1oqc - Revision history

OCA at 05:49, 17 April 2024

OCA — Wed, 17 Apr 2024 05:49:42 GMT

←Older revision		Revision as of 05:49, 17 April 2024
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	<StructureSection load='1oqc' size='340' side='right'caption='[[1oqc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1oqc' size='340' side='right'caption='[[1oqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oqc]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1OQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oqc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OQC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FAD:FLAVIN~~-~~ADENINE+DINUCLEOTIDE'>FAD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ALR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1oqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqc OCA], [~~http~~://pdbe.org/1oqc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1oqc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1oqc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1oqc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqc OCA], [https://pdbe.org/1oqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oqc RCSB], [https://www.ebi.ac.uk/pdbsum/1oqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oqc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ALR_RAT ALR_RAT]] FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Within the mitochondrial intermembrane space, participates in a chain of disulfide exchange reactions with MIA40, that generate disulfide bonds in a number of resident proteins with twin Cx3C and Cx9C motifs. May have a function in liver regeneration and spermatogenesis.<ref>PMID:8058770</ref>	+	[https://www.uniprot.org/uniprot/ALR_RAT ALR_RAT] FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Within the mitochondrial intermembrane space, participates in a chain of disulfide exchange reactions with MIA40, that generate disulfide bonds in a number of resident proteins with twin Cx3C and Cx9C motifs. May have a function in liver regeneration and spermatogenesis.<ref>PMID:8058770</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oqc ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oqc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The crystal structure of recombinant rat augmenter of liver regeneration (ALRp) has been determined to 1.8 A. The protein is a homodimer, stabilized by extensive noncovalent interactions and a network of hydrogen bonds, and possesses a noncovalently bound FAD in a motif previously found only in the related protein ERV2p. ALRp functions in vitro as a disulfide oxidase using dithiothreitol as reductant. Reduction of the flavin by DTT occurs under aerobic conditions resulting in a spectrum characteristic of a neutral semiquinone. This semiquinone is stable and is only fully reduced by addition of dithionite. Mutation of either of two cysteine residues that are located adjacent to the FAD results in inactivation of the oxidase activity. A comparison of ALRp with ERV2p is made that reveals a number of significant structural differences, which are related to the in vivo functions of these two proteins. Possible physiological roles of ALR are examined and a hypothesis that it may serve multiple roles is proposed.
-
-	The crystal structure of augmenter of liver regeneration: A mammalian FAD-dependent sulfhydryl oxidase.,Wu CK, Dailey TA, Dailey HA, Wang BC, Rose JP Protein Sci. 2003 May;12(5):1109-18. PMID:12717032<ref>PMID:12717032</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1oqc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Rose, J P~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Wang, B C~~]]	+	[[Category: Rose JP]]
-	[[Category: ~~Wu,~~ C K]]	+	[[Category: Wang B-C]]
-	[[Category: ~~Alr]]~~	+	[[Category: Wu C-K]]
-	~~[[Category: Helix~~-~~turn-helix]]~~	+
-	~~[[Category: Liver regeneration]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Sulfhydryl oxidase~~]]	+

OCA at 07:13, 9 December 2020

OCA — Wed, 09 Dec 2020 07:13:25 GMT

←Older revision		Revision as of 07:13, 9 December 2020
Line 1:		Line 1:

	==The crystal structure of augmenter of liver regeneration: a mammalian FAD dependent sulfhydryl oxidase==		==The crystal structure of augmenter of liver regeneration: a mammalian FAD dependent sulfhydryl oxidase==
-	<StructureSection load='1oqc' size='340' side='right' caption='[[1oqc]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1oqc' size='340' side='right'caption='[[1oqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oqc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1OQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oqc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1OQC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ALR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ALR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1oqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqc OCA], [http://pdbe.org/1oqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oqc RCSB], [http://www.ebi.ac.uk/pdbsum/1oqc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oqc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1oqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqc OCA], [http://pdbe.org/1oqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oqc RCSB], [http://www.ebi.ac.uk/pdbsum/1oqc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oqc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Rose, J P]]		[[Category: Rose, J P]]
	[[Category: Wang, B C]]		[[Category: Wang, B C]]

OCA at 07:52, 15 February 2018

OCA — Thu, 15 Feb 2018 07:52:53 GMT

←Older revision		Revision as of 07:52, 15 February 2018
Line 1:		Line 1:
		+
	==The crystal structure of augmenter of liver regeneration: a mammalian FAD dependent sulfhydryl oxidase==		==The crystal structure of augmenter of liver regeneration: a mammalian FAD dependent sulfhydryl oxidase==
	<StructureSection load='1oqc' size='340' side='right' caption='[[1oqc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1oqc' size='340' side='right' caption='[[1oqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ALR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ALR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqc OCA], [http://pdbe.org/1oqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oqc RCSB], [http://www.ebi.ac.uk/pdbsum/1oqc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqc OCA], [http://pdbe.org/1oqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oqc RCSB], [http://www.ebi.ac.uk/pdbsum/1oqc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oqc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oq/1oqc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oq/1oqc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oqc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:12, 11 September 2015

