1oc5 - Revision history

OCA at 12:34, 13 December 2023

OCA — Wed, 13 Dec 2023 12:34:52 GMT

←Older revision		Revision as of 12:34, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1oc5' size='340' side='right'caption='[[1oc5]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1oc5' size='340' side='right'caption='[[1oc5]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_16454 Atcc 16454~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OC5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Humicola_insolens Humicola insolens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OC5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=~~NAG~~:N-~~ACETYL~~-~~D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~MGL~~:O1-~~METHYL~~-~~GLUCOSE~~'>~~MGL~~</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc6\|1oc6]], [[1oc7\|1oc7]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MGL:O1-METHYL-GLUCOSE'>MGL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc5 OCA], [https://pdbe.org/1oc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oc5 RCSB], [https://www.ebi.ac.uk/pdbsum/1oc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oc5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc5 OCA], [https://pdbe.org/1oc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oc5 RCSB], [https://www.ebi.ac.uk/pdbsum/1oc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oc5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GUX6_HUMIN GUX6_HUMIN] Plays a central role in the recycling of plant biomass. The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the dissaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.<ref>PMID:9882628</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 16454~~]]	+	[[Category: Humicola insolens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Boyer, V]]	+	[[Category: Boyer V]]
-	[[Category: Davies~~, G J~~]]	+	[[Category: Davies GJ]]
-	[[Category: Driguez, H]]	+	[[Category: Driguez H]]
-	[[Category: Frandsen~~, T P]]~~	+	[[Category: Frandsen TP]]
-	~~[[Category: Ossowski, I Von~~]]	+	[[Category: Schulein M]]
-	[[Category: Schulein, M]]	+	[[Category: Varrot A]]
-	[[Category: Varrot, A]]	+	[[Category: Von Ossowski I]]
-	[[Category: ~~Cellobiohydrolase]]~~	+
-	~~[[Category: Cellulase]]~~	+
-	~~[[Category: Cellulose degradation]]~~	+
-	~~[[Category: Glycoside hydrolase family 6]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Processive mechanism~~]]	+

OCA at 07:11, 25 August 2021

OCA — Wed, 25 Aug 2021 07:11:21 GMT

←Older revision		Revision as of 07:11, 25 August 2021
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	<StructureSection load='1oc5' size='340' side='right'caption='[[1oc5]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1oc5' size='340' side='right'caption='[[1oc5]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oc5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_16454 Atcc 16454]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1OC5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_16454 Atcc 16454]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OC5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=~~MGL~~:O1-~~METHYL~~-~~GLUCOSE~~'>~~MGL~~</scene>, <scene name='pdbligand=~~NAG~~:N-~~ACETYL-D~~-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MGL:O1-METHYL-GLUCOSE'>MGL</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc6\|1oc6]], [[1oc7\|1oc7]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc6\|1oc6]], [[1oc7\|1oc7]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1oc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc5 OCA], [~~http~~://pdbe.org/1oc5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1oc5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1oc5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1oc5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc5 OCA], [https://pdbe.org/1oc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oc5 RCSB], [https://www.ebi.ac.uk/pdbsum/1oc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oc5 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 18:29, 20 November 2019

OCA — Wed, 20 Nov 2019 18:29:47 GMT

←Older revision		Revision as of 18:29, 20 November 2019
Line 1:		Line 1:

	==D405N mutant of the CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS in complex with methyl-cellobiosyl-4-deoxy-4-thio-beta-D-cellobioside==		==D405N mutant of the CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS in complex with methyl-cellobiosyl-4-deoxy-4-thio-beta-D-cellobioside==
-	<StructureSection load='1oc5' size='340' side='right' caption='[[1oc5]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='1oc5' size='340' side='right'caption='[[1oc5]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_16454 Atcc 16454]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_16454 Atcc 16454]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC5 FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1oc5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1oc5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cellobiohydrolase 3D structures\|Cellobiohydrolase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 16454]]		[[Category: Atcc 16454]]
		+	[[Category: Large Structures]]
	[[Category: Boyer, V]]		[[Category: Boyer, V]]
	[[Category: Davies, G J]]		[[Category: Davies, G J]]

