1oew - Revision history

OCA at 07:59, 15 November 2023

OCA — Wed, 15 Nov 2023 07:59:55 GMT

←Older revision		Revision as of 07:59, 15 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oew]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OEW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oew]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OEW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, ~~<scene name='pdbligand=THR:THREONINE'>THR</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 0.9Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SUI:(3-AMINO-2,5-DIOXO-1-PYRROLIDINYL)ACETIC+ACID'>SUI</scene>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SUI:(3-AMINO-2,5-DIOXO-1-PYRROLIDINYL)ACETIC+ACID'>SUI</scene>, <scene name='pdbligand=THR:THREONINE'>THR</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e5o\|1e5o]]~~, [[1e80\|1e80]], [[1e81\|1e81]], [[1e82\|1e82]], [[1eed\|1eed]], [[1ent\|1ent]], [[1epl\|1epl]], [[1epm\|1epm]], [[1epn\|1epn]], [[1epo\|1epo]], [[1epp\|1epp]], [[1epq\|1epq]], [[1epr\|1epr]], [[1er8\|1er8]], [[1gkt\|1gkt]], [[1gvt\|1gvt]], [[1gvu\|1gvu]], [[1gvv\|1gvv]], [[1gvw\|1gvw]], [[1gvx\|1gvx]], [[1od1\|1od1]], [[1oex\|1oex]], [[2er0\|2er0]], [[2er6\|2er6]], [[2er7\|2er7]], [[2er9\|2er9]], [[3er3\|3er3]], [[3er5\|3er5]], [[4ape\|4ape]], [[4er1\|4er1]], [[4er2\|4er2]], [[4er4\|4er4]], [[5er1\|5er1]], [[5er2\|5er2]]<~~/div></td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oew OCA], [https://pdbe.org/1oew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oew RCSB], [https://www.ebi.ac.uk/pdbsum/1oew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oew ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oew OCA], [https://pdbe.org/1oew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oew RCSB], [https://www.ebi.ac.uk/pdbsum/1oew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oew ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CARP_CRYPA CARP_CRYPA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Pepsin\|Pepsin]]		*[[Pepsin\|Pepsin]]
-	*[[Proteinase\|Proteinase]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Cryphonectria parasitica]]		[[Category: Cryphonectria parasitica]]
-	[[Category: Endothiapepsin]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Coates, L]]	+	[[Category: Coates L]]
-	[[Category: Cooper~~, J B~~]]	+	[[Category: Cooper JB]]
-	[[Category: Erskine~~, P T~~]]	+	[[Category: Erskine PT]]
-	[[Category: Gill~~, R S~~]]	+	[[Category: Gill RS]]
-	[[Category: Mall, S]]	+	[[Category: Mall S]]
-	[[Category: Myles~~, D A.A~~]]	+	[[Category: Myles DAA]]
-	[[Category: Wood~~, S P]]~~	+	[[Category: Wood SP]]
-	~~[[Category: Anisotropic refinement]]~~	+
-	~~[[Category: Aspartic proteinase mechanism]]~~	+
-	~~[[Category: Atomic resolution]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Succinimide~~]]	+

