1ole - Revision history

OCA at 07:14, 25 August 2021

OCA — Wed, 25 Aug 2021 07:14:50 GMT

←Older revision		Revision as of 07:14, 25 August 2021
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	<StructureSection load='1ole' size='340' side='right'caption='[[1ole]]' scene=''>		<StructureSection load='1ole' size='340' side='right'caption='[[1ole]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1OLE FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OLE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ole FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1ole PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ole ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ole FirstGlance], [https://www.ebi.ac.uk/pdbsum/1ole PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ole ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:50, 20 November 2019

OCA — Wed, 20 Nov 2019 18:50:40 GMT

←Older revision		Revision as of 18:50, 20 November 2019
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	==MODEL OF RAT ALPHA4BETA2 NICOTINIC RECEPTOR==		==MODEL OF RAT ALPHA4BETA2 NICOTINIC RECEPTOR==
-	<StructureSection load='1ole' size='340' side='right' caption='[[1ole]]' scene=''>	+	<StructureSection load='1ole' size='340' side='right'caption='[[1ole]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OLE FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OLE FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Le Novere]]		[[Category: Le Novere]]

OCA at 07:59, 15 February 2018

OCA — Thu, 15 Feb 2018 07:59:50 GMT

←Older revision		Revision as of 07:59, 15 February 2018
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OLE FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OLE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ole FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ole PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ole FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ole PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ole ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:33, 11 February 2016

OCA — Thu, 11 Feb 2016 09:33:55 GMT

←Older revision		Revision as of 09:33, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==MODEL OF RAT ALPHA4BETA2 NICOTINIC RECEPTOR==		==MODEL OF RAT ALPHA4BETA2 NICOTINIC RECEPTOR==
	<StructureSection load='1ole' size='340' side='right' caption='[[1ole]]' scene=''>		<StructureSection load='1ole' size='340' side='right' caption='[[1ole]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Le Novere]]		[[Category: Le Novere]]

OCA at 21:21, 10 September 2015

OCA — Thu, 10 Sep 2015 21:21:33 GMT

←Older revision		Revision as of 21:21, 10 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ole" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:32, 6 January 2015

OCA — Tue, 06 Jan 2015 07:32:26 GMT

←Older revision		Revision as of 07:32, 6 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OLE FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OLE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ole FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ole PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ole FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ole PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:30, 28 September 2014

OCA — Sun, 28 Sep 2014 17:30:02 GMT

←Older revision		Revision as of 17:30, 28 September 2014
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-	~~{{Theoretical_model}}~~	+	==MODEL OF RAT ALPHA4BETA2 NICOTINIC RECEPTOR==
		+	<StructureSection load='1ole' size='340' side='right' caption='[[1ole]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OLE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ole FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ole PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We constructed a three-dimensional model of the amino-terminal extracellular domain of three major types of nicotinic acetylcholine receptor, (alpha7)5, (alpha4)2(beta2)3, and (alpha1)2beta1gammadelta, on the basis of the recent x-ray structure determination of the molluscan acetylcholine-binding protein. Comparative analysis of the three models reveals that the agonist-binding pocket is much more conserved than the overall structure. Differences exist, however, in the side chains of several residues. In particular, a phenylalanine residue, present in beta2 but not in alpha7, is proposed to contribute to the high affinity for agonists in receptors containing the beta2 subunit. The semiautomatic docking of agonists in the ligand-binding pocket of (alpha7)5 led to positions consistent with labeling and mutagenesis experiments. Accordingly, the quaternary ammonium head group of nicotine makes a pi-cation interaction with W148 (alpha7 numbering), whereas the pyridine ring is close to both the cysteine pair 189-190 and the complementary component of the binding site. The intrinsic affinities inferred from docking give a rank order epibatidine > nicotine > acetylcholine, in agreement with experimental values. Finally, our models offer a structural basis for potentiation by external Ca2+.

-	~~[[Image~~:~~1ole~~.~~png\|left\|200px]]~~	+	Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites.,Le Novere N, Grutter T, Changeux JP Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3210-5. Epub 2002 Feb 26. PMID:11867716<ref>PMID:11867716</ref>

-	~~{{STRUCTURE_1ole\| PDB=1ole \| SCENE= }}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	==~~=MODEL OF RAT ALPHA4BETA2 NICOTINIC RECEPTOR===~~	+	== References ==
-		+	<references/>
-	~~{{ABSTRACT_PUBMED_11867716}}~~	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:011867716<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Le Novere]]		[[Category: Le Novere]]

OCA: Protected "1ole" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 09:20:40 GMT

Protected "1ole" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:20, 21 October 2012

OCA at 09:20, 21 October 2012

OCA — Sun, 21 Oct 2012 09:20:37 GMT

←Older revision		Revision as of 09:20, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1ole.png\|left\|200px]]		[[Image:1ole.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1ole\| PDB=1ole \| SCENE= }}		{{STRUCTURE_1ole\| PDB=1ole \| SCENE= }}

	===MODEL OF RAT ALPHA4BETA2 NICOTINIC RECEPTOR===		===MODEL OF RAT ALPHA4BETA2 NICOTINIC RECEPTOR===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11867716}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11867716 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11867716}}		{{ABSTRACT_PUBMED_11867716}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLE OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11867716~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011867716</ref><references group="xtra"/>
	[[Category: Le Novere]]		[[Category: Le Novere]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:08:36 2010''

OCA at 05:08, 8 April 2010

OCA — Thu, 08 Apr 2010 05:08:37 GMT

←Older revision		Revision as of 05:08, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1ole.png\|left\|200px]]

-	The ~~entry 1OLE~~ is ~~a Theoretical Model titled 'MODEL OF RAT ALPHA4BETA2 NICOTINIC RECEPTOR'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1ole", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1ole\| PDB=1ole \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===MODEL OF RAT ALPHA4BETA2 NICOTINIC RECEPTOR===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:52:~~14 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_11867716}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11867716 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11867716}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLE OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:11867716</ref><references group="xtra"/>
		+	[[Category: Le Novere]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:08:36 2010''