1oas - Revision history

OCA at 23:46, 27 December 2023

OCA — Wed, 27 Dec 2023 23:46:45 GMT

←Older revision		Revision as of 23:46, 27 December 2023
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	<StructureSection load='1oas' size='340' side='right'caption='[[1oas]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1oas' size='340' side='right'caption='[[1oas]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oas]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OAS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oas]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OAS FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PLP:PYRIDOXAL~~-~~5-PHOSPHATE'>PLP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Cysteine_synthase Cysteine synthase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.~~5~~.1.47 2.5.1.47]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oas OCA], [https://pdbe.org/1oas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oas RCSB], [https://www.ebi.ac.uk/pdbsum/1oas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oas ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oas OCA], [https://pdbe.org/1oas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oas RCSB], [https://www.ebi.ac.uk/pdbsum/1oas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oas ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CYSK_SALTY CYSK_SALTY]] Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product.	+	[https://www.uniprot.org/uniprot/CYSK_SALTY CYSK_SALTY] Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cysteine synthase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Burkhard, P]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-	[[Category: Cook~~, P F~~]]	+	[[Category: Burkhard P]]
-	[[Category: Hohenester, E]]	+	[[Category: Cook PF]]
-	[[Category: Jansonius~~, J N~~]]	+	[[Category: Hohenester E]]
-	[[Category: Rao~~, G S.J~~]]	+	[[Category: Jansonius JN]]
-	[[Category: Schnackerz~~, K D]]~~	+	[[Category: Rao GSJ]]
-	~~[[Category: Beta replacement enzyme]]~~	+	[[Category: Schnackerz KD]]
-	~~[[Category: Cystein biosynthesis]]~~	+
-	~~[[Category: Homodimer]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Plp dependent enzyme~~]]	+

OCA at 07:10, 25 August 2021

OCA — Wed, 25 Aug 2021 07:10:48 GMT

←Older revision		Revision as of 07:10, 25 August 2021
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	<StructureSection load='1oas' size='340' side='right'caption='[[1oas]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1oas' size='340' side='right'caption='[[1oas]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oas]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1OAS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oas]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OAS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cysteine_synthase Cysteine synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.47 2.5.1.47] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cysteine_synthase Cysteine synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.47 2.5.1.47] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1oas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oas OCA], [~~http~~://pdbe.org/1oas PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1oas RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1oas PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1oas ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oas OCA], [https://pdbe.org/1oas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oas RCSB], [https://www.ebi.ac.uk/pdbsum/1oas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oas ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CYSK_SALTY CYSK_SALTY]] Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product.	+	[[https://www.uniprot.org/uniprot/CYSK_SALTY CYSK_SALTY]] Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 18:49, 20 November 2019

OCA — Wed, 20 Nov 2019 18:49:15 GMT

←Older revision		Revision as of 18:49, 20 November 2019
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	==O-ACETYLSERINE SULFHYDRYLASE FROM SALMONELLA TYPHIMURIUM==		==O-ACETYLSERINE SULFHYDRYLASE FROM SALMONELLA TYPHIMURIUM==
-	<StructureSection load='1oas' size='340' side='right' caption='[[1oas]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1oas' size='340' side='right'caption='[[1oas]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oas]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oas]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAS FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Cysteine synthase]]		[[Category: Cysteine synthase]]
		+	[[Category: Large Structures]]
	[[Category: Burkhard, P]]		[[Category: Burkhard, P]]
	[[Category: Cook, P F]]		[[Category: Cook, P F]]

OCA at 07:35, 7 February 2018

OCA — Wed, 07 Feb 2018 07:35:44 GMT

←Older revision		Revision as of 07:35, 7 February 2018
Line 1:		Line 1:
		+
	==O-ACETYLSERINE SULFHYDRYLASE FROM SALMONELLA TYPHIMURIUM==		==O-ACETYLSERINE SULFHYDRYLASE FROM SALMONELLA TYPHIMURIUM==
	<StructureSection load='1oas' size='340' side='right' caption='[[1oas]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1oas' size='340' side='right' caption='[[1oas]], [[Resolution\|resolution]] 2.20Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_synthase Cysteine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.47 2.5.1.47] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_synthase Cysteine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.47 2.5.1.47] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oas OCA], [http://pdbe.org/1oas PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oas RCSB], [http://www.ebi.ac.uk/pdbsum/1oas PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oas OCA], [http://pdbe.org/1oas PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oas RCSB], [http://www.ebi.ac.uk/pdbsum/1oas PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oas ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/1oas_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/1oas_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:45, 7 February 2016

OCA — Sun, 07 Feb 2016 05:45:44 GMT

←Older revision		Revision as of 05:45, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oas ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:25, 9 September 2015

OCA — Wed, 09 Sep 2015 22:25:43 GMT

←Older revision		Revision as of 22:25, 9 September 2015
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	<StructureSection load='1oas' size='340' side='right' caption='[[1oas]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1oas' size='340' side='right' caption='[[1oas]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oas]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oas]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_synthase Cysteine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.47 2.5.1.47] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_synthase Cysteine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.47 2.5.1.47] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oas OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oas RCSB], [http://www.ebi.ac.uk/pdbsum/1oas PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oas OCA], [http://pdbe.org/1oas PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oas RCSB], [http://www.ebi.ac.uk/pdbsum/1oas PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1oas" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Cysteine synthase]]		[[Category: Cysteine synthase]]
-	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Burkhard, P]]		[[Category: Burkhard, P]]
	[[Category: Cook, P F]]		[[Category: Cook, P F]]