OCA — Fri, 11 Sep 2015 10:12:28 GMT

←Older revision		Revision as of 10:12, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1oqc' size='340' side='right' caption='[[1oqc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1oqc' size='340' side='right' caption='[[1oqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oqc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oqc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OQC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ALR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ALR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oqc RCSB], [http://www.ebi.ac.uk/pdbsum/1oqc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqc OCA], [http://pdbe.org/1oqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oqc RCSB], [http://www.ebi.ac.uk/pdbsum/1oqc PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1oqc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Rose, J P]]		[[Category: Rose, J P]]
	[[Category: Wang, B C]]		[[Category: Wang, B C]]

OCA at 14:58, 25 December 2014

OCA — Thu, 25 Dec 2014 14:58:33 GMT

←Older revision		Revision as of 14:58, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oqc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OQC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oqc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OQC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ALR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ALR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oqc RCSB], [http://www.ebi.ac.uk/pdbsum/1oqc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oqc RCSB], [http://www.ebi.ac.uk/pdbsum/1oqc PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ALR_RAT ALR_RAT]] FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Within the mitochondrial intermembrane space, participates in a chain of disulfide exchange reactions with MIA40, that generate disulfide bonds in a number of resident proteins with twin Cx3C and Cx9C motifs. May have a function in liver regeneration and spermatogenesis.<ref>PMID:8058770</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Rose, J P.]]	+	[[Category: Rose, J P]]
-	[[Category: Wang, B C.]]	+	[[Category: Wang, B C]]
-	[[Category: Wu, C K.]]	+	[[Category: Wu, C K]]
	[[Category: Alr]]		[[Category: Alr]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]

OCA at 00:07, 29 September 2014

OCA — Mon, 29 Sep 2014 00:07:22 GMT

←Older revision		Revision as of 00:07, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1oqc.~~png~~\|~~left~~\|200px]]	+	==The crystal structure of augmenter of liver regeneration: a mammalian FAD dependent sulfhydryl oxidase==
		+	<StructureSection load='1oqc' size='340' side='right' caption='[[1oqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1oqc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OQC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ALR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oqc RCSB], [http://www.ebi.ac.uk/pdbsum/1oqc PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oq/1oqc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of recombinant rat augmenter of liver regeneration (ALRp) has been determined to 1.8 A. The protein is a homodimer, stabilized by extensive noncovalent interactions and a network of hydrogen bonds, and possesses a noncovalently bound FAD in a motif previously found only in the related protein ERV2p. ALRp functions in vitro as a disulfide oxidase using dithiothreitol as reductant. Reduction of the flavin by DTT occurs under aerobic conditions resulting in a spectrum characteristic of a neutral semiquinone. This semiquinone is stable and is only fully reduced by addition of dithionite. Mutation of either of two cysteine residues that are located adjacent to the FAD results in inactivation of the oxidase activity. A comparison of ALRp with ERV2p is made that reveals a number of significant structural differences, which are related to the in vivo functions of these two proteins. Possible physiological roles of ALR are examined and a hypothesis that it may serve multiple roles is proposed.

-	~~{{STRUCTURE_1oqc\| PDB=1oqc \| SCENE= }}~~	+	The crystal structure of augmenter of liver regeneration: A mammalian FAD-dependent sulfhydryl oxidase.,Wu CK, Dailey TA, Dailey HA, Wang BC, Rose JP Protein Sci. 2003 May;12(5):1109-18. PMID:12717032<ref>PMID:12717032</ref>

-	~~===The crystal structure~~ of ~~augmenter of liver regeneration: a mammalian FAD dependent sulfhydryl oxidase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12717032}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1oqc]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1OQC OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012717032<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Rose, J P.]]		[[Category: Rose, J P.]]

OCA: Protected "1oqc" [edit=sysop:move=sysop]

OCA — Wed, 12 Dec 2012 21:55:17 GMT

Protected "1oqc" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:55, 12 December 2012

OCA at 21:55, 12 December 2012

OCA — Wed, 12 Dec 2012 21:55:13 GMT

←Older revision		Revision as of 21:55, 12 December 2012
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-	{{Seed}}
	[[Image:1oqc.png\|left\|200px]]		[[Image:1oqc.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1oqc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1oqc\| PDB=1oqc \| SCENE= }}		{{STRUCTURE_1oqc\| PDB=1oqc \| SCENE= }}

	===The crystal structure of augmenter of liver regeneration: a mammalian FAD dependent sulfhydryl oxidase===		===The crystal structure of augmenter of liver regeneration: a mammalian FAD dependent sulfhydryl oxidase===

		+	{{ABSTRACT_PUBMED_12717032}}

	==About this Structure==		==About this Structure==
-	~~1OQC~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQC OCA].	+	[[1oqc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQC OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12717032~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012717032</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Rose, J P.]]		[[Category: Rose, J P.]]
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	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Liver regeneration]]		[[Category: Liver regeneration]]
		+	[[Category: Oxidoreductase]]
	[[Category: Sulfhydryl oxidase]]		[[Category: Sulfhydryl oxidase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:39:14 2009''

