1nwh - Revision history

OCA at 09:26, 16 August 2023

OCA — Wed, 16 Aug 2023 09:26:19 GMT

←Older revision		Revision as of 09:26, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1nwh' size='340' side='right'caption='[[1nwh]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1nwh' size='340' side='right'caption='[[1nwh]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nwh]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium~~ influenzae~~" lehmann and neumann 1896~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1NWH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nwh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NWH FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=HTI:(4S)-4-{[(2S)-2-AMINO-3-OXOPROPYL]SULFANYL}-L-HOMOSERINE'>HTI</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[1gl3\|1gl3]]~~, [[~~1brm~~\|~~1brm]], [[1mc4\|1mc4]], [[1mb4\|1mb4]], [[1nx6\|1nx6~~]]~~</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HTI:(4S)-4-{[(2S)-2-AMINO-3-OXOPROPYL]SULFANYL}-L-HOMOSERINE'>HTI</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>asd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~727~~ "~~Bacterium influenzae~~" ~~Lehmann and Neumann 1896])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwh OCA], [https://pdbe.org/1nwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nwh RCSB], [https://www.ebi.ac.uk/pdbsum/1nwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nwh ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate~~-~~semialdehyde_dehydrogenase Aspartate~~-~~semialdehyde dehydrogenase], with EC number~~ [~~http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=1.~~2~~.1.11 1.2.1.11~~] </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1nwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwh OCA], [~~http~~://pdbe.org/1nwh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1nwh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1nwh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1nwh ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DHAS_HAEIN DHAS_HAEIN]] Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.<ref>PMID:12071715</ref>	+	[https://www.uniprot.org/uniprot/DHAS_HAEIN DHAS_HAEIN] Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.<ref>PMID:12071715</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacterium influenzae lehmann and neumann 1896]]
-	[[Category: Aspartate-semialdehyde dehydrogenase]]
-	[[Category: Large Structures]]
-	[[Category: Blanco, J]]
-	[[Category: Moore, R A]]
-	[[Category: Viola, R E]]
-	[[Category: Aspartate semialdehyde]]
-	[[Category: Aspartate semialdehyde dehydrogenase]]
	[[Category: Haemophilus influenzae]]		[[Category: Haemophilus influenzae]]
-	[[Category: ~~Hemithioacetal~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Oxidoreductase~~]]	+	[[Category: Blanco J]]
-	[[Category: ~~Tetrahedral intermediate~~]]	+	[[Category: Moore RA]]
		+	[[Category: Viola RE]]

OCA at 08:58, 2 December 2020

OCA — Wed, 02 Dec 2020 08:58:33 GMT

←Older revision		Revision as of 08:58, 2 December 2020
Line 1:		Line 1:

	==Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae as a Tetrahedral Hemithioacetal Reaction Intermediate at 2.0 A==		==Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae as a Tetrahedral Hemithioacetal Reaction Intermediate at 2.0 A==
-	<StructureSection load='1nwh' size='340' side='right' caption='[[1nwh]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1nwh' size='340' side='right'caption='[[1nwh]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nwh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1NWH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nwh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1NWH FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTI:(4S)-4-{[(2S)-2-AMINO-3-OXOPROPYL]SULFANYL}-L-HOMOSERINE'>HTI</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTI:(4S)-4-{[(2S)-2-AMINO-3-OXOPROPYL]SULFANYL}-L-HOMOSERINE'>HTI</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gl3\|1gl3]], [[1brm\|1brm]], [[1mc4\|1mc4]], [[1mb4\|1mb4]], [[1nx6\|1nx6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gl3\|1gl3]], [[1brm\|1brm]], [[1mc4\|1mc4]], [[1mb4\|1mb4]], [[1nx6\|1nx6]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">asd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">asd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1nwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwh OCA], [http://pdbe.org/1nwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nwh RCSB], [http://www.ebi.ac.uk/pdbsum/1nwh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nwh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1nwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwh OCA], [http://pdbe.org/1nwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nwh RCSB], [http://www.ebi.ac.uk/pdbsum/1nwh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nwh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1nwh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1nwh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aspartate-semialdehyde dehydrogenase 3D structures\|Aspartate-semialdehyde dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 40:
	[[Category: Bacterium influenzae lehmann and neumann 1896]]		[[Category: Bacterium influenzae lehmann and neumann 1896]]
	[[Category: Aspartate-semialdehyde dehydrogenase]]		[[Category: Aspartate-semialdehyde dehydrogenase]]
		+	[[Category: Large Structures]]
	[[Category: Blanco, J]]		[[Category: Blanco, J]]
	[[Category: Moore, R A]]		[[Category: Moore, R A]]

