1nyo - Revision history

OCA at 08:54, 10 April 2024

OCA — Wed, 10 Apr 2024 08:54:27 GMT

←Older revision		Revision as of 08:54, 10 April 2024
Line 1:		Line 1:

	==Solution structure of the antigenic TB protein MPT70/MPB70==		==Solution structure of the antigenic TB protein MPT70/MPB70==
-	<StructureSection load='1nyo' size='340' side='right'caption='[[1nyo~~]], [[NMR_Ensembles_of_Models \| 38 NMR models~~]]' scene=''>	+	<StructureSection load='1nyo' size='340' side='right'caption='[[1nyo]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nyo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NYO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nyo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NYO FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>mpt70/mpb70 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1773~~ "~~Bacillus tuberculosis~~" ~~(Zopf 1883) Klein 1884])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyo OCA], [https://pdbe.org/1nyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nyo RCSB], [https://www.ebi.ac.uk/pdbsum/1nyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nyo ProSAT], [https://www.topsan.org/Proteins/TBSGC/1nyo TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyo OCA], [https://pdbe.org/1nyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nyo RCSB], [https://www.ebi.ac.uk/pdbsum/1nyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nyo ProSAT], [https://www.topsan.org/Proteins/TBSGC/1nyo TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MP70_MYCTU MP70_MYCTU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nyo ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nyo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The closely related mycobacteria responsible for tuberculosis produce an unusually high number of secreted proteins, many of which are clearly implicated in pathogenesis and protective immunity. Falling within this category are the closely related proteins MPB70 and MPB83. The structure of MPB70 reveals a complex and novel bacterial fold, which has clear structural homology to the two C-terminal FAS1 domains of the cell adhesion protein fasciclin I, whose structures were reported very recently. Assessment of the surface features of MPB70, the sequence divergence between MPB70 and MPB83, the conservation of residues across a group of FAS1 domains, and the locations of disease-inducing mutations in betaig-h3 strongly suggests that MPB70 and MPB83 contain two functional surfaces on opposite faces, which are probably involved in binding to host cell proteins. This analysis also suggests that these functional surfaces are retained in the FAS1 proteins associated with mediating interactions between cells and the extracellular matrix (fasciclin I, periostin, and betaig-h3) and furthermore that some of the human corneal disease-inducing substitutions identified in betaig-h3 will perturb interactions at these sites.
-
-	Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal desease.,Carr MD, Bloemink MJ, Dentten E, Whelan AO, Gordon SV, Kelly G, Frenkiel TA, Hewinson RG, Williamson RA J Biol Chem. 2003 Oct 31;278(44):43736-43. Epub 2003 Aug 12. PMID:12917404<ref>PMID:12917404</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1nyo" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Bloemink, M J~~]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: ~~Carr, M D~~]]	+	[[Category: Bloemink MJ]]
-	[[Category: ~~Dentten, E~~]]	+	[[Category: Carr MD]]
-	[[Category: ~~Hewinson, R G~~]]	+	[[Category: Dentten E]]
-	[[Category: ~~Structural genomic~~]]	+	[[Category: Hewinson RG]]
-	[[Category: Williamson~~, R A]]~~	+	[[Category: Williamson RA]]
-	~~[[Category: Fasciclin domain]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Seven-stranded beta-barrel]]~~	+
-	~~[[Category: Tbsgc~~]]	+

OCA at 08:24, 23 February 2022

OCA — Wed, 23 Feb 2022 08:24:39 GMT

←Older revision		Revision as of 08:24, 23 February 2022
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	<StructureSection load='1nyo' size='340' side='right'caption='[[1nyo]], [[NMR_Ensembles_of_Models \| 38 NMR models]]' scene=''>		<StructureSection load='1nyo' size='340' side='right'caption='[[1nyo]], [[NMR_Ensembles_of_Models \| 38 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nyo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1NYO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nyo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NYO FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpt70/mpb70 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpt70/mpb70 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1nyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyo OCA], [~~http~~://pdbe.org/1nyo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1nyo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1nyo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1nyo ProSAT], [~~http~~://www.topsan.org/Proteins/TBSGC/1nyo TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyo OCA], [https://pdbe.org/1nyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nyo RCSB], [https://www.ebi.ac.uk/pdbsum/1nyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nyo ProSAT], [https://www.topsan.org/Proteins/TBSGC/1nyo TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:00, 2 December 2020

OCA — Wed, 02 Dec 2020 09:00:06 GMT

←Older revision		Revision as of 09:00, 2 December 2020
Line 1:		Line 1:

	==Solution structure of the antigenic TB protein MPT70/MPB70==		==Solution structure of the antigenic TB protein MPT70/MPB70==
-	<StructureSection load='1nyo' size='340' side='right' caption='[[1nyo]], [[NMR_Ensembles_of_Models \| 38 NMR models]]' scene=''>	+	<StructureSection load='1nyo' size='340' side='right'caption='[[1nyo]], [[NMR_Ensembles_of_Models \| 38 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nyo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1NYO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nyo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1NYO FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpt70/mpb70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpt70/mpb70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1nyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyo OCA], [http://pdbe.org/1nyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nyo RCSB], [http://www.ebi.ac.uk/pdbsum/1nyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nyo ProSAT], [http://www.topsan.org/Proteins/TBSGC/1nyo TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1nyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyo OCA], [http://pdbe.org/1nyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nyo RCSB], [http://www.ebi.ac.uk/pdbsum/1nyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nyo ProSAT], [http://www.topsan.org/Proteins/TBSGC/1nyo TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bloemink, M J]]		[[Category: Bloemink, M J]]
	[[Category: Carr, M D]]		[[Category: Carr, M D]]

OCA at 07:03, 7 February 2018

OCA — Wed, 07 Feb 2018 07:03:21 GMT

←Older revision		Revision as of 07:03, 7 February 2018
Line 1:		Line 1:
		+
	==Solution structure of the antigenic TB protein MPT70/MPB70==		==Solution structure of the antigenic TB protein MPT70/MPB70==
	<StructureSection load='1nyo' size='340' side='right' caption='[[1nyo]], [[NMR_Ensembles_of_Models \| 38 NMR models]]' scene=''>		<StructureSection load='1nyo' size='340' side='right' caption='[[1nyo]], [[NMR_Ensembles_of_Models \| 38 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1nyo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NYO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nyo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NYO FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpt70/mpb70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpt70/mpb70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyo OCA], [http://pdbe.org/1nyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nyo RCSB], [http://www.ebi.ac.uk/pdbsum/1nyo PDBsum], [http://www.topsan.org/Proteins/TBSGC/1nyo TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyo OCA], [http://pdbe.org/1nyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nyo RCSB], [http://www.ebi.ac.uk/pdbsum/1nyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nyo ProSAT], [http://www.topsan.org/Proteins/TBSGC/1nyo TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/1nyo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/1nyo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:34, 10 February 2016

OCA — Wed, 10 Feb 2016 02:34:24 GMT

←Older revision		Revision as of 02:34, 10 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nyo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:31, 11 September 2015

OCA — Fri, 11 Sep 2015 04:31:41 GMT

←Older revision		Revision as of 04:31, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1nyo' size='340' side='right' caption='[[1nyo]], [[NMR_Ensembles_of_Models \| 38 NMR models]]' scene=''>		<StructureSection load='1nyo' size='340' side='right' caption='[[1nyo]], [[NMR_Ensembles_of_Models \| 38 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nyo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NYO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nyo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NYO FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpt70/mpb70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 ~~Mycobacterium~~ tuberculosis])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpt70/mpb70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nyo RCSB], [http://www.ebi.ac.uk/pdbsum/1nyo PDBsum], [http://www.topsan.org/Proteins/TBSGC/1nyo TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyo OCA], [http://pdbe.org/1nyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nyo RCSB], [http://www.ebi.ac.uk/pdbsum/1nyo PDBsum], [http://www.topsan.org/Proteins/TBSGC/1nyo TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1nyo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Bloemink, M J]]		[[Category: Bloemink, M J]]
	[[Category: Carr, M D]]		[[Category: Carr, M D]]

OCA at 15:22, 5 January 2015

OCA — Mon, 05 Jan 2015 15:22:26 GMT

←Older revision		Revision as of 15:22, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nyo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NYO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nyo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NYO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpt70/mpb70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpt70/mpb70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nyo RCSB], [http://www.ebi.ac.uk/pdbsum/1nyo PDBsum], [http://www.topsan.org/Proteins/TBSGC/1nyo TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nyo RCSB], [http://www.ebi.ac.uk/pdbsum/1nyo PDBsum], [http://www.topsan.org/Proteins/TBSGC/1nyo TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Bloemink, M J.]]	+	[[Category: Bloemink, M J]]
-	[[Category: Carr, M D.]]	+	[[Category: Carr, M D]]
-	[[Category: Dentten, E.]]	+	[[Category: Dentten, E]]
-	[[Category: Hewinson, R G.]]	+	[[Category: Hewinson, R G]]
-	[[Category: ~~TBSGC, TB~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Williamson, R A.]]	+	[[Category: Williamson, R A]]
	[[Category: Fasciclin domain]]		[[Category: Fasciclin domain]]
	[[Category: Immune system]]		[[Category: Immune system]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category: Psi~~]]	+
	[[Category: Seven-stranded beta-barrel]]		[[Category: Seven-stranded beta-barrel]]
-	[[Category: Structural genomic]]
-	[[Category: Tb structural genomics consortium]]
	[[Category: Tbsgc]]		[[Category: Tbsgc]]

