1o5e - Revision history

OCA at 23:46, 27 December 2023

OCA — Wed, 27 Dec 2023 23:46:21 GMT

←Older revision		Revision as of 23:46, 27 December 2023
Line 3:		Line 3:
	<StructureSection load='1o5e' size='340' side='right'caption='[[1o5e]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='1o5e' size='340' side='right'caption='[[1o5e]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1o5e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O5E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1o5e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O5E FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=132:6~~-~~CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE'>132</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1p57\|1p57]]~~</~~div~~>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=132:6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE'>132</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPN OR TMPRSS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5e OCA], [https://pdbe.org/1o5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o5e RCSB], [https://www.ebi.ac.uk/pdbsum/1o5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o5e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5e OCA], [https://pdbe.org/1o5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o5e RCSB], [https://www.ebi.ac.uk/pdbsum/1o5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o5e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HEPS_HUMAN HEPS_HUMAN]] Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL.<ref>PMID:21875933</ref> <ref>PMID:15839837</ref>	+	[https://www.uniprot.org/uniprot/HEPS_HUMAN HEPS_HUMAN] Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL.<ref>PMID:21875933</ref> <ref>PMID:15839837</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chan, H]]	+	[[Category: Chan H]]
-	[[Category: Gjerstad, E]]	+	[[Category: Gjerstad E]]
-	[[Category: Ho~~, J D~~]]	+	[[Category: Ho JD]]
-	[[Category: Janc~~, J W~~]]	+	[[Category: Janc JW]]
-	[[Category: Katz~~, B A~~]]	+	[[Category: Katz BA]]
-	[[Category: Luong, C]]	+	[[Category: Luong C]]
-	[[Category: Mackman~~, R L~~]]	+	[[Category: Mackman RL]]
-	[[Category: McGrath~~, M E~~]]	+	[[Category: McGrath ME]]
-	[[Category: Mortara, K]]	+	[[Category: Mortara K]]
-	[[Category: Somoza~~, J R~~]]	+	[[Category: Somoza JR]]
-	[[Category: Sprengeler~~, P A~~]]	+	[[Category: Sprengeler PA]]
-	[[Category: Tang, J]]	+	[[Category: Tang J]]
-	[[Category: Verner, E]]	+	[[Category: Verner E]]
-	[[Category: Williams~~, S R~~]]	+	[[Category: Williams SR]]
-	[[Category: Young~~, W B]]~~	+	[[Category: Young WB]]
-	~~[[Category: Conserved water displacement hydrogen bond deficit]]~~	+
-	~~[[Category: Factor viia]]~~	+
-	~~[[Category: Hepsin]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: S1 site]]~~	+
-	~~[[Category: Scavenger receptor cysteine-rich domain]]~~	+
-	~~[[Category: Selectivity]]~~	+
-	~~[[Category: Serine protease]]~~	+
-	~~[[Category: Serine protease ala190 upa]]~~	+
-	~~[[Category: Srcr]]~~	+
-	~~[[Category: Thrombin]]~~	+
-	~~[[Category: Trypsin~~]]	+

OCA at 15:06, 27 October 2021

OCA — Wed, 27 Oct 2021 15:06:38 GMT

←Older revision		Revision as of 15:06, 27 October 2021
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	<StructureSection load='1o5e' size='340' side='right'caption='[[1o5e]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='1o5e' size='340' side='right'caption='[[1o5e]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1o5e]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1O5E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1o5e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O5E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=132:6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE'>132</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=132:6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE'>132</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p57\|1p57]]</div></td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p57\|1p57]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPN OR TMPRSS1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPN OR TMPRSS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1o5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5e OCA], [~~http~~://pdbe.org/1o5e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1o5e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1o5e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1o5e ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5e OCA], [https://pdbe.org/1o5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o5e RCSB], [https://www.ebi.ac.uk/pdbsum/1o5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o5e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HEPS_HUMAN HEPS_HUMAN]] Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL.<ref>PMID:21875933</ref> <ref>PMID:15839837</ref>	+	[[https://www.uniprot.org/uniprot/HEPS_HUMAN HEPS_HUMAN]] Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL.<ref>PMID:21875933</ref> <ref>PMID:15839837</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:04, 2 December 2020

OCA — Wed, 02 Dec 2020 09:04:00 GMT

←Older revision		Revision as of 09:04, 2 December 2020
Line 1:		Line 1:

	==Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)==		==Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)==
-	<StructureSection load='1o5e' size='340' side='right' caption='[[1o5e]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='1o5e' size='340' side='right'caption='[[1o5e]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1o5e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5E OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1O5E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1o5e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1O5E FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=132:6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE'>132</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=132:6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE'>132</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p57\|1p57]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p57\|1p57]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPN OR TMPRSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPN OR TMPRSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1o5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5e OCA], [http://pdbe.org/1o5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o5e RCSB], [http://www.ebi.ac.uk/pdbsum/1o5e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1o5e ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1o5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5e OCA], [http://pdbe.org/1o5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o5e RCSB], [http://www.ebi.ac.uk/pdbsum/1o5e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1o5e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chan, H]]		[[Category: Chan, H]]
	[[Category: Gjerstad, E]]		[[Category: Gjerstad, E]]

OCA at 07:13, 7 February 2018

OCA — Wed, 07 Feb 2018 07:13:07 GMT

←Older revision		Revision as of 07:13, 7 February 2018
Line 1:		Line 1:
		+
	==Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)==		==Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)==
	<StructureSection load='1o5e' size='340' side='right' caption='[[1o5e]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='1o5e' size='340' side='right' caption='[[1o5e]], [[Resolution\|resolution]] 1.75Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p57\|1p57]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p57\|1p57]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPN OR TMPRSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPN OR TMPRSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5e OCA], [http://pdbe.org/1o5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o5e RCSB], [http://www.ebi.ac.uk/pdbsum/1o5e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5e OCA], [http://pdbe.org/1o5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o5e RCSB], [http://www.ebi.ac.uk/pdbsum/1o5e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1o5e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o5/1o5e_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o5/1o5e_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:42, 7 February 2016

OCA — Sun, 07 Feb 2016 16:42:37 GMT

←Older revision		Revision as of 16:42, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o5e ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:20, 10 September 2015

OCA — Thu, 10 Sep 2015 03:20:35 GMT

←Older revision		Revision as of 03:20, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1o5e' size='340' side='right' caption='[[1o5e]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='1o5e' size='340' side='right' caption='[[1o5e]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1o5e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O5E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1o5e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O5E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=132:6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE'>132</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=132:6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE'>132</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p57\|1p57]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p57\|1p57]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPN OR TMPRSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPN OR TMPRSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o5e RCSB], [http://www.ebi.ac.uk/pdbsum/1o5e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5e OCA], [http://pdbe.org/1o5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o5e RCSB], [http://www.ebi.ac.uk/pdbsum/1o5e PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1o5e" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chan, H]]		[[Category: Chan, H]]
	[[Category: Gjerstad, E]]		[[Category: Gjerstad, E]]

OCA at 16:46, 24 December 2014

OCA — Wed, 24 Dec 2014 16:46:57 GMT

←Older revision		Revision as of 16:46, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o5e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O5E FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o5e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O5E FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=132:6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE'>132</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=132:6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE'>132</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p57\|1p57]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p57\|1p57]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPN OR TMPRSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPN OR TMPRSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o5e RCSB], [http://www.ebi.ac.uk/pdbsum/1o5e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o5e RCSB], [http://www.ebi.ac.uk/pdbsum/1o5e PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HEPS_HUMAN HEPS_HUMAN]] Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL.<ref>PMID:21875933</ref> <ref>PMID:15839837</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chan, H.]]	+	[[Category: Chan, H]]
-	[[Category: Gjerstad, E.]]	+	[[Category: Gjerstad, E]]
-	[[Category: Ho, J D.]]	+	[[Category: Ho, J D]]
-	[[Category: Janc, J W.]]	+	[[Category: Janc, J W]]
-	[[Category: Katz, B A.]]	+	[[Category: Katz, B A]]
-	[[Category: Luong, C.]]	+	[[Category: Luong, C]]
-	[[Category: Mackman, R L.]]	+	[[Category: Mackman, R L]]
-	[[Category: McGrath, M E.]]	+	[[Category: McGrath, M E]]
-	[[Category: Mortara, K.]]	+	[[Category: Mortara, K]]
-	[[Category: Somoza, J R.]]	+	[[Category: Somoza, J R]]
-	[[Category: Sprengeler, P A.]]	+	[[Category: Sprengeler, P A]]
-	[[Category: Tang, J.]]	+	[[Category: Tang, J]]
-	[[Category: Verner, E.]]	+	[[Category: Verner, E]]
-	[[Category: Williams, S R.]]	+	[[Category: Williams, S R]]
-	[[Category: Young, W B.]]	+	[[Category: Young, W B]]
	[[Category: Conserved water displacement hydrogen bond deficit]]		[[Category: Conserved water displacement hydrogen bond deficit]]
	[[Category: Factor viia]]		[[Category: Factor viia]]