OCA at 06:00, 28 April 2021

OCA — Wed, 28 Apr 2021 06:00:48 GMT

←Older revision		Revision as of 06:00, 28 April 2021
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	<StructureSection load='1oew' size='340' side='right'caption='[[1oew]], [[Resolution\|resolution]] 0.90Å' scene=''>		<StructureSection load='1oew' size='340' side='right'caption='[[1oew]], [[Resolution\|resolution]] 0.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oew]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1OEW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oew]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OEW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THR:THREONINE'>THR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THR:THREONINE'>THR</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SUI:(3-AMINO-2,5-DIOXO-1-PYRROLIDINYL)ACETIC+ACID'>SUI</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SUI:(3-AMINO-2,5-DIOXO-1-PYRROLIDINYL)ACETIC+ACID'>SUI</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5o\|1e5o]], [[1e80\|1e80]], [[1e81\|1e81]], [[1e82\|1e82]], [[1eed\|1eed]], [[1ent\|1ent]], [[1epl\|1epl]], [[1epm\|1epm]], [[1epn\|1epn]], [[1epo\|1epo]], [[1epp\|1epp]], [[1epq\|1epq]], [[1epr\|1epr]], [[1er8\|1er8]], [[1gkt\|1gkt]], [[1gvt\|1gvt]], [[1gvu\|1gvu]], [[1gvv\|1gvv]], [[1gvw\|1gvw]], [[1gvx\|1gvx]], [[1od1\|1od1]], [[1oex\|1oex]], [[2er0\|2er0]], [[2er6\|2er6]], [[2er7\|2er7]], [[2er9\|2er9]], [[3er3\|3er3]], [[3er5\|3er5]], [[4ape\|4ape]], [[4er1\|4er1]], [[4er2\|4er2]], [[4er4\|4er4]], [[5er1\|5er1]], [[5er2\|5er2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e5o\|1e5o]], [[1e80\|1e80]], [[1e81\|1e81]], [[1e82\|1e82]], [[1eed\|1eed]], [[1ent\|1ent]], [[1epl\|1epl]], [[1epm\|1epm]], [[1epn\|1epn]], [[1epo\|1epo]], [[1epp\|1epp]], [[1epq\|1epq]], [[1epr\|1epr]], [[1er8\|1er8]], [[1gkt\|1gkt]], [[1gvt\|1gvt]], [[1gvu\|1gvu]], [[1gvv\|1gvv]], [[1gvw\|1gvw]], [[1gvx\|1gvx]], [[1od1\|1od1]], [[1oex\|1oex]], [[2er0\|2er0]], [[2er6\|2er6]], [[2er7\|2er7]], [[2er9\|2er9]], [[3er3\|3er3]], [[3er5\|3er5]], [[4ape\|4ape]], [[4er1\|4er1]], [[4er2\|4er2]], [[4er4\|4er4]], [[5er1\|5er1]], [[5er2\|5er2]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1oew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oew OCA], [~~http~~://pdbe.org/1oew PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1oew RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1oew PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1oew ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oew OCA], [https://pdbe.org/1oew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oew RCSB], [https://www.ebi.ac.uk/pdbsum/1oew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oew ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Pepsin\|Pepsin]]		*[[Pepsin\|Pepsin]]
		+	*[[Proteinase\|Proteinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:02, 10 July 2019

OCA — Wed, 10 Jul 2019 06:02:09 GMT

←Older revision		Revision as of 06:02, 10 July 2019
Line 1:		Line 1:

	==ATOMIC RESOLUTION STRUCTURE OF NATIVE ENDOTHIAPEPSIN==		==ATOMIC RESOLUTION STRUCTURE OF NATIVE ENDOTHIAPEPSIN==
-	<StructureSection load='1oew' size='340' side='right' caption='[[1oew]], [[Resolution\|resolution]] 0.90Å' scene=''>	+	<StructureSection load='1oew' size='340' side='right'caption='[[1oew]], [[Resolution\|resolution]] 0.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OEW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OEW FirstGlance]. <br>
Line 38:		Line 38:
	[[Category: Cryphonectria parasitica]]		[[Category: Cryphonectria parasitica]]
	[[Category: Endothiapepsin]]		[[Category: Endothiapepsin]]
		+	[[Category: Large Structures]]
	[[Category: Coates, L]]		[[Category: Coates, L]]
	[[Category: Cooper, J B]]		[[Category: Cooper, J B]]

OCA at 05:59, 20 June 2018

OCA — Wed, 20 Jun 2018 05:59:18 GMT

←Older revision		Revision as of 05:59, 20 June 2018
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	</div>		</div>
	<div class="pdbe-citations 1oew" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1oew" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pepsin\|Pepsin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:29, 7 February 2018