OCA at 07:21, 7 February 2018

OCA — Wed, 07 Feb 2018 07:21:21 GMT

←Older revision		Revision as of 07:21, 7 February 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae as a Tetrahedral Hemithioacetal Reaction Intermediate at 2.0 A==		==Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae as a Tetrahedral Hemithioacetal Reaction Intermediate at 2.0 A==
	<StructureSection load='1nwh' size='340' side='right' caption='[[1nwh]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1nwh' size='340' side='right' caption='[[1nwh]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">asd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">asd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwh OCA], [http://pdbe.org/1nwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nwh RCSB], [http://www.ebi.ac.uk/pdbsum/1nwh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwh OCA], [http://pdbe.org/1nwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nwh RCSB], [http://www.ebi.ac.uk/pdbsum/1nwh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nwh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nwh_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nwh_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1nwh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1nwh" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Aspartate-semialdehyde dehydrogenase\|Aspartate-semialdehyde dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:57, 10 February 2016

OCA — Wed, 10 Feb 2016 04:57:36 GMT

←Older revision		Revision as of 04:57, 10 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nwh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:36, 11 September 2015

OCA — Fri, 11 Sep 2015 05:36:06 GMT

←Older revision		Revision as of 05:36, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1nwh' size='340' side='right' caption='[[1nwh]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1nwh' size='340' side='right' caption='[[1nwh]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nwh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Haemophilus_influenzae Haemophilus~~ influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NWH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nwh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NWH FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTI:(4S)-4-{[(2S)-2-AMINO-3-OXOPROPYL]SULFANYL}-L-HOMOSERINE'>HTI</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTI:(4S)-4-{[(2S)-2-AMINO-3-OXOPROPYL]SULFANYL}-L-HOMOSERINE'>HTI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gl3\|1gl3]], [[1brm\|1brm]], [[1mc4\|1mc4]], [[1mb4\|1mb4]], [[1nx6\|1nx6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gl3\|1gl3]], [[1brm\|1brm]], [[1mc4\|1mc4]], [[1mb4\|1mb4]], [[1nx6\|1nx6]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">asd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 ~~Haemophilus~~ influenzae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">asd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nwh RCSB], [http://www.ebi.ac.uk/pdbsum/1nwh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwh OCA], [http://pdbe.org/1nwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nwh RCSB], [http://www.ebi.ac.uk/pdbsum/1nwh PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1nwh" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacterium influenzae lehmann and neumann 1896]]
	[[Category: Aspartate-semialdehyde dehydrogenase]]		[[Category: Aspartate-semialdehyde dehydrogenase]]
-	[[Category: Haemophilus influenzae]]
	[[Category: Blanco, J]]		[[Category: Blanco, J]]
	[[Category: Moore, R A]]		[[Category: Moore, R A]]
Line 43:		Line 44:
	[[Category: Aspartate semialdehyde]]		[[Category: Aspartate semialdehyde]]
	[[Category: Aspartate semialdehyde dehydrogenase]]		[[Category: Aspartate semialdehyde dehydrogenase]]
		+	[[Category: Haemophilus influenzae]]
	[[Category: Hemithioacetal]]		[[Category: Hemithioacetal]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Tetrahedral intermediate]]		[[Category: Tetrahedral intermediate]]

OCA at 11:56, 25 December 2014

OCA — Thu, 25 Dec 2014 11:56:12 GMT

←Older revision		Revision as of 11:56, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nwh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NWH FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nwh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NWH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTI:(4S)-4-{[(2S)-2-AMINO-3-OXOPROPYL]SULFANYL}-L-HOMOSERINE'>HTI</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTI:(4S)-4-{[(2S)-2-AMINO-3-OXOPROPYL]SULFANYL}-L-HOMOSERINE'>HTI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gl3\|1gl3]], [[1brm\|1brm]], [[1mc4\|1mc4]], [[1mb4\|1mb4]], [[1nx6\|1nx6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gl3\|1gl3]], [[1brm\|1brm]], [[1mc4\|1mc4]], [[1mb4\|1mb4]], [[1nx6\|1nx6]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">asd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">asd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nwh RCSB], [http://www.ebi.ac.uk/pdbsum/1nwh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nwh RCSB], [http://www.ebi.ac.uk/pdbsum/1nwh PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DHAS_HAEIN DHAS_HAEIN]] Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.<ref>PMID:12071715</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Aspartate-semialdehyde dehydrogenase]]		[[Category: Aspartate-semialdehyde dehydrogenase]]
	[[Category: Haemophilus influenzae]]		[[Category: Haemophilus influenzae]]
-	[[Category: Blanco, J.]]	+	[[Category: Blanco, J]]
-	[[Category: Moore, R A.]]	+	[[Category: Moore, R A]]
-	[[Category: Viola, R E.]]	+	[[Category: Viola, R E]]
	[[Category: Aspartate semialdehyde]]		[[Category: Aspartate semialdehyde]]
	[[Category: Aspartate semialdehyde dehydrogenase]]		[[Category: Aspartate semialdehyde dehydrogenase]]
-	[[Category: Haemophilus influenzae]]
	[[Category: Hemithioacetal]]		[[Category: Hemithioacetal]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Tetrahedral intermediate]]		[[Category: Tetrahedral intermediate]]