OCA at 17:58, 28 September 2014

OCA — Sun, 28 Sep 2014 17:58:46 GMT

←Older revision		Revision as of 17:58, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1o5e.~~png~~\|~~left~~\|200px]]	+	==Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)==
		+	<StructureSection load='1o5e' size='340' side='right' caption='[[1o5e]], [[Resolution\|resolution]] 1.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1o5e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O5E FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=132:6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE'>132</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p57\|1p57]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPN OR TMPRSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o5e RCSB], [http://www.ebi.ac.uk/pdbsum/1o5e PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o5/1o5e_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A site-directed mutant of the serine protease urokinase-type plasminogen activator (uPA), was produced to assess the contribution of the Ser190 side-chain to the affinity and selectivity of lead uPA inhibitors in the absence of other differences present in comparisons of natural proteases. Crystallography and enzymology involving WT and Ala190 uPA were used to calculate free energy binding contributions of hydrogen bonds involving the Ser190 hydroxyl group (O(gamma)(Ser190)) responsible for the remarkable selectivity of 6-halo-5-amidinoindole and 6-halo-5-amidinobenzimidazole inhibitors toward uPA and against natural Ala190 protease anti-targets. Crystal structures of uPA complexes of novel, active site-directed arylguanidine and 2-aminobenzimidazole inhibitors of WT uPA, together with associated K(i) values for WT and Ala190 uPA, also indicate a significant role of Ser190 in the binding of these classes of uPA inhibitors. Structures and associated K(i) values for a lead inhibitor (CA-11) bound to uPA and to five other proteases, as well as for other leads bound to multiple proteases, help reveal the features responsible for the potency (K(i)=11nM) and selectivity of the remarkably small inhibitor, CA-11. The 6-fluoro-5-amidinobenzimidzole, CA-11, is more than 1000-fold selective against natural Ala190 protease anti-targets, and more than 100-fold selective against other Ser190 anti-targets.

-	~~{{STRUCTURE_1o5e\| PDB=1o5e \| SCENE= }}~~	+	Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).,Katz BA, Luong C, Ho JD, Somoza JR, Gjerstad E, Tang J, Williams SR, Verner E, Mackman RL, Young WB, Sprengeler PA, Chan H, Mortara K, Janc JW, McGrath ME J Mol Biol. 2004 Nov 19;344(2):527-47. PMID:15522303<ref>PMID:15522303</ref>

-	~~===Dissecting and Designing Inhibitor Selectivity Determinants at~~ the ~~S1 site Using an Artificial Ala190 Protease (Ala190 uPA)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15522303}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1o5e]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1O5E OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015522303<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chan, H.]]		[[Category: Chan, H.]]

OCA: Protected "1o5e" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 20:52:59 GMT

Protected "1o5e" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:52, 5 December 2012

OCA at 20:52, 5 December 2012

OCA — Wed, 05 Dec 2012 20:52:55 GMT

←Older revision		Revision as of 20:52, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1o5e.png\|left\|200px]]		[[Image:1o5e.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1o5e", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1o5e\| PDB=1o5e \| SCENE= }}		{{STRUCTURE_1o5e\| PDB=1o5e \| SCENE= }}

	===Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)===		===Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15522303}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15522303 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15522303}}		{{ABSTRACT_PUBMED_15522303}}

	==About this Structure==		==About this Structure==
-	~~1O5E~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5E OCA].	+	[[1o5e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5E OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15522303~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015522303</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chan, H.]]		[[Category: Chan, H.]]
Line 43:		Line 31:
	[[Category: Factor viia]]		[[Category: Factor viia]]
	[[Category: Hepsin]]		[[Category: Hepsin]]
		+	[[Category: Hydrolase]]
	[[Category: S1 site]]		[[Category: S1 site]]
	[[Category: Scavenger receptor cysteine-rich domain]]		[[Category: Scavenger receptor cysteine-rich domain]]
	[[Category: Selectivity]]		[[Category: Selectivity]]
		+	[[Category: Serine protease]]
	[[Category: Serine protease ala190 upa]]		[[Category: Serine protease ala190 upa]]
	[[Category: Srcr]]		[[Category: Srcr]]
	[[Category: Thrombin]]		[[Category: Thrombin]]
	[[Category: Trypsin]]		[[Category: Trypsin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:11:38 2009''