OCA at 13:05, 28 September 2014

OCA — Sun, 28 Sep 2014 13:05:50 GMT

←Older revision		Revision as of 13:05, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1nyo.~~png\|left~~\|200px]]	+	==Solution structure of the antigenic TB protein MPT70/MPB70==
		+	<StructureSection load='1nyo' size='340' side='right' caption='[[1nyo]], [[NMR_Ensembles_of_Models \| 38 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1nyo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NYO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpt70/mpb70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nyo RCSB], [http://www.ebi.ac.uk/pdbsum/1nyo PDBsum], [http://www.topsan.org/Proteins/TBSGC/1nyo TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/1nyo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The closely related mycobacteria responsible for tuberculosis produce an unusually high number of secreted proteins, many of which are clearly implicated in pathogenesis and protective immunity. Falling within this category are the closely related proteins MPB70 and MPB83. The structure of MPB70 reveals a complex and novel bacterial fold, which has clear structural homology to the two C-terminal FAS1 domains of the cell adhesion protein fasciclin I, whose structures were reported very recently. Assessment of the surface features of MPB70, the sequence divergence between MPB70 and MPB83, the conservation of residues across a group of FAS1 domains, and the locations of disease-inducing mutations in betaig-h3 strongly suggests that MPB70 and MPB83 contain two functional surfaces on opposite faces, which are probably involved in binding to host cell proteins. This analysis also suggests that these functional surfaces are retained in the FAS1 proteins associated with mediating interactions between cells and the extracellular matrix (fasciclin I, periostin, and betaig-h3) and furthermore that some of the human corneal disease-inducing substitutions identified in betaig-h3 will perturb interactions at these sites.

-	~~{{STRUCTURE_1nyo\| PDB=1nyo \| SCENE= }}~~	+	Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal desease.,Carr MD, Bloemink MJ, Dentten E, Whelan AO, Gordon SV, Kelly G, Frenkiel TA, Hewinson RG, Williamson RA J Biol Chem. 2003 Oct 31;278(44):43736-43. Epub 2003 Aug 12. PMID:12917404<ref>PMID:12917404</ref>

-	~~===Solution structure~~ of the ~~antigenic TB protein MPT70/MPB70===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12917404}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1nyo]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012917404<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Bloemink, M J.]]		[[Category: Bloemink, M J.]]

OCA: Protected "1nyo" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 19:37:52 GMT

Protected "1nyo" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:37, 5 December 2012

OCA at 19:37, 5 December 2012

OCA — Wed, 05 Dec 2012 19:37:49 GMT

←Older revision		Revision as of 19:37, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1nyo.png\|left\|200px]]		[[Image:1nyo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1nyo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1nyo\| PDB=1nyo \| SCENE= }}		{{STRUCTURE_1nyo\| PDB=1nyo \| SCENE= }}

	===Solution structure of the antigenic TB protein MPT70/MPB70===		===Solution structure of the antigenic TB protein MPT70/MPB70===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12917404}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12917404 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12917404}}		{{ABSTRACT_PUBMED_12917404}}

	==About this Structure==		==About this Structure==
-	~~1NYO~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA].	+	[[1nyo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYO OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12917404~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012917404</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Bloemink, M J.]]		[[Category: Bloemink, M J.]]
Line 32:		Line 20:
	[[Category: Williamson, R A.]]		[[Category: Williamson, R A.]]
	[[Category: Fasciclin domain]]		[[Category: Fasciclin domain]]
		+	[[Category: Immune system]]
	[[Category: Protein structure initiative]]		[[Category: Protein structure initiative]]
	[[Category: Psi]]		[[Category: Psi]]
Line 38:		Line 27:
	[[Category: Tb structural genomics consortium]]		[[Category: Tb structural genomics consortium]]
	[[Category: Tbsgc]]		[[Category: Tbsgc]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:43:03 2009''