1oaq - Revision history

OCA at 08:56, 10 April 2024

OCA — Wed, 10 Apr 2024 08:56:30 GMT

←Older revision		Revision as of 08:56, 10 April 2024
Line 3:		Line 3:
	<StructureSection load='1oaq' size='340' side='right'caption='[[1oaq]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1oaq' size='340' side='right'caption='[[1oaq]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oaq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OAQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oaq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OAQ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1oar\|1oar]]~~, [[~~1oau~~\|~~1oau~~]]~~, [[1oax\|1oax]], [[1oay\|1oay]], [[1oaz\|1oaz]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oaq OCA], [https://pdbe.org/1oaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oaq RCSB], [https://www.ebi.ac.uk/pdbsum/1oaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oaq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oaq OCA], [https://pdbe.org/1oaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oaq RCSB], [https://www.ebi.ac.uk/pdbsum/1oaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oaq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LV1B_MOUSE LV1B_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oaq ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oaq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	A single antibody was shown to adopt different binding-site conformations and thereby bind unrelated antigens. Analysis by both x-ray crystallography and pre-steady-state kinetics revealed an equilibrium between different preexisting isomers, one of which possessed a promiscuous, low-affinity binding site for aromatic ligands, including the immunizing hapten. A subsequent induced-fit isomerization led to high-affinity complexes with a deep and narrow binding site. A protein antigen identified by repertoire selection made use of an unrelated antibody isomer with a wide, shallow binding site. Conformational diversity, whereby one sequence adopts multiple structures and multiple functions, can increase the effective size of the antibody repertoire but may also lead to autoimmunity and allergy.
-
-	Antibody multispecificity mediated by conformational diversity.,James LC, Roversi P, Tawfik DS Science. 2003 Feb 28;299(5611):1362-7. PMID:12610298<ref>PMID:12610298</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1oaq" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: James~~, L C~~]]	+	[[Category: James LC]]
-	[[Category: Roversi, P]]	+	[[Category: Roversi P]]
-	[[Category: Tawfik, D]]	+	[[Category: Tawfik D]]
-	~~[[Category: Allergy]]~~	+
-	~~[[Category: Conformational diversity]]~~	+
-	~~[[Category: Ige]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Multispecificity~~]]	+

OCA at 07:10, 25 August 2021

OCA — Wed, 25 Aug 2021 07:10:45 GMT

←Older revision		Revision as of 07:10, 25 August 2021
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	<StructureSection load='1oaq' size='340' side='right'caption='[[1oaq]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1oaq' size='340' side='right'caption='[[1oaq]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oaq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1OAQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oaq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OAQ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oar\|1oar]], [[1oau\|1oau]], [[1oax\|1oax]], [[1oay\|1oay]], [[1oaz\|1oaz]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1oar\|1oar]], [[1oau\|1oau]], [[1oax\|1oax]], [[1oay\|1oay]], [[1oaz\|1oaz]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1oaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oaq OCA], [~~http~~://pdbe.org/1oaq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1oaq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1oaq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1oaq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oaq OCA], [https://pdbe.org/1oaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oaq RCSB], [https://www.ebi.ac.uk/pdbsum/1oaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oaq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 18:28, 20 November 2019

OCA — Wed, 20 Nov 2019 18:28:49 GMT

←Older revision		Revision as of 18:28, 20 November 2019
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	==Free conformation Ab1 of the IgE SPE-7==		==Free conformation Ab1 of the IgE SPE-7==
-	<StructureSection load='1oaq' size='340' side='right' caption='[[1oaq]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='1oaq' size='340' side='right'caption='[[1oaq]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oaq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oaq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAQ FirstGlance]. <br>
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: James, L C]]		[[Category: James, L C]]

OCA at 07:16, 7 February 2018

OCA — Wed, 07 Feb 2018 07:16:04 GMT

←Older revision		Revision as of 07:16, 7 February 2018
Line 1:		Line 1:
		+
	==Free conformation Ab1 of the IgE SPE-7==		==Free conformation Ab1 of the IgE SPE-7==
	<StructureSection load='1oaq' size='340' side='right' caption='[[1oaq]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1oaq' size='340' side='right' caption='[[1oaq]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1oaq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oaq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAQ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oar\|1oar]], [[1oau\|1oau]], [[1oax\|1oax]], [[1oay\|1oay]], [[1oaz\|1oaz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oar\|1oar]], [[1oau\|1oau]], [[1oax\|1oax]], [[1oay\|1oay]], [[1oaz\|1oaz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oaq OCA], [http://pdbe.org/1oaq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oaq RCSB], [http://www.ebi.ac.uk/pdbsum/1oaq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oaq OCA], [http://pdbe.org/1oaq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oaq RCSB], [http://www.ebi.ac.uk/pdbsum/1oaq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oaq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/1oaq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/1oaq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:50, 7 February 2016

OCA — Sun, 07 Feb 2016 20:50:24 GMT

←Older revision		Revision as of 20:50, 7 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oaq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:52, 10 September 2015

