1opg - Revision history

OCA at 05:49, 17 April 2024

OCA — Wed, 17 Apr 2024 05:49:30 GMT

←Older revision		Revision as of 05:49, 17 April 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1opg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OPG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1opg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OPG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1opg OCA], [https://pdbe.org/1opg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1opg RCSB], [https://www.ebi.ac.uk/pdbsum/1opg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1opg ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1opg OCA], [https://pdbe.org/1opg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1opg RCSB], [https://www.ebi.ac.uk/pdbsum/1opg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1opg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IGHG1_MOUSE IGHG1_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1opg ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1opg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Cell surface receptors called integrins mediate diverse cell adhesion phenomena through recognition of the sequence arginine-glycine-aspartic acid (RGD) present in proteins such as fibronectin and fibrinogen. Platelet aggregation in hemostasis is mediated by the binding of fibrinogen to the gpIIb/IIIa integrin. The OPG2 antibody binds the gpIIb/IIIa receptor and acts as a ligand mimic due to the presence of an arginine-tyrosine-aspartic acid (RYD) sequence in the CDR3 loop of the heavy chain. The RYD loop and side chains are ordered in the 2.0-A resolution crystal structure of the Fab fragment from this antireceptor antibody. Moreover, the RYD loop assumes two clearly defined conformations that may correspond to the orientations of the loop in the free state or bound to integrin. This molecule will serve as a tool for understanding protein-integrin recognition in platelet aggregation and other RGD-mediated cell adhesion interactions.
-
-	Crystal structure of the OPG2 Fab. An antireceptor antibody that mimics an RGD cell adhesion site.,Kodandapani R, Veerapandian B, Kunicki TJ, Ely KR J Biol Chem. 1995 Feb 3;270(5):2268-73. PMID:7836460<ref>PMID:7836460</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1opg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 30:		Line 24:
	*[[Sandbox 20009\|Sandbox 20009]]		*[[Sandbox 20009\|Sandbox 20009]]
	*[[3D structures of human antibody\|3D structures of human antibody]]		*[[3D structures of human antibody\|3D structures of human antibody]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ely~~, K R~~]]	+	[[Category: Ely KR]]
-	[[Category: Kodandapani, R]]	+	[[Category: Kodandapani R]]
-	[[Category: Veerapandian, B]]	+	[[Category: Veerapandian B]]
-	~~[[Category: Cell adhesion molecule]]~~	+
-	~~[[Category: Immunoglobulin~~]]	+

OCA at 09:19, 8 September 2021

OCA — Wed, 08 Sep 2021 09:19:29 GMT

←Older revision		Revision as of 09:19, 8 September 2021
Line 3:		Line 3:
	<StructureSection load='1opg' size='340' side='right'caption='[[1opg]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1opg' size='340' side='right'caption='[[1opg]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1opg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1OPG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1opg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OPG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1opg OCA], [~~http~~://pdbe.org/1opg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1opg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1opg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1opg ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1opg OCA], [https://pdbe.org/1opg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1opg RCSB], [https://www.ebi.ac.uk/pdbsum/1opg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1opg ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 28:		Line 28:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Sandbox 20009\|Sandbox 20009]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:43, 20 November 2019

OCA — Wed, 20 Nov 2019 18:43:04 GMT

←Older revision		Revision as of 18:43, 20 November 2019
Line 1:		Line 1:

	==OPG2 FAB FRAGMENT==		==OPG2 FAB FRAGMENT==
-	<StructureSection load='1opg' size='340' side='right' caption='[[1opg]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1opg' size='340' side='right'caption='[[1opg]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1opg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OPG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1opg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OPG FirstGlance]. <br>
Line 25:		Line 25:
	</div>		</div>
	<div class="pdbe-citations 1opg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1opg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Ely, K R]]		[[Category: Ely, K R]]
	[[Category: Kodandapani, R]]		[[Category: Kodandapani, R]]

OCA at 07:52, 15 February 2018

OCA — Thu, 15 Feb 2018 07:52:45 GMT

←Older revision		Revision as of 07:52, 15 February 2018
Line 1:		Line 1:
		+
	==OPG2 FAB FRAGMENT==		==OPG2 FAB FRAGMENT==
	<StructureSection load='1opg' size='340' side='right' caption='[[1opg]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1opg' size='340' side='right' caption='[[1opg]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1opg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OPG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1opg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OPG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1opg OCA], [http://pdbe.org/1opg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1opg RCSB], [http://www.ebi.ac.uk/pdbsum/1opg PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1opg OCA], [http://pdbe.org/1opg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1opg RCSB], [http://www.ebi.ac.uk/pdbsum/1opg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1opg ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 9:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/1opg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/1opg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1opg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 25:
	</div>		</div>
	<div class="pdbe-citations 1opg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1opg" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Antibody\|Antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:18, 11 September 2015

