1od7 - Revision history

OCA at 12:36, 13 December 2023

OCA — Wed, 13 Dec 2023 12:36:09 GMT

←Older revision		Revision as of 12:36, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1od7' size='340' side='right'caption='[[1od7]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1od7' size='340' side='right'caption='[[1od7]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1od7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OD7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1od7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OD7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SUW:ME~~-~~A-9-N-(NAPHTHYL-2-CARBONYL)-AMINO-9-DEOXY-NEU5AC'>SUW</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1qfo\|1qfo]], [[1qfp\|1qfp]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SUW:ME-A-9-N-(NAPHTHYL-2-CARBONYL)-AMINO-9-DEOXY-NEU5AC'>SUW</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1od7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od7 OCA], [https://pdbe.org/1od7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1od7 RCSB], [https://www.ebi.ac.uk/pdbsum/1od7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1od7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1od7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od7 OCA], [https://pdbe.org/1od7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1od7 RCSB], [https://www.ebi.ac.uk/pdbsum/1od7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1od7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SN_MOUSE SN_MOUSE]] Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hematopoiesis. May act as a counter-receptor for CLEC10A in lymph node.<ref>PMID:15364954</ref>	+	[https://www.uniprot.org/uniprot/SN_MOUSE SN_MOUSE] Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hematopoiesis. May act as a counter-receptor for CLEC10A in lymph node.<ref>PMID:15364954</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Brossmer, R]]	+	[[Category: Brossmer R]]
-	[[Category: Crocker~~, P R~~]]	+	[[Category: Crocker PR]]
-	[[Category: Jones~~, E Y~~]]	+	[[Category: Jones EY]]
-	[[Category: Kelm, S]]	+	[[Category: Kelm S]]
-	[[Category: Maenaka, K]]	+	[[Category: Maenaka K]]
-	[[Category: Maenaka, T]]	+	[[Category: Maenaka T]]
-	[[Category: Zaccai~~, N R]]~~	+	[[Category: Zaccai NR]]
-	~~[[Category: Carbohydrate binding]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin superfamily]]~~	+
-	~~[[Category: Inhibitor design]]~~	+
-	~~[[Category: Lectin-immnue system complex]]~~	+
-	~~[[Category: Lectin/immnue system]]~~	+
-	~~[[Category: Siglec~~]]	+

OCA at 09:56, 12 May 2021

OCA — Wed, 12 May 2021 09:56:58 GMT

←Older revision		Revision as of 09:56, 12 May 2021
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	<StructureSection load='1od7' size='340' side='right'caption='[[1od7]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1od7' size='340' side='right'caption='[[1od7]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1od7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1OD7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1od7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OD7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SUW:ME-A-9-N-(NAPHTHYL-2-CARBONYL)-AMINO-9-DEOXY-NEU5AC'>SUW</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SUW:ME-A-9-N-(NAPHTHYL-2-CARBONYL)-AMINO-9-DEOXY-NEU5AC'>SUW</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qfo\|1qfo]], [[1qfp\|1qfp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qfo\|1qfo]], [[1qfp\|1qfp]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1od7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od7 OCA], [~~http~~://pdbe.org/1od7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1od7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1od7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1od7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1od7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od7 OCA], [https://pdbe.org/1od7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1od7 RCSB], [https://www.ebi.ac.uk/pdbsum/1od7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1od7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SN_MOUSE SN_MOUSE]] Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hematopoiesis. May act as a counter-receptor for CLEC10A in lymph node.<ref>PMID:15364954</ref>	+	[[https://www.uniprot.org/uniprot/SN_MOUSE SN_MOUSE]] Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hematopoiesis. May act as a counter-receptor for CLEC10A in lymph node.<ref>PMID:15364954</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:56, 7 August 2019

OCA — Wed, 07 Aug 2019 06:56:48 GMT

←Older revision		Revision as of 06:56, 7 August 2019
Line 1:		Line 1:

	==N-terminal of Sialoadhesin in complex with Me-a-9-N-(naphthyl-2-carbonyl)-amino-9-deoxy-Neu5Ac (NAP compound)==		==N-terminal of Sialoadhesin in complex with Me-a-9-N-(naphthyl-2-carbonyl)-amino-9-deoxy-Neu5Ac (NAP compound)==
-	<StructureSection load='1od7' size='340' side='right' caption='[[1od7]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='1od7' size='340' side='right'caption='[[1od7]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1od7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1od7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OD7 FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/od/1od7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/od/1od7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Brossmer, R]]		[[Category: Brossmer, R]]

