1o8o - Revision history

OCA at 12:31, 13 December 2023

OCA — Wed, 13 Dec 2023 12:31:20 GMT

←Older revision		Revision as of 12:31, 13 December 2023
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	<StructureSection load='1o8o' size='340' side='right'caption='[[1o8o]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1o8o' size='340' side='right'caption='[[1o8o]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1o8o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O8O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1o8o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O8O FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1eav\|1eav]]~~, [[~~1o8n~~\|~~1o8n~~]]~~, [[1o8q\|1o8q]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o8o OCA], [https://pdbe.org/1o8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o8o RCSB], [https://www.ebi.ac.uk/pdbsum/1o8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o8o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o8o OCA], [https://pdbe.org/1o8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o8o RCSB], [https://www.ebi.ac.uk/pdbsum/1o8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o8o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CNX1_ARATH CNX1_ARATH]] Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:15504727</ref> <ref>PMID:16636046</ref> <ref>PMID:12590921</ref> <ref>PMID:15306815</ref>	+	[https://www.uniprot.org/uniprot/CNX1_ARATH CNX1_ARATH] Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:15504727</ref> <ref>PMID:16636046</ref> <ref>PMID:12590921</ref> <ref>PMID:15306815</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hecht~~, H J~~]]	+	[[Category: Hecht HJ]]
-	[[Category: Kuper, J]]	+	[[Category: Kuper J]]
-	[[Category: Mendel~~, R R~~]]	+	[[Category: Mendel RR]]
-	[[Category: Schwarz, G]]	+	[[Category: Schwarz G]]
-	[[Category: Winking, J]]	+	[[Category: Winking J]]
-	~~[[Category: Cnx1g]]~~	+
-	~~[[Category: Molybdenum cofactor biosynthesis]]~~	+
-	~~[[Category: Mutant~~]]	+

OCA at 07:09, 25 August 2021

OCA — Wed, 25 Aug 2021 07:09:52 GMT

←Older revision		Revision as of 07:09, 25 August 2021
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	<StructureSection load='1o8o' size='340' side='right'caption='[[1o8o]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1o8o' size='340' side='right'caption='[[1o8o]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1o8o]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1O8O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1o8o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O8O FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eav\|1eav]], [[1o8n\|1o8n]], [[1o8q\|1o8q]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1eav\|1eav]], [[1o8n\|1o8n]], [[1o8q\|1o8q]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1o8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o8o OCA], [~~http~~://pdbe.org/1o8o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1o8o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1o8o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1o8o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o8o OCA], [https://pdbe.org/1o8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o8o RCSB], [https://www.ebi.ac.uk/pdbsum/1o8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o8o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CNX1_ARATH CNX1_ARATH]] Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:15504727</ref> <ref>PMID:16636046</ref> <ref>PMID:12590921</ref> <ref>PMID:15306815</ref>	+	[[https://www.uniprot.org/uniprot/CNX1_ARATH CNX1_ARATH]] Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:15504727</ref> <ref>PMID:16636046</ref> <ref>PMID:12590921</ref> <ref>PMID:15306815</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 18:12, 20 November 2019

OCA — Wed, 20 Nov 2019 18:12:01 GMT

←Older revision		Revision as of 18:12, 20 November 2019
Line 1:		Line 1:

	==The active site of the molybdenum cofactor biosynthetic protein domain Cnx1G==		==The active site of the molybdenum cofactor biosynthetic protein domain Cnx1G==
-	<StructureSection load='1o8o' size='340' side='right' caption='[[1o8o]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='1o8o' size='340' side='right'caption='[[1o8o]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o8o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O8O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o8o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O8O FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Hecht, H J]]		[[Category: Hecht, H J]]
	[[Category: Kuper, J]]		[[Category: Kuper, J]]

OCA at 07:01, 7 February 2018

OCA — Wed, 07 Feb 2018 07:01:17 GMT

←Older revision		Revision as of 07:01, 7 February 2018
Line 1:		Line 1:
-	==~~THE ACTIVE SITE OF THE MOLYBDENUM COFACTOR BIOSYNTHETIC PROTEIN DOMAIN CNX1G~~==	+
		+	==The active site of the molybdenum cofactor biosynthetic protein domain Cnx1G==
	<StructureSection load='1o8o' size='340' side='right' caption='[[1o8o]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1o8o' size='340' side='right' caption='[[1o8o]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o8o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O8O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o8o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O8O FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eav\|1eav]], [[1o8n\|1o8n]], [[1o8q\|1o8q]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eav\|1eav]], [[1o8n\|1o8n]], [[1o8q\|1o8q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o8o OCA], [http://pdbe.org/1o8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o8o RCSB], [http://www.ebi.ac.uk/pdbsum/1o8o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o8o OCA], [http://pdbe.org/1o8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o8o RCSB], [http://www.ebi.ac.uk/pdbsum/1o8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1o8o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/1o8o_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/1o8o_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:08, 7 February 2016

OCA — Sun, 07 Feb 2016 20:08:32 GMT

←Older revision		Revision as of 20:08, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o8o ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:36, 10 September 2015

OCA — Thu, 10 Sep 2015 04:36:27 GMT

←Older revision		Revision as of 04:36, 10 September 2015
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	<StructureSection load='1o8o' size='340' side='right' caption='[[1o8o]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1o8o' size='340' side='right' caption='[[1o8o]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1o8o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O8O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1o8o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O8O FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eav\|1eav]], [[1o8n\|1o8n]], [[1o8q\|1o8q]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eav\|1eav]], [[1o8n\|1o8n]], [[1o8q\|1o8q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o8o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o8o RCSB], [http://www.ebi.ac.uk/pdbsum/1o8o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o8o OCA], [http://pdbe.org/1o8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o8o RCSB], [http://www.ebi.ac.uk/pdbsum/1o8o PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1o8o" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arabidopsis thaliana~~]]	+	[[Category: Arath]]
	[[Category: Hecht, H J]]		[[Category: Hecht, H J]]
	[[Category: Kuper, J]]		[[Category: Kuper, J]]