OCA at 07:16, 7 February 2018

OCA — Wed, 07 Feb 2018 07:16:56 GMT

←Older revision		Revision as of 07:16, 7 February 2018
Line 1:		Line 1:
-	==D405N ~~MUTANT OF THE~~ CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS ~~IN COMPLEX WITH METHYL~~-~~CELLOBIOSYL~~-4-~~DEOXY~~-4-~~THIO~~-~~BETA~~-D-~~CELLOBIOSIDE~~==	+
		+	==D405N mutant of the CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS in complex with methyl-cellobiosyl-4-deoxy-4-thio-beta-D-cellobioside==
	<StructureSection load='1oc5' size='340' side='right' caption='[[1oc5]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1oc5' size='340' side='right' caption='[[1oc5]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_16454 Atcc 16454]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_16454 Atcc 16454]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=~~NAG~~:N-~~ACETYL~~-~~D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~MGL~~:O1-~~METHYL~~-~~GLUCOSE~~'>~~MGL~~</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MGL:O1-METHYL-GLUCOSE'>MGL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc6\|1oc6]], [[1oc7\|1oc7]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc6\|1oc6]], [[1oc7\|1oc7]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc5 OCA], [http://pdbe.org/1oc5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oc5 RCSB], [http://www.ebi.ac.uk/pdbsum/1oc5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc5 OCA], [http://pdbe.org/1oc5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oc5 RCSB], [http://www.ebi.ac.uk/pdbsum/1oc5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oc5 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/1oc5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/1oc5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1oc5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1oc5" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cellobiohydrolase\|Cellobiohydrolase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:09, 8 February 2016

OCA — Mon, 08 Feb 2016 20:09:33 GMT

←Older revision		Revision as of 20:09, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oc5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:58, 10 September 2015

OCA — Thu, 10 Sep 2015 14:58:53 GMT

←Older revision		Revision as of 14:58, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1oc5' size='340' side='right' caption='[[1oc5]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1oc5' size='340' side='right' caption='[[1oc5]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Humicola_insolens Humicola insolens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_16454 Atcc 16454]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MGL:O1-METHYL-GLUCOSE'>MGL</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MGL:O1-METHYL-GLUCOSE'>MGL</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc6\|1oc6]], [[1oc7\|1oc7]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc6\|1oc6]], [[1oc7\|1oc7]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-~~cellobiosidase~~ Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oc5 RCSB], [http://www.ebi.ac.uk/pdbsum/1oc5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc5 OCA], [http://pdbe.org/1oc5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oc5 RCSB], [http://www.ebi.ac.uk/pdbsum/1oc5 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1oc5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cellulose 1,4-beta-cellobiosidase]]~~	+	[[Category: Atcc 16454]]
-	~~[[Category: Humicola insolens~~]]	+
	[[Category: Boyer, V]]		[[Category: Boyer, V]]
	[[Category: Davies, G J]]		[[Category: Davies, G J]]