OCA at 10:06, 1 November 2017

OCA — Wed, 01 Nov 2017 10:06:07 GMT

←Older revision		Revision as of 10:06, 1 November 2017
Line 1:		Line 1:
-	==N-~~TERMINAL OF SIALOADHESIN IN COMPLEX WITH ME~~-A-9-N-(~~NAPHTHYL~~-2-~~CARBONYL~~)-~~AMINO~~-9-~~DEOXY~~-~~NEU5AC~~ (NAP ~~COMPOUND~~)==	+
		+	==N-terminal of Sialoadhesin in complex with Me-a-9-N-(naphthyl-2-carbonyl)-amino-9-deoxy-Neu5Ac (NAP compound)==
	<StructureSection load='1od7' size='340' side='right' caption='[[1od7]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1od7' size='340' side='right' caption='[[1od7]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SUW:ME-A-9-N-(NAPHTHYL-2-CARBONYL)-AMINO-9-DEOXY-NEU5AC'>SUW</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SUW:ME-A-9-N-(NAPHTHYL-2-CARBONYL)-AMINO-9-DEOXY-NEU5AC'>SUW</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qfo\|1qfo]], [[1qfp\|1qfp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qfo\|1qfo]], [[1qfp\|1qfp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1od7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od7 OCA], [http://pdbe.org/1od7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1od7 RCSB], [http://www.ebi.ac.uk/pdbsum/1od7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1od7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od7 OCA], [http://pdbe.org/1od7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1od7 RCSB], [http://www.ebi.ac.uk/pdbsum/1od7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1od7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1od7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:46, 11 September 2015

OCA — Fri, 11 Sep 2015 07:46:25 GMT

←Older revision		Revision as of 07:46, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1od7' size='340' side='right' caption='[[1od7]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1od7' size='340' side='right' caption='[[1od7]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1od7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OD7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1od7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OD7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SUW:ME-A-9-N-(NAPHTHYL-2-CARBONYL)-AMINO-9-DEOXY-NEU5AC'>SUW</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SUW:ME-A-9-N-(NAPHTHYL-2-CARBONYL)-AMINO-9-DEOXY-NEU5AC'>SUW</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qfo\|1qfo]], [[1qfp\|1qfp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qfo\|1qfo]], [[1qfp\|1qfp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1od7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1od7 RCSB], [http://www.ebi.ac.uk/pdbsum/1od7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1od7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od7 OCA], [http://pdbe.org/1od7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1od7 RCSB], [http://www.ebi.ac.uk/pdbsum/1od7 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1od7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Brossmer, R]]		[[Category: Brossmer, R]]
	[[Category: Crocker, P R]]		[[Category: Crocker, P R]]

OCA at 13:25, 25 December 2014

OCA — Thu, 25 Dec 2014 13:25:48 GMT

←Older revision		Revision as of 13:25, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1od7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1od7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OD7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SUW:ME-A-9-N-(NAPHTHYL-2-CARBONYL)-AMINO-9-DEOXY-NEU5AC'>SUW</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SUW:ME-A-9-N-(NAPHTHYL-2-CARBONYL)-AMINO-9-DEOXY-NEU5AC'>SUW</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qfo\|1qfo]], [[1qfp\|1qfp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qfo\|1qfo]], [[1qfp\|1qfp]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1od7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1od7 RCSB], [http://www.ebi.ac.uk/pdbsum/1od7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1od7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1od7 RCSB], [http://www.ebi.ac.uk/pdbsum/1od7 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SN_MOUSE SN_MOUSE]] Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hematopoiesis. May act as a counter-receptor for CLEC10A in lymph node.<ref>PMID:15364954</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Brossmer, R.]]	+	[[Category: Brossmer, R]]
-	[[Category: Crocker, P R.]]	+	[[Category: Crocker, P R]]
-	[[Category: Jones, E Y.]]	+	[[Category: Jones, E Y]]
-	[[Category: Kelm, S.]]	+	[[Category: Kelm, S]]
-	[[Category: Maenaka, K.]]	+	[[Category: Maenaka, K]]
-	[[Category: Maenaka, T.]]	+	[[Category: Maenaka, T]]
-	[[Category: Zaccai, N R.]]	+	[[Category: Zaccai, N R]]
	[[Category: Carbohydrate binding]]		[[Category: Carbohydrate binding]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 15:35, 28 September 2014