OCA — Fri, 11 Sep 2015 16:18:20 GMT

←Older revision		Revision as of 16:18, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1opg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OPG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1opg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OPG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1opg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1opg RCSB], [http://www.ebi.ac.uk/pdbsum/1opg PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1opg OCA], [http://pdbe.org/1opg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1opg RCSB], [http://www.ebi.ac.uk/pdbsum/1opg PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1opg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:19, 6 January 2015

OCA — Tue, 06 Jan 2015 08:19:54 GMT

←Older revision		Revision as of 08:19, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1opg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OPG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1opg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OPG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1opg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1opg RCSB], [http://www.ebi.ac.uk/pdbsum/1opg PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1opg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1opg RCSB], [http://www.ebi.ac.uk/pdbsum/1opg PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ely, K R.]]	+	[[Category: Ely, K R]]
-	[[Category: Kodandapani, R.]]	+	[[Category: Kodandapani, R]]
-	[[Category: Veerapandian, B.]]	+	[[Category: Veerapandian, B]]
	[[Category: Cell adhesion molecule]]		[[Category: Cell adhesion molecule]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

OCA at 00:07, 29 September 2014

OCA — Mon, 29 Sep 2014 00:07:15 GMT

←Older revision		Revision as of 00:07, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1opg.~~png\|left~~\|200px]]	+	==OPG2 FAB FRAGMENT==
		+	<StructureSection load='1opg' size='340' side='right' caption='[[1opg]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1opg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OPG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1opg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1opg RCSB], [http://www.ebi.ac.uk/pdbsum/1opg PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/1opg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cell surface receptors called integrins mediate diverse cell adhesion phenomena through recognition of the sequence arginine-glycine-aspartic acid (RGD) present in proteins such as fibronectin and fibrinogen. Platelet aggregation in hemostasis is mediated by the binding of fibrinogen to the gpIIb/IIIa integrin. The OPG2 antibody binds the gpIIb/IIIa receptor and acts as a ligand mimic due to the presence of an arginine-tyrosine-aspartic acid (RYD) sequence in the CDR3 loop of the heavy chain. The RYD loop and side chains are ordered in the 2.0-A resolution crystal structure of the Fab fragment from this antireceptor antibody. Moreover, the RYD loop assumes two clearly defined conformations that may correspond to the orientations of the loop in the free state or bound to integrin. This molecule will serve as a tool for understanding protein-integrin recognition in platelet aggregation and other RGD-mediated cell adhesion interactions.

-	~~{{STRUCTURE_1opg\| PDB=1opg \| SCENE= }}~~	+	Crystal structure of the OPG2 Fab. An antireceptor antibody that mimics an RGD cell adhesion site.,Kodandapani R, Veerapandian B, Kunicki TJ, Ely KR J Biol Chem. 1995 Feb 3;270(5):2268-73. PMID:7836460<ref>PMID:7836460</ref>

-	~~===OPG2 FAB FRAGMENT===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_7836460}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1opg]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA].~~	+

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:007836460<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ely, K R.]]		[[Category: Ely, K R.]]

OCA at 20:13, 20 October 2012

OCA — Sat, 20 Oct 2012 20:13:58 GMT

←Older revision		Revision as of 20:13, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1opg]] is a 2 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA].	+	[[1opg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA].

	==See Also==		==See Also==

OCA: Protected "1opg" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 09:49:38 GMT

Protected "1opg" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:49, 27 July 2012

OCA at 09:49, 27 July 2012

OCA — Fri, 27 Jul 2012 09:49:37 GMT

←Older revision		Revision as of 09:49, 27 July 2012
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-	{{Seed}}
	[[Image:1opg.png\|left\|200px]]		[[Image:1opg.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1opg\| PDB=1opg \| SCENE= }}		{{STRUCTURE_1opg\| PDB=1opg \| SCENE= }}

	===OPG2 FAB FRAGMENT===		===OPG2 FAB FRAGMENT===

-
-	<!--
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	{{ABSTRACT_PUBMED_7836460}}		{{ABSTRACT_PUBMED_7836460}}

	==About this Structure==		==About this Structure==
-	~~1OPG~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA].	+	[[1opg]] is a 2 chain structure of [[Antibody]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA].
		+
		+	==See Also==
		+	*[[Antibody\|Antibody]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~7836460~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:007836460</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ely, K R.]]		[[Category: Ely, K R.]]
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	[[Category: Veerapandian, B.]]		[[Category: Veerapandian, B.]]
	[[Category: Cell adhesion molecule]]		[[Category: Cell adhesion molecule]]
-		+	[[Category: Immunoglobulin]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 03:35:44 2009''~~	+