OCA — Thu, 10 Sep 2015 04:52:26 GMT

←Older revision		Revision as of 04:52, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1oaq' size='340' side='right' caption='[[1oaq]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1oaq' size='340' side='right' caption='[[1oaq]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oaq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oaq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAQ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oar\|1oar]], [[1oau\|1oau]], [[1oax\|1oax]], [[1oay\|1oay]], [[1oaz\|1oaz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oar\|1oar]], [[1oau\|1oau]], [[1oax\|1oax]], [[1oay\|1oay]], [[1oaz\|1oaz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oaq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oaq RCSB], [http://www.ebi.ac.uk/pdbsum/1oaq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oaq OCA], [http://pdbe.org/1oaq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oaq RCSB], [http://www.ebi.ac.uk/pdbsum/1oaq PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1oaq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: James, L C]]		[[Category: James, L C]]
	[[Category: Roversi, P]]		[[Category: Roversi, P]]

OCA at 16:40, 5 January 2015

OCA — Mon, 05 Jan 2015 16:40:27 GMT

←Older revision		Revision as of 16:40, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oaq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oaq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oar\|1oar]], [[1oau\|1oau]], [[1oax\|1oax]], [[1oay\|1oay]], [[1oaz\|1oaz]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oar\|1oar]], [[1oau\|1oau]], [[1oax\|1oax]], [[1oay\|1oay]], [[1oaz\|1oaz]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oaq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oaq RCSB], [http://www.ebi.ac.uk/pdbsum/1oaq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oaq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oaq RCSB], [http://www.ebi.ac.uk/pdbsum/1oaq PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: James, L C.]]	+	[[Category: James, L C]]
-	[[Category: Roversi, P.]]	+	[[Category: Roversi, P]]
-	[[Category: Tawfik, D.]]	+	[[Category: Tawfik, D]]
	[[Category: Allergy]]		[[Category: Allergy]]
	[[Category: Conformational diversity]]		[[Category: Conformational diversity]]

OCA at 05:25, 3 October 2014

OCA — Fri, 03 Oct 2014 05:25:02 GMT

←Older revision		Revision as of 05:25, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1oaq~~\| ~~PDB~~=1oaq \| ~~SCENE~~= }}	+	==Free conformation Ab1 of the IgE SPE-7==
-	===~~Free conformation Ab1~~ of the ~~IgE SPE~~-7===	+	<StructureSection load='1oaq' size='340' side='right' caption='[[1oaq]], [[Resolution\|resolution]] 1.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_12610298}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1oaq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1oar\|1oar]], [[1oau\|1oau]], [[1oax\|1oax]], [[1oay\|1oay]], [[1oaz\|1oaz]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oaq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oaq RCSB], [http://www.ebi.ac.uk/pdbsum/1oaq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/1oaq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A single antibody was shown to adopt different binding-site conformations and thereby bind unrelated antigens. Analysis by both x-ray crystallography and pre-steady-state kinetics revealed an equilibrium between different preexisting isomers, one of which possessed a promiscuous, low-affinity binding site for aromatic ligands, including the immunizing hapten. A subsequent induced-fit isomerization led to high-affinity complexes with a deep and narrow binding site. A protein antigen identified by repertoire selection made use of an unrelated antibody isomer with a wide, shallow binding site. Conformational diversity, whereby one sequence adopts multiple structures and multiple functions, can increase the effective size of the antibody repertoire but may also lead to autoimmunity and allergy.

-	~~==About this Structure==~~	+	Antibody multispecificity mediated by conformational diversity.,James LC, Roversi P, Tawfik DS Science. 2003 Feb 28;299(5611):1362-7. PMID:12610298<ref>PMID:12610298</ref>
-	~~[[1oaq]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA].~~	+

-	~~==See Also==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	*[[Ribosomal protein S6\|Ribosomal protein S6]]	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:012610298</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: James, L C.]]		[[Category: James, L C.]]

OCA at 08:42, 30 October 2013

OCA — Wed, 30 Oct 2013 08:42:00 GMT

←Older revision		Revision as of 08:42, 30 October 2013
Line 1:		Line 1:
-	[[Image:1oaq.png\|left\|200px]]
-
	{{STRUCTURE_1oaq\| PDB=1oaq \| SCENE= }}		{{STRUCTURE_1oaq\| PDB=1oaq \| SCENE= }}
-		+	===Free conformation Ab1 of the IgE SPE-7===
-	===~~FREE CONFORMATION AB1 OF THE IGE~~ SPE-7===	+
-		+
	{{ABSTRACT_PUBMED_12610298}}		{{ABSTRACT_PUBMED_12610298}}

	==About this Structure==		==About this Structure==
-	[[1oaq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_rattus Rattus rattus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA].	+	[[1oaq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA].

	==See Also==		==See Also==
Line 14:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:012610298</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012610298</ref><references group="xtra"/><references/>
-	[[Category: ~~Rattus rattus~~]]	+	[[Category: Mus musculus]]
	[[Category: James, L C.]]		[[Category: James, L C.]]
	[[Category: Roversi, P.]]		[[Category: Roversi, P.]]
	[[Category: Tawfik, D.]]		[[Category: Tawfik, D.]]
	[[Category: Allergy]]		[[Category: Allergy]]
-	[[Category: Antibody]]
	[[Category: Conformational diversity]]		[[Category: Conformational diversity]]
	[[Category: Ige]]		[[Category: Ige]]
		+	[[Category: Immune system]]
	[[Category: Multispecificity]]		[[Category: Multispecificity]]

OCA at 07:49, 20 October 2012

OCA — Sat, 20 Oct 2012 07:49:48 GMT

←Older revision		Revision as of 07:49, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1oaq]] is a 2 chain structure ~~of [[Ribosomal protein S6]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA].	+	[[1oaq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA].

	==See Also==		==See Also==