OCA at 17:56, 24 December 2014

OCA — Wed, 24 Dec 2014 17:56:56 GMT

←Older revision		Revision as of 17:56, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o8o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O8O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o8o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O8O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eav\|1eav]], [[1o8n\|1o8n]], [[1o8q\|1o8q]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eav\|1eav]], [[1o8n\|1o8n]], [[1o8q\|1o8q]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o8o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o8o RCSB], [http://www.ebi.ac.uk/pdbsum/1o8o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o8o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o8o RCSB], [http://www.ebi.ac.uk/pdbsum/1o8o PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CNX1_ARATH CNX1_ARATH]] Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:15504727</ref> <ref>PMID:16636046</ref> <ref>PMID:12590921</ref> <ref>PMID:15306815</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
-	[[Category: Hecht, H J.]]	+	[[Category: Hecht, H J]]
-	[[Category: Kuper, J.]]	+	[[Category: Kuper, J]]
-	[[Category: Mendel, R R.]]	+	[[Category: Mendel, R R]]
-	[[Category: Schwarz, G.]]	+	[[Category: Schwarz, G]]
-	[[Category: Winking, J.]]	+	[[Category: Winking, J]]
	[[Category: Cnx1g]]		[[Category: Cnx1g]]
	[[Category: Molybdenum cofactor biosynthesis]]		[[Category: Molybdenum cofactor biosynthesis]]
	[[Category: Mutant]]		[[Category: Mutant]]

OCA at 13:37, 28 September 2014

OCA — Sun, 28 Sep 2014 13:37:32 GMT

←Older revision		Revision as of 13:37, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1o8o.~~png~~\|~~left~~\|200px]]	+	==THE ACTIVE SITE OF THE MOLYBDENUM COFACTOR BIOSYNTHETIC PROTEIN DOMAIN CNX1G==
		+	<StructureSection load='1o8o' size='340' side='right' caption='[[1o8o]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1o8o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O8O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eav\|1eav]], [[1o8n\|1o8n]], [[1o8q\|1o8q]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o8o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o8o RCSB], [http://www.ebi.ac.uk/pdbsum/1o8o PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/1o8o_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The final step of molybdenum cofactor biosynthesis in plants is catalyzed by the two-domain protein Cnx1. The G domain of Cnx1 (Cnx1G) binds molybdopterin with high affinity and transfers molybdenum to molybdopterin. Here, we describe the functional and structural characterization of structure-based Cnx1G mutants. For molybdopterin binding residues Thr542 and Ser573 were found to be important because different mutations of those residues resulted in 7- to 26-fold higher k(D) values for molybdopterin binding. Furthermore, we showed that the terminal phosphate of molybdopterin is directly involved in protein-pterin interactions as dephosphorylated molybdopterin binds with one magnitude of order lower affinity to the wild-type protein. Molybdopterin binding was not affected in mutants defective in Ser476, Asp486, or Asp515. However, molybdenum insertion was completely abolished, indicating their important role for catalysis. Based on these results we propose the binding of molybdopterin to a large depression in the structure of Cnx1G formed by beta5, alpha5, beta6, and alpha6, whereas the negatively charged depression formed by the loop between beta3 and alpha4, the N-terminal end of alpha2, the 3(10) helix, and the region between beta6 and alpha6 is involved in catalysis.

-	~~{{STRUCTURE_1o8o\| PDB=1o8o \| SCENE= }}~~	+	The active site of the molybdenum cofactor biosynthetic protein domain Cnx1G.,Kuper J, Winking J, Hecht HJ, Mendel RR, Schwarz G Arch Biochem Biophys. 2003 Mar 1;411(1):36-46. PMID:12590921<ref>PMID:12590921</ref>

-	~~===THE ACTIVE SITE OF THE MOLYBDENUM COFACTOR BIOSYNTHETIC PROTEIN DOMAIN CNX1G===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12590921}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1o8o]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012590921<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Hecht, H J.]]		[[Category: Hecht, H J.]]

OCA: Protected "1o8o" [edit=sysop:move=sysop]

OCA — Wed, 12 Dec 2012 21:43:23 GMT

Protected "1o8o" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:43, 12 December 2012

OCA at 21:43, 12 December 2012

OCA — Wed, 12 Dec 2012 21:43:19 GMT

←Older revision		Revision as of 21:43, 12 December 2012
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-	{{Seed}}
	[[Image:1o8o.png\|left\|200px]]		[[Image:1o8o.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1o8o\| PDB=1o8o \| SCENE= }}		{{STRUCTURE_1o8o\| PDB=1o8o \| SCENE= }}

	===THE ACTIVE SITE OF THE MOLYBDENUM COFACTOR BIOSYNTHETIC PROTEIN DOMAIN CNX1G===		===THE ACTIVE SITE OF THE MOLYBDENUM COFACTOR BIOSYNTHETIC PROTEIN DOMAIN CNX1G===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12590921}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_12590921}}		{{ABSTRACT_PUBMED_12590921}}

	==About this Structure==		==About this Structure==
-	~~1O8O~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA].	+	[[1o8o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8O OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12590921~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012590921</ref><references group="xtra"/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Hecht, H J.]]		[[Category: Hecht, H J.]]
Line 33:		Line 21:
	[[Category: Molybdenum cofactor biosynthesis]]		[[Category: Molybdenum cofactor biosynthesis]]
	[[Category: Mutant]]		[[Category: Mutant]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:12:42 2009''