OCA — Wed, 07 Feb 2018 07:29:55 GMT

←Older revision		Revision as of 07:29, 7 February 2018
Line 1:		Line 1:
		+
	==ATOMIC RESOLUTION STRUCTURE OF NATIVE ENDOTHIAPEPSIN==		==ATOMIC RESOLUTION STRUCTURE OF NATIVE ENDOTHIAPEPSIN==
	<StructureSection load='1oew' size='340' side='right' caption='[[1oew]], [[Resolution\|resolution]] 0.90Å' scene=''>		<StructureSection load='1oew' size='340' side='right' caption='[[1oew]], [[Resolution\|resolution]] 0.90Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5o\|1e5o]], [[1e80\|1e80]], [[1e81\|1e81]], [[1e82\|1e82]], [[1eed\|1eed]], [[1ent\|1ent]], [[1epl\|1epl]], [[1epm\|1epm]], [[1epn\|1epn]], [[1epo\|1epo]], [[1epp\|1epp]], [[1epq\|1epq]], [[1epr\|1epr]], [[1er8\|1er8]], [[1gkt\|1gkt]], [[1gvt\|1gvt]], [[1gvu\|1gvu]], [[1gvv\|1gvv]], [[1gvw\|1gvw]], [[1gvx\|1gvx]], [[1od1\|1od1]], [[1oex\|1oex]], [[2er0\|2er0]], [[2er6\|2er6]], [[2er7\|2er7]], [[2er9\|2er9]], [[3er3\|3er3]], [[3er5\|3er5]], [[4ape\|4ape]], [[4er1\|4er1]], [[4er2\|4er2]], [[4er4\|4er4]], [[5er1\|5er1]], [[5er2\|5er2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5o\|1e5o]], [[1e80\|1e80]], [[1e81\|1e81]], [[1e82\|1e82]], [[1eed\|1eed]], [[1ent\|1ent]], [[1epl\|1epl]], [[1epm\|1epm]], [[1epn\|1epn]], [[1epo\|1epo]], [[1epp\|1epp]], [[1epq\|1epq]], [[1epr\|1epr]], [[1er8\|1er8]], [[1gkt\|1gkt]], [[1gvt\|1gvt]], [[1gvu\|1gvu]], [[1gvv\|1gvv]], [[1gvw\|1gvw]], [[1gvx\|1gvx]], [[1od1\|1od1]], [[1oex\|1oex]], [[2er0\|2er0]], [[2er6\|2er6]], [[2er7\|2er7]], [[2er9\|2er9]], [[3er3\|3er3]], [[3er5\|3er5]], [[4ape\|4ape]], [[4er1\|4er1]], [[4er2\|4er2]], [[4er4\|4er4]], [[5er1\|5er1]], [[5er2\|5er2]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oew OCA], [http://pdbe.org/1oew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oew RCSB], [http://www.ebi.ac.uk/pdbsum/1oew PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oew OCA], [http://pdbe.org/1oew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oew RCSB], [http://www.ebi.ac.uk/pdbsum/1oew PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oew ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oe/1oew_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oe/1oew_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1oew" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1oew" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Pepsin\|Pepsin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:05, 9 February 2016

OCA — Tue, 09 Feb 2016 12:05:33 GMT

←Older revision		Revision as of 12:05, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oew ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:04, 10 September 2015

OCA — Thu, 10 Sep 2015 22:04:46 GMT

←Older revision		Revision as of 22:04, 10 September 2015
Line 7:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5o\|1e5o]], [[1e80\|1e80]], [[1e81\|1e81]], [[1e82\|1e82]], [[1eed\|1eed]], [[1ent\|1ent]], [[1epl\|1epl]], [[1epm\|1epm]], [[1epn\|1epn]], [[1epo\|1epo]], [[1epp\|1epp]], [[1epq\|1epq]], [[1epr\|1epr]], [[1er8\|1er8]], [[1gkt\|1gkt]], [[1gvt\|1gvt]], [[1gvu\|1gvu]], [[1gvv\|1gvv]], [[1gvw\|1gvw]], [[1gvx\|1gvx]], [[1od1\|1od1]], [[1oex\|1oex]], [[2er0\|2er0]], [[2er6\|2er6]], [[2er7\|2er7]], [[2er9\|2er9]], [[3er3\|3er3]], [[3er5\|3er5]], [[4ape\|4ape]], [[4er1\|4er1]], [[4er2\|4er2]], [[4er4\|4er4]], [[5er1\|5er1]], [[5er2\|5er2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5o\|1e5o]], [[1e80\|1e80]], [[1e81\|1e81]], [[1e82\|1e82]], [[1eed\|1eed]], [[1ent\|1ent]], [[1epl\|1epl]], [[1epm\|1epm]], [[1epn\|1epn]], [[1epo\|1epo]], [[1epp\|1epp]], [[1epq\|1epq]], [[1epr\|1epr]], [[1er8\|1er8]], [[1gkt\|1gkt]], [[1gvt\|1gvt]], [[1gvu\|1gvu]], [[1gvv\|1gvv]], [[1gvw\|1gvw]], [[1gvx\|1gvx]], [[1od1\|1od1]], [[1oex\|1oex]], [[2er0\|2er0]], [[2er6\|2er6]], [[2er7\|2er7]], [[2er9\|2er9]], [[3er3\|3er3]], [[3er5\|3er5]], [[4ape\|4ape]], [[4er1\|4er1]], [[4er2\|4er2]], [[4er4\|4er4]], [[5er1\|5er1]], [[5er2\|5er2]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oew RCSB], [http://www.ebi.ac.uk/pdbsum/1oew PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oew OCA], [http://pdbe.org/1oew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oew RCSB], [http://www.ebi.ac.uk/pdbsum/1oew PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1oew" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:59, 5 January 2015