OCA at 15:45, 5 January 2015

OCA — Mon, 05 Jan 2015 15:45:08 GMT

←Older revision		Revision as of 15:45, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Humicola_insolens Humicola insolens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Humicola_insolens Humicola insolens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MGL:O1-METHYL-GLUCOSE'>MGL</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MGL:O1-METHYL-GLUCOSE'>MGL</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc6\|1oc6]], [[1oc7\|1oc7]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc6\|1oc6]], [[1oc7\|1oc7]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oc5 RCSB], [http://www.ebi.ac.uk/pdbsum/1oc5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oc5 RCSB], [http://www.ebi.ac.uk/pdbsum/1oc5 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Cellulose 1,4-beta-cellobiosidase]]		[[Category: Cellulose 1,4-beta-cellobiosidase]]
	[[Category: Humicola insolens]]		[[Category: Humicola insolens]]
-	[[Category: Boyer, V.]]	+	[[Category: Boyer, V]]
-	[[Category: Davies, G J.]]	+	[[Category: Davies, G J]]
-	[[Category: Driguez, H.]]	+	[[Category: Driguez, H]]
-	[[Category: Frandsen, T P.]]	+	[[Category: Frandsen, T P]]
-	[[Category: Ossowski, I Von.]]	+	[[Category: Ossowski, I Von]]
-	[[Category: Schulein, M.]]	+	[[Category: Schulein, M]]
-	[[Category: Varrot, A.]]	+	[[Category: Varrot, A]]
	[[Category: Cellobiohydrolase]]		[[Category: Cellobiohydrolase]]
	[[Category: Cellulase]]		[[Category: Cellulase]]

OCA at 16:54, 28 September 2014

OCA — Sun, 28 Sep 2014 16:54:45 GMT

←Older revision		Revision as of 16:54, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1oc5.~~png~~\|~~left~~\|200px]]	+	==D405N MUTANT OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH METHYL-CELLOBIOSYL-4-DEOXY-4-THIO-BETA-D-CELLOBIOSIDE==
		+	<StructureSection load='1oc5' size='340' side='right' caption='[[1oc5]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1oc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Humicola_insolens Humicola insolens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MGL:O1-METHYL-GLUCOSE'>MGL</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc6\|1oc6]], [[1oc7\|1oc7]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oc5 RCSB], [http://www.ebi.ac.uk/pdbsum/1oc5 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/1oc5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The enzymatic digestion of cellulose entails intimate involvement of cellobiohydrolases, whose characteristic active-center tunnel contributes to a processive degradation of the polysaccharide. The cellobiohydrolase Cel6A displays an active site within a tunnel formed by two extended loops, which are known to open and close in response to ligand binding. Here we present five structures of wild-type and mutant forms of Cel6A from Humicola insolens in complex with nonhydrolyzable thio-oligosaccharides, at resolutions from 1.7-1.1 A, dissecting the structural accommodation of a processing substrate chain through the active center during hydrolysis. Movement of ligand is facilitated by extensive solvent-mediated interactions and through flexibility in the hydrophobic surfaces provided by a sheath of tryptophan residues.

-	~~{{STRUCTURE_1oc5\| PDB=1oc5 \| SCENE= }}~~	+	Structural basis for ligand binding and processivity in cellobiohydrolase Cel6A from Humicola insolens.,Varrot A, Frandsen TP, von Ossowski I, Boyer V, Cottaz S, Driguez H, Schulein M, Davies GJ Structure. 2003 Jul;11(7):855-64. PMID:12842048<ref>PMID:12842048</ref>

-	~~===D405N MUTANT OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH METHYL-CELLOBIOSYL-4-DEOXY-4-THIO-BETA-D-CELLOBIOSIDE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12842048}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1oc5]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Humicola_insolens Humicola insolens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA].~~	+

	==See Also==		==See Also==
	*[[Cellobiohydrolase\|Cellobiohydrolase]]		*[[Cellobiohydrolase\|Cellobiohydrolase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012842048<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Cellulose 1,4-beta-cellobiosidase]]		[[Category: Cellulose 1,4-beta-cellobiosidase]]
	[[Category: Humicola insolens]]		[[Category: Humicola insolens]]

OCA at 11:20, 20 October 2012

OCA — Sat, 20 Oct 2012 11:20:11 GMT

←Older revision		Revision as of 11:20, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1oc5]] is a 1 chain structure ~~of [[Cellobiohydrolase]]~~ with sequence from [http://en.wikipedia.org/wiki/Humicola_insolens Humicola insolens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA].	+	[[1oc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Humicola_insolens Humicola insolens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC5 OCA].

	==See Also==		==See Also==

OCA: Protected "1oc5" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 05:01:32 GMT

Protected "1oc5" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:01, 26 July 2012