OCA at 17:39, 17 February 2009

OCA — Tue, 17 Feb 2009 17:39:17 GMT

←Older revision		Revision as of 17:39, 17 February 2009
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-	[[Image:1oqc.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1oqc.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1oqc\| PDB=1oqc \| SCENE= }}		{{STRUCTURE_1oqc\| PDB=1oqc \| SCENE= }}

-	~~'''~~The crystal structure of augmenter of liver regeneration: a mammalian FAD dependent sulfhydryl oxidase~~'''~~	+	===The crystal structure of augmenter of liver regeneration: a mammalian FAD dependent sulfhydryl oxidase===

-
-	==Overview==
-	The crystal structure of recombinant rat augmenter of liver regeneration (ALRp) has been determined to 1.8 A. The protein is a homodimer, stabilized by extensive noncovalent interactions and a network of hydrogen bonds, and possesses a noncovalently bound FAD in a motif previously found only in the related protein ERV2p. ALRp functions in vitro as a disulfide oxidase using dithiothreitol as reductant. Reduction of the flavin by DTT occurs under aerobic conditions resulting in a spectrum characteristic of a neutral semiquinone. This semiquinone is stable and is only fully reduced by addition of dithionite. Mutation of either of two cysteine residues that are located adjacent to the FAD results in inactivation of the oxidase activity. A comparison of ALRp with ERV2p is made that reveals a number of significant structural differences, which are related to the in vivo functions of these two proteins. Possible physiological roles of ALR are examined and a hypothesis that it may serve multiple roles is proposed.

	==About this Structure==		==About this Structure==
-	1OQC is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQC OCA].	+	1OQC is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQC OCA].

	==Reference==		==Reference==
-	~~The crystal structure of augmenter of liver regeneration: A mammalian FAD-dependent sulfhydryl oxidase., Wu CK, Dailey TA, Dailey HA, Wang BC, Rose JP, Protein Sci. 2003 May;12(5):1109-18.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12717032 12717032]~~	+	<ref group="xtra">PMID:12717032</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Single protein]]
	[[Category: Rose, J P.]]		[[Category: Rose, J P.]]
	[[Category: Wang, B C.]]		[[Category: Wang, B C.]]
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	[[Category: Liver regeneration]]		[[Category: Liver regeneration]]
	[[Category: Sulfhydryl oxidase]]		[[Category: Sulfhydryl oxidase]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 04~~:09:~~19 2008~~''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:39:14 2009''

OCA at 01:09, 3 May 2008

OCA — Sat, 03 May 2008 01:09:20 GMT

←Older revision		Revision as of 01:09, 3 May 2008
Line 1:		Line 1:
	[[Image:1oqc.gif\|left\|200px]]		[[Image:1oqc.gif\|left\|200px]]

-	~~{{Structure~~	+	<!--
-	~~\|PDB= 1oqc \|SIZE=350\|CAPTION=~~ <~~scene name='initialview01'>1oqc</scene>, resolution 1.80Å~~	+	The line below this paragraph, containing "STRUCTURE_1oqc", creates the "Structure Box" on the page.
-	~~\|SITE= <scene name='pdbsite=CTA:Putative+Catalytic+Site'>CTA</scene>~~, ~~<scene name='pdbsite=CTB:Putative+Catalytic+Site'>CTB</scene>~~, ~~<scene name='pdbsite=CTC:Putative+Catalytic+Site'>CTC</scene> and <scene name='pdbsite=CTD:Putative+Catalytic+Site'>CTD</scene>~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>~~	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	~~\|ACTIVITY=~~	+	or leave the SCENE parameter empty for the default display.
-	~~\|GENE= ALR~~ (~~[http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]~~)	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_1oqc\| PDB=1oqc \| SCENE= }}
-	~~\|RELATEDENTRY=~~	+
-	\|~~RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol~~=1oqc ~~FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id~~=~~1oqc OCA], [http://www.ebi.ac.uk/pdbsum/1oqc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oqc RCSB]</span>~~	+
-	}}	+

	'''The crystal structure of augmenter of liver regeneration: a mammalian FAD dependent sulfhydryl oxidase'''		'''The crystal structure of augmenter of liver regeneration: a mammalian FAD dependent sulfhydryl oxidase'''
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	[[Category: Wang, B C.]]		[[Category: Wang, B C.]]
	[[Category: Wu, C K.]]		[[Category: Wu, C K.]]
-	[[Category: ~~alr~~]]	+	[[Category: Alr]]
-	[[Category: ~~helix~~-turn-helix]]	+	[[Category: Helix-turn-helix]]
-	[[Category: ~~liver~~ regeneration]]	+	[[Category: Liver regeneration]]
-	[[Category: ~~sulfhydryl~~ oxidase]]	+	[[Category: Sulfhydryl oxidase]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:09:19 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Mar 30 22~~:48:48 2008''	+