OCA — Mon, 05 Jan 2015 16:59:40 GMT

←Older revision		Revision as of 16:59, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OEW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OEW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THR:THREONINE'>THR</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THR:THREONINE'>THR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SUI:(3-AMINO-2,5-DIOXO-1-PYRROLIDINYL)ACETIC+ACID'>SUI</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SUI:(3-AMINO-2,5-DIOXO-1-PYRROLIDINYL)ACETIC+ACID'>SUI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5o\|1e5o]], [[1e80\|1e80]], [[1e81\|1e81]], [[1e82\|1e82]], [[1eed\|1eed]], [[1ent\|1ent]], [[1epl\|1epl]], [[1epm\|1epm]], [[1epn\|1epn]], [[1epo\|1epo]], [[1epp\|1epp]], [[1epq\|1epq]], [[1epr\|1epr]], [[1er8\|1er8]], [[1gkt\|1gkt]], [[1gvt\|1gvt]], [[1gvu\|1gvu]], [[1gvv\|1gvv]], [[1gvw\|1gvw]], [[1gvx\|1gvx]], [[1od1\|1od1]], [[1oex\|1oex]], [[2er0\|2er0]], [[2er6\|2er6]], [[2er7\|2er7]], [[2er9\|2er9]], [[3er3\|3er3]], [[3er5\|3er5]], [[4ape\|4ape]], [[4er1\|4er1]], [[4er2\|4er2]], [[4er4\|4er4]], [[5er1\|5er1]], [[5er2\|5er2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5o\|1e5o]], [[1e80\|1e80]], [[1e81\|1e81]], [[1e82\|1e82]], [[1eed\|1eed]], [[1ent\|1ent]], [[1epl\|1epl]], [[1epm\|1epm]], [[1epn\|1epn]], [[1epo\|1epo]], [[1epp\|1epp]], [[1epq\|1epq]], [[1epr\|1epr]], [[1er8\|1er8]], [[1gkt\|1gkt]], [[1gvt\|1gvt]], [[1gvu\|1gvu]], [[1gvv\|1gvv]], [[1gvw\|1gvw]], [[1gvx\|1gvx]], [[1od1\|1od1]], [[1oex\|1oex]], [[2er0\|2er0]], [[2er6\|2er6]], [[2er7\|2er7]], [[2er9\|2er9]], [[3er3\|3er3]], [[3er5\|3er5]], [[4ape\|4ape]], [[4er1\|4er1]], [[4er2\|4er2]], [[4er4\|4er4]], [[5er1\|5er1]], [[5er2\|5er2]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oew RCSB], [http://www.ebi.ac.uk/pdbsum/1oew PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oew RCSB], [http://www.ebi.ac.uk/pdbsum/1oew PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: Cryphonectria parasitica]]		[[Category: Cryphonectria parasitica]]
	[[Category: Endothiapepsin]]		[[Category: Endothiapepsin]]
-	[[Category: Coates, L.]]	+	[[Category: Coates, L]]
-	[[Category: Cooper, J B.]]	+	[[Category: Cooper, J B]]
-	[[Category: Erskine, P T.]]	+	[[Category: Erskine, P T]]
-	[[Category: Gill, R S.]]	+	[[Category: Gill, R S]]
-	[[Category: Mall, S.]]	+	[[Category: Mall, S]]
-	[[Category: Myles, D A.A.]]	+	[[Category: Myles, D A.A]]
-	[[Category: Wood, S P.]]	+	[[Category: Wood, S P]]
	[[Category: Anisotropic refinement]]		[[Category: Anisotropic refinement]]
	[[Category: Aspartic proteinase mechanism]]		[[Category: Aspartic proteinase mechanism]]