OCA at 08:20, 24 December 2014

OCA — Wed, 24 Dec 2014 08:20:09 GMT

←Older revision		Revision as of 08:20, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oas]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oas]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_synthase Cysteine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.47 2.5.1.47] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_synthase Cysteine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.47 2.5.1.47] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oas OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oas RCSB], [http://www.ebi.ac.uk/pdbsum/1oas PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oas OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oas RCSB], [http://www.ebi.ac.uk/pdbsum/1oas PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CYSK_SALTY CYSK_SALTY]] Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	[[Category: Cysteine synthase]]		[[Category: Cysteine synthase]]
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
-	[[Category: Burkhard, P.]]	+	[[Category: Burkhard, P]]
-	[[Category: Cook, P F.]]	+	[[Category: Cook, P F]]
-	[[Category: Hohenester, E.]]	+	[[Category: Hohenester, E]]
-	[[Category: Jansonius, J N.]]	+	[[Category: Jansonius, J N]]
-	[[Category: Rao, G S.J.]]	+	[[Category: Rao, G S.J]]
-	[[Category: Schnackerz, K D.]]	+	[[Category: Schnackerz, K D]]
	[[Category: Beta replacement enzyme]]		[[Category: Beta replacement enzyme]]
	[[Category: Cystein biosynthesis]]		[[Category: Cystein biosynthesis]]

OCA at 14:07, 28 September 2014

OCA — Sun, 28 Sep 2014 14:07:02 GMT

←Older revision		Revision as of 14:07, 28 September 2014
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-	[[~~Image~~:1oas.~~png\|left~~\|200px]]	+	==O-ACETYLSERINE SULFHYDRYLASE FROM SALMONELLA TYPHIMURIUM==
		+	<StructureSection load='1oas' size='340' side='right' caption='[[1oas]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1oas]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OAS FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_synthase Cysteine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.47 2.5.1.47] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oas OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oas RCSB], [http://www.ebi.ac.uk/pdbsum/1oas PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/1oas_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The last step in cysteine biosynthesis in enteric bacteria is catalyzed by the pyridoxal 5'-phosphate-dependent enzyme O-acetylserine sulfhydrylase. Here we report the crystal structure at 2.2 A resolution of the A-isozyme of O-acetylserine sulfhydrylase isolated from Salmonella typhimurium. O-acetylserine sulfhydrylase shares the same fold with tryptophan synthase-beta from Salmonella typhimurium but the sequence identity level is below 20%. There are some major structural differences: the loops providing the interface to the alpha-subunit in tryptophan synthase-beta and two surface helices of tryptophan synthase-beta are missing in O-acetylserine sulfhydrylase. The hydrophobic channel for indole transport from the alpha to the beta active site of tryptophan synthase-beta is, not unexpectedly, also absent in O-acetylserine sulfhydrylase. The dimer interface, on the other hand, is more or less conserved in the two enzymes. The active site cleft of O-acetylserine sulfhydrylase is wider and therefore more exposed to the solvent. A possible binding site for the substrate O-acetylserine is discussed.

-	~~{{STRUCTURE_1oas\| PDB=1oas \| SCENE= }}~~	+	Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium.,Burkhard P, Rao GS, Hohenester E, Schnackerz KD, Cook PF, Jansonius JN J Mol Biol. 1998;283(1):121-33. PMID:9761678<ref>PMID:9761678</ref>

-	~~===O-ACETYLSERINE SULFHYDRYLASE FROM SALMONELLA TYPHIMURIUM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9761678}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1oas]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Salmonella_enterica_subsp~~.~~_enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1OAS OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:009761678<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Cysteine synthase]]		[[Category: Cysteine synthase]]
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]

OCA: Protected "1oas" [edit=sysop:move=sysop]

OCA — Wed, 12 Dec 2012 22:04:55 GMT

Protected "1oas" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:04, 12 December 2012

OCA at 22:04, 12 December 2012

OCA — Wed, 12 Dec 2012 22:04:42 GMT

←Older revision		Revision as of 22:04, 12 December 2012
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-	{{Seed}}
	[[Image:1oas.png\|left\|200px]]		[[Image:1oas.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1oas", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1oas\| PDB=1oas \| SCENE= }}		{{STRUCTURE_1oas\| PDB=1oas \| SCENE= }}

	===O-ACETYLSERINE SULFHYDRYLASE FROM SALMONELLA TYPHIMURIUM===		===O-ACETYLSERINE SULFHYDRYLASE FROM SALMONELLA TYPHIMURIUM===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9761678}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 9761678 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_9761678}}		{{ABSTRACT_PUBMED_9761678}}

	==About this Structure==		==About this Structure==
-	~~1OAS~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Salmonella_typhimurium~~ Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAS OCA].	+	[[1oas]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAS OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9761678~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009761678</ref><references group="xtra"/>
	[[Category: Cysteine synthase]]		[[Category: Cysteine synthase]]
-	[[Category: Salmonella typhimurium]]	+	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Burkhard, P.]]		[[Category: Burkhard, P.]]
	[[Category: Cook, P F.]]		[[Category: Cook, P F.]]
Line 35:		Line 23:
	[[Category: Cystein biosynthesis]]		[[Category: Cystein biosynthesis]]
	[[Category: Homodimer]]		[[Category: Homodimer]]
		+	[[Category: Lyase]]
	[[Category: Plp dependent enzyme]]		[[Category: Plp dependent enzyme]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:43:30 2009''