OCA at 13:55, 28 September 2014

OCA — Sun, 28 Sep 2014 13:55:31 GMT

←Older revision		Revision as of 13:55, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1nwh.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae as a Tetrahedral Hemithioacetal Reaction Intermediate at 2.0 A==
		+	<StructureSection load='1nwh' size='340' side='right' caption='[[1nwh]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1nwh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NWH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTI:(4S)-4-{[(2S)-2-AMINO-3-OXOPROPYL]SULFANYL}-L-HOMOSERINE'>HTI</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gl3\|1gl3]], [[1brm\|1brm]], [[1mc4\|1mc4]], [[1mb4\|1mb4]], [[1nx6\|1nx6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">asd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nwh RCSB], [http://www.ebi.ac.uk/pdbsum/1nwh PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nwh_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structural analysis of an enzymatic reaction intermediate affords a unique opportunity to study a catalytic mechanism in extraordinary detail. Here we present the structure of a tetrahedral intermediate in the catalytic cycle of aspartate-beta-semialdehyde dehydrogenase (ASADH) from Haemophilus influenzae at 2.0-A resolution. ASADH is not found in humans, yet its catalytic activity is required for the biosynthesis of essential amino acids in plants and microorganisms. Diaminopimelic acid, also formed by this enzymatic pathway, is an integral component of bacterial cell walls, thus making ASADH an attractive target for the development of new antibiotics. This enzyme is able to capture the substrates aspartate-beta-semialdehyde and phosphate as an active complex that does not complete the catalytic cycle in the absence of NADP. A distinctive binding pocket in which the hemithioacetal oxygen of the bound substrate is stabilized by interaction with a backbone amide group dictates the R stereochemistry of the tetrahedral intermediate. This pocket, reminiscent of the oxyanion hole found in serine proteases, is completed through hydrogen bonding to the bound phosphate substrate.

-	~~{{STRUCTURE_1nwh\| PDB=1nwh \| SCENE= }}~~	+	Capture of an intermediate in the catalytic cycle of L-aspartate-beta-semialdehyde dehydrogenase.,Blanco J, Moore RA, Viola RE Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12613-7. Epub 2003 Oct 14. PMID:14559965<ref>PMID:14559965</ref>

-	~~===Crystal Structure~~ of ~~Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae as a Tetrahedral Hemithioacetal Reaction Intermediate at 2~~.~~0 A===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14559965}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1nwh]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWH OCA].~~	+

	==See Also==		==See Also==
	*[[Aspartate-semialdehyde dehydrogenase\|Aspartate-semialdehyde dehydrogenase]]		*[[Aspartate-semialdehyde dehydrogenase\|Aspartate-semialdehyde dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014559965<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Aspartate-semialdehyde dehydrogenase]]		[[Category: Aspartate-semialdehyde dehydrogenase]]
	[[Category: Haemophilus influenzae]]		[[Category: Haemophilus influenzae]]

OCA at 16:24, 20 October 2012

OCA — Sat, 20 Oct 2012 16:24:27 GMT

←Older revision		Revision as of 16:24, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1nwh]] is a 2 chain structure ~~of [[Aspartate-semialdehyde dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWH OCA].	+	[[1nwh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWH OCA].

	==See Also==		==See Also==

OCA: Protected "1nwh" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 21:35:14 GMT

Protected "1nwh" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:35, 26 July 2012

OCA at 21:35, 26 July 2012

OCA — Thu, 26 Jul 2012 21:35:13 GMT

←Older revision		Revision as of 21:35, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1nwh.png\|left\|200px]]		[[Image:1nwh.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1nwh", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1nwh\| PDB=1nwh \| SCENE= }}		{{STRUCTURE_1nwh\| PDB=1nwh \| SCENE= }}

	===Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae as a Tetrahedral Hemithioacetal Reaction Intermediate at 2.0 A===		===Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae as a Tetrahedral Hemithioacetal Reaction Intermediate at 2.0 A===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14559965}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14559965 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14559965}}		{{ABSTRACT_PUBMED_14559965}}

	==About this Structure==		==About this Structure==
-	~~1NWH~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWH OCA].	+	[[1nwh]] is a 2 chain structure of [[Aspartate-semialdehyde dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWH OCA].
		+
		+	==See Also==
		+	*[[Aspartate-semialdehyde dehydrogenase\|Aspartate-semialdehyde dehydrogenase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14559965~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014559965</ref><references group="xtra"/>
	[[Category: Aspartate-semialdehyde dehydrogenase]]		[[Category: Aspartate-semialdehyde dehydrogenase]]
	[[Category: Haemophilus influenzae]]		[[Category: Haemophilus influenzae]]
Line 33:		Line 24:
	[[Category: Haemophilus influenzae]]		[[Category: Haemophilus influenzae]]
	[[Category: Hemithioacetal]]		[[Category: Hemithioacetal]]
		+	[[Category: Oxidoreductase]]
	[[Category: Tetrahedral intermediate]]		[[Category: Tetrahedral intermediate]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:36:41 2009''