014 05:31:18 GMT

←Older revision		Revision as of 05:31, 30 April 2014
Line 1:		Line 1:
-	[[Image:~~1nw1~~.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of Choline Kinase==
		+	<StructureSection load='1nw1' size='340' side='right' caption='[[1nw1]], [[Resolution\|resolution]] 2.02Å' scene=''>
		+	== Structural highlights ==
		+	[[1nw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. <br>
		+	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nw1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	== Publication Abstract from PubMed ==
		+	Choline kinase catalyzes the ATP-dependent phosphorylation of choline, the first committed step in the CDP-choline pathway for the biosynthesis of phosphatidylcholine. The 2.0 A crystal structure of a choline kinase from C. elegans (CKA-2) reveals that the enzyme is a homodimeric protein with each monomer organized into a two-domain fold. The structure is remarkably similar to those of protein kinases and aminoglycoside phosphotransferases, despite no significant similarity in amino acid sequence. Comparisons to the structures of other kinases suggest that ATP binds to CKA-2 in a pocket formed by highly conserved and catalytically important residues. In addition, a choline binding site is proposed to be near the ATP binding pocket and formed by several structurally flexible loops.

-	~~{{STRUCTURE_1nw1\| PDB=1nw1 \| SCENE= }}~~	+	The crystal structure of choline kinase reveals a eukaryotic protein kinase fold.,Peisach D, Gee P, Kent C, Xu Z Structure. 2003 Jun;11(6):703-13. PMID:12791258<ref>PMID:12791258</ref>

-	~~===Crystal Structure~~ of ~~Choline Kinase===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	== References ==
-	~~{{ABSTRACT_PUBMED_12791258}}~~	+	<references/>
-		+	__TOC__
-	~~==About this Structure==~~	+	</StructureSection>
-	~~[[1nw1]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA].~~	+	[[Category: Caeel]]
-		+
-	==~~See Also==~~	+
-	*[[Hemoglobin\|Hemoglobin]]	+
-		+
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:012791258<~~/~~ref~~><~~ref group="xtra">PMID:015258570</ref><references group="xtra"~~/>	+
-	[[Category: ~~Caenorhabditis elegans~~]]	+
	[[Category: Choline kinase]]		[[Category: Choline kinase]]
	[[Category: Gee, P.]]		[[Category: Gee, P.]]