OCA — Sun, 28 Sep 2014 15:35:12 GMT

←Older revision		Revision as of 15:35, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1od7.~~png~~\|~~left~~\|200px]]	+	==N-TERMINAL OF SIALOADHESIN IN COMPLEX WITH ME-A-9-N-(NAPHTHYL-2-CARBONYL)-AMINO-9-DEOXY-NEU5AC (NAP COMPOUND)==
		+	<StructureSection load='1od7' size='340' side='right' caption='[[1od7]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1od7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OD7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SUW:ME-A-9-N-(NAPHTHYL-2-CARBONYL)-AMINO-9-DEOXY-NEU5AC'>SUW</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qfo\|1qfo]], [[1qfp\|1qfp]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1od7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1od7 RCSB], [http://www.ebi.ac.uk/pdbsum/1od7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/od/1od7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Siglec family of receptors mediates cell surface interactions through recognition of sialylated glycoconjugates. The crystal structure of the N-terminal immunoglobulin-like domain of the Siglec sialoadhesin (SnD1) in complex with 2,3-sialyllactose has informed the design of sialic acid analogs (sialosides) that bind Siglecs with significantly enhanced affinities and specificities. Binding assays against sialoadhesin (Sn; Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4) show a 10- to 300-fold reduction in IC(50) values (relative to methyl-alpha-Neu5Ac) for three sialosides bearing aromatic group modifications of the glycerol side chain: Me-alpha-9-N-benzoyl-amino-9-deoxy-Neu5Ac (BENZ), Me-alpha-9-N-(naphthyl-2-carbonyl)-amino-9-deoxy-Neu5Ac (NAP), and Me-alpha-9-N-(biphenyl-4-carbonyl)-amino-9-deoxy-Neu5Ac (BIP). Crystal structures of these sialosides in complex with SnD1 suggest explanations for the differences in specificity and affinity, providing further ideas for compound design of physiological and potentially therapeutic relevance.

-	~~{{STRUCTURE_1od7\| PDB=1od7 \| SCENE= }}~~	+	Structure-guided design of sialic acid-based Siglec inhibitors and crystallographic analysis in complex with sialoadhesin.,Zaccai NR, Maenaka K, Maenaka T, Crocker PR, Brossmer R, Kelm S, Jones EY Structure. 2003 May;11(5):557-67. PMID:12737821<ref>PMID:12737821</ref>

-	~~===N-TERMINAL OF SIALOADHESIN IN COMPLEX WITH ME-A-9-N-(NAPHTHYL-2-CARBONYL)-AMINO-9-DEOXY-NEU5AC (NAP COMPOUND)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12737821}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1od7]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012737821<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Brossmer, R.]]		[[Category: Brossmer, R.]]

OCA: Protected "1od7" [edit=sysop:move=sysop]

OCA — Wed, 12 Dec 2012 22:17:03 GMT

Protected "1od7" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:17, 12 December 2012

OCA at 22:16, 12 December 2012

OCA — Wed, 12 Dec 2012 22:16:54 GMT

←Older revision		Revision as of 22:16, 12 December 2012
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-	{{Seed}}
	[[Image:1od7.png\|left\|200px]]		[[Image:1od7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1od7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1od7\| PDB=1od7 \| SCENE= }}		{{STRUCTURE_1od7\| PDB=1od7 \| SCENE= }}

	===N-TERMINAL OF SIALOADHESIN IN COMPLEX WITH ME-A-9-N-(NAPHTHYL-2-CARBONYL)-AMINO-9-DEOXY-NEU5AC (NAP COMPOUND)===		===N-TERMINAL OF SIALOADHESIN IN COMPLEX WITH ME-A-9-N-(NAPHTHYL-2-CARBONYL)-AMINO-9-DEOXY-NEU5AC (NAP COMPOUND)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12737821}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12737821 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12737821}}		{{ABSTRACT_PUBMED_12737821}}

	==About this Structure==		==About this Structure==
-	~~1OD7~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA].	+	[[1od7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12737821~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012737821</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Brossmer, R.]]		[[Category: Brossmer, R.]]
Line 37:		Line 25:
	[[Category: Immunoglobulin superfamily]]		[[Category: Immunoglobulin superfamily]]
	[[Category: Inhibitor design]]		[[Category: Inhibitor design]]
		+	[[Category: Lectin-immnue system complex]]
		+	[[Category: Lectin/immnue system]]
	[[Category: Siglec]]		[[Category: Siglec]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:21:56 2009''

OCA at 15:21, 17 February 2009

OCA — Tue, 17 Feb 2009 15:21:56 GMT

←Older revision		Revision as of 15:21, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1OD7 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA].	+	1OD7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD7 OCA].

	==Reference==		==Reference==
-	Structure-guided design of sialic acid-based Siglec inhibitors and crystallographic analysis in complex with sialoadhesin., Zaccai NR, Maenaka K, Maenaka T, Crocker PR, Brossmer R, Kelm S, Jones EY, Structure. 2003 May;11(5):557-67. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12737821 12737821]~~	+	<ref group="xtra">PMID:12737821</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Single protein]]
	[[Category: Brossmer, R.]]		[[Category: Brossmer, R.]]
	[[Category: Crocker, P R.]]		[[Category: Crocker, P R.]]
Line 40:		Line 39:
	[[Category: Siglec]]		[[Category: Siglec]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 00~~:18:56 ~~2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:21:56 2009''