OCA at 18:30, 28 September 2014

OCA — Sun, 28 Sep 2014 18:30:25 GMT

←Older revision		Revision as of 18:30, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1oew.~~png~~\|~~left~~\|200px]]	+	==ATOMIC RESOLUTION STRUCTURE OF NATIVE ENDOTHIAPEPSIN==
		+	<StructureSection load='1oew' size='340' side='right' caption='[[1oew]], [[Resolution\|resolution]] 0.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1oew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OEW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THR:THREONINE'>THR</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SUI:(3-AMINO-2,5-DIOXO-1-PYRROLIDINYL)ACETIC+ACID'>SUI</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5o\|1e5o]], [[1e80\|1e80]], [[1e81\|1e81]], [[1e82\|1e82]], [[1eed\|1eed]], [[1ent\|1ent]], [[1epl\|1epl]], [[1epm\|1epm]], [[1epn\|1epn]], [[1epo\|1epo]], [[1epp\|1epp]], [[1epq\|1epq]], [[1epr\|1epr]], [[1er8\|1er8]], [[1gkt\|1gkt]], [[1gvt\|1gvt]], [[1gvu\|1gvu]], [[1gvv\|1gvv]], [[1gvw\|1gvw]], [[1gvx\|1gvx]], [[1od1\|1od1]], [[1oex\|1oex]], [[2er0\|2er0]], [[2er6\|2er6]], [[2er7\|2er7]], [[2er9\|2er9]], [[3er3\|3er3]], [[3er5\|3er5]], [[4ape\|4ape]], [[4er1\|4er1]], [[4er2\|4er2]], [[4er4\|4er4]], [[5er1\|5er1]], [[5er2\|5er2]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oew RCSB], [http://www.ebi.ac.uk/pdbsum/1oew PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oe/1oew_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The X-ray structures of native endothiapepsin and a complex with a hydroxyethylene transition state analog inhibitor (H261) have been determined at atomic resolution. Unrestrained refinement of the carboxyl groups of the enzyme by using the atomic resolution data indicates that both catalytic aspartates in the native enzyme share a single negative charge equally; that is, in the crystal, one half of the active sites have Asp 32 ionized and the other half have Asp 215 ionized. The electron density map of the native enzyme refined at 0.9 A resolution demonstrates that there is a short peptide (probably Ser-Thr) bound noncovalently in the active site cleft. The N-terminal nitrogen of the dipeptide interacts with the aspartate diad of the enzyme by hydrogen bonds involving the carboxyl of Asp 215 and the catalytic water molecule. This is consistent with classical findings that the aspartic proteinases can be inhibited weakly by short peptides and that these enzymes can catalyze transpeptidation reactions. The dipeptide may originate from autolysis of the N-terminal Ser-Thr sequence of the enzyme during crystallization.

-	~~{{STRUCTURE_1oew\| PDB=1oew \| SCENE= }}~~	+	Atomic resolution analysis of the catalytic site of an aspartic proteinase and an unexpected mode of binding by short peptides.,Erskine PT, Coates L, Mall S, Gill RS, Wood SP, Myles DA, Cooper JB Protein Sci. 2003 Aug;12(8):1741-9. PMID:12876323<ref>PMID:12876323</ref>

-	~~===ATOMIC RESOLUTION STRUCTURE OF NATIVE ENDOTHIAPEPSIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12876323}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1oew]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1OEW OCA].~~	+

	==See Also==		==See Also==
	*[[Pepsin\|Pepsin]]		*[[Pepsin\|Pepsin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012876323<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Cryphonectria parasitica]]		[[Category: Cryphonectria parasitica]]
	[[Category: Endothiapepsin]]		[[Category: Endothiapepsin]]

OCA at 13:46, 20 October 2012

OCA — Sat, 20 Oct 2012 13:46:51 GMT

←Older revision		Revision as of 13:46, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1oew]] is a 1 chain structure ~~of [[Pepsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEW OCA].	+	[[1oew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEW OCA].

	==See Also==		==See Also==